Understanding PHI and PSI Angles, Ramachandran Plots, & Newman Projections

This video was created using models, images, and inspiration from the Proteopedia page: The Ramachandran Principle Phi (φ) and Psi (ψ) Angles in Proteins
proteopedia.org/wiki/index.ph...
REFERENCES:
• Ramachandran, G.N.; Ramakrishnan, C.; Sasisekharan, V. (1963). "Stereochemistry of polypeptide chain configurations". Journal of Molecular Biology. 7: 95-9.
• Prilusky J, Hodis E, Canner D, Decatur W, Oberholser K, Martz E, Berchanski A, Harel M, Sussman JL. Proteopedia: A status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol. 2011 Apr 23. PMID:21536137 doi:10.1016/j.jsb.2011.04.011

[@_jeena]

There's no way I'd have grasped the concept of these torsion angles if it weren't for this video. I owe you my life, no jokes.

[@gg025]

im glad im not the only one

[@chakubanga1]

Hahahaha. NO Comments. Otherwise the list will get longer 😂😂😂😂

[@scruffymakaveli6870]

Criminally underrated video. You are awesome.

[@stellyd3752]

Dr G N Ramachandran would have been so delighted to see your video if he was still amidst us. He did an amazing discovery and I have tried reading Lehninger, Voet to truly grasp the concept of phi and psi and no book could have done more justice to his contribution than your animated video. Heartfelt thanks.

[@gyaneshshukla1946]

The best Ramachandran plot explaination on the internet.

[@dmajumdar2059]

This is the best video on dihedral angles out there!

[@rabrojonel]

I truly did not understand phi/psi angles and Ramachandran plots until watching this video. It was really helpful, thanks!

[@mimosveta]

I don't think those who wrote my book understood them either. like, at no point did they clarify that 6 atoms were co-planar, which to me seems kinda crucial...

[@ogunoluwamayowa4749]

You always have a way of explaining things in an awesome way

[@marahsaad9047]

Great job, this video allowed me to understand what I have been not understood for 3 years now.

[@trixstandflipped]

Fantastic video with awesome visualizations. Thanks!

[@goncalosoares8420]

been reading my ptts for more than an hour and understood more from these 10 minutes . . .

[@jhankargarg7327]

Both the video and the link provided in description is very helpful Thank you for making my concept clear. It was so confusing earlier

[@astrobiojoe7283]

This is the best video on dihedral angles!

[@yazzydrazzy]

What an amazing video!!! Thank you so much

[@divyanshdixit933]

Thank you for this, I'll be forever grateful 💓

[@anirbanbhowmik1416]

Thank you very much for this video! I might have never figured out what these dihedral angles phi and psi actually mean from those textbook descriptions. You know, they should really suggest something like a student should refer to a good KZbin video for a better understanding, sometimes. And, I don't think not many people understand this concept clearly (even those who've been teaching this). Thank you very much! ❤️✨

[@sathyamurthys9855]

THANK YOU FOR THE VIDEO MAKER AND THE PROTEOPEDIA FOR PROVING SUCH DETAILED EXPLANATION

[@sudippattanayek6760]

You have done an excellent presentation.

[@rehabalsaleh166]

Amazing! Thanks a lot! This definitely helped.

[@mathiasverbeke9817]

A great visualization, thanks!

[@Clockworkbio]

Oh you KNOW it's a good day when there's a new Molecular Memory tutorial!

[@adhoccerswings]

VERY clear video, thanks! You'd think "basic" stuff like phi and psi would be difficult to forget but apparently not. My mnemonic; "NCC phi psi"; phi N-CC, psi NC-C. Middle C being the alpha carbon, of course - kinda intuitive and easy to remember since N -> C and "phi psi" is in alphabetical order (h before s; phi before psi)

[@MolecularMemory]

Thanks for sharing your mnemonic!

[@adwaitdighe4342]

cool!...h before s 🤣🤣

[@SherKhan0122]

Brilliant video. Thanks!

[@rajatkumarparida4542]

thanks a lot for the amazing visualization, and this is helpful to me......

[@jdmccool1]

You do such a great job at visualization that it would be awesome if you could make a video series around group theory. Symmetry is so hard to visualize and I feel you would do an awesome job!

[@gabrielqin9687]

Hi, is there any recommendation for group theory? I am a math-beginner for a biology major, but currently I need to deal with Euclidean group in molecular symmetry.

[@franklinpulikkottil7826]

Amazing! Concise and understandable ☺️ Thanks a lot. And for the proteiopedia link

[@jessicalv6442]

AMAZING!!!!! Thanks!!!

[@johnman1626]

Really really osum explanation great work

[@Ash-vl5ph]

Amazing video!!

[@ishakashyap6974]

So so thankful to you...

[@levydo8051]

This saved me from hours struggling understanding phi and psi angles

[@VenusAndMoon]

this video saved my life, thxxxx ❤❤❤❤❤

[@doctorumar1700]

excellent PLEASE KEEP THIS CONTINUE

[@simonlo2532]

Great video!!!!

[@Theabok853]

Excellent video and explanation

[@ericmartz9100]

Really well done!

[@herrmanselcher1632]

Beautiful, thank you

[@shafiurrahaman3396]

Incredibly helpful video on these dihedral angles, i for one really struggled to understand phi and psi from static 2D images - (for me they seemed to always be 180 in diagrams!). As soon as the image rotated in 3D space it all clicked and the clock diagrams were a nice touch as well for keeping track.

[@sayanghosh123]

Great explanation, Thank Youuu

[@jacktietjen]

Fantastic!!!

[@felixbaez9439]

Excelent video!

[@jamesbean9396]

So damn clear! appreciate

[@marioncaramel2415]

THANK YOU SO MUCH !

[@syedjamal3262]

Great job

[@thex5772]

Thank you soooo much. I subbed

[@Thinker-gd8ck]

Thanks for sharing!

[@tanushri4236]

Wowww 😍

[@mahvishathar6483]

Thank you .

[@infinightsky53]

Thank you so much

[@tamilbiology5078]

Dr Gn Ramachandran is from my state tamilnadu , India

[@Hyumifu]

thank you so much!!!!!

[@divyarana3637]

lovely

[@soumyaartz8912]

Thank you

[@rimplekour3882]

Well done

[@jkg6491]

From a native speaker, his name is pronounced " Rama-Chunn-Drun/Dran". Also thank you, great video yet again

[@tandelchandni1273]

yeah thank you

[@HydroZxZInferno]

I wonder if you would be interested in speaking at an event my university is going to hold in connection with the UK Biochemical Society for the students. I have always found your pymol videos to be extremely well explained and clear! please reply if this is something you'd be interested in. Best, Will

[@kgranalysis1052]

Good video and

[@siddheshshewade7063]

we are saying that at particular values of phi and psi we have to look down in ramchandran plot and we will get an idea of its secondary structure but the plot u displayed is for alanine so if there is a peptide solely made up of alanine only then it can be true but if we are having variety of other amino acids in our peptide then how can we surely say that at those values corresponding will be the secondary structure. I mean the plot would have to change in that case

[@hansenyang4014]

Hello I am learning this outside of the textbook for research. Can I ask why the substituents on the nitrogen are 180 degrees to each other? Shouldn't the nitrogen atom also have a lone pair so the substituents have to be 120 degrees or less apart? If this is a convention in some textbooks can someone explain the logic? Thanks very much. Edit: I think I just figured it out. Since the nitrogen is in resonance with the carbonyl, it does not have a lone pair and the N atom is essentially planar with only two substituents. It looks very cursed to have two groups 180 to each other in a Newman projection.

[@shujahat_8c]

Why do we study this

[@Helpnote9987]

To figure out the specific rotation of the N-c alpha and c-c alpha bonds of amino acids residues that forms peptide bonds .

[@aswinikumar8503]

❤️

[@mimosveta]

we people are collectively insane...

[@meghashreeguha99]

03:15

[@namy7506]

It's Raaaaama-'cha'-ndran, cha as in cherish. Not Sharon. Raamachandran Great video tho❤

[@AmruMagdy]

I truly did not understand phi/psi angles and Ramachandran plots until watching this video. It was really helpful, thanks!

[@asiakhatoon954]

Thank you