Perhaps you didn't perform better because of the side effects of a high dosage of stimulants, which wouldn't be that much of an issue if you took 20mg as opposed to 200mg.

How can a scientist use fahrenheit rather than celsius?.... And I was expecting Kelvin 😅

Scoville is a made up uncountable thing (not a unit) so the Guiness book is a joke

In Sweden we have this saying: "Är munnen dum, får pruppen lida". Which is hard to translate, but it means that your asshole suffers for your mouths stupidity. This time though, it seems like they stood to suffer together in solidarity for the stupidity of the brain.

I've tasted capsicum oleorsin, 🌶️🌶️🌶️🌶️🌶️🫘

My uncle use to make Birtch beer from natural sources

FYI those lime squeezers work the other way around. Flat face of the lime goes towards the holes and then the whole thing is pushed inside out by the press

AIUI caffeine is faster onset than theobromine because the methylation allows it to pass through the blood-brain barrier.

I had a hemorrhagic stroke when I was eighteen due to overdosing on 2CB. Blood pressure skyrocketed. It damaged the part of my brain that controls the beta system of my heart. Now I have extreme and chronic tachycardia. I’m on a beta blocker which makes me feel mostly normal again but if I drink even 2 milligrams of caffeine, I get heart palpitations. I drank a Dr. Pepper once which has about 42mg of caffeine and it sent me into repeated tonic seizures due to how fast my heart was beating. Heart rate was 240+ for hours. The highest recorded blood pressure was 220/169. Anyway, before my stroke (which was December of 2014) I drank caffeine all day every day. Coffee, tea, sodas, energy drinks, whatever. Now all I drink is water because I once mistakenly drank an orange crush thinking it was caffeine free like Fanta. I wonder if the chemical synthesized here would have any effect on my heart rate. It would be an interesting test to run.

Why ? 1.There are already excellent naturally occurring variants of caffeine (theacrine, methylliberine) which are much better than caffeine, primarily because they don’t cause ‘jitters’. 2. Why would anyone want to synthesise caffeine when you can buy it in bulk online ? I bought a half kilo for about $15. 3. Caffeine and its variants are not ‘recreational drugs’. For fug sake. They are functional. They maintain alert awakeness. That’s all. I guess that *could* be called recreational if you’re too sleep deprived to have fun - because you abuse recreational drugs. You may as well call aspirin a recreational drug, because you can enjoy being high with less of the headache caused by sleep deprivation (from too many recreational drugs). 4. There is a fantastic, underrated, *free* high obtainable by getting good sleep and nutrition, and having something more worthwhile to do than just tweaking your brain chemistry out of sheer boredom.

That's why I don't trust the US FDA, banning harmless stuff and toxic chemicals is fine, but that are banned in the EU

"Do not try this at home, this is an untested chemical" so if im gathering this correctly your saying we should sniff it?

Your experience on 200mg of DMAX makes me confident that it could be a better alternative to caffeine for people with high blood pressure (such as myself - I go into Tachycardia easily but still use Red Bulls to go into dish cleaning beast mode at work). I would like to see more research come of this and eventually see it being using in energy drinks as a smarter compound.

I dont understand the point of extreme hotsauces. Its not even enjoyable

bro made a real life stamina potion

I wonder if it affects ADHD symptoms. Potentially a good option for ADHDers with heart problems

Okay. So where do we pre-order?

The very first lab assignment we had in my undergrad organic chem class was extracting caffeine from tea leaves. I thought it was an incredibly useful lesson, considering.

thanks bro u helped me so much

Can you please do a video on synthesizing Dimethyltryptamine from Indole-3-carbinol

Spicy air is no joke I made it impossible to breath in a small apartment adding too much chili peppers to tacos

Made the air spicy 😂

Anxiety in a bottle. Wonderful.

I imagine this would be insanely dumb to take with a medication like bupropion which already comes with a warning about lowering seizure thresholds....

Long come ups on drugs are usually due to it having an active metabolite and if it is noticeable, it is probably more powerful. It is possible that you didn't notice the prime effects of the drug because it may have less of the "shaky" or "stimmy" effect. Some drugs can be hard to notice if you don't know what the effects. Also cross tolerance with caffeine may have come into play. The metabolite may be more "stimmy", so you noticed. Caffeine definitely can cause that general sense of anxiety.

5% aq solution of LiCl and extract with an organic solvent, would've saved you a lot of headache with getting rid of the DMF

Albert Hoffman 1943 vibes

This could potentially be a good treatment for Parkinson’s disease. Adenosine A2 antagonists help treat Parkinson’s, but caffeine may be dangerous to use for Parkinson’s due to its action at other adenosine receptors.

I was initially thinking it would be theophylline or theobromine

uhh.. at 13:30 you juice the lime but its actually supposed to go in the other way, that presses out the juice through the bottom of the press instead of out the top... it looks weird but it works way better than putting it in the way you did. Sorry to be that guy.

When you were saying as a chemist that you needed something stronger... We need to cook, Jesse.

Oopsie, next time I’ll wager you will be more careful? Either that or you will have an urgent appointment with mr Darwin…

Why not use a dessicator to help remove excess solvent? (Just curious)

Next experiment - Creates a clean anything detergent, using Chlorine Trifluoride

design the probes to hang onto street signs

I just purchased some pepper X seeds on eBay last week.

You put the lime in backwards juicing it lol

man its really strange how you wasnt able to distinguish 20mg from 200mg just by looking at the volume of piles

Is this similar to DMAA - 1,3 dimethylamylamine? I know some preworkout companies have added 60-100mgs of that with 300+ mgs of caffeine. Ive used them and maybe its just me but the caffeine definitely feels like it hits harder or feels more intense - and i have a very high tolerance for caffeine. Also have a euphoria and hyper focus from the DMAA

You sound like huggbees and this also feels like a how it's made episode

Apart from the spice, can we just talk about how crunchy those wings sounded?

12:21 You were so brave tasting that amount of scoville. 16,000,000,000 scoville! Wow! I do not want to eat that!

If you search for "1-Allyl-3,7-dimethylxanthine" (switching allyl and dimethyl to order alphabetically) then you find a few more results with interesting information, like the melting point etc. The problem is that somehow google search and stuff seems to be really specific about the order, otherwise you don't find as much info.

How did you realize that you misread the scale? 🤔

do dimethyltryptamine next

i have never seen drink like the root beer, does the safrole make a person high?

Damn root beer addicts always extracting things from Natural Things

I've got a bottle of the Last Dab Xperience and I was pleasantly surprised by how tasty it is in addition to its potent heat.

This guy is smart, funny, and handsome? Pack it up guys, we're done.

Hey um, you put the lime in upside down… 13:29