To bad this discovery was so late, otherwise we might have gotten another ones of Shulgins books, this time CiHKAL :)
@GAFUKIS4 ай бұрын
Lmfao cubanes I have known and loved
@meloney4 ай бұрын
@@GAFUKIS that would have been so great. In an alternate timeline maybe.
@GAFUKIS4 ай бұрын
@@meloney ikr!!! I have pikhal and its great, maybe cikhal would have been better 😂😂
@meloney4 ай бұрын
@GAFUKIS cubaned MDMA or Amphetamin. Damn might be even better with fewer side effects medically. I get prescribed amphetamine and I'd love to test cubephetamine
@GAFUKIS4 ай бұрын
@@meloney i get prescribed methylphenidate and would love to see cubylphenidate
@C4pungMaster4 ай бұрын
Great vid. It falls in quite nicely for me as more relaxing than "hardcore" science explanations or reading actual papers, but also not too meme-fied and lose all seriousness. Just the right amount of information and jokes imo.
@chemistrycapital4 ай бұрын
Thank you, that’s the goal I have for these videos!
@barfbot4 ай бұрын
agree its so helpful to get a lay of the land
@AmaroqStarwind4 ай бұрын
Now to find out if living organisms can synthesize cubic functional groups.
@chemistrycapital4 ай бұрын
That would be impressive 😂
@markharder36764 ай бұрын
On which planet? 🎉
@AmaroqStarwind4 ай бұрын
@@markharder3676 Any planet.
@Artyomi4 ай бұрын
@@markharder3676Cube earth obviously
@luckyblockfatality4 ай бұрын
@@markharder3676you should see what some people are doing with yeast
@NautsuJJR4 ай бұрын
tiniest detail that I noticed was incorrect: naloxone has a hydroxyl group on carbon-14 (the carbon where the chiral hydrogen is highlighted) instead of a hydrogen. this is because without the hydroxyl group, most allylmorphines also function as k-opioid receptor agonists, which can cause problems with confusion, dysphoria and hallucinations.
@chemistrycapital4 ай бұрын
Ah this is true, I must have forgot to add it in when I copied the structure of morphine in ChemDraw, I will add a note in the description correcting this.
@geekswithfeet91374 ай бұрын
You know what, turning a fentanyl OD into a salvia trip could have some utility in teaching value lessons
@mvmusic84674 ай бұрын
@@geekswithfeet9137 Naloxone already throws you into precipitated withdrawals, thats already an eye opening spiritual experience without the need for kappa agonism on top.
@alllove17544 ай бұрын
I've been waiting to see the cubane derivatives of phenethylamines.
@meloney4 ай бұрын
Waiting for cubephetamine.
@alllove17544 ай бұрын
@@meloney yup.. and then the 3,4 mdcubylma that will happen
@meloney4 ай бұрын
@@alllove1754 i loved the first few times. Had (the not cube obvs) a few weeks ago for the first time in over 8 years. Didn't like it anymore at all:( Maybe the power of the cube will help.
@marcrhoades95484 ай бұрын
Already on it ...
@usedcars95214 ай бұрын
haven't we all...
@Flesh_Wizard4 ай бұрын
"I'm not like the other addicts, I only smoke cubic crack"
@chemistrycapital4 ай бұрын
😂
@peterdinkler49504 ай бұрын
the new office stimulant sweeping the nation.
@antifreeze-30degrees494 ай бұрын
What about cubic speed (Amphetamine. Amcubamine.)? And cubic meth (Methamphetamine. Methamcubamine.)? And cubic super speed (Ethylamphetamine. Ethylamcubamine.)?
@pitchblack29834 ай бұрын
@@antifreeze-30degrees49Don‘t see why it wouldn‘t work
@Yasmine-zk1ni4 ай бұрын
@@antifreeze-30degrees49 my thoughts exactly. would it even be illegal though
@nachocheese1324 ай бұрын
I'm not a chemist and organic chemistry is as far as I've learned. This cubane stuff is fascinating
@chemistrycapital4 ай бұрын
Nice to see the content is interesting to non-chemists as well!
@ChemicaLove4 ай бұрын
thanks for posting the papers' links
@chemistrycapital4 ай бұрын
No problem!
@hytago33384 ай бұрын
This is the video I have been waiting on!
@chemistrycapital4 ай бұрын
That’s amazing!
@minddrug7094 ай бұрын
Cubane is when you blast cocaine with high-volume of Nirvana’s music until it turns into this.
@Deadsetmadlad4 ай бұрын
Great pacing and visuals! Did not feel overwhelming to watch. You’re a great communicator. Subbed
@chemistrycapital4 ай бұрын
Thank you so much!
@calvinhochberg53264 ай бұрын
I saw the drug structure on the thumbnail and my immediate thought was this wasn't cubane on cocaine but an opiate with cubane. I was not disappointed when I found they just added it to all kinds of drugs.
@jonathonkane76384 ай бұрын
These med chem videos are perfectly structured and informative! I never thought of cubane as a bioisostere of benzene and id love to test this out on several of my projects!
@jonathonkane76384 ай бұрын
The best part is they won’t have pi interactions with the aromatic residues!
@chemistrycapital4 ай бұрын
Thank you! glad to see they are reaching the right people
@Chemicator4 ай бұрын
Great explanation👍 the persistence of strained molecules like cubane, propellane and cyclopropane is very interesting in chemistry.
@chemistrycapital4 ай бұрын
Definitely, also BCP’s are a big thing med Chem right now
@RomanBekker20224 ай бұрын
to be honest, cyclopropane isn't all that stable -- it was way too prone to produce a BIG BADABOOM in the operating room 🙂it was even more problematic in that regard than ether vapour or ethylene (can be compared to acetylene though) 🙂 this was the main reason why it was phased out as an anaesthetic other than BADABOOM, nausea and vomiting and adrenaline cardiosensibilization -- it was great in the sense that it, much like ether, had low toxicity, wide therapeutic margin, could be used in hemodynamically unstable, highly traumatized, volume depleted patients it also had the ability to provide EXCELLENT analgesia for looong hours after the surgery, much like ether vapor -- which greatly reduced the amount of opioids needed for postoperative analgesia
@RomanBekker20224 ай бұрын
love the cubanized benzocaine version :) I think cubocaine would have much longer T1/2 in the body, so sucking a cubocaine / rafathricin tablet for sore throat would provide much longer local anaesthesia than its currently used benzocaine counterpart :)
@chemistrycapital4 ай бұрын
It’s funny that they actually refer to it as cubocaine in the paper
@peterdinkler49504 ай бұрын
oh damn, they'll never let this see the light of day.
@bigredinfinity31264 ай бұрын
Wow great video you definitly earned my subscription
@chemistrycapital4 ай бұрын
Thank you!
@Kencohtman4 ай бұрын
Great video lad 💪
@chemistrycapital4 ай бұрын
Thank you mate ❤️
@benmcreynolds85814 ай бұрын
It'd be so interesting to see if a cubane derivative of an opioid medicine could help us discover new More balanced, therapeutic pain medicine options
@bdnugget4 ай бұрын
At 1:25 at the tribrominated ethyleneketal, I believe the bromines should all be on the alpha carbons, so one of them has two bromines on it.
@chemistrycapital4 ай бұрын
You are correct, I have included updated slides in the description
@7stiano1234 ай бұрын
Proposing a new compound and then creating it is some Tony stark stuff
@chemistrycapital4 ай бұрын
What amazes me the most is they had no idea if it could be made or if it was stable. At least with complex natural product synthesis you know that it is possible to make somehow, even if that’s through biosynthesis.
@jerry379024 күн бұрын
Can’t wait for cubethylamines to become a thing.
@chemistrycapital24 күн бұрын
Haha, check my community posts…
@eddywolton63974 ай бұрын
Cubane analogues of drugs are getting to be my favourite group of organic compounds, cubed dmt would be an epic sample to have
@antifreeze-30degrees494 ай бұрын
Amcubamine, Methamcubamine, and Ethylamcubamine would be cool. Also, the cubane version of Selegiline, L-Deprenyl, D-Deprenyl, and racemic D, L-Deprenyl. Modafinil and Armodafinil is cool, and so are Flodafinil and Hydrafinil, so maybe cubane versions of them would be cool. There's also Propylhexedrine and Norpropylhexedrine. Stack Propylhexedrine with Quercetin (widens blood vessels) and Tropoflavin (neuroprotectant against excitotoxicity and neurotoxicity) would be good. Always stack stimulants with Tropoflavin.
@mouhammeddaouayry4 ай бұрын
Once again an amazing video.
@chemistrycapital4 ай бұрын
Thank you, glad you enjoyed it!
@derenjoy3r4 ай бұрын
ok now you have my sub
@chemistrycapital4 ай бұрын
Amazing
@arvifox51704 ай бұрын
Amazing video on an amazing topic ❤
@chemistrycapital4 ай бұрын
Thank you!
@Adam-l3f4f4 ай бұрын
Far out what an epic story behind the original synthesis
@chemistrycapital4 ай бұрын
Must have been a relief when they finally completed the synthesis and realised it was stable 😂
@bugabateinc9714 ай бұрын
interesting, but tricky to synthesize
@thenetgamer24 ай бұрын
Back to the watchlist I guess.
@michaelhicks86034 ай бұрын
Hey man just want to say that this was a sick video.
@chemistrycapital4 ай бұрын
Thank you, many more to come :)
@BrotherLuke2008Ай бұрын
cool video
@jaimeortega49404 ай бұрын
Really cool!
@chemistrycapital4 ай бұрын
It is isn’t it!
@douro20Ай бұрын
I'd like to see triflucuburon commercialised.
@chemistrycapitalАй бұрын
Quite a few trifluorocubanes are commercially available!
@douro20Ай бұрын
@@chemistrycapital I actually meant diflucuburon. It's the cubane analogue of the popular insecticide diflubenzuron and it's been found to be significantly more effective.
@BrotherLuke2008Ай бұрын
hamilton morris needs to know about this :)
@chemistrycapitalАй бұрын
Haha, hopefully one day he finds this channel :)
@markharder36764 ай бұрын
Octanitrocubane go much boom boom. As I recall, det. velocity is about 10,000 m/sec.
@Flesh_Wizard4 ай бұрын
Octaazacubane is boomier. Detonation velocity estimated to be 15 km/sec.
@cannack4 ай бұрын
first time I saw the structure of adapalene, I was like *what the actual f* is this Cubanes are even more mysterious, an addictive rabbit hole. the potential for new energetics, perhaps a replacement for lead-azide type devices, or an advanced TNT/RDX/PETN replacement is promising.
@chemistrycapital4 ай бұрын
Yeah this is the other major area of research into cubanes and is also very interesting
@Flesh_Wizard4 ай бұрын
Octaazacubane. 8 nitrogens in a cube
@noobyfromhell4 ай бұрын
Cubanse when Civvie?!
@MaybeTogether4 ай бұрын
What would happen if we put cubane in caffeine?
@eadantrimble45144 ай бұрын
Research chemical Pt2?
@letzte_maahsname4 ай бұрын
it would absolutely revitalize the scene with blanket bans. one can hope.
@coledavidson56304 ай бұрын
Organic chemistry is pure gibberish to me but i still find these videos interesting lol
@ShouldOfStudiedForTheTest4 ай бұрын
Now imagine fighting against another level of ring strain and annelating cubane on benzene and heteroaromats.
@chrisfrey65024 ай бұрын
you kinda ignored the detail, that Tom tried the sinthesis from houshold substances and hardware store ingridients... It is kind of not fair to compare the two
@kitsumyr97524 ай бұрын
it sucks that cubane died early. he made really great music with Nirvana
@graymie4 ай бұрын
This is so fucking cool, thank you for posting
@chemistrycapital4 ай бұрын
Thank you for watching!
@mrcrazyhair92304 ай бұрын
Interesting vid!
@chemistrycapital4 ай бұрын
Thank you!
@_sh11234 ай бұрын
Thank you, quite interesting. A molecule for minecraft aficionados and lovers of the Art.
@chemistrycapital4 ай бұрын
Never thought about the fact it looks like a Minecraft block, but now I won’t be able to unsee this 😂
@ezekielmulder10564 ай бұрын
This was a super cool video but my main question is how you pronounce methyl and allyl groups. I have always pronounce methyl rather than mEthyl. Is that common where ever you are from? Also I don’t mean to shame at all so if this is a line of questioning that uncomfortable, feel free to ignore me
@chemistrycapital4 ай бұрын
This is the English pronunciation which is different to the American pronunciation. “Amide” is also another chemistry word which is pronounced different.
@remmymartinnn70924 ай бұрын
Kurt Cubane
@chemistrycapital4 ай бұрын
Honestly took me longer that I thought to get all the nirvana references which poor because I am a fan.
@vitalic_drms4 ай бұрын
thats cubane. mayne.
@dsdy12054 ай бұрын
Cubane is nice, but what about tetrahedrane?
@chemistrycapital4 ай бұрын
Now that would be impressive
@DR-544 ай бұрын
Could this perhaps be used to prevent the metabolism of dextromethorphan? DXM's most medically important uses, as what is basically a superdrug at this point, all share a similarity in that its metabolism needs to be inhibited. Specifically, dextrorphan (DXO) is typically unwanted besides niche uses for dissociative-anesthetic therapy akin to ketamine therapy. However, the other metabolites of DXM are wanted as they are neuroprotective and seem to help cancel out some of the possible negatives that DXM would otherwise have so perhaps it would be foolish to assume a cubane version of DXM would be able to have the same therapeutic success. However, it would likely limit abuse. Another interesting drug that could benefit from it is salvinorin A which has poor absorption due to its fast metabolism. It could help with making salvinorin analogs for use as a k-opioid receptor mediated anesthetic that are long lasting.
@ichbintoll71284 ай бұрын
Nice vid
@chemistrycapital4 ай бұрын
Thank you!
@cubee41084 ай бұрын
me fr
@chemistrycapital4 ай бұрын
Username checks out
@CatboyChemicalSociety4 ай бұрын
cubometh
@wilinja4 ай бұрын
i wasn't aware of the race of youtubers, do like Sams channel but didn't see his method. did however watch most of Tom's synthesis and considering his location both his lab/shed in the rural Australian outback idk but seems there was a slight advantage
@chemistrycapital4 ай бұрын
Yeah to be honest it wasn’t much of a race. In Sams first video on the topic he had already completed the synthesis of the di-acid.
@lop21674 ай бұрын
I wanna try cubococaine
@jaketonsbeek88844 ай бұрын
could it be used in opiods or benzos
@chemistrycapital4 ай бұрын
Did you not see the part about opioid antagonists?
@WilliamGomez-ek7sd4 ай бұрын
Disculpen, la locura es una droga o es un quimico que nace con el humano
@schlomper4 ай бұрын
My drug of choice is and always has been HIV medication.
@chemistrycapital4 ай бұрын
Interestingly one of the first uses of Cubane was in HIV medication
@aloedg31914 ай бұрын
Cubetamine
@AmielKefer3 ай бұрын
Thanks for the Vidio it seved my ass in my final Presentation exsam culdn´d hav don it with aut it.
@chemistrycapital3 ай бұрын
No worries, glad I could help!
@mihaleben60514 ай бұрын
What
@rickydominguez8134 ай бұрын
Looking for Tom’s comment 🌝
@chemistrycapital4 ай бұрын
Haha, that would be cool
@trueKENTUCKY4 ай бұрын
lmao 🤣 Cancer cure 1million dollar company
@ManuDunno4 ай бұрын
Tom caught an L. This is what you get for living somewhere where Christmas is in summer.