So, I’d like to start in the field of protein folding but don’t know where to start… I know Alphafold is a tool that few are ready for with its huge potential applications. I would like to use it and I learned how the program works overall. My question is: How can I get the knowledge to use this tool? Which courses (online if possible) can I take? Thanks in advance!!

Confusing explanation! Seems like visualisation did not correspond to what you were saying and did not help!

Amazing content It's great you're sharing this information in such an accessible way I have a small critque. The animations are a bit jarring, with too many things moving, appearing and rotating. This gives me the sensation of being overwhelmed. I can't give a simple solution since it is a matter of artistic choice. Some animations are crucial but stripping out as much unnecessary visual information as possible while keeping it beautiful would no doubt increase the amount people enjoy your videos. A specific example is at 4:13 I'm already overwhelmed by the amount of information I'm getting, that having the box outline get drawn in and the amino acids move into place is extra unnecessiary stuff that my brain has to decide it's okay to ignore since that's meaningless with respect to the lesson. It takes a split second to parse but this sort of thing is happening on almost every frame and it makes the experience less pleasant by adding mental load. Especially when so many animations do convey meaning, like an arrow appearing, a bond breaking or atoms shifting. It makes the meaningless animations stand out even more. I like your style a lot and I can see this took a lot of effort to create but also keep in mind cases where less would be more.

This video is surprisingly less clear and harder to understand than the other ones 🤔

Great channel! But the stuff from 9:10 to 15:25 is simply incorrect in presenting that the predators would be generating periodic animal population cycles, because these cycles manifest A) when predators are experimentally excluded, and also B) when there are no real threat of predators (on a small island for example). In fact, all hypothesis expaining periodic animal population cycles via environmental and/or intrinsic interactions have failed. Not one of them can explain 1) the multiannual phase-dependent physiological and behavioral oscillations that repeat in the same order from cycle to cycle no matter the location/environment, 2) why these oscillations are commong among the animal kingdom no matter the cycle's period, that can vary from 2 years to over 60 years, or 3) why the cycles synchronize or produce 'traveling waves' between populations of the same species - and often among sub-species - within a metapopulation. Traditional hypotheses have been relying on these factors as an explanation: predators, nutrition availability, pathogens, density-dependence & epigenetic effects, weather patterns (including climate change), etc. But if all species exhibit a similar pattern no matter the environment, the explanation cannot be the environment, now can it..? One of the few articles admitting the failures of all environmental hypotheses is 'Population cycles: Generalities, exceptions and remaining mysteries' by Judith H Myers. So, while it is true that environmetal factors such as predators modify the population counts during the cycles' different phases, it is simply impossible for the environment to generate the cycles. My suggestion is simply to discard all previous hypotheses, and look to chronobiology for a universal solution: only an innate chronobiological mechanism can generate a periodic hormone cycle that is common among the animal kingdom. No other hypothesis is even viable, because they are full of massive holes that few dare to admit. Others just believe in the vague yet easily falsifiable environmental hypotheses, because nothing better has been available - until now that chronobiology acknowledges the existence of multiannual hormone cycles.

The good question is how fast it is?

Great video! Since it is an introduction to protein structures, it would be neat to see how exactly are proteins composed from smaller parts. Like, how amino acids come together to form the structure in the first place, without the helix/sheet simplification.

I love this channel

2 ~ 10% of DNA is about building hardware (body structure & appearance) ~ 60% is about coding the software (brain, memory, nerves, skills) like OS. There is a big portion of DNS they call 'Junk DNA' which is not. actually we can't see or witness the OS part of DNA manipulation that easy, so we have labeled them as "Junk DNA."

2 ~ 10% of DNA is about building hardware (body structure & appearance) ~ 60% is about coding the software (brain, memory, nerves, skills) like OS. There is a big portion of DNS they call 'Junk DNA' which is not. actually we can't see or witness the OS part of DNA manipulation that easy, so we have labeled them as "Junk DNA."

How many segments are made concurrently so the folding doesn’t interfere with each other like parallel processing 😂🧐 probably as many start and stop codons are in the genome for that protein to make a larger structure 😂

Awesome video, thanks

I would love a more higher level video, this explanation was beautiful but I have heard it many times and believe you can produce very good technical content

I loved the drill bit analogy! As someone who's also starting out making mol bio videos, I am always looking for simple analogies. In my AlphaFold video, I used "differently charged string of beads floating in water" to explain protein folding :D

which video did the mcd burger flipper guy comment on?

Molecular biology forever

How do you make these animation. Which tool did you use. (2:31)

So basically, protiens are large inu shibas holding miniature inu shibas and saying "now kiss".

This is quite possibly my favorite channel. Very easy to follow along, A lot of care, effort, and time put into them. Narrated by cute disembodied nerd voice. Yet so underrated it's heartbreaking.

WOW! This was amazing!! Thanks dude

Excellent video. Congratulations

Lovely video and explanation on enzymes! Also the jujutsu kaisen references were great lol, I somehow expected you to make one when you mentioned pocket dimensions and rules 😂

your videos are very interesting

This video was great!

Some constructive criticism: when you are talking about a specific part of a protein or other molecule on screen, always make sure to highlight that part of the graphic. Something as simple as an arrow or circle would be very helpful. There were a few times in this video where you would be explaining a specific part of a protein, but there would be no indication of what part you were referring to. Unless the viewer happens to be familiar with protein structure and terminology, its easy to get lost without highlights.

Lonsdale would be proud of the benzene representation in those molecules, some awesome animations too!

I know what's going to be the most viewed part of the video

great

So a drug can work by blocking an enzyme's active site? Can a drug modify an enzyme's structure permanently?

Wait... so a target protein needs to be unfolded into an amino acid string for chymotrypsin to cut it?

As a layman, his is the least understandable video you've made so far. Where even is the "s1-pocket" in your graphic?

Ugh I hate being the second poster of the day

Is it nature's design? It may be one way to say how the approach You start sees time. Consider a future approach which links causal time and reversal of the causal chain to actively defend reverse appearance of each target molecule. The trail is visible.

You know, you inspired me to do the Nanobiology study. I'm in the third year now and I think this was the best decision I've made. Thank you for your work, keep it up!

🎉🎉🎉❤❤❤

Go to surfshark.com/nanorooms for 4 extra months of Surfshark

It’s unlikely that all of these mechanism ( resulting in each organism prepared for surviving in their precise proper environment ) is the fruit of random mutations over billion years, even the simplest form of life is too ingenious, and like what you exposed for example in the video of cycle cell signal ( the auto regulations by feedback and the pattern that it result ) all animals with their precise (physical and behaviors ) characteristics in a local area act like different repressor and activator needed to regulate the presence of each of them needed to support all of them ( and in the macro macro scale ) all of the interactions of all animals and plants in each local area is needed to permit to the living things to live, survive. What a complex and absolutely fragile thing that are « life »

Our cells did great for eons than doctors showed up and now we have problems

if the best thing you can call it is a programming language, maybe, possibly there's just the tiniest hint there to be had? Or maybe coulda shoulda kind of woulda plus a few million years and "out came this calf" ... oh sorry wrong thread, I mean, "out came these motor proteins and machinery and coding and data compression and constantly fresh almost daily for the last 30 years supplies of cellular and protein structural evidence of a level of intelligence and capability so off the charts it's only deniable by the kind that dies of thirst at the bottom of a lake". They got the "patchwork" part right since you could hardly make it more ad hoc.

'We are beautifully complex indeed.'

3D printed from the inside. You're being replaced.

Has anybody seen the butterfly alphabet poster? Some of this stuff looks like a copy clone of that poster.

7:36 are these dot products protein kinases? That’s what they remind me of?

Bio sensors are the future

It's differential equations

Hello

Hello, I am a high school student who is into biological mathematics, but I found a gap between it and my current math knowledge.What topics do you recommend me to look at first, so I can strength my background?😢(I finished high school math)

Why its underrated

2:27: I guess something that wasn't mentioned here was that this 'setup' is isothermic meaning there's no change in temp' inside the sealed container. For this to happen the heat would escape out of the side of the container as fast as adiabatic heat is introduced (heat under compression like the type when bike tyres are pu.ped and they feel warm). So I guess if heat from outside the container/piston was added in (like with a Bunsen burner or something) to expand the gas to its original state i.e. same initial volume, pressure and temp', would that count as a reversible process?