Skip the rodent tests and sell it as a research chemical.... fck sfty I wnt drgs! In all honesty, with the sheer number of phenethylamine type research chemicals that were cranked out by Chinese Iabs, I wonder how many of them were neurotoxic or caused any other lasting damage to the test subjects. MDMA being a former research chemical itself, when MDA got banned labs shifted to the next best thing from shulgin´s wizard hat.

But does it make dance music sound brilliant?

Not approved so pharma companies can patent these instead. Hundreds of thousands of people have used MDMA, often many times and we just do not see neurotoxicity at scale.

It's all very well to tweak a molecule like that and examine how it might be metabolized etc. but the most important factor by far is how does it feel ? and by and large from what I have seen messing with the methylenedioxy bridge in MDMA does not lead to a better molecule , in terms of it's effects. Shulgin did a little research into this, nothing good came of it. It would be great if MDMA can get a new status, but because of it's past as a rave drug , all that history generally scuttles any attempts. Heroin is still available in the U.K. as an example of one that bucked the trend, but the f*cking DEA are no ones friend when it comes to trying to have a little harmless fun.

Adam; Baby Slits; Beans; Blue Kisses; Blue Superman; Bombs; Booty Juice (dissolved in liquid); Candy; Chocolate Chips; Clarity; Dancing Shoes; Decadence; Disco Biscuits; Doctor; Domex (ecstasy mixed with PCP); Drop; E; E-Bomb; Essence; Eve; Go; Goog; Green Apple; Happy Pill; Hug; Hug Drug; Kleenex; Love Doctor; Love Drug; Love Flip (taken with mescaline); Love Potion #9; Love Trip (ecstasy mixed with mescaline); Lover’s Speed; Malcolm X; Moon Rock; Peace; Pingaz; Pingers; Rolls; Rolling; Running; Scooby Snacks; Skittle; Smacks; Slits; Smarties; Speed for Lovers; Sweets; Tacha; Thizz; Vitamin E; Vowels; White Mercedes; X; XTC; Yokes

Why not benzotriazol core? More easily accessible via diazonation and cyclization of diamine

I love how much flak Tom has gotten for falling short of the synthesis, I followed it for probably 2 yrs and I stopped after every video showed him failing on the UV step lol. Still, Tom’s among my favorite, love his wet and dirty chemistry. You’re pretty awesome too lol

I need some.....send it!!!

To be very honest, I expect that the reduced efficacy at the 5-HT2 receptors even when paired with similar potency for DAT, SERT and NERT is going to lead to subjectively subpar effect. The main reason why some synthetic tryptamines with low/moderate affinity for DAT, SERT and NERT have strong stimulant/euphoric properties is due to their much stronger 5-HT2 agonism. This seems to create a balloon effect that much enhances the subjective experience of a moderate catecholamine increase.

Doesn't a large part of MDMA's neurotoxicity come from the excititoxicity? I really don't think any drug that aggressively revert neurotransmitter tranaporters could be used for lengthy treatment. Personally I've had mediocre experiences with the drug itself when I experimented with it. It's very dangerous to use synthetic feelings as therapy in my opinion, substances that promote functional connectivity reorganisation by affecting the DMN in a therapeutic setting make a lot more sense.

Reduced binding at 5HT-2a might greatly reduce the antidepressant and antitrauma/anti-ptsd effects.

Yoo, i have never seen a video where literally everything in depth corresponds to my study biofarmaceutical science in the netherlands. The flow of the video is really good and neat. Explains everything just enough for me to understand. I'll be watching some more of your videos in the coming weeks. Keep it up man! Ggs 🙌

Gooofyyy ahhh compound 😭😭😭

It's super nice that research is more common these days and we now can use the help modelling software as well. Makes sense, that MDMA itself ist just the beginning of a new path on understanding and fine tuning this specific type of interaction and effect on humans. It's some sort of gateway drug to who knows what. In the last century we found some molecules that alter our mind and mess around with it and now we can precisely modify its function and get the respond that we'd like to have. Also we get a better understanding of how our brain works, if we examine it from different sides. Thanks for the video!

Iv mdma at 70 to 90mg the rush felt like electricity all thru my body n after a while when i could stand up my pupils were almost the size of my iris. But it something i wont repeat due to ill health but damn i still remember the intensity of the experience even today. N this was in 2007

Yeah yeah. The issue with MDMA is that it cannot be monetized. New analogues can. There should be an investigation into the people controlling the accesability of MDMA.

sucks with mdma the true affect is only the first time you do it

Sounds like a good replacement for therapeutic users and ravers who opt to use such a substance.

ODMA looks promising!

My medicine 💊 last 30 years

That's it I'm becoming a chemist

98-01 I took MDMA and went to underground raves in Detroit best time of my life

5map is mdma like a not brain toxic

6-apb deserves to be investigated, it really has some therapeutic properties. It helped me understand the source of bad behavior i had toward the world. It feels like a combination of a stimulant, an empathogen and a psychedelic. It helps with diving in old wounds and traumas without feeling terrified and facing questions or truths we use to keep under the carpet in everyday life.

I've taken MDMA and had shrooms. MDMA a few times, and completely laughed my a** off, which my sides hurt for days lol. Shrooms only once and I experience what I was hoping for. Now that's not saying it doesn't cause I have friends that say they've had amazing experiences on shrooms.

You don't need any drugs, all you have to do is believe. Yes, these drugs can get you into state where you can process traumatic events better, but you can definitely do it sober too, you just have to believe. Close your eyes and look inside your soul. Forgive. It's better to take drugs for fun rather than being dependent on them and losing your power of will, if you really have to. But you will endup either realizing that they don't make you anyone better, or you will endup somehow dependent on them. In the end it's always power of will which will save you. I'm telling you so you don't have to it's in your hands

We gon did it on tonight

People have used mdma quite safely for some time, this just seems like big pharma stepping in and separating the common person further away from the source. Alcohol, nicotine, and prescription drugs, legal sources of hardship for many. The war on drugs is a war on us. Cool science stuff tho

The main reason for this is obviously to allow big pharma companies to create a patent to make money out of it . Cures with no possibility of creating a patent are always stopped .

5mapb 6mapb is similar mdma Bk MDMA methylone also and very easy can made it without lab equipment very quik

MDMA kept me going when I had nothing, and nobody.

Removing the internal self navigational nature of 5ht2A destroys the point and purpose of internal navigation and empathy towards oneself & others with sudden introspection that won’t happen anymore, I predict it’s dopergenic response & amphetamine structure to be more focused towards adhd treatment & other dopamine deficiencies. Cubane remains a promising alternative tho as you have described with the receptor site mappings it’s about frequency modulation across protein folds like tuning an instrument as Tesla says crystals sing & you are brainwaves you are the frequencies and Tesla even describes how & why crystals sing and resonate.. recreate the “song” or frequency along the desired pathway. The chemical structure might not even resemble this stuff at all anymore..

Get on it China/NL!

Ughhh.. do they need any human test groups? This guy right hur!

That would be great news for ADHD people.

I did mdma once every 60 days for 5 years with my gf, we have only had positive results from doing it this long. People are really paranoid about mdma.

Sassefras oil

Using MDMA for PTSD is like smoking cigarettes for overeating

MDMA is a drug and chemical created in the lab. No thanks. I'm gonna stick with old Peyote/San Pedro cactus.

Mdma 2 before gta 6

sure. but most of the bad side-effects come from cutting with crap or from dangerous compounds like pma. Both a direct result of the most damaging gov policies of all time, making these things illegal, which ultimately did nothing to stop their use, as was the case with prohibition. They refuse to admit of this course. Can't wait till these ppl and gone and can't affcect humainty with insane/demonic policies/corrupt systems

omg

Five topics to fix society via discussion: -Anti-natalism vs Natalism -The 3 basic needs/prenatal needs Three things necessary for human evolution that are provided while in the womb which are; food, shelter and medical care. -Platinum rule Do whatever makes one happier unless it interferes with another persons ability to do the same. -MBTI (research yours and connect with others) -Art (pick one and get better at it!)

So the analogs regulations and laws have been overturned? Will a local sherrif even care?

My friend is kind of dumb so he’s asking… is this chemistry actually developing a safer better MDMA or is it just a push for big pharma to get a patentable drug. Are there RC’s that safety profiles as good or better than this new drug?

I think they're removing important activity and should stop looking at the psychedelic attributes as a negative side effect.

Crazy ive found my new love ❤️

Improved safety damn mdma feels extremely safe at a normal recreational dose

Kurt Cubane would be proud.

contact me if u wanna make it