Using Artificial Intelligence to Detect Antibiotic Resistance

Susceptible or resistant? When it comes to treating bacterial infections, the answer is crucial.
In the clinic, microbiologists test bacterial isolates from patients to determine whether they are susceptible or resistant to a given antibiotic.
The downside: clinical testing methods can take up to 2 days, during which patients may be treated with suboptimal antibiotics.
But artificial intelligence could help. Scientists are finding ways to use Ai and machine learning to develop testing tactics that are easy, accurate-and quick.
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Featured Study
Zagajewski A., et al. Deep learning and single-cell phenotyping for rapid antimicrobial susceptibility detection in Escherichia coli. Communications Biology, Nov. 14, 2023. www.nature.com/articles/s4200...
Additional Sources
Andersson D., et al. Mechanisms and clinical relevance of bacterial heteroresistance. Nature Reviews Microbiology, June 24, 2019. www.nature.com/articles/s4157...
Bhattacharyya R.P., et al. Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination. Nature Medicine, Nov. 25, 2019. www.nature.com/articles/s4159...
Ding Y., et al. Artificial intelligence-assisted point-of-care testing system for ultrafast and quantitative detection of drug-resistant bacteria. SmartMat, May 10, 2023. onlinelibrary.wiley.com/doi/f...
Hu X., et al. Novel Clinical mNGS-Based Machine Learning Model for Rapid Antimicrobial Susceptibility Testing of Acinetobacter baumannii. Journal of Clinical Microbiology, April 6, 2023. journals.asm.org/doi/10.1128/...
Maheshwari R. What is Deep Learning AI? Forbes Advisor, April 3, 2023. www.forbes.com/advisor/in/bus...
Pascucci M., et al. AI-based mobile application to fight antibiotic resistance. Nature Communications, Feb. 19, 2021. www.nature.com/articles/s4146...
Prinzi, A. Updating Breakpoints in Antimicrobial Susceptibility Testing. Asm.org, Dec. 13, 2023. asm.org/Articles/2022/Februar...
Stokes J.M., et al. A Deep learning Approach o Antibiotic Discovery. Cell, Feb. 20, 2020. doi.org/10.1016/j.cell.2020.0...
Wang, S., et al. A Practical Approach for Predicting Antimicrobial Phenotype Resistance in Staphylococcus aureus Through Machine Learning Analysis of Genome Data. Frontiers in Microbiology, March 2, 2022. www.frontiersin.org/articles/...
Wong F., et al. Discovery of a structural class of antibiotics with explainable deep learning. Nature, Dec. 20, 2023. www.nature.com/articles/s4158...
Vasala A., et al. Modern Tools for Rapid Diagnostics of Antimicrobial Resistance. Frontiers in Cellular and Infection Microbiology. July 15, 2020. doi.org/10.3389%2Ffcimb.2020....
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[@alexanderzagajewski7921]

First author on the deep learning paper here, thank you for a thorough yet accessible review of our work! Great job!

[@allysonvach704]

I love this! Working with AST testing for years, I'm happy to see some promising developments in reducing turn around time! One of our biggest complaints from clinicians is how long the test takes and the short stability period of microbiology specimens. I would be interested to see if this could be implemented in the physician offices that usually send to reference labs. With the quick TAT, you could prescribe patients the most effective antibiotics same day.

[@alexanderzagajewski7921]

First author of the paper here. 😀This is certainly the project goal, deploying this in primary care settings to reduce AMR burden and improve surveillance - we're trying to get there as soon as we can!

[@pradipgawande9324]

Great information.

[@MicrobioAbhi]

Thank you so much 😊

[@wailsalah1362]

Thank you for your updates and we still working on

[@oghmp8649]

Very interesting and innovative method!

[@harounalboani189]

That's amazing we appreciate 🙏

[@DDAABBSS2000]

All this science, study, and development, but humans are still fighting each other, unfortunately.. I am sad about this

[@HatiKeseorangan]

the scientist is not figuring out the smart way to use light or electron but actually they already exist in our life, but the riddle and mystery is solve... i just wanna know the real mystery how PROTEIN become conciseness by talking each other using this quantum energy.... but i think i get it now.... huhu...