In Vitro DDI Drug Transporter Studies ADME 101 Webinar: Efflux and Uptake Transporters

Originally aired: June 2020
Presenter: Andrew Taylor, Ph.D., Services Technical Support Manager
Drug transport can be thought of as the AD&E in ADME, as transporters are responsible for absorption, distribution, tissue-specific drug targeting, and elimination of drugs. Since they are involved in so much of the movement of a compound through the body, they can be involved in many drug-drug interactions (DDI). The clearance of transporter substrates can be impacted by transporter inhibitors or inducers which can lead to toxicity or loss of efficacy.This short, information-packed webinar features:
- An overview of drug transporters, including ATP-binding cassette (ABC) and solute carrier (SLC)
- Why drug transporter studies are important, including a real world example
- An explanation of transporter expression and function
- Regulatory guidance on transporters, including FDA, EMA & PMDA
- Inhibition and substrate transporter study design, including Efflux Transporter Transwell Assays, SLC Transporter Uptake Assays, and BSEP and MRP2 Vesicle Assays
- An example of study result data
- Different transporter study and test system options and more...
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About the presenter: Dr. Andrew G. Taylor received his Ph.D. from University of California San Diego. He joined XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies in compliance with Good Laboratory Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met.