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Neuromyelitis optica (NMO) Spectrum Disease is an autoimmune disease that is triggered. The onset of NMO is currently unknown. It is also unknown why people with NMO experience different levels of severity during attacks. Many factors like viruses, vaccines, environment and more are currently being studied as scientists work to discover what triggers NMO attacks and how to prevent future attacks. Understanding this is a critical step in finding a cure for NMO.