Restrictive Lung Diseases - Interstitial Pulmonary Fibrosis. Pathology, Clinical, Tests, Treatment

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This video presents the introduction to restrictive lung diseases. We will discuss:
Definition
Types
Extrapulmonary restrictive lung diseases
* Obesity
* Scoliosis
Pulmonary parenchymal restrictive lung diseases
* Idiopathic
* Autoimmune
* Granulomatous (Wagner's granulomatosis, Sarcoidosis)
* Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
* Other irritants
* Chronic infections (Tuberculosis)
Neuromuscular restrictive lung diseases
* Myasthenia gravis
* Diaphragm issues
* Polio
Cellular events/pathogenesis
* Damaged Type I Pneumocytes
* Hypertrophy of Type II Pneumocytes
* Irritated epithelium
* Irritated macrophages
* Apoptosis of epithelium
* Tissue damage leading to local inflammation and lung destruction/scaring.
* Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
* Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
* Fibroblasts overactivity resulting in more extracellular matrix and hardening.
* Epithelial-mesenchymal transformation.
* Smooth muscle proliferation.
* Respiratory interface thickening. Disrupted gaseous exchange.
Clinical:
Dry hacking cough
* Dyspnea
* Hypoxia
* Respiratory alkalosis
* Late inspiratory crackles
Abnormal chest X-Ray
* Reduced volume in chest X-Ray
* Lower lobes show more involvement and the reason why.
* Right heart failure/cor pulmonale
Lung Function Changes
* FEV1/FVC ratio increases above 80% (normal or above normal)
Treatment
* Anti-inflammatory (may not be very effective)
* TGF Beta-blockers
* Oxygen
* Lung transplant ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[@kishwarbanotelar3282]

I have never saw the teacher like you .. You are so great..if these type of teachers teach in my college I will definitely become a doctor one day..thank you so much mobeen sir..

[@DrBeenMedicalLectures]

I am glad that lectures are valuable. Check out tons of more lectures on drbeen.com.

[@grntara78]

Wow....you are the only one....who can make restrictive lung diseases understandable...thanks a lot for the lecture.

[@m-HamzaQayyum]

Sir, I think decrease CO2 from blood to cause build up CO2 in blood and hence Respiratory acidosis will develop not alkalosis. Plz correct me if I'm wrong

[@irinarakovicprivatepractice]

Well done! It's so much fun to listen to you! Thank you!

[@drshivamtomar511]

At 15:58 you said elevated co2 in blood cause respiratory alkalosis... I think its cause respiratory acidosis..

[@AsadUllah-wp8hn]

Increase CO2 pressure suppose to cause Respiratory Acidosis rather than Alkalosis BTW nice explanation Sir

[@dr.faizanali4770]

Sir .. as co2 cant go outside during exchange , how it cause alkalosis ? There must be acidosis

[@muskandeshwal9299]

Such an amazing lecture......very conceptual ......thank you so much❤️❤️

[@khamikos1]

excellent.you are a great teacher. keep it up. thanks fromGreece

[@DrBeenMedicalLectures]

My pleasure. We got tons of content on drbeen.com. Check it out.

[@fatimaemad7402]

Sir , you said the irritant will cause apoptosis of epithelium then you said that pneumocyte type ii will be hypertrophied and thus making more pneumocytes type i so where the apotopsis exactly occurs?

[@user-jj1nm4sx6w]

wouldn't the increasing of co2 pressure in the blood cause acidosis not alkalosis ? . thank you for the lecture

[@cristinavanloon8028]

yes it would cause respiratory acidosis! the lecture is great though.

[@claudeanurudha7907]

Great lecture.Very educational and clear.Thank you.

[@gins8781]

A comprehensive explanation.

[@DrBeenMedicalLectures]

Thank you!

[@thivz6630]

This was an amazing lecture! Thank you sir 😊

[@motocephalic]

very good presentation, reminds me of respiratory school.

[@prashantj50]

Nice job sir , specially fev1 ,about restrictive lung disease have more elastic

[@vinitasolanki3218]

Thanks a lot sir... Keep it up... Your videos are very helpful

[@ayudiahmayasari1182]

Finally i can understand..bravo.good explaining

[@zareenakhan1536]

Sir whyy respiratory alkalosis occurs if co2 cant go out there should be respiratory acidosis????

[@sindook6085]

Amazing teacher. Masterhood at display. Great teachers are are always Purposeful.

[@DrBeenMedicalLectures]

Thank you dear!

[@PrabhatKumar-mu1nr]

Nice Lecture, Thank You Sir.!

[@DrBeenMedicalLectures]

My pleasure.

[@blessedcharles2279]

Good lecture God bless you

[@helean1344]

This is so great ,thank you so much

[@usmleislife3396]

grt lecture sir.... sir plz make vedio on general pharmacology which is highly tested in usmle..

[@shamimakhanam261]

Amazing

[@tenderprecious]

Thank you for your work 💓

[@abhisek241288]

around 16 minutes mark I guess that should be respiratory acidosis.

[@geraldhoskins1506]

I agree with DrAbhisek Nanda - the increased interstitium thickness initially results in a localized acidosis due to the inability for CO2 to diffuse and leave the blood vessel. It isn't until there is a response from the patient (in which they would be breathing more deeply or more rapidly) that there is the potential for hyperventilation... However, hypercapnia is the primary driver for breathing - once that is resolved, the hypoxemia may not be sufficient enough to justify breathing as deeply/rapidly. Instead, the patient will feel tired, but generally more comfortable than symptoms associated with hypercarbia, so I posit to you that there will continue to be a compensated respiratory acidosis until late-stage processes in the disease occur.

[@9032290952]

yes even great teachers make mistakes

[@dr.priyankaganglani895]

it would b acidosis!!

[@rogodanelena2721]

i think it's correct alkalosis because co2+h20=h2co3 which is a normal compensatory mechanism of the body. So if co2 increases, also h2co3 increases so it gives alkalosis

[@rogodanelena2721]

this happens over time. initially the body develops acidosis, but as time goes by, the kidneys start to produce more bicarbonate to compensate the acidosis, so finally we have alkalosis.

[@clintchimbangu2476]

Good lecturer , but I thought increase in carbon dioxide pressure would cause metabolic acidosis, ..

[@fatimaemad7402]

Respiratory acidosis

[@drhumzaashrafsial6500]

Exactly

[@jindijulie105]

THANK YOU SO MUCH !

[@DrBeenMedicalLectures]

You are very welcome.

[@cmikewilson]

This was helpful. Thanks.

[@thandimtshali3465]

Thank you for this 🙏

[@paulwang7765]

you're a god ! appreciate this so much :)

[@mairakhan8586]

great lectr,thanku sir.

[@ramnathyaduwanshi9579]

Sir please upload complete lecture on COPD 🙏🙏🙏🙏

[@maleeshajayasundara6318]

Thank you very much.

[@mustaquenadaf18]

@15:52 it should be respiratory acidosis not alkalosis

[@gunabharathi3152]

Sir... Would u take respiratory failure lectures???

[@sanjusingh8124]

Thank you so much sir 🙏

[@harikrishna70]

thanks sir we want more lecturere s from you plzzzzzzzzzzzzzz

[@dr.md.atiqurrahman4802]

Excellent

[@mohammedumarfarooqui6373]

You are awesome sir

[@kushaltarafder6425]

Thank you sir😊

[@devangikapadiya986]

Thank you sir

[@srirambhardwaj2343]

Thank.you.so.much.sir.

[@arjunharikumar9040]

If sarcoidosis is a restrictive lung disease then why does it show a different kind of pathology

[@ayudiahmayasari1182]

Nice ..thanks

[@dutarnab]

Sir, why do we usually have tremors of rib casge for patients with Idiopathy interstitial fibrosis or lung disease.

[@muskandeshwal9299]

Sir please make a video on wbc disorders.....🥺🥺

[@dharmrajmaurya605]

thank you so much

[@DrBeenMedicalLectures]

Your are very welcome.

[@iambikash6596]

Thank you sir ....i wish if only i would get a lecturer like you

[@anildutta2750]

thnx a lot sir😊😊😊😊

[@MuntazerAyyed]

Great ❤️

[@jamalsayed8828]

Sir I need your all lecture where to get those ?

[@muzaffarshah9319]

Top class

[@shrutikshirsagar4537]

1st you said transforming growth facter then after some time tumour growth factor.....

[@yasirhasnat9795]

Thank you so much sir

[@DrBeenMedicalLectures]

Very welcome!

[@Vd.Krishna]

Tq so much

[@drabhishekparihar]

Sir Is this resp alkalosis Or resp acidosis?

[@debbieautry-skubik6594]

I'm not a teacher or student but I do have Restrictive Airway Disease at 32% and Chronic Obstructive Pulmonary Disease at 52% pluse Asthma which were caused by a Ventilator I was on while in my long Coma. I NEVER smoked one day in my Life. I am 62 years old and very ANGRY cause I was healthy all my LIFE until 3 years ago! How does this happen?

[@ishwaryapatil3429]

Awesome ur

[@shery123love]

great lecture sir !

[@freedomuk9418]

Hi pls give some advice they told me I've got ristrictive lung I dont smoke am so stressted as dont know what's happening to me pls help any advice

[@triargotube]

Grupo de HP no facebook facebook.com/groups/683424751844146/

[@champion8912]

why cracles

[@deepankarkaushik6384]

Can you tell what to do in ild last stage

[@triargotube]

Grupo de HP no facebook facebook.com/groups/683424751844146/

[@raghavsoni717]

Bestttt

[@doctorashraf7731]

Jesus bless you

[@DrBeenMedicalLectures]

Thank you

[@jayantclasses3089]

Sir, my father is suffering from "cronic I L D", and he is near about 70. Doctor has told that 60% of the lungs has been ruptured. I want to ask that, is it curable or not ? This very disease caused due to infection.

[@kellyjoplin3153]

Excellent

[@paulvijith2732]

Thank you sir