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Vaccine Spike vs. SARS-COV-2 Spike
There has been a lot of discussion for the spike and ACE2 binding. I have recorded many talks on this topic as well. However, an important piece missing for us has been to understand the difference of the spike between the vaccine and the virus. Let's review these differences.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Nov. 17 2022
DrBeen: Medical Education Online
www.drbeen.com/
SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies | SpringerLink
link.springer.com/article/10....
SARS-CoV-2 structural features may explain limited neutralizing-antibody responses | npj Vaccines
www.nature.com/articles/s4154...
SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic | Signal Transduction and Targeted Therapy
www.nature.com/articles/s4139...
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen | PNAS
www.pnas.org/doi/10.1073/pnas...
An mRNA Vaccine against SARS-CoV-2 - Preliminary Report | NEJM
www.nejm.org/doi/full/10.1056...
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern | PNAS
www.pnas.org/doi/full/10.1073...
Frontiers | Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design
www.frontiersin.org/articles/...
Closing coronavirus spike glycoproteins by structure-guided design - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Prefusion Coronavirus Spike Proteins and Their Use | Technology Transfer
www.techtransfer.nih.gov/bund...
Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine - UT News
news.utexas.edu/2020/08/05/lo...
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets | eLife
elifesciences.org/articles/63646
Epitope - Wikipedia
en.wikipedia.org/wiki/Epitope