Sjogren's syndrome (Part 2) - Clinical features and Histopathology

Sjogren’s syndrome (SS) is an autoimmune, chronic inflammatory disease characterized by dense infiltration of lymphocytes in the exocrine glands. Essentially, the body’s own immune cells, the lymphocytes, attack and infiltrate various exocrine glands and cause their functional impairment.
Here's Part 1 of Sjogren's Syndrome 👉 • Sjogren's syndrome (Pa...
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References and further reading:
💡Bayetto K, Logan RM. Sjögren’s syndrome: a review of aetiology, pathogenesis, diagnosis and management. Aust Dent J. 2010 Jun;55 Suppl 1:39-47.
💡Ramos-Casals M, Font J. Primary Sjögren’s syndrome: current and emergent aetiopathogenic concepts. Rheumatology (Oxford). 2005 Nov;44(11):1354-67.
💡Mavragani CP, Moutsopoulos HM. Sjögren syndrome. CMAJ : Canadian Medical Association Journal. 2014;186(15):E579-E586.
💡Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T: The diagnosis and treatment of Sjögren’s syndrome. Dtsch Arztebl Int 2017; 114: 354-61.
💡Shiboski CH, Shiboski SC, Seror R, et al.: 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren’s syndrome: a consensus and datadriven methodology involving three international patient cohorts. Arthritis Rheumatol 2017; 69: 35-45.
💡Neville BW, Damm DD, Allen CM, Chi A. Oral and Maxillofacial Pathology. South Asian ed. Elsevier; 2016.
💡Sapp,Eversole,Wysoki. Contemporary Oral and Maxillofacial Pathology. 2nd ed.Mosby;2004.
💡Regezzi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinicopathologic correlations.5th ed. Elsevier Saunders;2008.
💡Fletcher C. Diagnostic Histopathology of Tumors:Volume 1. 3rd ed.Elsevier;2007
Image Attribution:
💡1st Histology image (left)
Histopathologic image of focal lymphoplasmacytic infiltration in the minor salivary gland associated with Sjögren syndrome. Lip biopsy. H & E stain/ CC BY-SA 3.0
💡2nd Histology image (right)
Section from salivary gland showing dense lymphoid infiltrate around and within ductal epithelium-Lympho epithelial lesion/ CC BY-SA 4.0
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