Kevin Bioinformatics

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@inamulhaq6704 5 күн бұрын

Thanks Kevin. I had a doubt regarding the reference genome. Like if I want to align wrt to SARS Cov2 reference genome from NCBI, how does the software like ugnene or mafft know that its a reference genome. Like I input multiple sequences into a single file only

@darksider9587 6 күн бұрын

thank you so much. crystal clear explanation

@shreybae93 Ай бұрын

Spent almost 45 minutes trying to understand how to construct a BWT from a suffix array and this video explained it in 5 minutes. Thank you!

@Maggie-xx2is 7 ай бұрын

Thank you so much I finally understood this one day before the final, lol

@rajaramansoundararajan8246 8 ай бұрын

Well presented .... So Smooth !

@allergictoalliteration6033 Жыл бұрын

The clarity and pace of your lectures is excellent. However, I also appreciate your attention to "smaller" details like adding captions, dividing your videos into chapters, and organizing your content into a playlist. I can imagine you put in a lot of time and work into these extra perks, and I'm really thankful you did so. Cheers from the Netherlands. :)

@KevinBioinformatics Жыл бұрын

Thanks for your comments! Hope the videos are useful for you!

@ndagijimanafrankaimeerodri8893 Жыл бұрын

Thank you a lot!! I learned more in 10 minutes than I learned in a 3 hour class !!! Everything is clear and the slides are vet informative!!

@KevinBioinformatics Жыл бұрын

Happy that the video was useful for you!

@alexlee3511 Жыл бұрын

You explain it so well! But i wanna know if there is any reliable software recommend for sequence alignment since i found so many different software online

@preetyyadav8543 Жыл бұрын

this is the most simplified video i have found on the internet fir alignemnts thankyou so much kevin, subscribed.

@Angelica-dx2sr Жыл бұрын

Thank you so much!

@Nokoli_ Жыл бұрын

thanks a lot. that was super helpful

@lotuzz7409 2 жыл бұрын

Very understandable and informative, thank you!

@pccfs 2 жыл бұрын

Thanks for your brilliant work!

@KevinBioinformatics 2 жыл бұрын

Thanks for watching!

@chitranshsinghchauhan6338 2 жыл бұрын

Wow nice explanation 🙏

@KevinBioinformatics 2 жыл бұрын

Hope it was useful for you!

@sbdranjani 2 жыл бұрын

Well explained Sir.. Thanks for this video

@KevinBioinformatics 2 жыл бұрын

Thank you for watching!

@dariusduesentrieb 2 жыл бұрын

So it's basically O(2^n)?

@KevinBioinformatics 2 жыл бұрын

The number of possible alignments is exponential with respect to the lengths of the input sequences, but as you can see in the later micro-modules, it is possible to find the optimal alignments in polynomial time.

@lyhongngoc4038 2 жыл бұрын

Hi, why is V(a,A) = 0.7? I'm still confused on that part. Any explanation is greatly appreciated!

@KevinBioinformatics 2 жыл бұрын

V(a,A) is the probability of the sub-tree rooted at node a when its parent, node d, takes nucleotide A. This probability is equal to the probability of having A at time 0 and also A at time t_{ad}=1. By the Jukes-Cantor model, this probability is 1 - 3 * alpha =1 - 3 * 0.1 = 0.7.

@mohamedkafafy6832 2 жыл бұрын

great and simple

@KevinBioinformatics 2 жыл бұрын

Glad you liked it!

@oldPrince22 2 жыл бұрын

Very good videos. Thanks a lot Prof. Yip

@KevinBioinformatics 2 жыл бұрын

Thanks. Hope the videos are useful for you.

@oldPrince22 3 жыл бұрын

雪中送炭的視頻，希望今晚都刷完

@oldPrince22 3 жыл бұрын

哇講的真的好好

@KevinBioinformatics 3 жыл бұрын

Thanks! Hope you enjoy the videos.

@lamjason4081 3 жыл бұрын

Thanks prof. Yip I am a CUHK student as well

@minhaoling3056 3 жыл бұрын

Hi , how do you ensure that by defining likelihood as summing all the possible ancestor states will give the best parameter estimates for a particular ancestor state? I was thinking maybe different ancestor state will have different sets of best parameters.

@KevinBioinformatics 3 жыл бұрын

In this approach, based on the externally specified prior distribution of the states at the root node, summing over all possible state combinations at the internal nodes gives the overall data likelihood because the different state combinations are mutually exclusive. If the basic assumptions behind this model are not true, or if additional information is available, the calculations can be modified accordingly.

@minhaoling3056 3 жыл бұрын

Hi is this the last section of your modules ? Is it possible that I can get the slides from your modules ?

@AshishSingh-sy3gn 3 жыл бұрын

Thanks a lot for adding new videos, your videos are and very well explained.

@KevinBioinformatics 3 жыл бұрын

Thanks. Hope you enjoy the videos!

@AdityaSharma-vi8ky 3 жыл бұрын

wow

@AdityaSharma-vi8ky 3 жыл бұрын

nice

@mukailarashid5428 3 жыл бұрын

You nailed it again Sir!

@mukailarashid5428 3 жыл бұрын

Sir, you did a really good job in this video. It's been a year since i started learning bioinformatics but I was never sure of what was going on until I came across this video. I decided to comment before even finishing the video because I already got 90 percent of the concept. Thanks a lot.

@KevinBioinformatics 3 жыл бұрын

That's great. Hope you also like the other videos in this channel!

@ama-tu-an-ki 3 жыл бұрын

How is this calculated in bayesian terms? What are the assumed priors? This must be an infuriating probabilistic problem, if we can't even assume the distribution of mutation frequency?

@gouthams6711 3 жыл бұрын

the calculation of ur 2ed table is wrong

@KevinBioinformatics 3 жыл бұрын

Thank you for your comment. Could you explain how it is wrong?

@vikaanissimova6058 3 жыл бұрын

Thank you so much! I'm reading a publication about MSA and your videos helped me understand sequence alignment! Very wonderful explanations - by far the best video about sequence alignment on KZbin.

@KevinBioinformatics 3 жыл бұрын

Thanks for watching!

@MrSoumyaBanerjee 3 жыл бұрын

I had little prior knowledge of bioinformatics, but your excellent video made me lose my fear of it, thank you so very much.

@josephhoracek6477 3 жыл бұрын

Thanks!!! this helps a lot

@KevinBioinformatics 3 жыл бұрын

Thanks for watching!

@tayyabsheikh4021 3 жыл бұрын

Precise and well articulated. Perfect!

@KevinBioinformatics 3 жыл бұрын

Thank you for watching!

@asayimusa 3 жыл бұрын

this is great! Thank you so much

@KevinBioinformatics 3 жыл бұрын

Thanks for watching!

@haleemabibi4123 3 жыл бұрын

This was super helpful!

@KevinBioinformatics 3 жыл бұрын

Thanks for watching!

@JJ-lo6up 3 жыл бұрын

will you upload more video about bioinformatics algorithm, such as pca, umap... it's so clear for me to understand, thank you

@KevinBioinformatics 3 жыл бұрын

Yes, some more videos will be uploaded in the coming months. Stay tuned!

@AF-hv4yy 3 жыл бұрын

You explained more in 11 minutes than my professor in 4 weeks, thank you

@KevinBioinformatics 3 жыл бұрын

Thanks for watching!

@AqleemAbbas 3 жыл бұрын

@@KevinBioinformatics Your lectures are awesome, If any post doc position in your lab let me know

@hannahcarrillo9435 3 жыл бұрын

This was really helpful, and I was able to get a better understanding of this topic. Thank you!

@KevinBioinformatics 3 жыл бұрын

Glad to know that! Thanks for watching.

@knowledgehunter6539 3 жыл бұрын

Wow!! My name is Kevin too. So happy to subscribe to your channel🤗🤗 I really need in depth knowledge in Bioinformatics for my masters thesis.

@KevinBioinformatics 3 жыл бұрын

Hope the videos are useful for you! Comments are welcome.

@oliverwilliams9507 3 жыл бұрын

This is an excellent video, thank you very much!

@KevinBioinformatics 3 жыл бұрын

Thank you. Hope it was useful for you.

@KevinBioinformatics 4 жыл бұрын

Thanks for watching. Hope it was useful for you.

@jingzhang5008 4 жыл бұрын

that is so clear! thank you!

@babangapu8189 4 жыл бұрын

Honestly, this is the best and simplest explanation

@KevinBioinformatics 4 жыл бұрын

Thanks for watching. Hope it was useful for you.

@gabeclark8050 4 жыл бұрын

excellent video - extremely concise A+ good work

@KevinBioinformatics 4 жыл бұрын

Thanks for watching. Hope it was useful for you.

@inshaishrat4371 4 жыл бұрын

really helpful and easy explanation. thanks :)

@KevinBioinformatics 4 жыл бұрын

Thanks for watching. Hope it was useful for you.

@sumto7871 4 жыл бұрын

how do i know the distance between 2 hub is 1? where is the hint? the math also works when distance between hub go larger and the branches linking hub to B and D shorter

@KevinBioinformatics 4 жыл бұрын

Sorry for the late reply -- I didn't get the email notification of your comment for some reason. That distance is 1 because it is calculated by d(AC,B)/2 + [u(AC)-u(B)]/[2(3-2)] = 6/2 + [10-14]/2 = 3 - 2 = 1.

@sagek7949 4 жыл бұрын

This was very helpful. Subscribed! I look forward to watching more videos. Thank you so much.

@KevinBioinformatics 4 жыл бұрын

Thanks for watching. Hope it was useful for you.

@arielleariella3487 4 жыл бұрын

Why is it important to generate alignment sequences using protein sequences and not DNA sequences?

@KevinBioinformatics 4 жыл бұрын

Usually there is a higher level of conservation at the protein level, and thus protein sequences can be better aligned than DNA sequences.

@arielleariella3487 4 жыл бұрын

@@KevinBioinformatics thanks 😊. I have exams in two days and I really needed to understand that concept.

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