2024: Emerging Therapies and Parkinson’s

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In this video, Dr. Soania Mathur interviews Dr. Michael Okun about emerging therapies for Parkinson’s, including continuous infusion levodopa, cell replacement research, repurposed diabetes medication, and more!
For additional information about topics discussed in this webinar, please visit our blog: davisphinneyfoundation.org/we...
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0:00 - Introduction
2:27 - Advances in Carbidopa and Levodopa
9:48 - Are there other similar medications coming out?
16:00 - Will there be advancements in non-motor symptoms?
24:34 - Adaptive DBS
35:53 - Disease modification, regenerative medicine, and stem cell research
43:30 - Other medications for Parkinson’s and thinking about emerging therapies
55:24 - Conclusion

[@marthasuareztorres1791]

What a useful and hopeful webinar!!! So easy to understand with this two experts! Thanks!!!

[@splashesin8]

This has been very helpful. I'm glad there is getting to be a way to differentiate and sort what dopamine will help and not likely help.

[@newworld6474]

Dr. Soania Mathur your symptoms seem be well controlled having PD for 25 years ... what do you do to control it ? ... after 4 years I am having difficulty with right hand tremor ... i take a levodopa pill before sleep and maybe a half a dose at around 2am and maybe at 5 am - ish .... during the day my medicine doesn,t help the tremor very well anymore so i sneak some extra that sometimes help a bit ... try dbs? Canada

[@casualonemmo-player2167]

... i was just about to ask if she was sick... the amount of movements with the entire body (and espesially when speaking) made me "nouseous".

[@davisphinneyfdn]

Dr. Mathur takes an active approach to managing her Parkinson's symptoms, including medications and daily exercise. Specific questions about individual treatments are best asked of your care team--especially related to DBS as there is an involved process to determine if one is a good candidate for that treatment. Tremor can be treatment resistant, and it is sometimes not well-managed by levodopa. Also, note that for each person, symptoms that are not levodopa responsive are also typically not responsive to DBS therapy. Here is a research article describing some treatments for Parkinson's-related tremor: www.ncbi.nlm.nih.gov/pmc/articles/PMC10041452/

[@maryestes9349]

I understand that Michael J Fox had brain surgery to cause micro-strokes. Where are we with that type of therapy

[@klaracsehneszantai3984]

Köszönöm szépen hasznos volt

[@caros4490]

Very informative. I'd like to get one of those patches. Thanks for all the information.

[@juliajimenez7157]

Buenas tardes sería muy interesante e importante que la presentación la pasaran al español gracias

[@davisphinneyfdn]

Julia, gracias por tu mensaje. Por el momento, sólo te podemos sugerir la traducción automática que KZbin ofrece al español. Para eso tienes que ir al ícono de "setting" en este video, dar clic, darle clic donde dice "Subtitles/CC" y activar la opción "English [autogenerated]". Después de eso, debajo de esa opción se debe haber activado la opción "Auto-Translate", haga clic allí y busque el idioma "Spanish" para que los subtítulos aparezcan en español. Si tienes otras preguntas, nos puedes escribir en español a [e-mail] y te invitamos a que sigas nuestro canal de KZbin de la Davis Phinney Foundation www.youtube.com/@DavisPhinneyFdnEnEspanol

[@klaracsehneszantai3984]

Köszönöm szépen,meg akkor is hasznos ha acommentet értem ❤

[@kimchewng4928]

😊

[@kimchewng4928]

😊

[@Lesparkinson2016]

Wgat is the Neupro patch do . I wear 10mg daily the last 6 years

[@davisphinneyfdn]

The Neupro patch delivers the dopamine agonist rotigotine through the skin, directly into the bloodstream, 24 hours a day. You can read our article about the neupro patch here: davisphinneyfoundation.org/rotigotine/ In this emerging therapies webinar, Dr. Okun and Dr. Mathur discuss subcutaneous infusion systems that will deliver levodopa.

[@newworld6474]

What do people say about Dr David Sinclair's work on reverse aging of the body/brain to regrow a broad range of brain / nerve / body cells etc to reverse the damage done?

[@davisphinneyfdn]

Dr. Sinclair's work is interesting, and there are some studies investigating some of the compounds he discusses as possible interventions in Parkinson's. At present, though, more research is needed. Some more information is available here: scienceofparkinsons.com/2022/03/11/nad-2/

[@user-qe6bl1lb7u]

Sinclair is a fraud.

[@klaracsehneszantai3984]

Csak a kommenteket látom magyarul lehetne?

[@skiph3]

How about making PD go away via a nutrition route versus a big pharma route. Oh, no money would be made taking that route.

[@davisphinneyfdn]

Thanks for your comment! We recently had a webinar on about nutrition and Parkinson's. You can view that here: kzbin.info/www/bejne/kGmTeHiHrNKVkKs It's certainly true that nutrition and diet warrant more investigation, and many people with Parkinson's notice that their diet influences their experience of living with Parkinson's. At least at present, however, pharmaceutical interventions are important parts of living well with Parkinson's for most people.

[@SheilaPhillips-xg5gx]

@@davisphinneyfdn 12:49 12:49 😊

[@tharanathsuvarna9665]

Looks like the host lady is suffering from diskynesia

[@davisphinneyfdn]

Dr. Mathur does experience dyskinesia, and you're right to observe that this dyskinesia is apparent in the video.

[@tootalljones77]

Stop wasting time & resources on more drugs or band-aid fixes, and focus on fetal stem cell therapies.

[@davisphinneyfdn]

Thanks for your comment. Cell replacement therapies are undoubtedly important and exciting! In this video, while Dr. Okun says explicitly that he doesn't want dampen excitement about cell replacement therapies, he also observes that there are many questions remaining about efficacy of these treatments. We'll learn more as trials for these treatments move forward. On that front, there was news two days ago about advancements in a clinical trial in the US: www.prnewswire.com/news-releases/aspen-neuroscience-announces-first-patient-dosed-in-first-in-human-phase-12a-clinical-trial-of-autologous-neuronal-cell-replacement-therapy-for-parkinsons-disease-302119216.html Also, note that there are complications with fetal stem cells--both practical and regulatory--and that other ways of deriving cells for cell replacement therapies prove more practical. In addition to our blog post, which is featured as a link in the description above, you can find more information about cell replacement therapies in this article written by multiple global leaders in cell replacement therapies for Parkinson's: content.iospress.com/articles/journal-of-parkinsons-disease/jpd160798