Low Dose Naltrexone (LDN) - Mechanism of Action

Low Dose Naltrexone (LDN) - Mechanism of Action
LDN is used for chronic diseases, multiple sclerosis, autoimmune thyroid disease, and various cancers. Let's review its mechanism of action.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Feb. 2 2022
Naltrexone | Naltrexone - Bupropion Combination - Mechanism of Action
psychscenehub....
IL-6 in Inflammation, Immunity, and Disease - PMC
www.ncbi.nlm.n...
Ventral tegmental area - Wikipedia
en.wikipedia.o...
Mesolimbic pathway - Wikipedia
en.wikipedia.o...
Striatum - Wikipedia
en.wikipedia.o...
Frontiers | Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors | Immunology
www.frontiersi...

[@TheGodWalk]

I’m so glad I stumbled on this video. I’ve been using LDN for 4 months now, since I went to see a new functional doctor for mast cell activation dysfunction (MCAS). It was an absolute godsend, especially as I had covid in June and then again in December last year. I’m also epileptic. My histamines were flaring all the time and I couldn’t get a good night’s sleep. From the first night I took LDN, everything calmed down and I sleep like a baby now. I’m also so much more motivated and content in every way. I have a much better tolerance to exercise. It’s an amazing drug for anyone battling with nervous system or autoimmune disease.

[@ScottDieken]

Wow i hope it has the same effect on sleep for me. I can't sleep without xanax, and my doctor won't prescribe it.

[@beatricejacobowitz7264]

May I ask what dose you started at and what dose you found most helpful?

[@TheGodWalk]

@@beatricejacobowitz7264 I use 1.5mg at 21:00 every night.

[@leannshort2211]

I think a leaky gut is also a very real issue. I am currently doing the GAPS nutritional protocol. I started it Jan 2022 but was only able to stay on it for a few months before going to a low histamine diet because I just couldn’t incorporate a lot of the homemade probiotic rich foods that the protocol requires. However I wish I had just stuck with it because all the low histamine diet did for me was continue to take out foods until I was down to eating 8 foods! I should’ve pushed through SLOWLY the histamine intolerance issues. I have currently restarted with GAPS and have been on it for a month. So far so good, just going very slowly this time. The GAPS main source of fixing leaky gut is meat stock, (chicken broth) to seal and heal your gut lining, homemade probiotic foods, lots of high quality animal fats, tallow, lard, ghee. Now, I also got Covid in April 2021. I have long Covid and have been suffering since. I had all sorts of weird health issues for years prior to contracting Covid. Severe Congestion, diagnosed chronic, sinusitis and allergic rhinitis. This only got worse and more symptoms appeared after getting Covid. I have been taking Ivermectin for 3 weeks and am adding LDN today. I hope it helps! It’s a long prescription but hoping after I finish it, symptoms don’t return!

[@lynnjohnson651]

What dose did you take of Naltrexone.

[@tonyaaberli5145]

Thank you for this. I have Gulf War Illness and have inflammation of my joints but all blood tests have been normal. I don’t think I have ever had my IL6 checked. I’m trying LDN now praying it helps.

[@Total_Body_Fitness_USA]

I used LDN when I contracted COVID in June 2020 and again in January 2022 and my immune system ran like a fine tuned Swiss Watch. I also used Sulforaphane which stops IL-6 as well. Used a couple of other things, but this last go around with COVID my low grade fever only lasted 36 hours or so. Had the sniffles for a few more days but no big deal. I'm 57 and not vaccinated and no underlying medical issues. LDN works and it has countless health benefits! Excellent video explaining the details!

[@Shasha8674]

LDN helps block gluten which you can do yourself, but hidden gluten is harder to avoid which LDN helps being a low dose. People may not realize gluten is hurting them. Those are the ones who infections may hurt more since gluten hurts the gut lining so less nutrients absorb like Zn/Mg. This vax/infection may lower Zn/Mg and many are not taking supplements or are gluten free which helps them absorb more nutrients. LDN helps the gut lining, by blocking gluten from making the immune system go down and do autoimmune attacks.

[@jeanniehorneman6965]

How did you get LDN? Where, from who?

[@Total_Body_Fitness_USA]

@@auggie1790 I had COVID in June 2020 and low grade fever of 99-100.8 for 12 days along with loss of sense of smell and taste for 4 of those days. Also had back pain that was pretty significant for about a week. I woke up on the 13th day with no fever and no symptoms except for fatigue that lasted another week or so. I am in the health field as well studying functional integrative medicine for the last 8 years and clinical exercise physiology for the last 27 years. I've been studying this virus since the day it hit the USA. There are other supplements I took that prevented replication and decreased viral load so I'm sure that had something to do with it. However, the LDN works very well too.

[@Total_Body_Fitness_USA]

@@jeanniehorneman6965 It's prescribed by a physician. Most physicians who practice holistic, integrative, or functional medicine will prescribe it for you. Search online for LDN and you might find one who can prescribe it through telemedicine.

[@Shasha8674]

@@jeanniehorneman6965 LDN can be from any doctor who is open to giving it. Alternative doctors or psychiatrists or regular doctors can give it. It is from a compounding pharmacy and sent to the person. It is about $1 a day and is like s miracle to help health if taken before bed. Some take it earlier in the day since at night it may give too much energy. It helps heal the gut lining from gluten and helps the immune system not attack from gluten. It may cause some constipation, but people can drink more water or adjust the dose. There is a group on Facebook about LDN.

[@aleenarae89]

Im on day 3 praying this makes me feel half normal again after long covid made me feel like a shell of myself. Staying positive and knowing i will be better soon

[@thegrymwolf6360]

Did you find LDN helpful?

[@maxine1019]

It stopped my long-COVID and NOH research also confirms efficacy. Works on many other immune and autoimmune diseases. Doesn’t work in all cases. Could be dosing or other issues, but it’s definitely worth a try and the side effect profile is minimal and can usually be handled by cutting the dose and then re-upping as your body gets used to it, I personally experience vivid dreams for a few days, one of the known side effects. No nightmares so I enjoyed myself and got good night sleep

[@louisebriere753]

It was a miracle drug for my long covid issues since december 2020. I was desperate to find someting other than antidepressant for the pain. Antidepressant were causing me more brain fog and weight gain. LDN took a while to kick in for the pain, but I felt better after a week! I had to lower the starting dose as I wad having headaches. But even at a low dose of .05, it was working. I'm thankful that my doctors are open minded enough to prescribe it even if it needs to be compounded.

[@ThisBloke760]

Hang in there, some have quick relief others takes longer. I’m starting week 5 and initially I felt better but stupidly did too much too soon so I crashed. I’m expecting it’ll take a few months before I feel real results. Continue resting and pacing, don’t push yourself

[@sami-pe1no]

​@@ThisBloke760 IAM 2 months on currently at 4.5 mg for the last 10 Days.. Can't say that I feel any benefits.... Wondering if I need to increase or do 4 days on and then 3 days off.

[@Sungodv]

LDN needs to be more widely prescribed to patients from compounding pharmacies. I have taken LDN for over a decade with no side effects

[@samanthatorres9517]

Did you take it consistently without stopping? What happens when you stop?

[@Sungodv]

@@samanthatorres9517 Yes. I did stop here in the last few years, but have gone back to it to help with long Covid (china's SARS CoV2)

[@Bloomkorth2]

I have been taking LDN for chronic inflammation for about 6 months now and I just wanna give this drug a big hug, too. Wonderful to listen to your explanation of the mechanism of action!! Thank you, Dr. Bean! 🤗

[@vickydittfield9822]

I loved it also,when you said that a big hug would be in order were LDN a person. It’s a life enhancer for me,in providing a block of energy,less pain and cognitive assistance ❤🎉😊

[@lisamarie73100]

I'm starting at 4.5 mg tonight for rheumatoid arthritis and horrible inflammation. How long did it take for you to know it was working for you. How long should I give it before trying another drug?

[@seanvogel8067]

⁠@@lisamarie73100, I can give you one perspective. I've been looking into this for sometime now, and some people say it starts working the first day, but I see people saying try it for up to two months. For a neurological damage but I think it takes longer. Also, if you have unwanted side effects, you can try a lower dose. 4.5 is kind of in the middle of the range 0.5 to about 6 mg. Some people even go lower than 0.5. Please treat this as only one small source of information.

[@stephaniekelly3223]

All of your discussions are great, but I had to comment on this one- outstanding teaching!! The way you presented this makes it so clear and easy to understand. Your visual drawings and verbal analogies such as "... imagine you are in a room half filled with water..." help to clarify concepts which may not be so easy to conceptualize. Not sure if teaching has been something you have worked on or it just came naturally, but either way we are lucky to have access to your wonderful teaching- thank you!!

[@kerrymartin7557]

He is a pretty talented guy!

[@altheeaself76]

He is awesome 👏

[@ernairvine6810]

YES totally in agreeance with that input!!

[@Tinky456]

I agree. Really great. Who can prescribe me, my GP is ignorant of these things. I can't even get a rheumatology referral!!

[@mammajeanine]

Hi Dr. Been, these lectures are such a gift. It's like being back in college without the looming, staggering, debt. I just bought you 3 coffees, wish I could do more. Don't lose faith in the power of honestly and transparently disseminating these studies for us. Keep on keeping on!

[@stefrzchicago]

I am on LDN and have been for 3 years. Hasn't helped me throughout this COVID and long COVID journey that I know of.

[@lawrenbordelon4012]

I just started LDN yesterday for long covid! I’m TWO YEARS OUT, This video made me shed tears of JOY!!!! THANK YOU!!! I do have some questions, I wish I could ask..

[@adanguerra6351]

How are things coming along?

[@marlac.876]

I’m finally trying it for long haul - how are you doing in it

[@michelleg6]

My ldn is on the way & I’m so excited. I keep checking the mail. I have Fibromyalgia & Hashimotos among other things! Hoping for some relief 🥲

[@lindadobszay8272]

Hi Michelle, how did it go? I'm starting with 1.5 tonight for Hashimoto's and fatigue.

[@evanwilliamson3602]

I’m 28 years of age (male), I have ASD, ME/CFS, chronic pain and just been diagnosed with Rheumatoid Arthritis. LDN and high dose CBD is my first go-to.

[@nikhilreddy6476]

How much cbd

[@alexisflowers4440]

I’m 23 and just started taking it for RA. Do you take anything else for RA?

[@evanwilliamson3602]

@@nikhilreddy6476 - 500mg CBD ISOLATE (250mg x2 daily). I’d recommend the isolate as it’s cheaper and pure CBD. Remember it’s fat soluble, so mix in some oil like hempseed oil or olive oil.

[@evanwilliamson3602]

@@alexisflowers4440 - Hope it helps. No I don’t take anything else apart from “weed” and CBD of course.

[@alexisflowers4440]

@@evanwilliamson3602 same. also curcumin and boswellia. look into those and good luck. does your onset of ra have anyhting to do with you getting covid?

[@williamblaney3316]

I suffer from ptsd and fibro, have for over a decade. Nothing else touched the fibro pain. One low dose the first night my pain has been reduced an incredible amount. It is very strange but welcome compared to the other drugs they give

[@georgiamackinlay5706]

Fascinating! I actually use LDN to treat CRPS and its the only thing that helps. Drs very reluctant to orescribe it, thankfully my GP is amazing and looked at the studies I had and let me try it

[@nathanhyde2079]

All you had to do was tell them you wanted to cut down on drinking alcohol.

[@miaisheree]

LDN saved my life!!!

[@DrZ-notthatone]

Yes the pain gate theory - the brain is amazing!

[@AlpacaRenee]

A friend told me about this presentation…amazing, brilliant and easy to understand. THANK YOU SO MUCH! I was just diagnosed with Hashi’s. Learning so much! God bless you!

[@Shasha8674]

LDN is awesome help to help the immune system work right. LDN helps the gut lining by blocking gluten's harm, but is a low dose so trying to eat gluten free may help the immune system etc..

[@sherrieh2062]

Thank you Dr Been for this discussion. I’ve been on LDN for over 3 1/2 years, as prescribed by my alternative doctor, for fibromyalgia. It has to be made by a compounding pharmacy because LDN used for fibro is really used as an off-label drug, since it’s not actually FDA approved for autoimmune diseases and fibromyalgia. I have to pay a LOT for a 1-month supply x’s 12 (p/year). Maybe that has changed in the last few years…I will have to check with my doctor to see if I am able to get it through a regular pharmacy now. 🥰

[@gilbertosilva3869]

Research Co Q10 (ubiquinol) for fibromyalgia.

[@elizabethguenther7319]

My internist listened to me when I tried to be in a clinical trial for LDN and couldn't get in. He taught me to grind up one 50 mg. pill, then add 30 ml of water. So I am now tiered up to 5ml per night. I use an oral plastic syringe marked with lines to draw out the mixture I keep in fridge, using a brown tint cough syrup bottle. One pill of Naltrexone 50mg= 6 doses for the LDN. Less than 10 bucks/month.

[@monicaweaver4522]

Maizie - Yes, check on the price again, perhaps with a different compounding pharmacy. I use Belmar Pharmacy in CO and mail order three months at a time and in the past 5 years have never paid more than approx $15/ mo. First couple of nights had very vivid dreams, not bad just bright, bizarre dreams then great results for fibromyalgia.

[@adyarym]

@@elizabethguenther7319 - Hi! And how about tolerance? Is it well tolerated?

[@geauxp]

@@elizabethguenther7319 Hey Elizabeth!! This is close to what I do.

[@angp2027]

So glad I found this video... I have been struggling with new onset autoimmunity and one of my providers will be trying me on this...im very excited to be trying it. I have been trying to do more research on it.

[@jaktag]

i love this as i have Multiple Sclerosis and had it for 30 years and theres a lot of people i know take low dose naltraxone for there MS with very good results,i keep thinking of trying it but i am a bit scared to take drugs.Its a case of it works very well for some and not at all for others.There is one lady i know of that was very ill and very disabled with her MS and when she started taking it she could live a normal life and her MS symptoms went away.

[@TheJoan48]

Since you know so many people who have had good results, why are you so afraid? It's not like you're inexperienced on this subject. The doctor said to start out with a tiny dose and not go up, or be in no hurry to go up because that could cause side effects and to increase the dose slowly if side effects develop, back off. It's not like a doctor wouldn't be watching you.. Seems like getting control of MS symptoms would be worth a shot. You'll never know if it works for you without trying.

[@jaktag]

@@TheJoan48 very true i think i am scared of taking it and it not working if you know what i mean.

[@BrandonGreenShow]

@@jaktag did you try it?

[@susantisdell1725]

Inflammation of body from pancreatitis, MS, ME, and Fibromyalgia which is neurological disorders that isn't fully understood by many Doctors. How does methadone or Naltrexone affect inflammation. I take Suldinac twice a day. Amyloid come from where? Liver disease? NFLD? I take vitamin D3 and zinc supplements calcium,magnesium, b complex.

[@ScottDieken]

methadone relives pain also but causes liver issues. u must be of methadone for a long time before using ldn ask doctor

[@andocobo]

Been taking LDN for a few months to help with long covid, it has helped a little - still working up to my target dose

[@retke922]

Do you have some side effects? And what dose do you take? Thanks for answering

[@xtian384]

@@retke922 I guess we'll never know

[@browneyedgirlFL67]

@Jongy Grangason have you reached your target dose? How are you doing?

[@AlexSelf-Help]

@Jongy did you have any sexual side effects while on LDN? Like weak orgasms/no joy, and much less sexual interest? Thank you!

[@simhifree2416]

Dr. I'm one of the users that took the wrong dose of LDN, causing the worst dreams. It was so horrible that I didn't want to go through the process of finding a better doze.

[@chrisshepherd828]

Most people that this happens to tend to take the LDN by 5pm eve, some earlier. I’ve been taking now for 5years and just adjusted the time of taking until my body adapted to it.

[@danielvarela5519]

I had this too but I thought it was because of the melatonin high dose?

[@princesssweetpea9205]

WOW... Thank You!!! I have taken LDN for a few years now, when it began to be tried for Fibromyalgia... I also happen to have Hashimotos and other conditions. THIS IS EYE OPENING! Te fact that the benefits can also come from immune system modulation. This is mind blowing. I am wondering if I should try to go up to 3 doses of the low dose per day???? I would be happy to be a scientific trial guina pig on that.

[@princesssweetpea9205]

Okay, I am taking 4.5, so three of those would be to much, and could actually diminish the benefit. Thanks!

[@AnnieOBrienAnnie]

Please don't do that. When you take the right dose for you (1.5mg-4.5mg range) it blocks the receptors for the shortest most optimal time. Then your body is tricked into tripling your endorphins and increasing OGF/Met enkephalin up to 12-15 fold. If you keep dosing you will block the receptors for an extended period not allowing this rebound effect and the rebound effect to take place so your body won't have time to rebound and increase endorphin and ogf production.

[@gordongroves8519]

Let us bow down and beg the FDA and CDC for our lives and our children's' lives

[@SMARTvoterWorld]

If maintaining high antibodies all the time is a bad thing is that not a risk from boosting?

[@katesnyder6415]

LDN doesn’t boost immunity

[@carrievieira5894]

Ty so much for this discussion. I’ve been thinking about trying this for chronic sx/AI. I did t understand the exact mechanisms until now. I will talk to a provider. Thanks again.

[@harveyhowson4639]

But why can’t we get it prescribed in the U.K. and why don’t rheumatologists know about it ?

[@877swissmiss]

So well explained, once again! 🙏🏻

[@erinhession]

This was very helpful info, thanks so much!

[@carolmaples7854]

When is it too late to try LDN for chronic disease? How long (roughly) would one use it to pause the immune system creating IL6?

[@xylmorph8297]

never too late. It may help stop progression or slow progression. Read more at ldn research trust

[@carlaveliz8475]

Excellent presentation and explanation . Thank you so much

[@Pmjs]

I have Psoriatic Arthritis on Cimzia have read IL 6 has a pathogenic role in PsA. I recently stopped Cimzia due to Dental Surgery next week. My PsA has flared up in 1wk . I inject Cimzia every 2wks.

[@angelasprayberry65]

Just prescribed LDN and very excited. My body has been stuck in a constant fight or flight mode due to childhood trauma, chronic inflammation and hopefully LDN will help with my ic pain. Will follow up..

[@bene7464]

Have autoimmune disorder just waiting for my LDN to get filled, fingers crossed 🤞🏻

[@dennisgarber]

Think about it. For example, when I was younger I found that I could eat 300-400 calories of lean meat, and not get hungry or think about food for 10 hours. Any fiber at the same calories bloated me and passed out of the stomach in 90 minutes, leaving me starving. My job was lifting 40 lb things all day and going up and down ladders. Thus, I learned that all plants were a waste of calories, because my goal, in the year 2000, was calorie counting to loose weight. So, a 1100 calorie day, cutting out foods with inadequate hunger satiation was a whole lot easier on a low carb diet. It is was also a lot easier to maintain the 60 lb in 6 month of weight loss. Hunger per calorie is the number one thing. For example, if you came out with a food that 100 calories stopped the hunger and gave all the energy you need for the next 24 hours, you would not compare a 1500 calorie diet of that food with 1500 calories of a balanced diet. That would be stupid. Just as stupid as this study. The idea of low carb is to keep the body burning fat, and not switch over to glucose burning beyond the glucose that the liver makes. It is also about keeping insulin low by zero carbs, or as low as possible. It is best to burn your own fat, which is why all diets can dip into a ketotic state. It is a matter of how much you are knocking yourself out of ketosis by eating sugar in any form, including carbs.. One diabetic doctor pointed out that he can make the thinnest person fat, by prescribing insulin.

[@DevineOne]

Many can't change a lifetime of eating habits unfortunately. Again there is a lot of dogma out there and people can't seem to get past that and educate themselves apart from yourself. I am also keto/carnivore. Never felt better and also experience the no hunger. I eat once or twice a day.

[@mattbellon828]

I've been a long hauler for 6 months. I did Dr. Patterson's cytokine panel and I have 7 markers high except for IL-6. Would LDN still be beneficial to take since my IL-6 is within normal range? And does it only target IL-6? Also they mentioned my T cells are washed out. Would this help with those as well? Thanks

[@sarahmcswan]

I'm so excited to start my LDN. Should arrive in a few days. I was diagnosed with MS in 2013. Fatigue and chronic pain since 2016. Then worst decision of my life!!! Got Lasiks in 2020. As of today 3/9/23. I'm still in pain from Lasik complications. For the past year and a half I have kept my ocular pain at a tolerable pain level using blood serum eye drops. Literally overnight beginning of January 2023 my eyes started hurting severely like right after Lasik surgery pre ast drops. Felt like I had sun tan lotion in my eyes 24/7. Pain in eyes non stop I wanted to kill myself Literally. I told my Neurologist about my severe increase in ocular pain and ge suggested LDN. Right now I'm keeping the pain again at a somewhat manageable pain level using Lotemax eye gel in conjunction with platelet rich plasma eye drops. And wearing moisture chamber goggles I had to buy for 200 dollars. I'm praying this LDN may help if only a little.

[@JuliePeterson-12345]

I’m so sorry you are going through this! Did you try LDN and if so, did it work?

[@CreativeEat]

Thank you for sharing your knowlege. I have taken ldn years ago and it has changed my life extremely positive. I also noticed an effect within a few hours with the first capsule of 1 mg. That's why I took it sometime in the morning because under all the enegy I couldn't sleep. Now and then I had auxh side effects like accelerated pulse / as if I had drunk too much coffee. In itself, as I said, it gave me new life. With currently, however, the effect disappeared. I have then first higher tosidrt on up to 3 mg. This brought no effect. On the contrary I had aif once more pain. Auh. at 1mg . Since I was aware of the effect mechanism, I had the idea to take less, so 0.5 mg. And lo and behold it worked again for a few weeks. At some point, however, more pain than before. Now I ask myself do you or someone else know something like that? And should I have dosed higher and or held out longer? That would really help me if someone could tell me something about it and I would be incredibly grateful :) Ps." I suffer from "Me/ Cfs" after an epstein barr infection 2008

[@devonseamoor]

Although Naltrexone helps to reduce MS symptoms, and improves quality of life, of wellbeing, the cause of the symptoms isn't addressed. As logic dictates, the unbalance in the physical system, nervous system, or tissue problems, the digestive system, may show itself by other symptoms. The body always tells us what's wrong, we only have to pay attention. I've known 4 women, most around 30, with MS, who all suffered from identity crisis, and became alienated from their bodies in a strange way. When we're not at home, burglars see their chance, see? The pain in my body tells me "You're not at home here".

[@karilockremwellness8123]

This was amazing! Thank you!

[@lynnewilley9464]

Wow great job ! Thanks!

[@withheart7662]

Are there blood tests that can identify the different toxic issues going on? Identify causes of chronic disease by bloodwork and symptom evidence.

[@christine21068]

Where can I find a prescriber to obtain this? No one locally will even consider trying it.

[@stefrzchicago]

Call your local Compounding pharmacy and ask if they can refer you to a few local doctors who prescribe LDN. I've found many great functional medicine doctors near me this way!

[@christine21068]

@@stefrzchicago Thank you!

[@kristin4840]

I tried taking this for my autoimmune and noticed I became VERY depressed. Is this common ?

[@chinogixxer7506]

I'm interested to see what responses you get... sorry you got depressed by the way. How long were you taking it? Did the depression go away if you stopped taking it?

[@Total_Body_Fitness_USA]

Take a lower dose. Start with 0.5mg and work up from there. It has countless health benefits. Some people can't tolerate it because it makes them too fatigued during the day. When this occurs it's most likely due to mitochondrial dysfunction. Get more sunlight and take a couple of supplements called MitoQ and MitoPure. Once the body compensates with the LDN you should actually become a happier person with a greater outlook on life. Best of luck!

[@kristin4840]

I was taking .5 for a month and then they increased it. I just became overwhelmed with sadness and at first , didn’t make the connection. Once I stopped taking it, I went back to my normal self. Tried again a few months later and had the same reaction. My autoimmune doesn’t bother me enough to take this stuff. I think I’m just sensitive to lots of medicines I’ve noticed. I’m doing the AIP diet now and that’s really helping. I hike every day in the sun also.

[@chinogixxer7506]

@@kristin4840 thank you. I appreciate it. Have had similar issues but never tried this. I love to hear new opinions though and I will look into AIP diet. I know for a fact I need to get out into the Sun and walk more

[@Shasha8674]

No gluten/dairy/soy/sugar/GMO/food with a label/heated oils..taking vitamins/good oils/minerals...probiotic/LDN..detoxing may help. LDN alone is not strong enough to block all the gluten a person may eat. Best is to try to eat 100% no gluten and let the LDN which is a low dose block what is in air/hidden in food etc.. Gluten is in wheat/barley/rye..oats/corn/rice. Rice is low in gluten. Wild rice has no gluten...is a grass.

[@Jamis714]

Thank you so much! if one has been on this medication for a long time would the production of IL6 make it so very hard to get off of that medication. And would ones vascular system be in halfway good shape due to the long time low il6

[@JaneSmith0709]

Good question.

[@skybox-101]

Sir, is the CD8t, the T cells that kill cancer cells? And does IL6 increase the CD8t? Don't we want CD8t to increase to kill more cancer cells? Are you saying LDN will lower the CD8t killer cells? Its seems we would want to increase killer T-Cells to kill cancer or tumors. A friend recently began ldn to hopefully help kill cancer.

[@Truth-4-Humanity]

Same question I have!

[@sprogovac]

Unfortunately, this is a sort of trade off of modulating the immune system. People with chronic overactive immune systems (eg allergies, autoimmune disorders) take medicines that downregulate their immune system which in turn predisposes them to certain cancers. When you up regulate your immune system, you run the risk of developing allergies and these same autoimmune disorders. However, someone would not take LDN for 'long COVID' for long periods of time, so it's not a big concern.

[@ggabbay0]

Make another change, then. Starve the cancer cells of carbs as well as you can.

[@HappyHealingTrain]

I wonder if one can take LDN with Fluvoxamine? I’m on 2 x 50 mg Fluvox and would love to add LDN. My Dr doesn’t really know…

[@annieoakley694]

I do. I've been on fluvoxamine for many years and Suboxone which has naloxone in it.

[@HappyHealingTrain]

@@annieoakley694 Thank you :)

[@PattyGehring]

Does the comment that LDN could completely eradicate Long covid assume that the patient takes the LDN for the remainder of their life? If not, how long would the eradication process take?

[@lawrenbordelon4012]

Same question..

[@michaelchapman7627]

Great question have either of you gotten an answer?

[@donnavogel7131]

Why is having high measles antibodies good (titers to a vaccine) but not good with foods or hashimotos? Are there different types of antibodies? Do you have a video on the differences or thoughts on antibodies?

[@Professional_Nobody]

I have ulcerative colitis and I’ve been told to try this treatment. Problem is, you can’t start it if you don’t have normal bowel movements. When the colitis hits, bowel movements become irregular. So the only time to start it is when I am 100 percent healthy and not suffering from the colitis…

[@ScottDieken]

Try sublingual. Where did you hear you can't start it with bowel issues. It does not fully absorb, but you get some, you get better it absorbs more or you adjust the dosage

[@akadee2986]

Thanks!

[@beatz3279]

I have started LDN for Chronic widespread pain, Fibro and CFS. It has made everything ten times worse. Wherever already hurt is intensified especially in upper back between shoulder blades and shoulder lower spine and right abdomen. I dont want to stop it as hoping what i have read is true thst you can be much worse before better as it can clear out dorment disease in body. Is this true as Im not sure if should be stopping as reacting to it or if its because system just more inflamed while it stimulates immune system to cleat out what has been causing long term illness. Any advice. Also the headaches are insane but more bearable than the inflammation im feeling in lung and heart chest area. Feels a bit like pneumonia type pain and inflammation. Im just hoping this is cause its sorting some stuff out in body and so to keep going with it and suck up the chronic inflammation and pain currently experiencing on 1.5mg of LDN.

[@care4teaching]

Did you keep with the ldn? If so, have you seen improvement in symptoms?

[@chetabird]

Ive had covid symptoms 2 mos, got pneumonia, and blood clot in my left lung. I Just got LDN 1.5mg. I saw your talk on flccc. I need to know how to take ldn. You said start w/ .5. So Im breaking open the 1.5 capsule to estimate .5, and taking that. You said if improvement in 1 week continue w the same. If no improvement, increase. So I could go to 1mg, up to 1.5? If improvement stay at .5, or should I eventually increase up to 1.5 even when I'm improving? How long should I take it? Should I continue w the blood thinner, been on it 20 days. Thank you!!

[@MrGirish1993]

Suppose I am suffering from long covid but don't have elevated IL-6, does LDN still help in that case?

[@momtazjee]

sir, I’ve recently been diagnosed with osteoporosis As well , forgot to mention.

[@MrSymbolic7]

So, is LDN by Prescription only and then you would need a educated Physician to prescribe it in the first place , not an easy task these Days , when they only go by what the I-Pad says to prescribe anyway !

[@DevineOne]

a person in my household got meningitis. The doctor required all of us to take 1 dose Ciprofloxacin 500mg . Since then I have had tinnitus about 1 month now. Would LDN help in this case?

[@ScottDieken]

Wow from one dose? Write that down somewhere so you do not ever take that antibiotic again. Let your doctor know

[@DevineOne]

@@ScottDieken yes, only one dose. It seems quite common after looking up and finding many others talking about their symptoms after.

[@LucyFre]

They say naltrexone is bad for liver?Perhaps in small dosage is not so bad?

[@MarkHarders-ss4zk]

Dr. I have *mild* brain fog from Covid 7 months ago. It,s present like a head ache, and want to clear. I have lessened to most your lecturs ang generally understand. I have bad Disc and take 50 MG of opiate for pain. Can you info suggest a likely solution to work w my doctor, as in your LDN lectur. Tks

[@cathiejoyyoung8349]

Thank you very much for this. I just got diagnosed with RA and am hopefully going to get some relief with LDN before going on MTX. I noticed you say that LDN should be started with steroids to break the cycle of inflammation. Do you have to take the combination?

[@jenniferwagner2929]

Hi there! Just curious if you ever got an answer to the question of using prednisone (steroid) at the start of ldn?

[@luxostucco2772]

Might be a silly question but could it help chronic back pain?

[@vibefrequencyable]

is there a test for overproduction of IL 6? does it cross or need to cross blood brain barrier as well?

[@hejjjj7210]

Can naltrexone defeat this feeling of having a mild fever without having a fever ? (long covid)

[@davep7456]

Sounds like hypothalamus problem but couldn’t hurt to try LDN for it

[@williamwattenbarger9180]

Anything on LDN for ankylosing spondylitis?

[@danmintern87]

Would like to know this also as I've just been diagnosed

[@kdzidoc]

Are you prescribing Q6H or QD or Q2D and what dose? 0.5mg-4mg?

[@joelbartlett5645]

I was just prescribed 50mg twice a day, after researching it I am going to reduce it to a LDN around 6mg a day, should I try for 6mg? that would be half of the 50 = 25 half of that 12.5 and then half of that 6.25 ... does that make sense. The Dr. who recommended it went over board

[@teresaring8049]

Can I take Naltrexone if I’m on the antidepressant Effexor. I feel desperate for help as I’m taking all the supplements recommended for long covid and Ivermectin but nothing is helping me feel better 😢

[@victorianalin5885]

I’ve been taking LDN for about 5-6 weeks (started 0,5mg working up to 1,5mg) but I feel like my brain fog is actually worse now… feeling better generally but my worst LC symptoms are neurological and definitely more pronounced after several weeks of Low LDN (I have MCAS so I always start low and slow)

[@tommyortiz6623]

Oh no LDN did not solve nuerological issues you had? What did you have? Nerve stabing random pains? That what I have nueritis is what they call it it’s bad. I was going try LDN. As an update I tried LDN with methyln blue as well as detoxing heavy metals and all is working

[@missysueanderson1338]

Many have reported that LDN takes months before they see improvement…and sometimes feel worse right out of the gate during titration.

[@faithf5846]

Personally I would keep the dose .5 mg. I cannot tolerate a higher dose but helps with my rheumatoid factor pain😊 Still works well on .5mg

[@timmyschannel5]

Helped me straight away , but I think I need to go on a higher dose as the lower does appears to have stopped

[@AlexSelf-Help]

did you have any sexual side effects while on LDN? Like weak orgasms/no joy, and much less sexual interest? Thank you!

[@Musika1321]

I have Gastroparesis but also Fibromyalgia. For the latter I take LDN and it appears to work but I read that LDN can slow stomach motility! Is this true and if so, should I stop the LDN? Thank you.

[@ScottDieken]

not a doctor but most doctors prescribe a laxative when prescribing any opiates. Senna is the favorite.

[@dianefarrell2343]

One more Really important question. If I am taking LDN, is it Ok to take Methalene Blue?

[@ryankittle3431]

It should be fine

[@superalien4781]

is it good for brain fog ?

[@pabloalatorre1728]

Does this work for alcohol use?

[@jcbanbury]

Oh come on

[@princesssweetpea9205]

QUESTION.... Would dose 4.5 twice a day be too much? THANKS!

[@stefrzchicago]

Yes too much. The standard dose is 4.5 daily

[@howardcalpas2322]

The Best time to take it is between 8 and 9 PM. Because the majority of endorphins are produced between 2 and 4 AM. The Ldn blocks endorphin production for 4 to 6 hours. When the Ldn wear's off the body reacts by tripling endorphin production and this modulate the immune system. Peace

[@gloglos100]

@@stefrzchicago that is only the arbitrary dose chosen by DrBihari back in 1985 as half way between 0 and 10mg. They knew zero of what DrBeen lectured about here, just opioids and endorphins. The UKLDN research institute still only considers the levo isomer which affects opioids and h3nce their max dose is 4.5 mg. And it’s point of maximum stimulation of the immune system and hence max reactions and also max immune modulation. A lot of pain people take 6 and over in the LDN range. I take 6 for asthma, one dose, had vegf attack on eyes while on steroids for 17 years and osteopenia and function of lungs reducing lungs by 70%. On 4.5 mg I had huge flooding mucus, so after looking at chart of isomer levo and dextrose isomer actions on dosing, took 6 mg and overnight the extreme flood of mucous stopped. 4.5mg was putting me into copd. I did not have the mucus problem before.

[@gloglos100]

@@howardcalpas2322 that’s because the LDN institute does not know about the dextro isomer which dr been talks about, whose effects are directly dose dependent, only the levo, the opioid receptor affecting isomer which has max effect at 4.5 then drops off. Stuck in 1985. . Peace.

[@calviv1]

@@howardcalpas2322 if it’s extended release like contrave will it still work

[@suryanarayanandorairaj131]

Can we use LDN twice a day

[@elainerobertson1988]

Keep researching - I believe you can. LDN Research KZbin have clips answering questions like this.

[@dengchensheng9279]

Hello Professor

[@framundajohnson2186]

Please help me. My 11 year old is on 50mg of Naltrexone and is suffering. He is autistic. From my research, he should have never been on that dose. Is that correct?

[@쉽다암치료-g5n]

3.5mg naltrexon

[@framundajohnson2186]

@@쉽다암치료-g5n should an autistic child ever be given 50mg????

[@쉽다암치료-g5n]

@@framundajohnson2186 3.5mg

[@framundajohnson2186]

@@쉽다암치료-g5n why would they ever give him 50mg?

[@쉽다암치료-g5n]

@@framundajohnson2186 i think they did not know. It was a big mistake.

[@bettyjeanpetrinovich7373]

Thank you for your thorough, complex, yet accessible explanation. When I started LDN for ME/CFS, it was like a low ceiling that was making me crouch all the time had been lifted. All the normal things I had been doing to optimize good health suddenly became effective, too. (No sugar, milk, wheat, industrial store-bought eggs, etc., good supplements, outdoor sunshine and fresh air, very gentle, limited exercise/ movement, etc.)

[@retke922]

Thanks for sharing! What dose do you take and for how long time?? Do you have any side effects? I do have ME/Cfs and fibromyalgia! And some kind of infection with flu symptoms.

[@taradrolma2774]

@@retke922 I have ME/CFS. I take an ultra low dose of LDN. There is a Facebook group LDN for people with ME/CFS and fibromyalgia and one for people with chronic disease and inflammation. Both are helpful. Dosing is extremely individual.

[@danielvarela5519]

@@retke922 I’ve been taking LDN for almost 2 months and I went from feeling like I’m gonna die, to I’m pretty much back to normal! 1mg a night for like a month and 2mg a night the second. I went off it and had only a few relapses and the strangest acne? Pimples. I’m just still having to deal with the high cholesterol situation? Covid does weird things to your body.. I’m 34 and have no underlying issues. I just wish I could have my children 6yrs old and 10 years old be on this, or something!? They have symptoms like me every day and doctors tell us we’re healthy??

[@virajdeshmukh9175]

@daniel valera you had long covid?

[@lauracowan100]

I feel that low ceiling! I'm about to get hold of LDN for my cfs/long covid

[@okthen9145]

Thank you doctor. The part of this lecture that talked about collagen overproduction really struck me. I ended up with ANA tests showing for Scleroderma (SCL70) as a post covid result. I had everything else as well - sore joints, sore muscles, fatigue, plus more. After going through 10 MD specialists an ND put me on LDN. I dealt with these long haul symptoms for 10 months before LDN was introduced. I am now a full year into my LDN regiment and my symptoms are so well controlled I sometimes think they're gone. Also, after a year and a half of high ANA test results the last test came back negative. Not sure if it's all thanks to LDN or LDN plus the other anti-inflammatories my ND has me on but either way I have improved.

[@xtian384]

so you never get off the medication??

[@prilby]

I had the EXACT SAME THING! positive ANA SCL-70 pain chronic fatigue. I already suffer with fibromyalgia. They also prescribed me LDN just started it. Hopefully it helps. I also take hydroxycloraquin and steroids for lupus which has helped some. I have been looking for others who got positive SCL-70 from Covid! So happy I found your comment

[@prilby]

P.s. my last ana came back negative as well. Ofcourse I had the more effective test done. The first two were done through labcorp but the last one my rheumatologist had done through Elissa which is more effective in testing for scleroderma

[@okthen9145]

@@xtian384 As long as you have autoimmune issues present you will need to treat them. Taking LDN is much better than taking chemo.

[@okthen9145]

@@prilby There are a few of us in my support groups. It's not unheard of at this point, unfortunately. I also had the ELISA test as well which indicated something outside of SCL. The Lab Corp constantly indicates SCL. In the end - more research will need to be done to determine if we're suffering from genetic triggered autoimmunity (disease) thanks to covid or if covid is somehow replicating an autoimmune response as a syndrome. I am at month 24 at this time of my longhaul hell. I am getting better but I can tell you I didn't bargain for longhaul to be two+ years and going.

[@battfamily435]

Been taking this 4.5 mg for the big C 5 years now and all is good. Thriving.

[@wheelzeightyone]

Thank you Dr Been. I am so glad you have shared this with the Cool Beens. I am immunocompromised and had suffered from Crohn's Disease for 8 years. I started using low dose Naltrexone about 2 years ago. I have had 95% healing including mucosal healing of my entire digestive system!! It has also brought me almost complete healing from Psoriasis. I have experienced no side effects. Compare that with the harsh side effects as the Doctor recommended prescription drugs. I simply dissolve one 50 mg tablet in water and so I can take 4.5mg before bedtime. Simple, effective and inexpensive. As Dr Been says it is a beautiful drug!!

[@thedevilsadvocate5210]

Do you have to go to the doctor to get this?

[@beatricejacobowitz7264]

Can I ask - how much water to dilute the 50mg naltrexone tablet. ?

[@AlexSelf-Help]

thank you! did you have any sexual side effects while on LDN? Like weak orgasms/no joy, and much less sexual interest? Thank you!

[@beckyharris347]

@@beatricejacobowitz7264I dissolve 50mg tablet in 50ml of distilled water. Then 1ml of solution gives 1mg of medication. 4.5ml of the solution will give 4.5mg of medication. That’s just how I do it.

[@rituparnsingh1725]

One of the best lectures ,I have attended. I know about LDN have intermittently used it. Stopped it ,but would now again use it. Basically what I understood is that LDN brings homeostasis to the system m And tries to reset it to factory made settings. That you food doctor. You are a voice of sanity in this cacophony. RESPECTS

[@NaveDelAmor]

Best advice is at the end -- how does it interact with other meds already being taken? Vit D also modulates immune system.

[@ME-hv9kx]

Some used Naltrexone for cancers …seems like a good medicine to help people with chronic disease.

[@michellewahl4756]

“Diseases of the soul are more dangerous and more numerous than those of the body. “Cicero

[@shubhamdahiya1677]

I’m worried mine are really of that kind

[@AnneGoggansQHHT]

I’ve been using LDN post Lyme and mold

[@DEEPAKVERMA-ul5cd]

Perhaps God has sent you on earth as His Messanger for such a period of Darkness as an illuminated pole of knowledge..

[@altheeaself76]

Question: Is it true that by overvaccinating and constantly having antibody soldiers running thru the blood stream could keep the immune system on alert for too long also? Thank you so much for all the lectures and work that you share.

[@ScottDieken]

yep

[@cfoster6804]

Yes, true.

[@drblaneyphysics]

I just learned LDN us used for lupus too. Best talk ever, thank you Dr. Been!!!

[@Stacylatchman]

Thank you so much for all you time and dedication to helping people with long covid and chronic illnesses. I got covid in March 2020 and have long covid symptoms up today. LDN has been on my list of medications to try and your explanation really made me understand how dangerous it is for our immune system to remain being activated for such a along time. It completely explains why my joint are only now starting to hurt so much and fatigue that never ends. I will definitely give LDN a try now. Thank you so much...

[@jhonybraavo]

Did you try ldn?

[@tammygravis1462]

I wish I knew all you did. If so, I'd been well so much sooner. Took me 1.5 years to figure out the vaccine destroyed my body. Day by day I'm coming back but what a devastation to my body. Thank you.

[@cespo77]

Are you taking LDN? Has it helped?

[@tammygravis1462]

Yes been taking it a couple years and it helps with pain a lot.@@cespo77

[@livia1256]

Have used this for my Hashimotos and it has worked tremendously for reducing my tpo antibodies

[@annakasprzak8371]

What is ur dosage and how did it takes for TPO to go down? Thanks!

[@georgemoller2206]

What a fantastic discussion with so many implications for many with autoimmune problems etc.

[@aremedyproject9569]

Can you please do a video on how Plaquenil works?

[@pennywittbrodtnear-deathpe6489]

He's done lots of videos on hydroxychloroquine. It's the same as plaquenil

[@CMoore8539]

As an ex-opiate addict and a sober alcoholic, maybe I should get on this medication.

[@ScottDieken]

yeah get a script for addiction and then compound it into smaller dosages. from what I have seen the larger doses won't work, why its called LDN. not HDN

[@lucyswannsunsafespace7313]

So glad to see this video! I was taking LDN back in 2010/11 for MS lesions. I had to stop taking it because doc wouldn’t prescribe any more. Mainly because I wouldn’t take the injections, I’m thinking. All those kick backs lol

[@danielvarela5519]

@@melodymelomaniac yes, it’s disgusting what the world has become or still is.. this is what it’s all about. Just people helping people. And spreading the truth. Love conquers all ❤️‍🩹

[@lucyswannsunsafespace7313]

Still taking no traditional MS treatments (injections, immunomodulators), yet MRI 2 weeks ago show no new lesions! In the 14 years since diagnosis, 24 since first almost certain MS symptom, NO progression! I’m convinced it was my diet that was making it worse, and I radically changed that since diagnosis. I only eat meals once a day, and a protein bar for brunch. I’m thinking eating whatever is fine, but very little of it. I basically “fast” most of the day every day. Wish I could say I’m feeling GREAT, but the damage has been done from lesions/scaring, so not likely to get rid of fatigue/temperature sensitivity/random muscle weakness, but I’ve learned how to manage and it’s not getting worse. LDN could potentially heal lesions, but not if I can’t get it. I’m at risk at the moment of losing the one thing that overcomes fatigue which is vyvanse, because my insurance doesn’t cover the one doc willing to prescribe and I’m racking up $150 bills every time I see her, every 3 months. That clinic has already sued me for past bill owed and I have to pay them. That’s been my life for many years now. It is what it is I guess.

[@danielvarela5519]

@@lucyswannsunsafespace7313 I heard that some people are getting LDN for as little as $15 a month!? Don’t give up! I know LDN helped me get back to feeling great again! I used it for 2 months.

[@charlesdavis7461]

When I used to jog, the endorphins would make even this depressed person feel great.

[@jac1161]

Yes, exercise doesn't do what it used to when you have long covid. Yyyyup. Was an active nurse, zumba instructor, hiker, skier, etc. Feel it....23 months.

[@charlesdavis7461]

@@jac1161 sorry, didn't mean to slight anyone with long covid just heard it spoke about for helping with depression I believe.

[@xander22m11]

Thank you for the great information Dr. I appreciate it so much

[@muinbear4702]

Thank you so much Dr been. Am going to approach doctors (again) armed with this information and see if I can finally get started on something to help break the cycle, having had LC since March 20 with many obvious symptoms pertaining to this pathway but no pro-active help. Just told nothing can be done & ivm not available yet nothing else suggested. I suggested it was mcas a year ago but wasn't heard. Just gave up. Meanwhile a year more of potential damage has been done. Bless you for all you do and have done, and I'm so pleased you and your family have recovered 🙏❤️ Well I didn't get any where! Told naltrexone only available in 50 mg. Now have the new omicron on top of LC. Struggling. On day 12. Left to suffer again. Don't know who to buy ivm or ldn from online. GP prescribed codeine for head pain which my body reacted badly to so am stuck taking paracetamol. Trying homeopathic remedies. Take high dose vit d and zinc. Complete lack of motivation to be pro active to treat covid in the uk. Left to your own devices unless unlucky enough to end up in hospital. They're not even debating ivm or other treatments. They're just apathetically waiting for the powers that be to tell them to do something. How can they let people suffer unnecessarily?? Without even trying to help?

[@ascendingwithrachellovell3239]

It only comes in a nasal spray in 4mg but not in a pill. I’m not sure if he covered that but that’s what we have in Canada so not sure if that helps you.

[@bigbugz2056]

You have to have a compounding pharmacy make the LDN for you. Make sure the pharmacy does not use the slow release form of naltrexone because you will not get the therapeutic benefits in the SR form.

[@muinbear4702]

@@bigbugz2056 thank you. I guess I will have to have a prescription from the doc for the pharmacy to make up and not sure they'll give me one. Will try. And also try to source a compounding pharmacy online.

[@youonlyliveonce6000]

What are the effects of LDN on blood clotting ? For example, if you have someone that's on a blood thinner, example eliquis. Is there literature to signify that LDN stabilizes blood clotting or makes it go up or go down, or doesn't work that way? Would appreciate a response and love your show! :-)

[@ΧαρηςΚαλογριδης-ξ7φ]

I'm interested too