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@judesterification 7 күн бұрын
Would a severe niacin deficiency, like having pellagra cause someone to have very fragile, weak and thin connective tissue. Like ligament and tendon?
@sm24california Ай бұрын
Does he dye his hair? Or is it natural
@nancycorrea9319 Ай бұрын
She And he, have beutiful skin. Why ?
@irenadurakic-edwards9577 2 ай бұрын
How can i take metfofmin when doctors wont prescribe me as i dont have diabetes?Where do i get berberine?Im in Europe. Thank you
@amielynn2657 2 ай бұрын
Can someone with hypothyroidism and also takes low dose of Levothyroxine take NMN??
@user-vb2ff3pn9z 2 ай бұрын
David said do not get X-ray (which damage DNA), but what about mammogram (which is a breast X-ray)?
@heidir8695 2 ай бұрын
Dr. SInclare, honestly speaking to me you have aged backwards. Looking alot younger than you were a few years back. I admire all you are doing, and am excited to supplementing supplements into my diet. Keep up the excellent good work. Blessings 10 years backwards
@gamer-xv8cw 2 ай бұрын
I love them both- but am I the only one who is extremely bothered by her restlessness.
@Doreensymonds-ss6ho 3 ай бұрын
Hi , I just started taking the supplements that you take. I take a statin prescribed by doctor will this interfere with the vitamins?
@galaxymetta5974 3 ай бұрын
Read transcript to overcome the poor audio. Cheers.
@marilouentrolizo3533 4 ай бұрын
Dr Sinclair how about those women who doesn't have ovarian reserve anymore,what is the best supplements?
@lornayeo3303 5 ай бұрын
Thank you both for your work to bring this to us, the general public 🙏🏼
@Baleiric 5 ай бұрын
Thank you for all this info. I've been fighting high cholesterol for decades. I've tried all the supplements known for better chol numbers, and they have not worked as well as caused digestive stress. Most statins cause muscle problems. Rosuvastatin is the best tolerated. But I worry about my mental health because I already have focus issues, with dementia in my family. I ate raw vegan for 2 years. I still had high cholesterol. Presently, my total cholesterol is over 250 with high proteins as well. I eat veggies, fruit, and fish on occasion. No dairy. Brain and heart support vit./supplements. I also tend to get palpitations (arrhythmias) from the longevity supplements. Seems I just can't win. But I keep trying things.
@ZmogusJaponija 3 ай бұрын
What about whole grains, nuts and seeds? I'd suggest you could read M. Greger's book - How not to die. Might be helpful.
@Baleiric 3 ай бұрын
@@ZmogusJaponija Well, yes I eat plenty of grains, seeds and nuts. I'm actually in very good shape for my age. I just have high cholesterol numbers, and medicate for hypothyroidism. I've been told by drs my organs run like a 20 year old.
@vincentack1323 5 ай бұрын
I went on PQQ 20mg per Day. Ngf went up. I wasnt able to do simple math.
@VoiceoverMomentum 5 ай бұрын
Guilty. I’m one in a million! Lactic Acidosis. Thank God the side effects did go away within 2 days of stopping it. It nearly killed me.
@ParulsPalate 5 ай бұрын
I have a question. You said in one of your videos that mtor senses low protein level in cells and then recycled the old protein. Therefore a low protein diet can trigger autophagy. But Indian diets are inherently low in protein. And there are all sort of nutritional deficiencies in the population. What do you have to say about that?
@ZmogusJaponija 3 ай бұрын
Yes, but autophagy won't help if people eating a) unhealthy food or b) low nutrition value food instead of protein. So you cannot eat for example pasta once per day and then trust the authopagy process to fix all the problems which comes out of it. So D. Sinclair and some other nutrition scientists are recommending to eat moderate protein diet, preferably from plant sources + resistance training, so you keep muscle mass as you old. And then switch off mTOR and swich on autophagy with looong fasting window (Sinclair eats once a day himself). Hope that hepls.
@tlindfld 5 ай бұрын
They fucking.
@user-hn9pg6ic3e 6 ай бұрын
Thank you so much…🙏🏼🤍
@magnetsa 6 ай бұрын
Take Berberine, Fisetin, Spermidine, Resveratrol, and NMN on non-exercise days and do not take them on exercise days. Is that correct?
@terrywalters5410 6 ай бұрын
They want to do it ❤
@kasiacatt8348 6 ай бұрын
Dr Sinclair does not look good.What happened?
@pastamandjinka 6 ай бұрын
I'm so glad for David Sinclair looking so well and happy-wish he will always stay that way-we need him! 🤩
@blakeshelton6646 7 ай бұрын
*promo sm*
@blancaungson4490 7 ай бұрын
Thank you! You’re a nice couple.😊
@tocitim 8 ай бұрын
David Sinclair!!!!... stop beating about the Bush, just be honest and bring on what you are saying. Doing talk nonsense. Bring the pill to people .
@elenabenjamin9980 8 ай бұрын
Thank you both of you! 🙏🏼🙏🏼💪
@elenabenjamin9980 8 ай бұрын
❤
@TheRomanPilgriminPerson 8 ай бұрын
I Love your emails Serena, the Best!
@TheRomanPilgriminPerson 8 ай бұрын
I prefer a tiny Italian teaspoon of raw dark brown sugar in my coffee and tea.
@TheRomanPilgriminPerson 8 ай бұрын
Your bios are magic.
@TheRomanPilgriminPerson 8 ай бұрын
I got rid of my eyeglasses decades ago, they broke so I went outside and focused on distant objects until I could see them. I was able to eliminate the eyeglass requirement from my driver’s license after decades of suffering with it.
@TheRomanPilgriminPerson 8 ай бұрын
After washing, I massage a good coconut oil into my face and neck with upward strokes, works for me and it doesn’t cost an arm and a leg and it smells delish!
@TheRomanPilgriminPerson 8 ай бұрын
I’ll have a hot dog now and then!
@TheRomanPilgriminPerson 8 ай бұрын
I don’t do well eating windows. I hour is my window if everything is already prepared, a little longer if I prepare as I go along.
@pastamandjinka 6 ай бұрын
1 hour..? what do you mean?
@TheRomanPilgriminPerson 8 ай бұрын
Starting in your 70s or 80s will net even greater results cause it’s needed most then. Your Information theory applies to all ages, the backup copy is still there. Don’t limit your own research work and don’t discourage people please. Many people are 70 or 80 at this time. Democratizing includes the Aging too, isn’t that what you’re all about?
@GeorgiosAndreasIoannou 8 ай бұрын
Any news with the new pill Dr Sinclair?
@XeNos3131 7 ай бұрын
Έτοιμο σε 10 χρόνια...
@lcb1250 8 ай бұрын
I can’t wait till Sinclair slowly walks back on all this anti-mTOR talk and acknowledges the importance of higher protein intake the older we get.
@LifeDIY 8 ай бұрын
I believe there was just recently a study on this - highlighting how extremely important protein is for older people!
@stefanisilva2493 8 ай бұрын
He does, everyone knows elderly should take a bit more protein. But this frailty in elderly thing is much more complex then protein, since that age frame has severe hormonal issues and both cultural and cronic pain conditions that lead to extreme sedentarism as huge factors for their sarcopenia.
@KTPurdy 7 ай бұрын
by definition activated mtor is the process of aging.
@mihaelafrincu8732 8 ай бұрын
Hi Serena and David I love your videos ,each one is full of precious info ( have changed a lot in my life) thank you so much. Now ,I would like Serena to tell us what to eat for a whole day as you look beautiful and healthy too Thank you
@mihaelafrincu8732 8 ай бұрын
Brilliant info,pl keep it up!
@mihaelafrincu8732 8 ай бұрын
Thank you both! So much precious info, keep it up guys!
@mihaelafrincu8732 8 ай бұрын
She looks fab!
@mihaelafrincu8732 8 ай бұрын
Serena,you are not only beautiful but smart too! Looking forward to more informative videos!
@StoptheClock1973 8 ай бұрын
You have a better workout on a meat based diet. A little mTOR stimulation is work the added muscle for longevity. Find at more at Stop the Clock with Brad. Keto Diet or Carnivore for longevity kzbin.info/www/bejne/qIjZdXuej99niKc
@pastamandjinka 6 ай бұрын
It seems you are more knowledgeable about gerontology, than the Harvard professor and renown scholar- D.S. 🤷♀
@zoewalker6630 8 ай бұрын
Can someone provide the metformin studies that David was suggesting no diabetic take to their doctor? Or is there a files section I am not seeing?
@angelaelizabethmccullough921 8 ай бұрын
Improve sound please!😊
@sunnylm2045 8 ай бұрын
Hi, I have a question since you both taking many drugs together, such as Resveratrol, NMN, taurine etc...how would you know which one is working????
@ireneso1671 8 ай бұрын
Thanks for the information ❤
@benssasiyacine 8 ай бұрын
Verry important vidéo 😊😊😊😊
@ancaunterweger2269 8 ай бұрын
Love you a loth bouth...really change my family life in good
@ancaunterweger2269 8 ай бұрын
Love you guys ❤ I am so happy that I read Dr David Sinclair book and that he is in collaboration with you Serena I am a dentist,I love to learn new things So thank you gays for everything ❤❤❤❤