10-Minute Neuroscience: Synapses

In this video, I cover the different components of a synapse, including the presynaptic neuron, postsynaptic neuron, synaptic cleft, and synaptic vesicles. I discuss how signals are propagated at chemical synapses through the use of neurotransmitters, as well as how neurotransmitters are removed from the synaptic cleft by enzymes and/or reuptake. I also cover the components and function of electrical synapses.
Key points:
00:00 General introduction to synapses
1:23 Different components of a chemical synapse
4:28 Termination of synaptic transmission (e.g., enzymes, reuptake)
6:55 Electrical synapses
REFERENCES:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, Mooney RD, Platt ML, White LE, eds. 2018. Neuroscience. 6th ed. New York. Sinauer Associates.
Siegelbaum ST, Fischbach GD. 2021. Overview of Synaptic Transmission. In: Kandel ER, Koester JD, Mack SH, Siegelbaum SA, eds. Principles of Neural Science, 6th ed. New York: McGraw-Hill.

[@bojan6368]

Absolutely amazing. Only a few people in this world possesss the talent to teach like this. Thank you

[@user-cy2nk2ew5z]

love the usage of drawings to explain synapses, it makes it more clear and understandable, I always prefer hand-drawings than online pictures

[@user-wx7mt3rh9t]

Thank you very much for this video!! I am learning neuroscience in Spanish instead of my native English and these videos are honestly a lifesaver!!!

[@ShaneBlick]

Just so you’re aware- the fact that you didn’t ask me to like and subscribe is exactly why I’ve liked and subscribed (Plus you’re videos are incredibly concise and easy to understand). Great job!

[@FunkZoneFitness]

I was looking for like a quick way to keep my neurology knowledge fresh. Big fan.

[@charcharbinx]

An excellent, thorough, but simple-to-understand explanation! Thank you. This really helped things click for me

[@takjest420]

Love your videos, keep them going.

[@erikvanachter3673]

Probably the best introduction one can find!

[@originalandfunnyname8076]

This is amazing, thank you. Extremely interesting and very well explained.

[@JohannaVenturoli]

Genious! We appreciate you tremendously!

[@Aram_sei_]

Amazing lecture.... Thanx a million ❤

[@arpitkumar4525]

Wow! Thanks a lot for such a clear explanation

[@TheMonks364]

Love this, thank you so much this benefited me greatly. A once confusing topic now easy to understand thanks again!

[@meghabohra0111]

Thank you so much sir for this wonderful explanation!

[@ChatterGee]

This was literally so much better than what was taught in my college. Thankyou so much! Your videos are so easy to understand and fun to learn from.

[@masembach]

Just finished your book. Great read. Thank you!

[@Neuroscientificallychallenged]

Thanks! I'm glad you enjoyed it!

[@figrollin]

Thanks for discussing the benefits of each; i never quite understood why evolution seemed to favour chemical synapses but it makes so much sense in terms of amplification.😊

[@neurosciencegirl]

Great video - thank you!

[@hyannwaldschmidt5377]

Very good content. Congrats!

[@aniruddha8560]

Very nice explanation sir. Now the conception is crystal clear for me. Thank you. 🎉🎉❤❤ .....from INDIA.

[@MonuVar]

Thank you for this amazing lec.😇😇

[@eirr4164]

This is great! Love the new book by the way 👍

[@Neuroscientificallychallenged]

Thanks, and I'm glad you're enjoying the book!!!

[@daniellelciell9310]

an hour before exam, and I got a whole chapter concept lol

[@zehra9096]

Hi! Could you do videos for all the different brain/neuroimaging techniques? Some of them are a bit hard to understand as they are abstract. Examples are PET, DTI, fNIRS, MRI, MRS, Animal lesions, DWI, hemodynamic methods, Pure insertion, fmri experiments design, SPECT, Causal methods like DBS, FUS, TMS (and variants of TMS), TCS and imaging genetics

[@user-qk8dd3dp3u]

I wish all teachers taught like this

[@fifatrickster51]

you should do a video about common syndromes/strokes in the brainstem etc

[@KakarotxAR]

well explained, thank u sir........

[@alishablavi4982]

سلام ممنون از راهنمایتون

[@user-by3oo9ky1w]

Hi i love your videos. Can you do one on cerebellar circuitry?

[@eliran-rdt]

Thank you

[@SarinaPeymani]

amazing

[@gryphonschnitzel7140]

thanks !

[@KeithOtisEdwards]

I'm here from hearing Marc Dingman on _Quirks & Quarks_ on CBC Radio. Very eloquent!

[@Neuroscientificallychallenged]

Thanks!

[@cdawg2923]

thanks

[@kathyp2865]

How are the products of enzymatic degradation taken back up into the neuron? Also through a transport protein?

[@mdenjoyer831]

thanks do you have any videos explaining the anatomy of the medulla for the columns and segments please

[@Neuroscientificallychallenged]

I have this explaining the anatomy of the medulla: kzbin.info/www/bejne/iGe7pX2FmtqbhMk And this, which focuses on the dorsal columns-medial lemniscus pathway: kzbin.info/www/bejne/pILJg4ibnbpnsLM

[@mdenjoyer831]

@@Neuroscientificallychallenged thank you so much

[@mdenjoyer831]

hi i'am having trouble understanting the visual cortex columns, is there any video that can help with that? i don't understand how these columns are positioned and 4th layer of the cortex

[@Neuroscientificallychallenged]

Unfortunately I don't yet have a video on that.

[@azertrdz]

Thanks ! Could you make a video about downregulation and upregulation please ?

[@Neuroscientificallychallenged]

It's a topic I've thought about making a video on for a while. At the very least, I'll try to incorporate it into a video on another topic.

[@guvencagil]

Super video. Thank you. The impression of most so-called educated folks, including me(oops), was that humans had the intellectual advantage of extra-stimulated electrical activity due to the large number of neurons in the human brain(now est. at 86bil). You're video, here, shows this commonized opinion to be wrong. The real interesting phenomena behind neurons, is why in all mammals most neurons are in the limbic system section known as the cerebellum. And why do elephants have very great portion of neurons in the cerebellum, as compared with humans? It's not like they could wind up tipping over. They could drink a whole tank of scotch and they would still wind up on all fours[warning: please do not try this experiment at home]. According to Animal Husbandrist Temple Grandin an elephant never forgets. And with over 3x the number of total brain neurons compared with a human in an equally proportionally-sized brain[human brain at 1.5 lbs and the elephant brain at 4.5] one has to wonder if not only are Dolphins and Whales smarter than humans but are Elephants smarter than humans as well. I guess humans make too many assumptions!

[@tsewangslittlesecret4622]

Can you please do a video on schizophrenia and dopamine pathway

[@Neuroscientificallychallenged]

kzbin.info/www/bejne/ppu3no2nd7N1bZo

[@vanavil6594]

I have down syndrome child speech problem how to strengthen communication signals

[@Quantramix]

Can u explain about brain computer interface which Elon Musk is focusing on

[@leiurus.]

I dont get this im so depressed and the anti depressant I want to try because its the weaker version of trazadone does this mean I so depressed my neurons are not working together thats why I feel like a zombie everyday

[@tijesunimiadeleke3263]

Jesus is the way to take away depression

[@leiurus.]

@@tijesunimiadeleke3263 you're right but also sleeping early waking early having a job or a motivator factor thats keeps you focused on a goal to accomplish in life i believe in Jesus but depression is no joke even my therapist had depression so noone is safe just because you believe in Jesus man

[@khara1452]

Thannk youuu veryy much May allah please you and guide you to islam

[@GonzaloAguiar-dt6cx]

S' 0:57