Muscle Abnormalities Worsen in Post Exertional Malaise

Muscle Abnormalities Worsen in Post Exertional Malaise
In this amazing study the Dutch researchers used muscle biopsies in the long COVID patients suffering from post-exertional malaise. They found that the muscle phenotype had changed resulting in lower excercise capacity. They also found mitochondrial function issues, and local amyloid accumulation. Macrophages and CD3+ T cells were also infiltrated in the muscle tissues. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications
www.nature.com/articles/s4146...
A discovery in the muscles of long COVID patients may explain exercise troubles
www.npr.org/sections/health-s...
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications - PubMed
pubmed.ncbi.nlm.nih.gov/35195...
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
emedicine.medscape.com/articl...
Treating the Most Disruptive Symptoms First and Preventing Worsening of Symptoms | Clinical Care of Patients | Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC
www.cdc.gov/me-cfs/healthcare...
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause? | Physiology
journals.physiology.org/doi/f....
Science Fact or Science Fiction? Lactic Acid Buildup Causes Muscle Fatigue and Soreness | Pfizer
www.pfizer.com/news/articles/...
Glycolysis - Wikipedia
en.wikipedia.org/wiki/Glycolysis
Human Skeletal Muscle Fiber Type Classifications
academic.oup.com/ptj/article/...
Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives
www.ncbi.nlm.nih.gov/pmc/arti...
Muscle Hypertrophy - an overview | ScienceDirect Topics
www.sciencedirect.com/topics/...
Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications
www.nature.com/articles/s4146...
A discovery in the muscles of long COVID patients may explain exercise troubles
www.npr.org/sections/health-s...

[@luvinmaks]

Yes! Thank you. I've been living with Chronic Fatigue Syndrome since 2002 and when I try to explain to doctors that it isn't just a tired feeling, it is an all over body feeling of unwellness, they just look at me like I'm crazy in the head.

[@derrickpromislow9210]

I know that look. I think it’s a little more complicated. They realize they don’t know what’s going on and that they’re not allowed to talk about it. They aren’t allowed to think for themselves and the boss institutions have no answers.

[@RC-fi4ix]

I had one years ago, b4 a fibromyalgia dx, tell me I was neurotic 😂 Soon after, I was referred to a specialist who gave the the dx it in a couple min

[@nunnayabiz7911]

Inflammation and starvation of oxygen and nutrients... of course we feel unwell.

[@micaineseeley5339]

You should look into CIRS treatment, helps my chronic fatigue immensely.

[@user-qy3qg8wo4i]

Doctor Been, thank you I have been recovering from this since October 9th of 2021. My doctor has been treating it like PMR with steroids. I go to therapy 3 times a week. I was completely healthy before i received the first vaccine. I was working shoveling and raking and repatition work, my hands swelled up and were on fire that day October 9th 2021 just 6 weeks after the Covid vaccine. They operated on one hand for carpal tunnel. The hand surgeon said he had never seen a muscle with so much tension he said it literally made and snape sound. He said he never experienced that ever. Then my arms ,walking and dressing and rolling over in bed. I was basically loosing everything. My atrophy accelerated, finally i found a doctor that started me on steroids and exercise/ therapy. I have felt these 2 years have been challenging but definitely I'm feeling stronger, because of low impact therapeutic exercises. Frustrated 4 months ago I started the Carnivore diet and stopped sugars and carbohydrates and immediately had no inflammation anymore. To my surprise my muscles were recovering better and feeling more like normal. I dropped all sugar and all carbohydrates and was amazed at how much more stamina, less pain, muscle recovery, and less fatigue I was experiencing as well as lost 25 lbs. Like i said they thought my hands were having carpal tunnel and did a surgery on just one hand and the surgeon said when he cut the tendon it snapped like a cable/ rubber band it totally freaked him out he had never experienced anything like it. No sugar and no carbohydrates or processed foods just meat and eggs and fish . Thank you this has been a very difficult journey and stay positive everyone 😊

[@KrisMcIntee]

Thank you for sharing your journey. We are not alone.

[@Mau365PP]

Thank you for not forgetting about us with LC, 19 months and still fighting 😢

[@anymoose6685]

Yeah, I remember early days post Covid I couldn’t sit for very long because I would get so fatigued just holding my head and body up. I couldn’t eat at the dining room with my family because I physically wasn’t strong enough. That’s fatigue like you can’t imagine.

[@ellenbruckermarshall4179]

This! Not able to walk or bike, or do some lifting like I used to. Muscles not getting oxygen, cramping, burning, pain. Malaise and difficulty moving days afterward. Muscle is growing knots of tissue that does not flex.

[@Investigativebean]

My husband started having symptoms that are akin to the issues I have experienced with post Lyme disease syndrome and Epstein Barr reactivation. I always felt that it was relative to the fascia being damaged. It feels like the flexibility is in inhibited no matter how much you try your move. You’re not just exhausted. You feel like the tin man or an overstuffed sausage.

[@drala108]

Having same issues 😢

[@Boone22]

It feels like you where ran over by a train 🚆

[@micaineseeley5339]

Have you tested for CIRS?

[@leesmoak3125]

Thank you for this discussion! For two years I have had problems with one of my legs. Recently I started slowly stretching and cycling a little bit. And I have noticed strength coming back into my muscle. And this discussion confirmed what I was experiencing!

[@hotbutterwell194]

Same for me. I'm able to bicycle about 6-8 k most days but walking any distance is painful at my right groin area. I had my last jab March 2021. Leg pain started then and has gotten significantly worse since September 2023. Let's hope that more help is on its way.

[@KrisMcIntee]

Thank you for encouragement to keep working!

[@Kathleen253]

Excellent discussion. Thank you for taking the time to present the topic properly. I suffer from muscle damage after a covid infection a littel over a year ago. I lifted an object I have moved many times. I did not realize that the covid had weakened me so as it was only very mild and only 3 days in duration. I felt like I was going to collapse before I could put the object down. After that I felt like my ribs werre damaged, I started physical therapy. After a year of daily light exercises for strengthening my back muscles I am beginning to feel normal again. Scary stuff.

[@matthieusuzor-pleau3157]

As always, very interesting discussion. My dx is post-vaccination syndrome and I had a myocarditis. I was athletic, but now can't exercise anymore. Only small cognitive task give me PEM. I understand the theory, but pratically, how to do light training to reverse muscle type while avoid PEM ? If it was easy, folks with ME/CFS should be cured with graded exercices therapy, but it's not the case.

[@mardyross2838]

35 years ago I was 28 and had CFS/ME onset and my primary doctor knew we had a cluster in my city and National Jewish from Denver had trained an ENT group and were to be referred to. They looked for EBV amount and they'd be elevated. Puffy under eye was a symptom they looked for in person. I'd benefit from a mid 1980s Cali doctor's research using a low dose antidepressant ... from before SSRIs i recall it was to do with dopamine maybe. Then he said And you want think you can but you need to exercise but never ever go past being tired. I'd start with a half a block and go back and collapse into the chair inside the door and feel at some level, better. I'd eventually complete my OT degree. Eventually just by others hearing of my recovery and once I was accessible in an outpatient clinic rather than inpatient, had people come for my help. It was only a handfull in 2007 but they all were reversed and improving. I'd have C 3 years ago last month and I just last month hiked as far as I had just before. I know the ME/ CFS / FMS world has high hopes post Covid research will bring more answers.

[@matthieusuzor-pleau3157]

I'm not sure to understand. You recovered from ME/CFS by low dose anti depressant and training harder than the Dr recommandations ?@@mardyross2838

[@barbarawarren9443]

Exactly.

[@maryreid2282]

I took chronic Fatigue or M.E. 44 years ago. I could hardly walk or think for 7yrs. Finally discovered vitamins and minerals. Now back to full health fitness. If not feeling so good I increase levels of supplements. It's worked for 35 yrs.

[@planegoodmusic]

@@maryreid2282which supplements helped you?

[@heathcliffebird7514]

I remember reading that when cells are virally infected, immune signalling will also down regulate mitochondrial function - possibly through the action of shunts which actively disable some of the metabolic pathways. I believe it was hypothesised that this is an evolutionary adaptation... if a cell is infected and surrounding cells are at risk, it might make sense for them to go into 'low power mode' to slow the spread of a virus while the immune system catches up. Inducing dysfunction in mitochondria could achieve that. There was an excellent paper written some time ago where cells from me/cfs patients with mitochondrial dysfunction were washed with healthy plasma and returned to normal. Healthy cells were washed with plasma from me/cfs patients and developed the same mitochondrial dysfunction. This might also be why IR/sunlight and methylene blue appear to have some positive effect? Thanks as always for the great work. :-)

[@angelbryan98]

What about ketosis? Wouldn't that also get rid of the dysfunctional cells?

[@lucyberlin7108]

@@angelbryan98 my loved one with moderate/severe ME/CFS feels the best when she's fasting, next best when she's in deep ketosis. The problem was that after a half-dozen cycles of multi-day fasting over 4-6 months she couldn't fast any more. My hypothesis is that with her limited food choices (due to MCAS and losing taste as well, she became deficient on some micronutrient(s)). Anyway, after a many month gap she tried fasting again and again had the fasting high-energy. So now she's doing intermittent fasting (19:5 or 20:4) and managing that. Some days better, but it's hard to stop on good days, so still gets PEM pretty often.

[@martinepeters9891]

Go keto or even carnivore to stay in ketosis. I feel good on it

[@9111logic]

Most interesting study, thank you for bringing it to our attention Dr. Mobeen 🥰🙏

[@ancabostinariu6550]

I rxperience constant muscle aches despite the fsct that i am fit and never stopped Exercising. I had 3 shots and experienced muscle pains imediately after the first one.

[@MM-qp4pd]

Same here. On my arms but I'm unvaccinated

[@colettemurray1234]

I suffer above from post statin toxicity

[@hollitheexaltedempress6957]

It sounds like the improper function of the muscle mitochondria could cause heart failure. It could be why young athletes are dropping dead. If the muscles are deteriorating and it is not something Drs and nurses are aware of the fatigue that students get after playing sports is going untreated. Sad for young people and there is not study on reactions to the jab with this pathology.

[@MM-qp4pd]

😢

[@barbarawarren9443]

Brilliant discussion, as always, Dr. Been. ❤

[@sousvide59too]

Clarifying previous comments: The references to lactic acid are interesting, and to the minor extent that this applies to me I can corroborate a bit of this. As a former gym rat, I'm familiar with the smell of lactic acid in the bloodstream. I'm coming up on three years with (almost certainly post-vx) Parsonage-Turner syndrome, so there should by now have been reinnervation. The affected muscles are still weak (4/5 according to the neurologist) and intolerant to exercise. I mentioned up-thread that this past week, it took three days to get back to an even keel after mincing 50g of arugula. When I attempt to use the affected muscles, and even when I do activities that passively pull them around, I can detect that smell. As well, there is the characteristic feeling of muscle exhaustion in those muscles. ... And here's some rife speculation about the pathophysiology: Could it be that in these cases the long covid (or etc) includes peripheral nerve damage leading to amyotrophy, and that it is in the nature of that amyotrophy that it is mostly the exercise-resistant fibres that are lost?

[@RC-fi4ix]

This is interesting, for sure. I had some crazy symptoms after being required to take several shots for a government job. A couple mos later I went hiking in the Colorado mountains. Something bit me. My legs soon became heavy, painful and I was not able to keep up w my long time exercise routine- walking 2 miles one day and biking 5 miles the next. Lifting at the gym a couple times a week. I had just been accepted into a Dietetics program, and followed through, even though I my legs were having trouble and I couldn't remember anything. I put so many hours in w repetitive study also. This was in a tiny farming community. My Dr was not sure what it was, didn't want to test for anything, so my sister bought a Lyme test and instructed me to take it to the lab at my Dr office. After about 3 weeks and no results, I called. They "lost" the test. After trying to get to the bottom of why Dr's weren't interested (even my rheumatologist just td me not to exercise- nothing else. ??? I did have a well managed fibromyalgia w no symptoms for a few years, and they weren't at all the same. We're experiments going on long b4 covid? My Nutrition instructor of 40 years couldn't pinpoint anything diet related. I poured over some medical books and was drawn to ATP production. Certainly, I was getting good nutrition, but why wasn't it being used by the mitochondria and cells? Why were my legs so weak that I felt like I was dragging them around for a couple of years. Fell a few times, tore meniscus- more trouble walking. After graduation I went to a new Dr whi did a Lyme test immediately. The symptoms were getting better by then (2.5 years later), but we wanted to know. No antibodies found. Now, w covid, we are being told by some that those go away after a few mos, which is counter to what we had studied..who knows? No antibodies found. So what was that mystery whatever going on, that sounds so much like this?

[@davidbarry6900]

This study on change of muscle type is very interesting in the context of a Japan study where scans showed increased glucose use in heart muscle tissue after vaccination. I'm curious if the same muscle transformation issue is affecting the heart in some people (but is labeled as a different condition in people affected that way).

[@denda2643]

You are a godsend, Dr. Mobeen. Thank you so much for your brillant content.

[@hotbutterwell194]

Thank you for your analysis. Finally biopsies looking at the right things! Thank you also for pointing out the sloppy NPR review, shame on them, especially since so many people hold them to such high esteem! Question: In the healthy control group, was the vaccinated status indicated? I think I just answered my question by looking at the study paper. Looks like 100% vaccinated in healthy control group and 96% in the long COVID group. It would be interesting to know how many shots, but still thankful for the research.

[@susanfitch1994]

Makes sense Dr Bean. I swam to stretch in the summer. Worked very well. Now now difficult. Walking and some stretching.. always

[@susanfitch1994]

But.. just walking like working slowly in the pool

[@robinhood4640]

When we are doing exercise we increase our need for oxygen. The oxygen is taken from the air, the air is affected by the crap we keep putting in it, the affects the crap has on the air, causes cellular dysfunction.

[@Boone22]

I ended up with the 2nd highest documented Titers of Epstien Barr virus in the USA in 1990 after a bout of meningitis. Doing a very simple thing as cooking dinner can knock me out.

[@wendylpa]

Same predicament after a wicked/6+ year/undiagnosed case of Epstein Barr Virus. By the time they found it (1991) - my body & muscles were WRECKED. MD's haven't a clue...so I'm hopeful that the volume of covid long haulers will force more studies like this one. I was long hauling before that was a thing! I can tell you that slow exercise isn't always a gateway to returning to moderate exercise. I've been stuck at slow pace since 1991. If I do anything more, I'm bedridden for 5-7 days. I've tried just about everything...considering Methylene Blue next.

[@actyrrel]

This is likely one of the most important studies and dr b video of the post pandemic. Zone 2 exercise and low/no carb along with fasting seems to be the ticket. As dr been said this will take time. Go slow. Be patient

[@gerardbiddle1808]

Thank you Dr Been for your presentation on post-exertional malaise in long COVID 19 patients and accompanying changes in muscle fibre types.

[@eliz8878]

Interesting & informative presentation---especially since I watched an online lecture yesterday given by Dr. Philip McMillan (Vejon), re: heart & mitochondria post-vx.

[@user-rz9pg5mk9h]

Excellent explanation. I was thinking if this change on muscle have anything to do about small fiber neuropathy that usually appear with ME/CFS in long covid and Vaccine injuries.

[@nunnayabiz7911]

I was already suffering chronic Lyme disease (which is quite similar in its effects, but I had learned to manage with dietary and herbal approaches) when I came down with Covid in Jan 2020. Eight to nine months later, I was suffering increased pain and fatigue which were harder to manage. Also, I noticed my veins varicosing like never before. I prefer to manage these issues naturally. (Doctors have never been of help for me anyway.) I have found that bromelain and garlic daily are essential for me to even have a fighting chance against pain and fatigue. Without garlic, in particular (which I take fresh, in/with food) I feel as if my muscles are working 2-3x harder. This does not surprise me since I know that garlic is: anti-inflammatory and antithrombotic, also antimicrobial, antiviral, and antioxidant. As a bonus, anticancer! Also, capsaicin (or even hot sauce) makes the appearance of bulging veins go away quickly. Results may vary!

[@MrTemplerage]

Do you think it might be the protein amyloids?

[@MrTemplerage]

It would contradict what Dr, Been said though. He specifically said, "...why mislead those who are suffering?" Around 44 45.

[@chelseyfrancismccarthy4214]

Long covid ?? Akin to post jibber?!!@#

[@nunnayabiz7911]

@@MrTemplerage I'm not sure. My best guess is it involves inflammation of vessel walls (vasculitis), and maybe both fibrin and platelet aggregation, since garlic can positively affect all three.

[@krystianantkowiak4964]

I had the strong infection in December 2021. Before that I was runner. My body recoverd after 18 months. My muscels were weak that I had problem to walk. Heart rate was unpredictable. What helps me were vitamin and mineral suplementation. No sugar and low carb diet, seasalt to hydrate. Herbs like Scutellaria, Hoytunia, Cryptolepis. Acupuntcure, meditation and prayer was very helpful. When I run 1 km after this experience I was crying with happines 😊

[@Threadbow]

Speak with prof Julia Newton at Newcastle. She's done research on mitochondrial function. Dr myhill has done muscle studies too. Hopefully that will find more research for you dr 🙏 Two day cpet is another way if patients are able to do this test. There are q10 plus magnesium to assist with other supplements that can help. At the v severe end even a few minutes will worsen patients. Kreb cycle is v important Yes cfs long covid are anaerobic. Lets hope for further research studies in this area.

[@RomperRuined]

Is this phenomenon also present in those who took the covid-19 injections?

[@wandadabrowskamd]

You are the treasure to medical sciences. Your comments are as valuable as papers you are discussing. Your work is appreciated by doctors, scientists and patients . Thank you Dr Bean!

[@lindee234]

Definitely crash after both mental and physical activity. It’s so defeating. My muscles are strung even in hands. Fingers are bending backwards when I use my hands and I have to pull them out and back in place. Just put down with pain all over body, to fibromyalgia. Happening now for 20 plus years and has deteriorated over time. Feels like you are pulling bags of cement instead of legs. Arms are the same. Back muscles the same.

[@Honey-tl8jc]

It is from the vaccines.

[@ptf55]

I wish.

[@johnlawrence8785]

Be nice if I could see a study on what causes my pre-exertion malaise.

[@Portia620]

I had exhaustion with no movement or activity with Graves’ disease!!! I had to lay down and rest walking half way thru my house!!! I would wake up with breathing similar to a workout. Thyroid does goofy things too and I wonder if it’s affected in COVID.

[@SaintTrinianz]

Deep breathing, walking outdoors in sunlight, vitamin D

[@susanfitch1994]

Yes

[@karlaadair6540]

😂 if only those things helped to restore health fully. The cause is much bigger than this simple, foundational life advice.

[@Threadbow]

Nope, not if yr anaerobic 😮 Vit d yes. Sun yes. Exercise no, only v carefully within the patients capacity This Exercise advice has made patients severe and even deaths.

[@Jennifer-gr7hn]

the foolish "medical community' put me into "PT" during my HELL acute phase from march 2020 to Dec 2020 -- HORRID.Abandoned by healthcare, nightmare! Then longhauler since. They should NOT have done that. I had encephalitis, myocarditis, vasculatis, nephritis...every itis. Did months of meds, and still doing EBOO, methylene blue, etc. I had to give yup nursing, teaching zumba, had to return four courses over time that I tried to do one at a time....and just now, starting to do light tap dancing but maaaan! I still have a very hard time getting a good big deep breath. :( @@Threadbow

[@youbetcha108]

@@Threadbowif a person is unable to enjoy a walk then this must be very serious. The commenter said walking is good but did not say exercise. Walking is vital to keep your muscle and brain connected. All kinds of neurons fire when the body is walking. Keep walking everyone!

[@casskidd1]

Great presentation thank you!...explains a lot of what many people are experiencing ..wow!

[@alisonreynolds3844]

Thank you so much for this video. I have me cfs and this research really sifts out alot of other theories such as clot. Pem, in cfs can be so bad the exersion from daily activities of living can fatigue you to the point of needing to lay down. Your presentation made sense of a complex article and remind us that main stream media is not capable of accurate reporting.

[@ey67]

Outstanding presentation. Great work.

[@user-te3yi3fw3n]

Dr been, you wrote the whole drawing program in C# yourself? That is amazing. Someday I would like to hear how you also have such a talent in software engineering. Of course your medical lectures are the best in the world

[@paulyoung4422]

The only solution is to, take the pain and keep using your muscles.

[@coraleigh9661]

Congratulations on your lovely drawing app! I wonder if this is the same case for fibromyalgia. Many yrs ago I participated in a study for FM. They gave us gentle movements to do, increasing slowly. Post exertional malaise went away and never came back, I can train hard at the gym.

[@sandrag8656]

Very interresting, thank you very much for sharing and explaining! Question I ask myself: Only post mallaise or also post vaccination ?

[@BOON2785]

This explains why methylene blue has been such a life saver for those who are suffering.

[@lucyberlin7108]

Explain?

[@BOON2785]

​@lucyberlin7108 MB supports mitochondrial health/donates ATP.

[@jazzmoon77]

I read something this week about some kind of plaque development inside the muscle fibres post Covid, leading to the weakness etc

[@mardyross2838]

That's sounding like findings 20 years ago in fibromyalgia folks' muscle fibers.

[@cherryb6105]

Thank you Dr Bean....that explanation was so very helpful.

[@carolberridge6102]

Thank you so much. Great presentation!

[@antiguarocks]

That was excellent. Thank you for all you do.

[@Jennifer-gr7hn]

HA! "Over 3 months post infection" hahaha....or year 4 for me. I do wonder (open to input!), would regular massage be helpful? Like a passive, relaxing exercise of the muscles? Also, IR sauna which mimic exercise but it's also passive? I was FOOLISHLY *(mainstream medicine) put into PT during my LONG hard, miserable horror acute phase in march 2020 when they were trying to make things look worse than it had to be, as the focus was getting a "shot" out and fired. I had systemic "itis"...every organ, from encephalitis to myocarditis, nephritis to vasculitis. It wasn't until my entrance to healing which was finding! ....that I started feeling better. All you are explaining is why HBOT, IV ozone but EBOO!!...EBOO+ IV Methylene Blue + IV NAD worked the BEST!! I'm 50% there but totally feel that 02 utilization issue, AND I have Anemia now due to covaids-related new onset fibroid which made the menses cycles from hell when I got the infection (NO injection). My poor mom! She had a mild case (and a daughter who helped her NOT deal what I had to, but the 2020 version was torture) but has muscular dystrophy. Poor thing started progressing, getting worse :( I hope that something helps her. I started baking soda, and brow bag breathing and KILLIN' the seed oils which oxidize and cause acidosis. Man this has been like 4 full time jobs (with fatigue brain to toe -- total disability and you can't "talk" your way, or "push your way" through! May this is why the sedentary did the best with this...they are lasy! We the sit and active...suffer. As they want it. This was TOTAL 'toxic shock syndrome'...sure does't seem 'viral'...maybe initially, which is why their was a whole set of 120s symptoms after the first 2 week. Dr Ardis may be right....venom.

[@janemerrittmckenna2386]

Love the art! The 1st one looks like me trying to get awake. PEM has been a major problem during my Long Covid ordeal! Thanks for this concise info!

[@clarissaharbor4966]

Thank you Dr Mobeen for this very amazing research finding. ..thank you for drawing the mechanisms...makes the easier to understand...this finding will be so helpful for helping those with lond covid

[@sylviegartner7284]

thank you so much for this AMAZING work!!! i observe these things in working with my patients but can't explain it for myself because the features didn't fit. so many missing links ... !!!!!!! 💖💖💖

[@fredbloggs8816]

Excellent Dr Been, really informative and hopeful too.

[@Portia620]

Smart man! I really enjoy these talk as I struggle sometimes to understand! Reminds me of college! ❤

[@sigrid2402]

Thank you Dr Been, you give me hope.

[@davidholcomb9961]

Thank you doctor for helping us see there is hope and there are steps that can help to reverse the fatigue that many of us experience with proper guidance. I must say all of this makes a tremendous amount of sense even if there are some conflicting reports, as you have shown. Now we must get doctors on board to help us to help ourselves; like getting inflammation under control and some sort of guided physical therapy and mental stress reduction.

[@nanallen1]

Post exertional malaise - 25 years. ( dx chronic fatigue syndrome/ fibromyalgia - biologist here) Cause ( 3 top neurosurgeons) - small posterior fossa ( Chiari 0) with a tight spinal cord. Unstable C1/ C2. Varying abnormal spinal fluid pressures in CNS. Too much pressure in lower brain can cause a hypersympathetic state. Had no major issues until neck injury. But son got symptoms following well documented EBV infection 3 decades ago. ProbAble Ehlers Danlos - resulting in multiple neck/ spinal instability.

[@judytansungmooi5313]

Thanks Dr. Bean for sharing your thoughts on this precious and important knowledge able information on this topic, interesting.

[@user-nu8eg8xg5h]

If this is possible from Covid infection, then it seems very likely it's possible from Covid "vaccination?" Could many of these "long covid" cases be just another form of "vaccine" injury? Thanks for your unbiased and truthful vids, DrBeen.

[@W.Eric.Anderson]

Great video! Thank you....perfect explanation

[@christine41861]

Thank you Dr Been!! Still loving you in that sweater!!! ❤ This talk really hit home for me! Disturbing tho… other authors misrepresented the study. Are folks on crazy pills??? 🙄

[@sheilayoung6276]

Thankyou. Learning a lot and hope it helps.

[@andreanewman9104]

Brilliant! Thank you for explaining. The results of this study make so much sense and it matches what I experience. I feel I have a better idea of what I'm dealing with now.

[@heathermildvan1337]

Thank you Dr. Been. Very interesting lecture.

[@1961Lara]

Thank you Dr Been!

[@donbruhn3037]

Best. Pod cast. Explanation. Ever. Made. In. Last. 4. Years. On. Covid. Long. What. A. Releaf. On. Brain. Thinking

[@pauldickinson5316]

It might explain why those who suffer from CFS have positive results on a keto diet, the muscle fibres will have to change to type 1 to use energy or wait for gluconeogenesis, if I was a muscle fibre I know what I'd do.

[@drpnlop1]

Excellent presentation of an interesting study. But Im left wondering to what extent were their observations in muscle simply due to the patient being bed ridden.

[@ptf55]

Wonderful video. Very helpful.

[@KatieZeldin]

Mitochondrial dysfunction, increased glycolysis, decreased cytotoxicity. Correct me if I'm wrong, don't those cause cancer? If I weren't already doing keto/fasting, I'd start immediately.

[@lessmith3799]

It's day 1011 of Parsonage-Turner (axon loss) and this fits me exactly. It took me 3days this past week to recover from mincing 50g of arugula.

[@susanfitch1994]

Excelent !!

[@777JC77]

I have fibromyalgia and psoriatic arthritis. This sounds like me.

[@nanallen1]

Me too - unstable neck/ pelvis. ProbAble EDS. But born with various structural issues.

[@sallyweiner4180]

Thank you so much

[@BuildOnLife]

Finaly some good explanation on PEM, instead of the normal perspective of "exercise is good for you, though it out you lazy..."

[@RonnieM]

Is the muscle fiber change a direct effect of the mitochondria not doing their job? Trying have humor in a bad situation, when i hit the brick wall I always say "crap i ran out of mitochondria". It sounds ridiculous and makes my laugh.

[@Portia620]

Humor is such amazing medicine in times of extreme hell!!! Been there done that with brain fog too.

[@cjclark1208]

Powerhouse of the cell, no power no…

[@wlfpac5607]

Maybe check to see if that NPR article was actually A.I. generated!?

[@furiousdoe7779]

Dr. Been , would Far Infra Red treatment or sunlight exposure on the muscle enhance improved recuperation of the muscle.

[@RC-fi4ix]

Thanks!

[@lynpatricia6854]

Is this the same as in Fibromyalgia sounds a lot like it.

[@mardyross2838]

..... sure sounding very similar .....

[@Jennifer-gr7hn]

but way worse and deeper in the root - these spike proteins are like VENOM (or are). Fibro doesn't involve vascular

[@mardyross2838]

@@Jennifer-gr7hn , there can be stiffening of vessles in those dx with FM.

[@tanu5628]

Awesome sir

[@alisonreynolds3844]

Your drawings are great, really help my understanding😅 this explaination is exactly what my body mucsles feel like. I tell doctors its like there isnt eniluf oxygen getting to my muscles, now i know essentially i am correct. This is a big step forward for chronic fatigue syndromes. Friends would say i was just deconditioned, sure however if u have PEM, you not going to train your way out of it. I hope this video is seen by all medical mds and those treating me cfs. Thnks dr. Bean

[@grazioso58]

thank you

[@PurposefulPorpoise]

Dr. Thank you for your excellent work and all you do for us. Question : Does the Mitochondrial dysfunction not pose an obstacle to switching muscle fiber types with light exercise? I am hesitant to start light exercise after 2 years with Long Covid only to discover that the mitochondrial dysfunction prevents the exercise+fibertype switch mechanic. I am no Doctor but its a question that has me concerned.

[@SeedsofEcofrog]

If you don't use it you lose it.

[@Boone22]

THANK YOU Dr. MoBeen! What about taking NAC,QUERCETIN,ZINC,BROMLAIN, also 8 IN 1 IMMUNE DEFENSE supplements to help with symptoms?

[@ryriffs]

Thank you doctor Syed!! You’re brilliant. I am vaccine injured. Do you know if they are doing any studies on these patients? Do you think it’s the same mechanism of disease?

[@matts4277]

For others information. I have found Metformin helping with my LC, I got it prescribed because is has been shown to prevent LC. I am taking a week off after a month to see if the effects are lasting. This is the first time that the effects have lasted beyond taking the therapy. Might be worth talking to your doctor about, but beware it does mess with the GI for the first week.

[@stevierusso529]

Experienced this very thing, muscle etc. living it! Add; recent; Hemophilus influenza, 73% w/ Peptoniphlus lacydonenisis 7% & staphylococcus epidermidis 20% now & all after just treating Groundglass densities/ lungs, Strongyloides found in blood work. 1 step forward 3, 4 steps back past 2.5 years. Chilly, sick hardly any fresh air or Sunshine, miss the 4 m. walks.

[@buzzy2587]

Thanks! You are fabulous! Investigating EVERY aspect, even NPR crap news. I wonder if the jabs are more the reason for so many problems. Perhaps, 1 or 2 jabs, then a bout of covid. Thats what I did, and since then, this normally very sporty person is pretty lazy feeling and so many muscular issues. But, I do lightly exercise daily.....

[@vicky_webcatuk]

Dr Been, do you think methelyn blue and infra red heat would be valuable as well as gentle exercise to start? - maybe a keto diet too for reducing inflammation? After 2 years my heart damage from Covid is recovering but bad exhaustion and very deteriorated muscles and tendons is causing multiple joint problems leading to a dislocated shoulder last weekend (during my sleep) on the rotator cuff issue shoulder, and the heat on that arm for 4 or 5 days had to be seen to be believed.. im just wondering where to safely start with fitness recovery support and the above options are what my gut feelings suggest, do they sound helpful to you or am i giving myself too much to do?

[@genehendrix1847]

What kind of exercise would be most beneficial though (or least damaging)? And surely duration of exercising is a factor too. Maybe you can go hard but for a very short time (before you start damaging your muscles beyond your capacity to recover in a reasonable time).

[@tomagoredo]

did they look for presence of S1 in muscles? if not why not

[@ground752]

I just see now that spike is basis of this problem and source of amaloid, and causing cancer

[@jonscott8586]

Myoadenylate deaminase (MADA) deficiency shows what an Adenosine disturbance can do. MADA is a defect in the gene that codes for the enzyme adenosine monophosphate deaminase, which results in a deficiency in energy production in skeletal muscle. Symptoms range from mild fatigue to severe rhabdomyolysis. Thus, intra and extracellular spike protein may have sufficient enzyme affinity to disrupt adenosine - inosine without genetic mutation. Related SARS spike has good affinity..... Adenosine Deaminase deficiency well known to cause blood and lung disorders, for example.

[@dsandman272]

Dr been can you review muscle twitching no one seems to know what’s going on but a lot of us are suffering from fasciculation’s all day post covid / post vax

[@lessmith3799]

... So if there is nerve damage leading to amyotrophy, could it be that the list muscle mass is primarily slow twitch?

[@PCMenten]

@18:40, are there implications for heart health? Autoimmune reaction to exertion.

[@miguelderijckke5907]

Seems to be logic and is maybe one of the mechanisms in the natural form of myocarditis postinfectious

[@tuulaniemi1826]

'Frame shifting' of the covid- mRNA reading in the ribosomes?

[@Threadbow]

Perhaps the mitochondria are blocked by viral or chemical. This was the case for me.

[@Jennifer-gr7hn]

which is why EBOO, NAD+ and methylene blue helps.

[@MM-qp4pd]

​@@Jennifer-gr7hnhow does one afford all this?any alternatives?

[@Threadbow]

@MM-qp4pd just look up on dr myhill uk dr. Free advice

[@Threadbow]

​@@Jennifer-gr7hnEBOO?

[@terraloft]

Transformational information...how to apply this to each individual, need the wisdom of our LORD who knows us perfectly