2-Minute Neuroscience: GABA

[@Del-Canada]

Can I have this comment pinned for no reason?

[@neurochallenged]

You got it.

[@tonetoobtwo]

@@neurochallenged lol

[@jojackborseman]

Pinned but still few likes. It's true. You can beg priority, but the world will never accept you if it's without quality

[@francenealexandre557]

@@jojackborsemanWell he’s gotten 32 likes 👍 so far🥳You’ve only gotten 2🫣

[@cesarcdx]

*In two minutes, you explained it much better than a Stanford professor.*

[@manictiger]

Professor: A^10B*SIGMA/12 CUBED * (2PI ROOT MU - 1/3 Electron spin) / SUMMATION OF ALPHA AT 95% CONFIDENCE * MASS OF THE SUN / (insert massive matrix of quantum shit) = the reason why A = D, assuming the distribution is normal and the 5th dimension shares at least 3 harmonic tachyon-neutrino sequences with the 3rd dimension, and given tri-lateral symmetry at the multiphasic band-pass * 6th Dimension joule output/p-hat ~ .73591223*omega bravo charlie foxtrot niner. KZbinr: If A = B = C = D, then A = D

[@lostinthoughts13]

@@manictiger lol quantum shit

[@kuhataparunks]

Holy crap this is the reason I came here haha

[@kaligdj]

lol facts

[@miloelite]

LMBO!! 🤣

[@georgeelgin3903]

I liked that u pointed out Gaba-A is CL releasing where as GABA-b is K+ attracting ! your statement that the functions are age related (brain maturation) seemed egnimatic, and i would have liked to clip that

[@neurochallenged]

Thank you!

[@beyzee8516]

*You are the father I'd never had, the brother everybody would want. You are the friend that everybody deserves. I don't know a better person. I DON'T know a better person* (inserts Oprah's voice)

[@leesonstream8493]

Lol I love how these comments are everywhere on KZbin. If one person is the best on every channel, who is the best anymore? Why I don't know! (Peter Griffin's voice)

[@tonetoobtwo]

Thanks for taking the time to produce these. I am refreshing my memory for an assignment, and these concise videos are incredibly helpful and are supporting my reading of many a clinical paper that I would otherwise spend much longer trying to synthesise.

[@mariociencia12]

Fantastic! Incredible! Amazing! Astounding! Astonishing! Mighty! Marvelous! Better than Marvel's superheroes movies!

[@GoldenGateNum9]

In regards to sleeping problems I think that food and herbs which increase GABA activity are a big piece of the puzzle, I have been experiencing insomnia for the past 3 years and have tried a Ashwagandha , Passion Flower and Chlorophyll combination which has been helping me sleep like a baby.

[@azmagaref]

Ashwagandha is terrible, dizziness coupled with irregular heart beats isn't a good side effect.

[@GoldenGateNum9]

@@azmagaref I take Nature's Answer in liquid drops 2ml a day, never experienced that before.

[@BlueTroll]

Mugwort is a GABA inhibitor.

[@azmagaref]

@@StudioLB Yes like me I remember! Me and you like some others, are susceptible to bad side effects of certain chemicals.

[@granjmy]

L-Theanine taken with GABA allows the GABA to cross the blood brain barrier.

[@idisbonalee]

Thank you for your simple and perfect explanation.

[@tomprovan50]

Gaba is synthesised from glutamate. Pathway needs vitamin B6. When working properly it inhibits the excitatory effect of glutamate. It can use two entry points one for chlorine and the other potassium. So, motion across a membrane can occur in more than one way. By concentration against a gradient, by sodium potassium channels, and by voltage gated channels. How do these affect Gaba? And what would the symptoms be when Gaba does not work meaning besides a lack of B6 would an out of balance set of the minerals involved affect which entry door is used?

[@thomsonchama1324]

The exact information I was looking for, thanks a lot 🙏

[@madisonla1803]

Thanks!

[@margueriteoreilly2168]

The Biochemistry of the Cells Is something missed by so many Brilliant lesson

[@yngfljm2277]

failed haiku

[@lukepetronella8732]

I'm taking Gaba supplements for extremely severe anxiety. I really did not want to take ssri's because I think they are scary as shit. So far its been a day and a half and I feel SO MUCH BETTER. I am only concerned because I find that I feel depersonalized. Hopefully once the anxiety subsides I can get off of these things and feel normal again.

[@dominiquefesta8571]

Hi Luke! I am curious to know your progress on Gaba supplements after two weeks. Hope it isn't too creepy-just a curious psych student lol

[@SunDogGod]

How are you feeling now? Because supposedly gaba supplements don’t cross the blood brain barrier

[@alanarcher5954]

Why are they better than SSRI's?

[@JonasAnandaKristiansson]

@@alanarcher5954 SSRI are absolute shite for everyone, certainly long term. Clouding our humanity, shoving it into the dark. Just fuck that shit, whenever possible for one to go off those monstrous drugs. There are so many better ways, than what the government and medical industry want to force us into.

[@lightbeingpontifex]

GABA blocks dopamine, dopamine turns into norepinephrine and epinephrine which keep you awake and give you anxiety,,,

[@nurulnabilah6941]

this 2-minutes explanation video is so satisfying

[@beautifulspirit2973]

I'm taking Golden Saffron GABA which made a huge difference to coming off tranquillisers. Only gripe is that they are so expensive but I think WELL WORTH the cost

[@Muuip]

Excellent concise presentation!! 👍👍👍 Thank you!

[@aserioussalamander9475]

i'm taking benzos for panick attacks. This video has been very imformative

[@dr.azad.agayev]

Activation of GABAb receptors causes the movement of K+ ions into the cell. Respects.

[@williamli7477]

Cud it be those find it effective used powder and the gaba went in thru under the tongue? Last few days i tried by taking 2 grams of glutamine along with 100 mg pharma gaba. The gaba for the last 2 years didn't have big but small effects for me. Now it's more effective, in 20 minutes it cud reduce my anxiety/ funny feeling at the stomach. Today i add another 100 mg of pharma gaba, but took out the powder, spraying half under the tongue, the other half swallow slowly with very little water. The calming effects are fast and effective.

[@27capricia]

Thank you so much for this video. You have saved me.

[@petrbohacek]

You sleep so good on GABA. I love it 😊

[@platonkouirouklis576]

Everytime i take a few mgrams of gaba my blood sugar drops instantly like I did insulin injection... what the hell happens really? Any advice/warning?

[@muhammedcagrkartal9954]

Brother you can teach anyone neuroscience It would be better if you could link these videos to phychological effects to your mind. Like effects of the hormones and receptors ?

[@annalikos3951]

So if GABAb allows K+ to flow freely, could that possibly affect hydration in some way?

[@isaiahmckeown-philip1238]

It does. It makes me dehydrated

[@freethinker8659]

it's really good , it's the first time that i watch one of your vedios and i like it ,👌👏

[@فلسطينيةمسلمة-ق4ب]

ما اروووووعك جد شكرا ...thanks you are wosem

[@evanlee6546]

Excellent, thanks

[@klara-sophie9006]

Thank you for this video Hope I will pass my final high school exam (i am from Germany)

[@jackbrzuch1977]

do you ever planned to make longer videos? It would be cool to know more than basics of this topics (especially neuropsychopharmacology), there is not many stuff on youtube that would explain that, definitely not like you do, specifically, conveniently and please open a patreon, youtube rewards some shit instead of quality content, all this time you are doing it non-profit

[@neurochallenged]

I'd like to someday do something like a 5-minute neuroscience series. But for now there are still a lot of topics I'd like to cover in the shorter format, and since this is just something I do in my spare time I don't have the time to tackle both formats simultaneously. I'll look into Patreon...thanks!

[@garyha2650]

Any foods that increase GAD?

[@lostinthoughts13]

Why don't they cancel college so we can stay at home and use these videos, we can go to college just for exams, cause they are teaching us complete crap.c

[@TheGhost-lm1xp]

lost in thoughts yeeeee but who will listen 🤣🤣

[@zebunker]

Clearly with that bad grammar, you did not pay attention in school.

[@9d8fb79fd8gb]

this didnt age well

[@elwinkel90]

Are you happy now?

[@lostinthoughts13]

@@zebunker my grammar is not bad, i simply edited the comment while i was half asleep and messed it up, and i fixed the problem now. Besides, i didn't learn english in school, if movies hadn't existed, i wouldn't have had the ability to talk to write comment in english, which isn't my first language.

[@briang.2218]

GABA-a and GABA-b? But what about GABA-gool?

[@CleopatraAGlider]

Watch it, Chrissy.

[@mr.nuna916]

More importantly what about YO gaba gaba

[@MohaZeine]

How much should lorazepam have effect duration or half life?

[@eclkt]

Thank you for your education

[@dmk8791]

So in other word's don't take GABA supplements while trying to study?

[@krzeszewski]

hiiii... could you do a video about the neuroscience of GHB?

[@bezuhv]

Can this help myotonia patients?

[@PakiPigeonsCanada]

So what does it do in plain english

[@alexsheremett3097]

great....❤❤❤

[@ambamb9905]

Think you very much for this video

[@himanshurunthala6851]

gaba is anabolic or catabolic? please explain.

[@danykhoriaty3071]

Please I have a question first at all in all cases of anesthesia there's gaba? Second question it's at the same time in gaba sodium blocked and chloride goes in and potassium goes out?

[@mylztv2841]

Thank you for sharing very helpful

[@ragavendran1887]

Simply better for understanding keep making more

[@jasonworden8209]

How does GABA supplements compare to Benzodiazepines? 🤔

[@joshuafreeman6720]

Don't work

[@jasonworden8209]

Great explanation

[@riffat1630]

Hi can somebody help answer this question? Can taking Pregnenolone in supplement form inhibit GABA calming function. As in, could it cause muscle spasms in the ear? Thank you in advance!

[@bikeninja956]

what is it used for in practice, why would someone supplement with GABA? my mother took some and she said it made her feel like crap

[@dolarrius]

Gaba or gabapantine?

[@denisecraft4376]

Hmm....Why is this not being used to treat fibromyalgia? Seems it might possibly be an effective treatment.

[@jeremyzutlas58]

GABA supplements don't cross the blood brain barrier well... I treat my fibromyalgia with 4000 IU of D3. Quality Magnesium.. magnesium oxide does not absorb well. Zinc... 50 mg a day. Other supplements that help tremendously are Creatine, Tumeric, and Omega 3 Fish Oil.

[@andreaspires520]

Does anyone know how long Gamma aminobutyric acid lasts in your system?

[@Pabloperes675]

It’s for life

[@mase8189]

@@Pabloperes675She probably means like a surplus.

[@MissPandora666]

Thank you!!! You've made a complex concept so easy to understand.

[@lousandy5739]

Affected my eye.seeing spots and patter ns

[@chorighj987]

Is it GABA A receptor or GABA a receptor or GABA (low)A receptors? My teacher asked this and i dont know ive searched online and cant find the answer. Also is it true that there is GABA C receptors? And how many subtypes does GABA a receptors have? help pls (T--T)

[@jasonsmith902]

Does it decrease cortisol (what are the long term effects)

[@reginapun7003]

what app did you use for this video? Can you give me the name of that teaching app thanks.

[@stinglp1198]

Has anyone used Gaba with brahmi or ashwagandha ?.

[@JAdrew]

If there is a high GABA amount in the central nucelus of amygdala, will it cause ansolute fearlessnes?

[@lightbeingpontifex]

It would cause absolute sleepiness,,, Adderall causes fearlessness,,,

[@joshrose6456]

Can gaba help with gabapentin withdrawal

[@Neginmohseni07]

Thank you so much

[@kokyu]

Like your work, thanks for the effort

[@VzMightyMousezV]

Thank you, gaba's effect was confusing me

[@GD15555]

wow mother nature really went beyond to make a human body so complicated

[@Twine219]

Could this be beneficial for decreasing intrusive thoughts?

[@zui1859]

probably

[@angelvalentynn]

My psychologist recommended it to me for that purpose so yes

[@TedOtis]

I'd love a laymen's version, is there a channel for that?

[@chapachuu]

This is the laymen's version. I don't think you can explain this stuff more simply than this. If you're struggling, I suggest going back to cell structure (neurons in particular) and working your way up from there.

[@killerpussy84]

For everyone who would also like a video they might understand better: kzbin.info/www/bejne/lWe9mYR-d7yLoKs It's 3 minutes and I now actually understand what GABA does

[@killerpussy84]

Explaining isn't the same as giving away information. This video has a lot of info, but it's definitely not explained as if the maker was talkong to somelne with no medical education. Which is a different talent than drawing sketches and throwing out terms that are only ever read in medical books. So no, this is NOT a leyman's version.

[@MrRawzoe]

Thank you

[@johnreder8167]

huh? soooo what does this thing have to do with sleep?

[@carladaher7672]

perfect timing

[@muhammedcagrkartal9954]

Thank you so much for the content

[@tammyporter4848]

You're a very good teacher...js.....can you use Gaba instead of a benzo...? And 5htp instead of ambien....asking for a friend.....lol....but really....I understand your not a dr and all that good stuff. But can you direct me like....where to find out? I mean......this stuff is pretty much over my head but....sigh....Im trying.....thank you so much.....

[@Nightly357]

Stay away from benzos. Xanax is the devil. Try weed, gabba and melatonin. Best wishes

[@tammyporter4848]

@@Nightly357 thank you

[@joshuafreeman6720]

Nope

[@garyha2650]

It eats (my words, or otherwise disrupts) GABA, the microscopic brain protozoa, cat-poop parasite, road rage parasite, toxoplasma gondii. So that's surely why you're all f'd up (reading these comments), I know because I was too. I'm looking for a way to knock it out behind the blood-brain barrier. In the meantime, with the patch of just restoring GABA I can be back to my normal real self again. The curious thing is that it also restores empathy for others, pretty dramatically for me, I guess because once there's no longer a chemical three-alarm fire in the brain from toxo (lack of GABA), one's true nature can be present there again. Simply put: This explains trolls and if in our water supply would produce world peace. But we might lose our edge a little. I'm guessing you're all pretty creative, it's that internal anxiety that makes us strive like mad to create something good.

[@zas881]

Very helpful thankyou

[@hemanhunters6783]

I take a Nervepain-medicin called GABAPENTIN. I have a hard time to understand what it really does. Could this have positive or negative effects on musclegrowth in anyway?

[@foxybrown2]

GABAPENTIN. Has some horrible side effects i did not take it. I went out and bought some GABA that's natural by the company NOW.

[@hemanhunters6783]

@@foxybrown2 Yes it really have side effects. But in what way is your GABA better? I guess they both work the same way, blocking receptors, or am I wrong?

[@Dani-uz2bk]

@@foxybrown2 how did you get on with it?

[@dero8808]

💗 allopregnanolone 💗 non-psychoactive calmness

[@starvinmarvin7964]

Dont mess with gaba receptors. Stay far away from benzos, they can turn your life upside down.

[@foxybrown2]

what are benzos?

[@Walsh25]

foxybrown2 don’t touch them they are poison get natural supplements of gaba stay away from Xanax

[@novitazefanya1432]

i constantly taking benzos( diazepam 2 mg) cause i can't sleep due to my perimenopausal symptom( i am 48)..its 2 years now..what can i do to let the benzos off?

[@lightbeingpontifex]

@@novitazefanya1432 5htp tryptophan GABA valerian melatonin weed alcohol,,,

[@leagueaddict8357]

@@novitazefanya1432 You should've asked your doctor for assistance in this, most medicine is just take slightly less over time untill you can quit safely.

[@stillmindster]

How many GABA-A receptors are in the human body?

[@naydumo5928]

how much GABA is there in the body? and how much is less, and how much is too much?

[@Sheahova]

alcohol and benzos heavily affect gaba hence why they are used to wean off of eachother.

[@UltraViolent21]

I love alcohol. I’ve had seven seizures. Bring the glutamate on. I hate my life and the GABA, is one of the only things that help me from depression. Doctors won’t prescribe benzodiazepines to an alcohol patient anymore. So I shall drink until the day in die.

[@kumardickshit1530]

Bro try the streets and look for lyrica not benzo

[@jbsilveradoo8788]

what a G for this video. :)

[@_moonstxrs_2425]

I’m taking neuroscience. Eveything anyone says is just a whole different language and I’m at struggling so bad :)

[@dyey5480]

I'm taking GABA suppliment, now my brain vibrates asf eveyday. It's disturbing asf.

[@Pabloperes675]

What

[@Ryzler13]

The entire internet wants to dose you up with GABA but no information to remove it. Who writes the internet?

[@moshemeyers4810]

I feel it would of been important to mentiuon GABA-b1 and b2 receptor and how both are needed in activation

[@jackbrzuch1977]

he had only 2 minutes tho

[@rmschindler144]

You really can't say that "CL" is chloride. It's "Cl," that lowercase "L" being significant.

[@rickyjackson1258]

I wish I knew the significance of an action potential. My quest continues l.

[@27capricia]

If you are still searching look up Bozeman science action potential. It will help in your quest. It help me .

[@32starsandsugar]

Luv u

[@neurochallenged]

luv you too

[@kallah4999]

You forgot about the GABAar channel, previously known as the GABAc channel.

[@privateprivate2421]

Easy peasy

[@strawberrycatastrofy257]

My psychiatrist could never

[@comarose]

Nice explanation. Could you enunciate some of the words clearer and slower for viewers not in the USA thank you

[@alfredoortega2685]

Alcohol...yep

[@dolarrius]

Don't mistake gaba for gabapantine

[@camouflage0731]

Unrelated but, do u have instagram? 😅🤣

[@neurochallenged]

No Instagram but yes Twitter (@neurochallenged) and Facebook (Neuroscientifically Challenged) 🙂

[@Sheeshening]

1st

[@ll5584]

@Sheesh 1st ? To show the world that you are an idiot ?

[@Omkar3324]

GABAGOOOOLLLLLL

[@billyrigoyourbeardedrealto1471]

Huh?

[@FIshfood500]

i need gaBA

[@azmagaref]

Me too, but without a Benzo ..

[@andrewfrancis1338]

NEVER TAKE A BENZO LONG TERM

[@y2kisfun]

IGOTADDSTUFFTHISINFOINMYBRAAAAAAINASAP

[@7Judy]

Confusing

[@CallMeBungus]

BOOM gaba BOOM acetylcholine BOOM higher iq

[@ceticamente]

GABA GABA HEY