#22 - The Cancer-Diet Connection & Otto Warburg - Nobel Scientist under Hitler | Sam Apple, Ravenous

All platforms / Episode Show Notes: livelongerworld.substack.com/...
Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.
Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.
It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!
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SAM APPLE LINKS:
Ravenous book: gladyshevlab.bwh.harvard.edu/
Website: www.samapple.com/
Twitter: / sam_apple1
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TIMESTAMPS:
0:00 Cancer as a disease of modern societies
1:27 Otto Warburg & the Cancer-Metabolic Connection
2:27 Warburg’s research on respiration
4:02 Why was cancer skyrocketing in Western societies?
9:17 Warburg Effect: Warburg’s research on cancer cells
15:00 Why do cancer cells take up so much glucose?
17:44 Cancer-Diet Connection
21:44 Cancer, Ketogenic diets & Fasting
23:43 Hibernation of the metabolic story of cancer
27:20 Hitler’s connection with cancer
30:07 Warburg’s arrogance
31:51 Why does cancer need glucose?
38:46 Warburg’s stigma: connecting with Nazi’s
40:51 Is insulin responsible for cancer?
48:00 Science is not immune from politics
50:24 Prostate cancer & obesity
52:13 Pendulum swing in cancer research
54:40 Mitochondria & Cancer Connection
57:07 Nazi’s fixation on cancer
Episode Show Notes: livelongerworld.substack.com/...
Live Longer World Season 1 Recap: livelongerworld.substack.com/...
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Stay in good health - Aastha.
#sugar #cancer #longevity #lifespan #healthspan

[@peterz53]

Thanks Aastha. On insulin, I recall a talk by Lewis Cantley (a prominent cancer researcher) in which he showed data in which the combination of low insulin and PI3 kinase inhibitors profoundly inhibited tumor growth (after inception of cancer). He also showed that while low insulin was due to a ketogenic diet it was not ketone bodies which inhibited tumor growth. His work lends credibility to fasting and other techniques for lowering insulin as having a role, maybe an adjunct role in cancer therapy.

[@tamerafrank4645]

I appreciate this info so much. 75% of my family has had cancer and prevention interests me greatly. Thank you.

[@rredding]

Interesting! People, when you own a male reproductive organ, hear me out. I guess that you, just like me, prefer to stay healthy and avoid disease, instead of treating it. So, this is not medical advice, but some things to think over. Beware, this is a long read! I did my own research (Google, KZbin) and found some factors that influence your future risk for prostate troubles. One important factor is age! Men above say 50-60 years are most at risk. 1. Deficiency in Iodine. Make sure you get at least 150 micrograms per day, but that is the absolute minimum. Japanse following the traditional diet, may get some 1000 - 3000 micrograms per day, and prostate cancer (also breast cancer for women) is ten times lower than when following the Western diet. If you take Iodine as a supplement, combine this with Selenium. You may get this from having one or two Brazil nuts (also known as Para nuts) daily, not more. Do your own research on these nuts. 2. Deficiency in vitamin K2. This vitamin lowers risk of prostate cancer, AND reduces risk of calcified organs and blood vessels, as it sends Calcium to your bones and teeth. Japanese traditionally eat natto, fermented beans and bacteria produced a lot of vitamin K2. Google vit K2 for yourself. 3.Boron. Boron lowers chances of getting prostate cancer. Many people are deficient in Boron when it is insufficient available in your food. It regulates Calcium and Magnesium, regulates sex hormones in men and women, activates brain activity (memory) AND is anti inflammatory. When you suffer from arthritis, 70% chance that some 9 mg/ day will fight the pain and within 1-3 months the symptoms are gone. Following maintenance dosis is 3-5 mg Boron per day. 4. Many people are deficient in vitamin D3, especially when living outside the tropics, when having dark skin or using sun cream, being senior, obese. D3 regulates many process in your body, and helps to avoid prostate, colon and breast cancer. Do your own research!. Your D3 level in a blood test should be 50-70 ng/ml (125-175 mol/l). When too low, use a good supplement. Guidelines tell you to take 10 or 20 micrograms per day (400 resp. 800 IU) but this is only good to avoid worst effects of deficiency. 10,000 IU per day is shown to be safe, but always combine with vit K2. A young, white skinned adult with uncovered arms and face will produce some 10,000-15,000 IU of vit D3 before burning in, say, 30 minutes. Agsin, don't trust me but do your own research! I took 10,000 daily for some months and had the blood value tested on the way. I reached 66 ng/ml, a perfect value. 5. If you are low on Zinc, this may harm you. Zinc is important for your genitals. If you are vegetarian or vegan, you probably are deficient in Zinc. Again, please do your own research, gain knowledge on the subject ✌🏻. 6. Cancer cells thrive on sugar. Chances are that you are pre-diabetic or diabetic-2 and not knowing it.. Problem is that your body will produce more and more insulin to get glucose out of the blood and into all cells in your body. Testing glucose won't show the problem until you are really progressed in the process. I know I was careless all my life, because I had a lean body. When I used a CGM (continuous glucose monitor) I knew that my body had a "metabolic syndrome" with peaking glucose values after a high carb meal. Your glucose should not get above 160 (EU: 9), mine peaked at 215 (EU: 12). Again: testing insulin response is better (Kraft test), but not every doctor will test it and it may be expensive. Okay, the cause is in the diet and only changing the diet will help you.... Medicines will only cover the symptoms.. you may start following a low carb (or even keto) diet. A whole plant based diet may be fine as well. This means avoiding sugar, refined carbs (bread, pasta, cookies, fruit juice and sodas) and get your HbA1c down to 4.7-5.5%, triglycerides below 2.5 (USA 85). Also, learn about the processed seed oils (canola, sunflower, sunflower, rapeseed, etc.) Being promoted as much more healthy than animal saturated fats, they promote chronic inflammation and are cause of modern Western disease, inducing cancer. Also read about omega 6:3 ratio's. Chances are that you consume processed, packaged foods, even when you think you about junk food. Again, don't depend on others, do your own research! 🙏🏻💚

[@livelongerworld]

Thanks for posting this detailed comment on your research! Yes, specially the points on deficiency in Vit K2, D3 and Zinc, I have an episode with Dr. Bruce Ames who discusses his micronutrient triage theory and discusses how deficiencies in micronutrients can cause trouble later in life.