[COMMENT NOT MADE BY MY MOM] 100th comint yey

finally i could understand Great great video 👌

Hello everyone, I hope that the information I share with you will be useful to complement the topic, as was the video. Apoptosis is a type of cell death, which is characterized by an orchestrated regulation of the disassembly of cell organelles, that is, it is a programmed cell death. This death is present in some types of damage, where cell viability is compromised: genetic mutations, or physiologically, to control cell number. There are two common mechanisms by which apoptosis occurs: one is the mitochondrial (intrinsic) pathway, where everything arises when the anti-apoptotic proteins (BCL2 and BCLXL) stop working, when the initiators of apoptosis (BAD, BIM, Puma or Noxa) send signals to the pro-apoptotic molecules (BAX and BAK), increasing the permeability of the mitochondrial membrane. The other mechanism is the extrinsic pathway, characterized by the binding and activation of the TNF-1 receptor, triggering in both pathways the activation of caspases (9 for the mitochondrial pathway and 8 or 10 for the extrinsic pathway), both pathways converge to activate other caspases (3 and 6). In addition to these two pathways, there are others that have been discovered somewhat recently, necroptosis, which has similar characteristics to necrosis and apoptosis; pyroptosis, which forms the inflammasome, triggering the classic symptoms of an infection or inflammation; and ferroptosis, caused by the accumulation of ROS and iron in the blood. All this triggers the release of nuclear fragments into the cell cytoplasm, to be finally digested by phagocytes. It is important to consider that apoptosis differs from necrosis due to mitochondrial damage. Finally, in the microscopic form, apoptosis can be visualized with reduction of cell size, chromatin condensation, vesicle formation and presence of macrophages.

Great explaination 👍

Excellent , as an oral pathologist i loved it

PLEASE MAKE MORE VEDIOS...TO MASTER ROBBINS.🎉ON GENERAL N SYSTEMATIC PATHOLOGY.

Thank you.

You are too good in explaining, very creative sir 😊

Awesome ❤

I spent an hour trying to figure out this mechanism based on my lectures in vain. You make this look so easy, man!!!! really appreciate this video you made!!!

Unique 🎆🎆

Fantastic

this is so good !! the animations are so fun and cute. easy and fun to learn... thank you so much for this !

great video, thank you for your effort

Super video 😁 best ❤ one to learn

Thank you for simplifying it and turn in into concept maps thats is easier for me to understand rather then reading in on a book ^_^

Tqs 🎉

Amazing😊😊❤❤

Besttttt

Thank you, there’s only soo much you can learn from uni slides. This very is very useful

Good one❤

thanks <3

Thank you so much sir grateful 🙏🏻😊

I don't understand why there are only a few likes on this channel!! Very amazinggg video!!!! I mean excellent representation! Appreciate your efforts.

you have saved my life

perfect❤

What a film...... 💯🤗❤️

Best lecture on salivary glands ❤

Thank you....

I am soooooo much glad to see this video that explains everything literally amazing Thankkkk youuu❤❤

At 3:08 you mentioned that mantle dentin doesn't have dentinal tubules, but i thought that this is where terminal branches are present, so how can it not have tubules? Thank you

😭🤌🏻Thank youuuuu !! Perfect Explanation heard so far!!😭🔥

Thank you❤, sooner or later i need to find videos to keep undestanding stuff on certain subjects so you have no idea how much of a piece of merry good news it is when i find you actually have a video explaining the topic😊

Hello sir just wanted to say that your videos helped me alot in acing my exams please keep posting as your videos are a life saver - thanks alot 3rd year BDS student from Karachi pakistan 🇵🇰

Hello sir, a second year mbbs student here… your videos are great. Please cover topics beyond dentistry syllabus also…

best

Your way of teaching with animated slides is mind-blowing 💎

Awesome video

4:32

This video made studying for the exam easier, thank you🫶🏻🩷🩷🩷

Such an amazing video! WOW! Thank you! :)

THANK YOU so much!!! Amazing video!

Thank you soooo much!!

Thank you

WOW. This was so well taught!

I saw this in a textbook once

Effort is Awesome!!!!

Wow, so great!

A perfect video , well explained and so smooth. made my day thank you🥰

This is so well explained !!❤