4 siblings with Angelman Syndrome

[@candiceakinsanya2128]

God bless these parents. Having one or two children with the disorder, but 4 has got to be challenging.

[@imonka100]

I would not judge these parents for having all these kids. Their first two kids were healthy and these 4 kids were born pretty close one after another not giving these parents any idea something is wrong until the last one was born. Even if the oldest of these 4 affected kids showed signs of disability, I bet they would not expect all of them to have such issues as it is considered a rare syndrom.

[@goombapizza6335]

No frickin way, I disagree wholeheartedly. After my first kid with a genetic disorder, I'm either stopping having kids (especially if I already have two healthy ones) or I'm running right to a genetic counseling clinic to find out if I carry a mutation that will make it happen again. If they find something, I'm getting my tubes tied.

[@imonka100]

@@goombapizza6335 Yes, that would be the responsible way to deal with this problem. But... they did not know only after the last one was born.

[@kimmark1291]

@@goombapizza6335 you have no Idea what you are talking about

[@RobertHicks007]

@@goombapizza6335 Why ? You can get checks for them . Government pays . Not much diffrent then having a normal gen alpha child (children of gen z) They are already being called “feral,” illiterate” and “doomed,” I dont see a problem life will find away

[@Candycane1007]

I have a son that 19 now with Angleman Syndrome. I couldn’t imagine having 4 kids with it. He still in diapers and don’t sleep and only four hours with meds. If you can give me any tips I would appreciate.

[@walkingphilosopher]

Please join the "Angelman Syndrome Foundation" group on facebook. They have tons of tips.

[@ffishfinger]

Someone help the poor guy staring at the Apple start up screen at the dinner table

[@kimmark1291]

Why does he need help???

[@fawn5159]

0:49 Awww I'm gonna cry

[@stepht7508]

Bless that family.I couldn't do it.I would have stopped after 2 since it's obvious it's genetic...more power to them...My family carries a genetic disease where if one of your parents carries the gene you have a 50% chance of inheriting the disease..But we can get tested before having children..

[@jeff-freehoke8012]

What a beautiful family. They seem so happy.

[@steffennijhuis4143]

jacco nouwen (28-12-1968)

[@atheistleftcomment1807]

How on Earth is it possible that all 4 kids have AS, which is so rare, and all 4 of them are 14??????

[@chelseylaw-lavante3552]

It's likely that both parents are carriers of the gene. and if that's the case, there's a 25% chance of them having children with this syndrome. I have a son with a similar syndrome and was told by genetics doctors that both myself and his father are carriers of the gene and that there's 1 in 4 chances of us having another child with the same syndrome. I know it's a year late but I hope that helps you understand.

[@cherrypeaches4906]

@@chelseylaw-lavante3552 it's actually going to happen when the chromosome passed on from the mother is selectively expressed over the one passed on from the father

[@christinaburton9297]

One of the parents probably has a balanced translocation.

[@LetsDanceTampa]

And they just keeeeppptttt having more. Super smart.

[@OWNReview]

@@LetsDanceTampa they probably didn't understand the science of it. To know that they have a 25percent chance each time, they would have needed to do a genetic test.

[@EvaLou42]

Currently pregnant and this syndrome is one that can be screened for during genetic testing (usually done super early in a pregnancy). I was under the impression that pretty much everyone is getting their fetus genetically screened nowadays… So it’s interesting that they opted out of those very standard tests, because they definitely could’ve known.

[@joannespera]

Not true.

[@daniellemiller2547]

So after having one kid diagnosed with angelman why on Earth would you keep having more kids. They couldve stopped there and had 3 kids m, having one special needs child instead of 4.

[@thomastrouble]

@panzer Ken 100%

[@dennikstandard]

Well to be fair, they were born year-by-year, and Angelman diagnosis doesn't get apparent until year 1 or so. So it's well possible they already had second or perhaps even third child on the way when they found out about the first one. But the fourth child was a strange choice, yes.

[@amnigma2342]

It's a rare genetic disease that can only affect 1 in 12k to 20k. They wouldn't know that it would affect VERY SUCCEEDING children they have. Some people with Angelman syndrome have siblings that were born luckier than they were. You can't blame the parents for something they don't have control over.

[@daniellemiller2547]

@@amnigma2342 There is nothing wrong with desiring a large family but when you are aware of a genetic disease that may potentially occur again in one of your kids, it is your responsibility to not actively bring more children into the world. This disease is serious, why would you as a parent keep reproducing and subjecting your children to this. It's horrible.

[@flxmkr]

You’re absolutely right. Everyone should be born without disabilities. Also, they should be born with white skin, blonde hair and blue eyes. And as soon as they reach senior age, they should be taken to a wild forest and kissed “goodbye”. Sound familiar? What gives us the right to decide who should be born? Where do we draw the line? It’s ok to be born with intellectual disabilities as long as they’re pretty? Or perhaps they are savants who can play concert music, so we’ll let those live. What about all these tide pod swallowing, roof jumping kids who are obviously jumping from some expensive homes? Are they any different because they CHOOSE to act this way? Or because they were born into wealthy homes? Sheesh, people, everyone has irreplaceable value. These kids are happy. Ask the parents to choose one child and they wouldn’t be able to. They are all wonderful human beings. And kudos to the father who didn’t stereotypically grab his keys and coat as soon as the diagnoses was delivered. Why? Love! These parents look happy, and those kids are loving. It’s a wonderful family. But to answer your question, their first two kids were average. They didn’t know these kids would be born this way. But I’ll say one thing: if the parents thought the disease was so horrible, maybe they would’ve chosen to stop at the third. But it’s not our place to decide how many kids they should’ve had under any circumstances.

[@mayjay26.xo_6]

I wouldn’t be able to live like this. Is the reason I refuse to have children. I’m scared they will get my genes … I’m born with physical paralysis, I was bullied to the point I wanted to kill myself! And there’s no efen way I want to have children that look like me or worse ! These parents are patient and loving . I don’t think I can have the patients for this…😭

[@ColYo-wr5ll]

I see your photo and I think you are beautiful! ❤

[@stormgirl09]

i got a question the older boy looks like he keeps looking at political stuff/news...i didnt know they were that high functioning enough to understand that type of stuff or even read whole articles! unless he is just pressing random stuff on the Ipad....kind like a toddler does.

[@katwalthall6990]

What will these children do when the parents pass away?

[@kimmark1291]

What do you care?

[@LukishiBrown]

Sadly unless there is a large extended family, a facility is the answer

[@cantpopdismolly]

@@LukishiBrownsad, but true. Without close family or friends, that’s likely the outcome. But hey, mom just wanted a big family!

[@appledapper]

After the 2nd....I mean why not adopt

[@LMBC6Brian]

This is one of those you should have had genetic screening before you kept having kids after the first, definitely after the second.

[@kimmark1291]

Wasn’t available

[@burntham113]

If you knew you had a high probability of having kids with AS, why would you have kids instead of adopting? That seems irresponsible to me.

[@jeff-freehoke8012]

"People with AS are sometimes referred to as "angels", both because of the syndrome's name and because of their youthful, happy appearance."

[@ultimadeplete8299]

They didn't know. Their first two kids weren't affected and the ones with AS were born pretty close together. A lot of people with AS don't get diagnosed for several years after birth. I would imagine none of them were diagnosed until all of them had already been born.

[@thatonechickyousaw]

Honestly, I have to completely agree. Bringing children into the world that are in pain, unable to truly communicate, and are going to suffer for the rest of their lives is absolutely irresponsible, and actually very selfish, cruel, and ridiculous. But mainly selfish and cruel. They knew something wasn't right with their third child. The parents themselves said that children with Angelman Syndrome are often misdiagnosed with other severe issues such as severe autism and/or cerebral palsy. Then their fourth was also born with the same "problems" (for lack of better word). So the parents continued *their* dream of having more children despite the fact that there seemed to be a *VERY* high likelihood of the following children having the same difficulties, where their kids are going to be suffering alone for their entire lives? (The parents themselves stated in this video that their children cannot communicate to tell them if they're in pain, have had nightmares, etc. So they go/suffer through all of these scary and hurtful things completely alone.) That is completely and utterly SELFISH. As for those who are going to claim that they had no clue what their children had, nor if their next children were going to have the same fate, gene therapy has been around for a very long time. It was VERY possible for them to have checked their genes for markers that would have resulted in disorders such as this. They could have even gotten their children's DNA checked to see if it was in their genes/DNA. But they chose not to. So, again, these two "parents" (I have to use this term loosely for these two, as they chose all of this and now whine that every day is a "challenge" for *them*. HONESTLY!?!?!), are SELFISH. Okay. Im finished now. I think. We'll see. lol

[@isabellacicchetti6058]

Ultima Deplete So they have six children? And some of the last four are twins? I can't believe. ....

[@isabellacicchetti6058]

thatonechickyousaw How can you know all these things about this unlucky family?

[@shadrachemmanuel1720]

Are you sure Louisa and Mark are not related. Because they look suspiciously alike. 🤔

[@spongedebfatpants1308]

They look EXACTLY alike.

[@Manderz89]

No they don’t

[@Manderz89]

@@spongedebfatpants1308not true

[@ChannonRx]

The parents look like they could be siblings

[@Manderz89]

No

[@atheistmommy3710]

I didn't know Angelman syndrome is inherited, I thought it happens spontaneously, how 4 of them in row have it?

[@walkingphilosopher]

There are more than one way the UBE3A gene can be defective. Usually it is through the deletion of a chunk of sequence in the chromosome 15. This is not inherited. But sometimes it is because the mother carries a POINT MUTATION. In this case, it may be inherited.

[@havenbastion]

Normally the father's copy of the gene is suppressed. His apparently isn't.

[@babygirlzmommy]

Genetic A.S comes from the mother. If its from the father its PraderWili

[@bostonlisa]

I’m so sad for family’s with kids like this.

[@allisonlew4508]

Why did they keep having children?

[@Manderz89]

Cause they are allowed

[@katez5205]

​@@Manderz89 just cus they're allowed doesn't mean they should.

[@maybelikealittlebit]

why they kept havin kids after the first two with AS and didn't choose to help the world by ADOPTING so they could have a bunch of kids is beyond my comprehension. Selfish in my opinion honestly. Genetics doesn't make you a good relative.

[@havenbastion]

Stop having kids!

[@christinaburton9297]

Does one of the parents have a balanced translocation?

[@CharlestonChica]

I know the mother said she wanted a big family, but I would have stopped after having a second kid with disabilities in a row tbh.

[@morghanchambers9138]

Exactly

[@missa9030]

No offense but I probably would have stopped after the first kid

[@justinlawrence7584]

I would have to

[@loekert3749]

I am happy my parents didn’t because my older brother has AS. I love him to bits :)

[@ChimeraGilbert]

We didn't even know what angelman syndrome was until all 4 of them were born! Please stop blaming us for something we didnt know about. My brothers and sisters are a gift, stop looking at it so 1 dimensionally

[@missa9030]

@@ChimeraGilbert I said I would I have stopped..I literally don’t care about anyone else’s family or what they decide to do, including yours.

[@ChimeraGilbert]

@@missa9030 yet here you are commenting on someones family so obviously you care enough to make a judgement. you say you wouldve stopped yet you still miss the fact that we didnt fucking know about the syndrome until later, so your comment is pretty void. if you literally didnt care you wouldnt have made such a dumb comment you foot.

[@mapagatu]

There are so many kids out there that need a home. Once it's pretty much established that your children will not be normal why keep at it? If you truly want children adopt, in those circumstances.

[@nikkitikki6648]

mapagatu you cannot assume people want to adopt. Adoption isn't meant for everyone. People have the right and freedom to give birth give to as many children as they want no matter what the circumstance. Orphans are not the responsibility of people who cannot(or should not according to you) have children of their own.

[@AN-zz8ps]

I completely agree! And once your gone what is the disabled child going to do?

[@joanbaczek2575]

They were born to close together to know before the 4th one. Drs didn’t notice when sending them home so why would a parent recognize it as a newborn

[@sanketsaini9024]

I salute......

[@KEBinAZ]

What is the likelihood of 4 of the kids having the same chromosomal disorder? This doesnt seem possible. And as far as the comments of this couple continuing to have kids despite the chromosomal disorders, I doubt the first two were even diagnosed in time, maybe they all weren't but this is certainly bizarre. I say the same thing about cystic fibrosis, which is inherited and totally different.

[@babygirlzmommy]

The mother is a Carrier, so it was a 50/50 chance..

[@kathmandoozle]

@@babygirlzmommy do you understand how genetics works?

[@babygirlzmommy]

@@kathmandoozle you mean do I understand how the genetics of a Syndrome that my child has, that The Gentisist doctor told me I was a Carrier of ( you know cause they did genetic tests on me as well) and had a 50/ 50 shot of passing it in works... yeah I got a Vague idea

[@babygirlzmommy]

@@kathmandoozle also angelman syndrome can happen by chance, even if the mother isn't a carrier...

[@kathmandoozle]

@@babygirlzmommy no, that's not how recessive genes work. It's not 50/50. IF you have BOTH parents who are carriers than you have a 50% chance of being a carrier and 25% chance of getting both genes from each parent and being at risk for the syndrome. That's if both parents are carriers.

[@kimmark1291]

Shame on every single one of you who has judged and thrown negativity to this family. Educate yourself!!!! Angelman Syndrome has several genotypes. Some types are inherited and children have been diagnosed improperly. To all you evil people I’m so glad you are so perfect!!!! These children are far better than you. Unconditional love. No judgement. Just forever pure and loving!!!!

[@nicoleventresca520]

Why the hell would u keep having kids

[@Bellakania520]

Just to let you know Angelman syndrome (AS) is not a disease it's a disability or condition

[@Manderz89]

It’s a disorder

[@sarajalbert4285]

proquo app??

[@joanbaczek2575]

If Andrew has Angelman Syndrome he wouldn’t have the capacity to learn to use assistive devices I think there something wrong with his diagnosis

[@KeeganMcKinney]

I feel bad for them

[@kimmark1291]

It’s challenging but these kids are amazing. Society needs to be inclusive

[@kittykatBflat]

Everyday is a challenge that they created you mean.

[@arcadegamer117]

kittykatBflat no duh. no need to be rude about it.

[@thatonechickyousaw]

kittykatBflat's not being rude at all. kitty's being completely honest, and it's actually important that this is pointed out. These parents are whining, and they chose this. They chose to not only continue to have kids though there was a large chance of them being afflicted with something like this, but did it because *they* wanted a large family. So they can stop complaining about it. (I have a large, longer, more substantiated post about all of this is up above, in reply to burntham113's, which at the very top. I'm #3 under him. Just wrote it.)

[@thatonechickyousaw]

Sandy Y. Exactly. Either they end up in long-term facilities or taken care of by siblings or other members of their family who become resentful. It hurts my heart, honestly, knowing their parents chose this.

[@flxmkr]

thatonechickyousaw ok, but look at the job security they are providing to care givers. Besides, every one of us could wind up in an extended care facility. If we don’t get In an accident that could leave us paralyzed or brain injured, we could get Alzheimer’s or lose our legs to diabetes. It’s not fair to try to place guilt on parents who decided to conceive and/or not abort, just because their kids are more prone to live long lives. What if you discover you have the Alzheimer’s gene? Or diabetes? Can you be certain you won’t be dependent on long term care in your life? The only difference between those kids and us is we haven’t developed anything that requires long term care...yet. There’s still time.

[@ChimeraGilbert]

@@thatonechickyousaw if you paid attention you would know that we didnt even know about the syndrome until all of them were born. my parents werent whining, they simply wanted to raise awareness, so please educate yourself and shut the hell up

[@عامرعامر-ظ1ع]

may God bless you

[@Candycane1007]

My husband and I have kids by previous spouse that normal so we decide to have a kid and it took six years what he had but the doctor did say it was a chance for us to to have another kid with the same Syndrome but I got my tune tide after he was born but I brush I had another kid after him so he could grow up with someone his age. Our other kids was a lot older.

[@Godschoosen1]

You sound stupid what's your point

[@LetsDanceTampa]

Not understandable; please rewrite.

[@Hayley123454]

Did you pass your lack of intelligence onto your children? Please tell me English is not your first language or something, because you make absolutely no sense. I will apologize if English is indeed not your first language.

[@pragmatic7green]

wishing them/us: health, freedom, independence, good fulltime jobs, subways trains mass-transit, science, learning, fairness, 💼🔑💼🔑💼🔑💼🔑💼🔑💼🔑💻💼🔑💻💼🔑💻🌷🍁💐🌹🌺🍀🌷🍁💐🌹🌺🍀🌷🍁💐🌹🌺🍀💼🔑💻💼🔑💻💼🔑💼🔑😁😊☺😉🌄🌅🌷🍁💐🌹🌺🍀💼🔑💻💼🔑💻

[@roxxi789]

this is cruel

[@AN-zz8ps]

AGREED!

[@sveiniscute9101]

Shut up Karen.

[@dentystastatysta5692]

what a blessing lol

[@nuxvomica1090]

Why is this a blessing?

[@spongedebfatpants1308]

Not stopping after the second one is selfish. Shame on you.

[@Manderz89]

Oh be quiet they aren’t selfish