3 Critical Breakthroughs in Stroke Research at Yale

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Stroke is far more common than you might realize, affecting more than 795,000 people in the U.S. every year. It is a leading cause of death and long-term disability. Yet until now, treatment options have been limited, despite the prevalence and severity of stroke.
Not so long ago, doctors didn’t have much more to offer stroke victims than empathy, says Kevin Sheth, MD, Division Chief of Neurocritical Care and Emergency Neurology. “There wasn’t much you could do.” But that is changing. Recent breakthroughs offer new hope to patients and families.
Beating the Clock
Think of stroke as a plumbing problem in the brain. It occurs when there is a disruption of blood flow, either because of a vessel blockage (ischemic stroke) or rupture (hemorrhagic stroke). In both cases, the interruption of blood flow starves brain cells of oxygen, causing them to become damaged and die. Delivering medical interventions early after a stroke can mean the difference between a full recovery and significant disability or death. Time matters.
Unfortunately, stroke care often bottlenecks in the first stage: diagnosis. Sometimes, it’s a logistical issue; to identify the type, size, and location of a stroke requires MRI imaging, and the machinery itself can be difficult to access. MRIs use powerful magnets to create detailed images of the body, which means they must be kept in bunker-type rooms, typically located in hospital basements. As a result, there is often a delay in getting MRI scans for stroke patients.
Dr. Sheth collaborated with a group of doctors and engineers to develop a portable MRI machine. Though it captures the images doctors need to properly diagnose stroke, it uses a less powerful magnet. It is lightweight and can be easily wheeled to a patient’s bedside. “It’s a paradigm shift - from taking a sick patient to the MRI to taking an MRI to a sick patient,” says Dr. Sheth.
Stopping the Damage
Once a stroke has been diagnosed, the work of mitigating the damage can begin.
“Brain tissue is very vulnerable during the first hours after stroke,” says vascular neurologist Nils Petersen, MD. He and his team are using advanced neuro-monitoring technology to study how to manage a patient’s blood pressure in the very acute phase after a stroke.
Dr. Petersen’s research shows that optimal stroke treatment depends on personalization of blood pressure parameters. But calculating the ideal blood pressure for the minutes and hours after a patient has a stroke can be complicated. It depends on a variety of factors-it is not a one-size-fits-all scenario.
Harnessing the Immune System
Launching an inflammatory reaction is how the body responds to injury anywhere in the body - including the brain, following stroke. However, in this case, the resulting inflammation can sometimes cause even more damage. But what if that immune response could be used to the patient’s advantage?
“We’re trying to understand how we can harness the immune system’s knowledge about how to repair tissues after they’ve been injured,” says Lauren Sansing, MD, Academic Chief of the Division of Stroke and Vascular Neurology.
Her team is working to understand the biological signals guiding the immune response to stroke. That knowledge can then direct the development of targeted therapeutics for the treatment of stroke that minimize early injury and enhance recovery.
“We want to be able to lead research efforts that change the lives of patients around the world,” says Dr. Sansing.
Learn about these developments and more in the video above.

[@ne1cup]

we need this. 1year after my stroke the neurologist told me if I had not improved by now it is likely I would be this way the rest of my life. I want a better answer

[@528freq8]

. Spinal etercept

[@christophertan5949]

Perispinal etanercept treatment

[@shivammiddha9831]

Recovery=efforts

[@garywalling4341]

@@christophertan5949 NO!

[@wompol7117]

not true. have neurologist use etanercept perispinal.

[@agohio8366]

Getting the exercises earlier is the toughest Weakness, fatigue, tiredness, shock etc are all on the way Its really a difficult time Pls help Good to know about this Thank you God bless 🙏

[@CameronTaylor-yo7ut]

God bless you all. I had a stroke at 32 because of something genetic in my vascular profile I’m now 33 and trying very hard to recover

[@Hartleymolly]

I’m 35, postpartum caused mine

[@muharramali6579]

Now what is your condition?

[@charmainelee8815]

You need to use any neuroplasticity that is left. To be able to stimulate any damaged pathways.

[@ranamitra9261]

Couldnt figure out - about what are the major breakthroughs - are there any new medecines invented or any other thing - would be very much obliged if you kindly furnish with the informations.

[@austinroberson8]

The first thing you have to do is put the patient on a 7 day fast. Of course give them electrolytes combined with MTC's that allow the patient to use the power of ketones to help the right meds and vitamins to pass the blood brain barrier. Unfortunately 99% of doctor know jack $h#t about nutrition. My aunt had leukemia and they fed her like 5 times a day. People if you want to heal your body stop eating. Take the right supplements and let your body do what it need to, instead of stuffing crap into it.

[@lindalai9092]

lol

[@garywalling4341]

No, the brain is 70% fat and cholesterol (myelin sheaths are made of it). Starving yourself won't help ya. However, correct diet definately a must.

[@user-kh5ke3qj1w]

I want the pse treatments but I don't have the money to get them like others do

[@pisces3121]

how much are they.

[@AtuaheneKelvin]

​@@pisces3121they are expensive..

[@tonybablony2041]

Awesome video

[@RedNeckSurgeyTech]

So what are the 3 things?

[@Hartleymolly]

I am 36 and a new mom, I can’t live like this

[@jennifercuddy5663]

Can’t we make nanobots coated with a plaque thinning substance to unclog arteries under the guidance of a cardiac surgeon? To search for them and repair preventably? Maybe become a routine screening like a colonoscopy?

[@paulgoss6786]

help me please!!!!

[@528freq8]

Perispinal etanercept! Your magic pill or in this case one dose shot

[@christophertan5949]

Perispinal etanercept treatment

[@launica209]

Does anyone know if the etanercept treatments have had a lasting effect?

[@tenabarnes3269]

Yes, there are KZbin videos on it, however, the Doctor will tell you that the treatment doesn’t work for everyone, but for the majority there is improvement.

[@ericrupert2687]

@@tenabarnes3269 it’s rather disappointing to be in the minority and have your wallet emptied

[@edlinke2368]

i watched peace on 60 min a woman had a dtroke and was given a drug just a few min later she changed like day and night why isnt thaydrug available to everyone or is it the money thing you dont get the drug if u cant pay it shpuldnt b that way health first even if its free

[@mpampistsotsos3629]

I m 4years ago post stroke my arm not recovery

[@christophertan5949]

Perispinal etanercept treatment

[@muharramali6579]

@@christophertan5949 what is this?

[@528freq8]

2 words...perispinal etanercept

[@fionatanzer5270]

Yes. Yale researchers should do a controlled study before writing off this very promising intervention

[@bethburn3237]

I across this video because I was looking for a better explanation about perispinal etanercept treatment having zero background on this topic after watching the 7 year old 60 Minutes piece. As I looked into it, the whole thing seemed so strange… the (valid) criticism 7 years ago was there is no double blind clinic trial on the treatment, so why does it take a decade and private individual donors to fund such a study? It’s also strange why once that study did have promising results in 2020, two years later, this topic doesn’t show signs it’s actually gaining momentum in medical journals. What am I missing?

[@jaywill4ever]

Is there anyone other than Dr. Tobinick currently offering this treatment? He seems to get mostly negative reviews online. Many patients have noticed no change whatsoever after spending so much money on this procedure.

[@christophertan5949]

@@bethburn3237 The Griffith university had already completed phase 2 clinical trials. The results will be soon published at thr end of the year 2022

[@ericrupert2687]

@@jaywill4ever i am one of the patients who had no improvement at all. Very disappointing.

[@sasoonzargarian8911]

MRI I helped to find but high rent and hard life and stressed meking strok fake and bad news meking pipole stressed some news spread to be hides from public only good news..please and government support to meking job electronics helped healty Brin