20.3 The Mechanisms of Nucleophilic Acyl Substitution | Organic Chemistry

[@mayadruch6909]

All of your videos are so helpful! Especially for orgo 2

[@ChadsPrep]

Glad to hear this, happy studying!

[@Design_With_Ahmed]

big love

[@ChadsPrep]

Welcome to the channel!

[@AlexisDelapuente]

Hey Chad, by any chance do you have a video showcasing activation using SoCL2 with carboxylic acid derivatives? I am confused as if we can use the lone pairs on the carbonyl oxygen to attack the S before we kick off the Cl and use this to drive it through its intermediate steps. Thanks and God Bless!

[@ChadsPrep]

Hey Alexis! Check this one out kzbin.info/www/bejne/i5nMl5egoZJ1qpY as I outline the mechanism here. Hope that helps!

[@abdoulazizdabo9064]

Thank you 🙏🏾

[@ChadsPrep]

You're welcome

[@robynmoore5857]

Thank you so much

[@ChadsPrep]

Very welcome.

[@danield8227]

Hey Chad, dumb question here, is nucleophilic acyl substitution the same as hydrolysis alcoholysis and aminolysis?

[@ChadsPrep]

Hi D! Nucleophilic Acyl Substitution is the general type of reaction/mechanism. When done with water it is referred to as hydrolysis, with an alcohol alcoholysis, or with an amine aminolysis. So these are all more specific examples of this general type of reaction. Hope this helps!

[@danield8227]

@@ChadsPrep Ah yes! Thank you, you’re the best Chad. Appreciate you

[@ChadsPrep]

Glad to help!

[@Urexboyfriend520]

which one is the rate limit step?

[@ChadsPrep]

For which reaction? Usually it is the initial addition step

[@willm3027]

This was awesome

[@ChadsPrep]

Thank you.