2,3 BPG and Hemoglobin

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[@Paramedic_Necromancer]

I'm a critical care paramedic studying for my flight paramedic licensing exam, this video was very helpful in conceptualizing 2,3 BPG's physiological role in respiration. Thank you for the great content!

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[@volo7]

my goodness you are a godsend... the way you explain this process with the help of your diagrams makes everything so coherent

[@vladimirtrump5637]

2,3 BPG formation occurs only in erythrocytes, not in the exercising cells! The reason that the 2,3 BPG is higher at tissue level RBCs is that the enzyme responsible for breakdown of 2,3 BPG (phosphatase) is pH sensitive - less active at a lower pH!

[@ellios5734]

thats my question

[@StudyBits3560]

Yes , I think when 2,3-BPG level increases during hypoxic conditions it binds to Hb and reduces its affinity for oxygen and may be this causes lowering of pH rendering phosphatase less effective .🤔

[@FantasticHermitCrab]

Hot damn, this was satisfying to watch, man! You demonstrate amazing comprehension of the subject and manage to introduce and present it in such a great, understandable and digestible way. I was a littlelost on the subject when I looked up this video, but you cleared it up perfectly. Thanks for the help and keep up the good work!

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medical intern here.. this guy nails it.. thanks for the video!!

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@AK Lectures Dude why didn't I have you as my instructor when I was in college?!!! Your explanation was brilliantly explained and made so much more sense!!! You are freaking awesome! Doing an online class for my BSN and have to take Biochem and this by far is the greatest!!! Looking forward to view your other vids on DNA, etc!!! You have a new SUBSCRIBER!!!

[@AKLECTURES]

haha well glad to hear that my content is helping! best of luck with your course

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Awesome explanation. Love from India. Best regards, Uma Srivastava

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after all years ı found this video and appreciate it :)

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Great teacher! Very clear and concise explanation. Thank you for providing such high-quality content!

[@aishavpmd]

Rapaport-Luebering Pathway occurs in RBC as one of its mechanism to metabolize glucose since RBS has no organelles for that. Please read it on Rodak's Hematology 4th Edition.

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Excellent video. Was refreshing my memory of this from physiology for biochemistry, and wow- Refreshed in 10 min. Awesome. Thank you for this. I'm going to subscribe.

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You are doing more for us than the AAMC

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This has really helped! Thanks for a very informative, thorough video

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Jay William Awesome to hear Jay, you're welcome!

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Very explicatory and always clear. It has been great to expand on my notes. Keep up the good work!

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Thanks for this step by step explananations that makes everything so clear suddenly. You have such a way to explain, and repeat !! Thanks so much

[@stephengarramone6056]

These were excellent lectures. Finally understood this physiologic principle.

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Stephen Garramone thanks! congrats ! :)

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I would really like to thank you for the great video and explanation. I have gotten to understand this part thanks to you. Keep up the good work!!

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always enjoy your lectures, keep the great word

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He is the best teacher ❤

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Wow! Thanks dude! Very clear and to the point

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Thank you for explaining such a simple concept that textbooks seem to gloss over!

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you're a life saver to us medical students, in short you're a "MED SAVER" thank you! :D

[@sirajkakar188]

Its bisphosphoglycerate Not a biphosphate.....

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This man is amazing. Enough said.

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This guy knows his shit!

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Amazing video! I have an exam in 2 hours, thank you very much :')

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Thank you! Those clips are gold!

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It's very very helpful..😊😊👌thank u

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very well explained, thank's man

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Great explanation

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great video and very to easy understand explanation!

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Very helpful. Thanks!

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AK Lectures~=~Guyton.🙆

[@ronin18D]

So, are you saying 2,3 DPG occupies a heme molecule not allowing O2 to bind thereby increasing the dissolved O2 concentration making it more available for tissue in need at lower pressures?

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You’re amazing! Thank you💕💕

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Amazing lecture ! thank you :)

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Very helpful.

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i wish you were my personal tutor, i would give you all my money. which is not much lol

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[@pascalHenrich]

massive teaching but how do the erythrocytes get rid of the BPG ?

[@alvinjohnmasaku2198]

Awesome work

[@AKLECTURES]

Alvinjohn Masaku thanks!

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thank you ...you are great..and smart ...

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This video is awesome

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I Love it!! Thank you!!! The best!!

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Have I told you lately that I love you

[@snehapadghan6007]

Very helpful thank you so much

[@andreabraquet4869]

Not a nurse or Dr, just a concerned mother. I have a 5 year old girl with high hemocrit, high platelets, high hemoglobin, slightly high calcium, slightly elevated potassium, and slightly elevated iron saturation. I've recorded all she drank and she is not dehydrated. Please help

[@andrewbergemann4878]

AK, Most 2,3BPG is actually produced within the erythrocyte.

[@luiseduardonavarroperalta297]

I have read today that the Blood Units have the disadvantage that they don’t have 2,3 DPG( or too few) . That’s why they aren’t good when they have to deliver oxygen. I don’t understand that . Because the tissues make 2,3 DPD when they are in Stress, that means that it shouldn’t be a problem . Or does it mean , that die Units too few DesoxyHb hat, that’s why 2,3DPG from ours tissues don’t help .???? Please help

[@oo-jii]

8:20 OMG EVERYTHING MAKES SENSE

[@NiranjanGyanchandani]

nice work there..:)

[@eunicetan5960]

hi,in the absence of bpg,isnt the curve rectangular hyprbola?

[@faizanfayaz8978]

Pretty helpful, thank you....

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thank you

[@nanobebe77]

Really helped, thanks.

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Nadin Arabi you're welcome!

[@hamayasin3084]

Thanks teacher

[@danyalahmed768]

Amazing

[@irineandrona7948]

Excellent video but I just don't get it, why will a measurable( high anyway quantity) of 2,3 BPG leave the cell in the first place and not became pyruvate? And the curve shouldn't stop in the region of the lungs as the BPG only binds to deoxyhemoglobin?

[@bublisoniya4292]

Thank you so much!

[@Mehu1997]

One question: how is it 2,3-BPG formed in the excising tissue? Doesn't it need BPG-mutase and isn't it only found in the red blood cells and placental cells? Or am I wrong?

[@DapaChrons]

1,3-BPG is found on the pathway of glycolysis, so it should be found along any cell using that process. BPG-mutase changes it to 2,3-BPG and is unique to blood cells and placental cells, but because of circulation I suppose it would be easy for the body to create that 2,3-BPG from 1,3-BPG. What I mean is, BPG-mutase and 1,3-BPG will be in close proximity to one another

[@DROCKJAMO]

awesome vid!

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Derick Brown thanks Derick!

[@melogasm]

You are awesome!

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+PMelograne thanks! :)

[@peyvandjadidi4395]

OMG :)) well- said teacher

[@Ak-un6ed]

Im really torn here. Can someone say this is accurate? The fact that he calls is biphosphate and the 2nd comment is someone pointing out another discrepancy. I don’t know much about BPG and came here to learn-saw he has a few videos on it but don’t want to waste the time if there is general disagreement on the accuracy

[@drcgiri09]

thank you so much

[@NieceyWeesey]

And one more thing, why are some haemoglobin molecules deoxygenated? Aren't they all supposed to be loaded with oxygen once they get to tissues so they can release their oxygen to the tissues that need it?

[@zeanaalkudsi531]

LIVE SAVIORRR , THANK YOU

[@evaafif7239]

So, what's happen after that for 3-phosphoglycerate? Is there any product for pyruvate or no?

[@seddikib.m4850]

Brilliant

[@fernandatellez6379]

You saved meeee!!

[@ann8302]

How would say this affects ETC? Are you increasing the final electron acceptor (O2) then because of this you require a higher metabolic rate of glycolysis and TCA?

[@evaafif7239]

No, this just happened in RBC, and at reason , no mitochondria init , they obtain their energy from anaerobic respiration by formation of lactic acid

[@cma44444444444444444]

I believe RBC are the only cells that produce 2,3BPG. Exercising cells sounds like you are saying any cell can produce.

[@aishavpmd]

I agree

[@mintesinotdesalegn4726]

i thank YOU!

[@fungaimusangomunei3267]

you the best!!!!

[@lopo1127]

Deoxyhaemaglobin binds to O2 or co2

[@pavithraNarasiman]

How can we decrease 2,3 BPG in RBC

[@NieceyWeesey]

Woah! Talk about HD

[@AKLECTURES]

Niecey Weesey Thanks! glad you appreciate that! :-)

[@NieceyWeesey]

And also, how does a deoxygenated haemoglobin molecule with 2,3-BPG finally become oxygenated? Because wouldn't the 2,3-BPG prevent haemoglobin from becoming oxygenated?

[@KeplerOC]

Hello , I’m from the future and I actually have the same question. Did you find the answer?

[@NieceyWeesey]

@@KeplerOC Hi, I finished my degree 4 years ago so I don't even remember studying this 🤣 I'm so sorry, I don't have the answers for you. I had to rewatch the video and my only guess is that the haemoglobin is initially saturated with oxygen and when the tissues are exercising, the 2,3-BPG binds to the deoxyhaemoglobin (after oxygen is released from blood to tissues and before it gets back to the lungs to be re-oxygenated). My guess is that there are still more haemoglobin molecules binding to oxygen compared to the 2,3-BPG otherwise we would run out of oxygen. OR that the binding of 2,3-BPG/conformational change is reversible and after oxygen is released to the tissues, the 2,3-BPG is then displaced by oxygen in order for the cells to become re-oxygenated and the 2,3-BPG is discarded somehow after its job of oxygenating the tissues is complete (I don't know if it's a waste bi product but I strongly suspect it is).

[@jimhempe7247]

I did an NCBI search and can't find any research to support the speakers contention that RBC import 2,3-BPG from plasma.

[@vladimirtrump5637]

2,3 BPG formation occurs only in erythrocytes, not in the exercising cells! The reason that the 2,3 BPG is higher at tissue level RBCs is that the enzyme responsible for breakdown of 2,3 BPG (phosphatase) is pH sensitive - less active at a lower pH.

[@faisalalkoblan9906]

my man!