Calculation of Steady state concentration on IV infusion

[@mounikanutakki5720]

How i missed ur channel, it's really heaven

[@bradleymurorua9816]

8:20 Could sir please explain how we got 3.32 relative 90% , though I know how we got the 95's and 99's%

[@drchetnmaaindia1110]

One of the good example for clinical pharmacokinetics exercise

[@bradleymurorua9816]

3:43 Hi, shouldn't we divide 10 by 60 since we are moving from minutes to hours, giving us 0.1666666667 hr?

[@kartikmittal8138]

It's not like changing unit of min to hr , instead its changing rate like how much clearance is there in 1 min? so for 60 min we have to multiply it by 60 hence 1 hr.

[@jaymadu4306]

very clear and well articulated. Keep the good work

[@product_of_grace24]

you are simply heaven sent! Thank you so much.

[@santhim6926]

Thankyou so much sir very clearly you explained

[@shubhamprajapati2698]

Sir if time required to acheive steady state depends on elimination half life then why we give loading dose to acheive steady state rapidly how it is possible?

[@dadid9182]

Good job👏.

[@egpat]

Thank you!

[@SapnaSharma-r4s4z]

Very clear explanation.... can you please share a video on how to make a template for NCA calculation?

[@aahana_bhattarai2870]

I can't thank u enough..thank u soo much sir 🙏

[@vigneshwaranravichandran9563]

Drug concentration = boomg to be given IV each 8 houre · Ty₂ = 6 hours, vd = 0.75 W/he. Cone at steady state 35mg, what is the infusion rate to be given Per hour to reach stready state Conc.

[@vigneshwaranravichandran9563]

Please answer for this question

[@tomcruise9317]

How cl =ke×vd can you ecplain or tell the source

[@saiteja6742]

Do all drugs need to achieve the steady state concentration after 4-5 half life in order to see the therapeutic effect ? Doesn't ibuprofen produce its effect from a single dose without 4-5 half life ?

[@egpat]

Therapeutic effect is not related with steady state concentration where the former is observed whenever the drug level in the blood raises above minimum effective concentration. But steady state is level of drug in the blood which is constant for certain duration during which we introduce the drug. It can be achieved by either IV infusion or multiple oral doses.

[@princecharming7315]

Great job

[@bhagyasreek5399]

Sir, would you please explain what is narrow therapeutic index clearly

[@leenaghaeb4747]

It's when a drug leads to serious adverse reactions. such as chemotherapy/cancer drugs their therapeutic index is very small. the wider the therapeutic index, the less toxic events for the patient

[@saiteja6742]

Sir do lecture video on how to maintain steady concentration, what is loading dose ,maintance of dose , compartment models??

[@egpat]

Sure

[@laylamedo]

Thanks Piece of cake

[@PrajwalSedain]

so can Cmax of an IV bolus be called as the steady state plasma concentration of that drug?

[@egpat]

Steady state can't be achieved by single administration such as IV bolus or single oral administration. In both of these Cmax can be achieved but it is not maintained for significant amount of time due to elimination. Steady state can be achieved only by either continuous IV infusion or multiple oral administration where rate of input it equal to rate of output.

[@pharmaboy1510]

Thnx,Sir

[@leenaghaeb4747]

Very helpful! thank you

[@egpat]

Glad it was helpful! Thanks for watching

[@obie6997]

Can I email you??