Upgrading the Physiological Relevance of Human Brain Organoids

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Recorded on 06/13/2024. [Show ID: 39456]
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[@ibomirzp8769]

Fantastic talk, I wonder, if you can facilitate growth by other signals, for example with chemical signals

[@jacobvandijk6525]

@ 0:06 JUST READ THIS AND YOU KNOW UCTV IS TRYING TO FOOL YOU ... AGAIN. WHAT A TERRIBLE WAY TO INTRODUCE A HARD WORKING PERSON. DISGUSTING!!!

[@quicknumbercrunch8691]

Thank you for this lecture. I study the workings of the brain on a functional level, and wish to learn more about the cellular level. I shall watch this lecture at least a second time, probably a third as well. At the start I was taken by the quote from Ramon Y Cajal. I have discovered how the brain creates thoughts, and in doing so came to understand some aspects of the brain and the universe that should be obvious, but are not because they are counterintuitive. For example, all perceptions are perceptions of neural network activity. The matter and energy comprising our environments do not look like anything. The color read is the neural activity resulting from electromagnetic energy striking the retinas and evoking a response. Red then is the neural activity of the sensory cortex interacting with the motor cortex in patterns that over time evoked Dopamine or some other neurotransmitter wiring together. The mechanism is as material as the sensors that open the grocery store doors as one approaches. Here Cajal statement is proven correct since we know something about the retinas responding to electromagnetic energy, so the universe contains such energy. Hearing is the neural activity stimulated by compression waves striking the inner ear drums and setting forth cochlear movements sending neural transmissions to sensory cortical areas which in turn interact with parts of the motor cortex to create a note like middle C. Brain activity shows that the universe has matter striking matter setting up compression waves. Then there are somewhere between zero and an infinite number of universe activities that we are not equipped to perceive. Are they mysteries or does one have to ask a question about something for it to be a mystery?

[@jacobvandijk6525]

Make a website and tell your stories there, please.

[@quicknumbercrunch8691]

@@jacobvandijk6525 Are you a troll?

[@johngrundowski3632]

Great over view and infomation. Thanks for this program♾️📚

[@sylvain75]

Britney Spears for President !