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Charles Sabine’s talk at the Huntington Society of Canada (HSC) National Conference will describe the lessons he learnt from his time at NBC, his family’s shocking Huntington disease (HD) story, and his discovery of the hugely underestimated prevalence of the disease due to centuries of shame and stigma. He will also relate the story of the unprecedented global collaboration between researchers and HD families that has made research into this field the most thrilling anywhere in medicine.