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This video provides an in-depth yet accessible explanation of the concept of afterload in cardiac physiology. Starting with a basic overview of the pressure-volume loop, the video visually illustrates key components like the end-diastolic and end-systolic pressure-volume relationships. It then delves into the definition of afterload as left ventricular wall stress during ejection, highlighting its calculation and practical clinical estimation. The video also connects afterload with systolic blood pressure, offering viewers a clear understanding of how blood pressure relates to cardiac afterload. Suitable for students, healthcare professionals, and anyone interested in cardiology, this video makes complex concepts easy to grasp.