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After being fully vaccinated, only 50% of people who are immunocompromised show an antibody response against COVID-19, compared with 100% of those with a typical immune system. Hopkins transplant surgeon Dr. Dorry Segev talks with Stephanie Desmon about how the immune response is blunted in individuals taking medications for organ transplants or WHO HAVE overactive immune systems, what antibody tests can and can’t tell us, and whether a third dose of vaccines could help the millions of Americans who remain unprotected from COVID despite being fully vaccinated.