A doctor's guide to MTHFR, and what you can do to boost its function regardless of your genetics.

🧡In this fun animated video, learn all about the MTHFR gene, the key gene controlling methylation/ detoxification in every cell of your body.
What conditions/ symptoms are associated with a mutation in the MTHFR gene?
How can you test for the MTHFR gene?
What supplements and lifestyle changes help boost the function of your MTHFR gene, regardless of your genetics?
Hear some exciting case examples on a variety of patients who improved their health after addressing their MTHFR gene mutation
Rajsree Nambudripad, MD is board-certified in internal medicine and the founder of OC Integrative Medicine in Fullerton, California.
🧡 Shop for Supplements by Dr. Rajsree:
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🧡 Methyl B Complex for MTHFR is available here:
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🧡 Methylation Support (same as MethylCPG in the video):
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🧡 Glutathione:
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⭐Learn more about her practice here:
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This information, including but not limited to, text, graphics, images and other material contained on this video and website are for informational and educational purposes only. No material in this video is intended to be a substitute for professional medical advice, diagnosis, treatment, or medical supplement approved by the Food and Drug Administration. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. No physician-patient relationship is created by this website or the information provided. Furthermore, neither Rajsree Nambudripad, MD or any contributor to this website, makes any representations, express or implied, with respect to the information provided herein or to its use.

[@ozywomandius2290]

I am thrilled to see a practitioner who is finally speaking to people with real info, knowing they can understand and use it. Thank you so much, this helps tremendously!

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@williamhenry3337]

I am 75 years old and have been retired for 5 years. I have watched OVER 6,000 health podcasts and this is theeee best podcast. It is so clear to understand. You don't need a PHD to understand the subject matter. I am MTHFR & Apoe2 so this helped a bunch. GREAT JOB! I just subscribed to your channel and a thumbs-up.

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@IreneYoungFoto]

OMG! This is brilliant. I have been wanting to understand exactly what you have explain for years. I cannot thank you enough!

[@drrajsree]

Thank you so much for your kind feedback. So glad it was helpful to you! Best wishes, RN

[@deniseshannon6035]

This made so much sense can you tell me where you practice is I would like to get a blood drawn . Thank you so much

[@drrajsree]

@@deniseshannon6035 I"m in southern California. Are you local? We currently have a waiting list for local patients.

[@joeking2471]

Please come to Australia for a while dr I will be the first to come see you. The health system here is disgusting no doctors talk about this

[@drrajsree]

Thank you all for watching! My Methyl B Complex for MTHFR is now available here: dr-rajsrees-public-supplement-store.myshopify.com/collections/essential-vitamins/products/methyl-b-complex Methylation Support (same as MethylCPG in the video): dr-rajsrees-public-supplement-store.myshopify.com/collections/metabolic-support/products/methylation-support Glutathione: dr-rajsrees-public-supplement-store.myshopify.com/products/glutathione?_pos=1&_sid=5c11e344f&_ss=r

[@dyvines]

Is this completely dairy free , gluten free, soy free , corn free? Including the capsules? Thank you!

[@dawndid5972]

I'm excited to bring this to my neurologist visit tomorrow because I've been having symptoms and problems regulating my emotions on a daily basis; my caring thoughtful and concerned great gynecologist from Stony Brook University Hospital in Stony Brook Long Island, NY to the time to do a DNA blood test back around 2008 or something. Well, I'm grateful for caring doctors like him and all doctors who take the time to properly diagnose issues then go above and beyond to really hear the patient as a human being, not just another patient. He had what I call.... patience for patients!!! Thank you for this elaborately educational video. I will be sure to take it to my next doctor's visit to compound the interest. My ❤ is thankful.

[@drrajsree]

@@dawndid5972 Thanks for watching and best wishes in your health, RN

[@paulagaudet7528]

I need a little help interpreting my 23& me download to Genetic genie shows heterozygous for MTHFR c665C>T which I think is the same as C667T but the alleles are called AG rather than CT and I’m not sure why.

[@drrajsree]

@@paulagaudet7528 Thanks for watching.

[@pradeepkumarmsreedharan2814]

Gifted teacher, simultaneously motivates and imparts knowledge. Salutes 🌹

[@drrajsree]

Thank you for watching! Appreciate your kind feedback.

[@jmauremootoo]

I stumbled upon your excellent video while researching methylation/MTHFR/Lifestyle medicine and looking for a short, simple but accurate explanation. Yours fits the bill perfectly, and is the best I have found so far. Keep up the good work

[@drrajsree]

Thank you for your feedback, it means a lot to me! Thanks for watching.

[@jennalcala8252]

I had my PE in 2015 and I’ve been trying to understand this all for years. This was a very clear video and easy to understand

[@davidchang8468]

This doctor is very generous and methodological in her dispatch of essential knowledge of body pathways and nutrients needed to live well. I always look forward to her next lecture.

[@drrajsree]

Thanks so much!

[@katintheoc]

Excellent, as always. I stumbled upon this video shortly after I messaged you my results...I should have known you had an awesome and informative video on the subject. Thanks!

[@drrajsree]

Thanks for watching Kat! Glad you found the video. We can discuss your results in detail when I see you next time. Best, RN

[@anonymous203020]

I learned I have the 677C T/T polymorphism and this video is so helpful in understanding how to treat it. You are really helping people improve their lives. Thank you!

[@drrajsree]

Thanks for watching!

[@Subspace._tripmine]

How did you get tested? What type of doctor or laboratory?

[@nordnerdmanda1745]

@@Subspace._tripmine my doctor ordered one for me called GeneSight

[@slina9691]

Thank you, doctor, for explaining things in a simple a superb way.

[@drrajsree]

Thanks so much for watching! Appreciate your kind feedback!

[@cassie8973]

Great video!! Your channel has helped me understand so much! I've been taking L-methyfolate for a few weeks now and realize I'm dreaming extremely often again. Even with interrupted sleep, I've still had dreams!! Overall fatigue is improving. Anyone else have similar experiences?

[@drrajsree]

Thanks so much for watching! Best wishes in your health, RN

[@drrajsree]

@@shankar0cr Thanks for watching.

[@shankar0cr]

@cassie8973 I have sleep issues as well. I thought it was more to do with Iron and B12 deficiency rather than Folate deficiency?

[@balancehealthnow]

This was so easy to understand, for such a difficult topic. I enjoy your style of teaching. Thank you for the work you do

[@drrajsree]

Thanks so much for watching and I appreciate your kind feedback!

[@Gigi-nv5ev]

This was an excellent presentation! I do know my MTHFR status & so does my husband, therefore, we know that our kids have this variant, as well! I wish that more people were aware of this. Thanking you for doing your part in the promotion of the MTHFR knowledge! ✨⭐️✨

[@drrajsree]

Thank you kindly!

[@Truerealism747]

What are your symptoms any pain

[@tsegeredatesfaye85]

Thank you for another great video ❤️ you are blessing to humanity ❤️🙏🏿

[@drrajsree]

You are so sweet Tess! Your kind words of encouragement always mean so much to me! Thanks so much for watching and supporting.

[@Sate0zu0flaca]

Fabulous!!!!!!!!! Thank you so much for your video, it's clear to explain the problem, the symptoms and the solution!

[@drrajsree]

Thanks so much for watching and for your kind feedback!

[@VMac-eg7fb]

Thank you Dr. Nambudripad, I have been following methylation for many yrs, since the Israelites first published their findings. Out of all teachings I have experienced, yours is outstanding. My cardiologist has me taking one pharma you mentioned but my insurance will not pay for it even though it is a major answer to all of my physical needs. It's amazing, the positive change in my attitude and physical health.

[@drrajsree]

Thanks so much for your kind support! 🙏 Great to hear from you. Best wishes in your health, RN

[@saleemshaikh1143]

Dear respected doc, the video was extremely informative, very well explained with all the necessary details, the only problem was the annoying music in the background which was causing distraction & making it difficult to concentrate. Thank you so much for this extraordinary video & God bless you.

[@drrajsree]

Thanks for watching!

[@UniquelyGeeky]

Yes I agree, the music made it hard to concentrate.

[@auviamiller7383]

Agree! Wish there was no music. I had to take a break in the middle cause the music was too much.

[@VesperGoes]

I agree. It was like having static in the background and couldn't focus.

[@coryburns9161]

Give me a break the music wasn't that bad

[@Angel_Dinev]

Another great video, nicely drawing out how to identify and overcome some of our inherited genetic issues. Thanks for supplying such an important knowledge in understandable means and providing practical advice how to proactively mitigate it!

[@drrajsree]

Thanks for watching and appreciate your feedback!

[@blr20401]

This is one of the best informational videos regarding this process and more importantly what we can do about it. Thank you!

[@drrajsree]

Thank you so much for watching!

[@jessicat3951]

Best video I have seen. Thank you for boiling it down!!!!!

[@drrajsree]

Thank you so much for your kind feedback!☺️

[@godschild7643]

I can't believe someone made a video on this!! It is so rarely discussed. I have mutations on both my mom and dad's side. A wonderful doc put me on Deplin about 7 years ago. My marbles (brain) are still intact but a lot of other health issues. Thank you. Thank you!!!! I will add some of what you suggested.

[@drrajsree]

Thanks so much for watching!

[@richmiller4626]

Great video-thank you! You have a gifted way of explaining information that is easily understood.

[@drrajsree]

Thank you so much!☺️

[@deepshadow1]

@@drrajsree In what quantity should I take all the various B vitamins with a value of 50? I already take about 5mg folate

[@TracyGram]

Thank you for making this easier to understand and including what to look for in our blood work and supplementation to help us. This could be the answer we have sought for over 20 years.

[@drrajsree]

Thanks for watching!

[@cyberfunk3793]

@@drrajsree For a layman the CDC page "MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects" seems to contradict with the info in this video: "5 things to know about the MTHFR C677T variant and folic acid People with MTHFR C677T variants can process all types of folate, including folic acid. Folate is a general term for many different types of vitamin B9. Folate includes naturally occurring folates in foods, such as leafy green vegetables, citrus fruits, and beans, and several types of folate in dietary supplements, such as folic acid and 5-methyltetrahydrofolate (5-MTHF). The MTHFR C677T variant affects how your body processes folate. You might have read or heard that folic acid is not safe if you have one or two copies of the MTHFR C677T variant. This is not true. Even if you have one or two copies of the MTHFR C677T variant, your body can safely and effectively process all different types of folate, including folic acid." Can you clarify on the significance on the different types of folate, is there some other references on the topic you could link?

[@drrajsree]

@@cyberfunk3793 Those with the MTHFR genotype, do better with methylfolate instead of folic acid.

[@cyberfunk3793]

@@drrajsree ok, some sources claim that is up to 40% that have at least one impaired gene so perhaps CDC is just living in the past then with their info.

[@drrajsree]

@@cyberfunk3793 Yes it's unfortunate but a lot of vitamins and fortified foods, even prenatal vitamins still use folic acid, but this is very outdated.

[@saratonnan]

Best video I've found that clearly explains the MTHFR mutation. Very well done! 👏👏👏

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@Annaislove70]

Thank you so much! This was so informative, I couldn’t understand why I can’t seem to loose weight & if I do it’s not very much. Instead of prescribing diet suppressants and all kinds of weight loss gimmicks, more doctors should be looking into this, which could definitely be the root cause of people having such a difficult time loosing weight & just continuing to get bigger & bigger, in addition to developing more & more health problems. I am going to get tested for this. I can’t even thank you enough, your video was amazing, very informative & easy to understand. 👏🏽👏🏽👏🏽

[@drrajsree]

Thank you so much for watching! Best wishes in your health, RN

[@cherylskelley523]

Life changing information. Thank you for your work in this arena.

[@drrajsree]

Thanks so much for watching! I appreciate your kind feedback.

[@frankevich]

Valuable video on a very important subject. Thank you Docotor Nambudripad!

[@drrajsree]

Thanks so much!

[@jordanj.5681]

Wow this is the best compilation of so much material into a digestible short video bravo!

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@jays1915]

Dr Rajsree…Thank you for all your videos. They are awesome and informative. I truly wish more doctors would be like you!!!!!!and not just default into being a new age pharmacist. Thank you for what you do! Your work Will help lots of people even the ones you cannot physically treat in your practice. I know these videos probably take up a lot of your time but we appreciate it

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@theophilustheophilus9153]

@@drrajsree I want to reiterate what the above poster said x1000. Your time and passion are a Godsend and labor of love that we all appreciate beyond words. Especially those of us who have an assigned allopathic doctor who just shuffles patients in and out as fast as they can, will not tolerate being asked questions, or requests for particular tests. 💛

[@xXxDisplayNamexXx]

I was told I’m double homozygous abnormal, but never knew how much of a difference it made. It recently has been literally killing me, and I am bipolar (thanks MTHFR) so it’s put me at the edge of what I can handle. Thank you so much for this info, my doctor isn’t even aware of this gene.

[@drrajsree]

Thanks for watching

[@madelinemelocriollo1092]

I have not been able to find a medical professional who gets the importance of this and still on the hunt for one today.

[@drrajsree]

@@madelinemelocriollo1092 Thanks for watching.

[@kellyh5250]

Hang in there Nick; it seems like too much to handle and manage. I'm trying to find my way in this hell-hole as well.

[@drrajsree]

@@kellyh5250 Thanks for watching.

[@therealPRD]

This video changed everything for me. Thank you.

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@cadenventures5]

Excellent video! Made this topic i just recently learned about very easy to understand. Thank you!

[@drrajsree]

Thanks so much for watching! 😊

[@mount78]

I recently discovered your channel and have been so impressed with your presentation style, especially the lectures. I been scouring YT for information about what may be causing my symptoms. Your videos about histamine intolerance have been eye opening and so helpful. Thanks for working so diligently and seriously on the gut biome issues. One thing I would suggest is drop the distracting music if it can in fact be called music. In most of the videos I need to pause and calm down. The background noise is so intense causes another of tension. Thanks!

[@drrajsree]

Thanks so much for watching and for your feedback. Hopefully you like my newer videos which have a lot quieter and gentler music. Best wishes, RN.

[@joeborgia9495]

You break it down to laymen terms and appreciate your time frame for results (6)months. I have started all the supplement recommendations and look forward to having my homocystine levels checked. 5 stars.

[@budchin1]

The last time I had to deal with biochemistry wasn't so much fun. This was a pleasant lecture.😊

[@drrajsree]

Thanks so much! :)

[@LibbyAnn026]

This was so clearly explained! Thank you so much. Instantly subscribed.

[@drrajsree]

Thanks so much for watching and subscribing! 😊

[@orkidiaalvarez4941]

Thank you! Thank you! Thank you!! So grateful that you made this video. Just got tested and I had no clue on what it meant and what to do about it. You gave us just that! Thank you! You are serving your purpose!! May God bless you 🙏

[@drrajsree]

Thank you so much for watching, and for such kind words of encouragement -- it means so much to me! Best wishes, RN

[@nadiablasigh377]

@@drrajsree Dear Doctor, thank you so much for your video. I have a mutation of factor II protrombina G20210A eterozigote and the mutation MTHRF C677T eterozigote. I would like to know your opinion and what should I take. Thank you. Nadia Blasigh

[@drrajsree]

@@nadiablasigh377 Methyl B. Complex is helpful. We ship throughout the US: dr-rajsrees-public-supplement-store.myshopify.com/collections/frontpage/products/methyl-b-complex

[@nadiablasigh377]

@@drrajsree I live in Italy. Could you deliver to Italy? My D-Dimer result was high too - 1257 and two days later I resulted positive to Covid. I was practically asymptotic. Do you have any suggestions on how to bring it down?

[@drrajsree]

@@nadiablasigh377 Unfortunately we only ship within the US at this time. Great to hear from you! Italy is one of my favorite countries.

[@grantgardson]

I'm a carrier of mthfr disorder, thanks mom, but now I know why it's so difficult to get out of my emotional trenches.

[@forcedanonymity2500]

because you latched onto garbage

[@jennalcala8252]

@@forcedanonymity2500have a blessed day, clearly you need it

[@lindamorales7647]

I've been waiting for this video! Thanks so much for making it!

[@drrajsree]

Thanks so much Linda! Hope you enjoy the video.

[@Cobaltblueprism]

Excellent video with clear explanations and examples. Subscribed!!!

[@drrajsree]

Thanks so much for your support!

[@beehappycoleman7159]

Indeed, you are a gifted physician and teacher. Though may I ask that on other videos, or this one, that you turn the volume on the background music way down? Its distressing to filter music competing for the valuable information that you are imparting, especially those with depression, ADHD, anxiety. It's too much chaos to the ears. Many thanks. I love the video and your information.

[@drrajsree]

Thanks for watching and your feedback.

[@mitchellseddon1762]

What's even more mindblowing is that because MTHFR can reduce B12 B9 absorption, ADHD symptoms can appear from lack of B12 and B9 - BECAUSE the vitamins are not giving you that dopamine / serotonin gain, THEREFORE is ADHD a vitamin absorption deficiency because of MTHFR?

[@Sir-Reborn]

Wonderful video, but I want to point out one consideration to keep in mind. On top of the MTHFR and MTRR genes, another one to keep an eye out for is COMT - which complicates the process a bit if you have. COMT, like MTHFR, has numerous functions I won't go into; but relavent to this video & MTHFR positive individuals is it affects the 'treatment plan' since Methylcobalamin isn't recommended (and methyl-donors in general for that matter) In terms of vitamin b12, hydroxocobalamin is generally seen as the best / most accepted form for individuals with COMT; or COMT + MTHFR. The issue is its not super bio-available in oral form, so you might have to speak with a health care provider about higher doses; sublingual doses; or injections Alternatively adenosylcobalamin also supposedly works, but my knowledge is thin on that specific varient. And then in terms of what form of B9 / folate to take, I'd also recommend speaking with a HCP since it complicated the process, depending on what combination of genes you are (homo vs hetero) and your individual response. Some do fine with methylfolate, some require lower doses, some require alternative forms. I'm not your HCP so I won't be making any recommendations on that.

[@drrajsree]

Thanks for watching

[@nashcotten3684]

This is a beautiful explanation, thank you.

[@drrajsree]

Thanks for watching!

[@BernardBertrand]

WOW this is the best explanation on the topic I have seen ! Thank you so much

[@drrajsree]

Thanks so much for watching! 😊

[@Masounss]

What a wonderful explanation Thank you dr. I found out that I am heterozygous. 2 months ago my homocysteine was 46 and by taking 15 mg. Calcium Folinate daily it came down to 17

[@drrajsree]

Thanks so much for watching. Wow that’s an amazing improvement in homocystine.

[@evonchristie2549]

So much great info, but hard to listen to through the background music when you have anxiety because of the Mfer gene mutation.

[@drrajsree]

thanks for your feedback

[@mazzy131]

I just received my gene study and watching this video reallllllly helped me understand what the paper work was explaining. Thank you! Great advice too! I will be sure to talk with my doctor about the supplements you have suggested.

[@drrajsree]

Thanks so much for watching!

[@billrener4897]

Talk with your doctor?! Conventional doctors know virtually nothing about nutrition. They know about pharmaceuticals. Unfortunately, physicians like Dr. Rajsree are very rare.

[@SamanthaJee]

Great video! Love the visuals and you made it easy to understand. Thank you

[@drrajsree]

Thanks so much for watching! 😊

[@vannelysrivera8358]

This video is great! Question if you dont tolerate well the methylated B complex, do you recommend adding the glutathione or just doing the glutathione alone? Thanks!

[@drrajsree]

Glutathione is helpful! Either way!

[@marylou7230]

My son just tested positive for the gene mutation. Both he and his father have super high hystamine (allergic to everything) this video is a lifesaver-thank you!!!

[@drrajsree]

Thanks so much for watching! So glad you found it helpful.

[@marylou7230]

@@drrajsree How long after starting the two products you mentioned will patients start to see an improvement in their histamine?

[@drrajsree]

@@marylou7230 Usually I re-test homocysteine after 3 months

[@Butterflylovely5]

Hi I do have this gene mutation along with DAO gene mutations and others that make my histamine super crazy high, did your husband and son got better after this treatment?

[@dianaflorinap]

Thank you for this! I will do those tests. I love the way you explain.

[@drrajsree]

Thanks so much for watching! 😊

[@trevorlove7290]

thank you for this amazing education!!

[@drrajsree]

Thanks for watching Trevor! Appreciate your feedback.

[@jeffg.3250]

Great video. For those who want TMG as well, would we take Methyl CpG in addition to Methyl B Complex? Or instead of? I'm assuming just the CpG and not both.

[@drrajsree]

Some people take both, but that can be a lot of B6, so some people just take Methyl CPG.

[@cassiraffe8939]

I have MTHFR and a systemic nickel allergy syndrome, many supplements for methyl B12 have nickel or cobalt used in the making of them that are not ideal for SNAS. Do you have any advice for what would be best for me? I want to be healthy but im facing alot. Thankyou in advance 💖

[@drrajsree]

I’m sorry to hear this. Unfortunately I’m not sure what to advise. Thanks for watching.

[@girl81ful]

I have been looking for information for a very long time about what this enigmatic MTHFR actually is. I wasted a lot of time on some confusing explanations in other videos on YT. Only Dr. Nambudripad explained in simple words what it is and what it is used for in the body. Thank you very much Doc!

[@drrajsree]

Thanks so much for watching! 😊

[@jennifermizban1371]

Excellent info!! Thank you!

[@drrajsree]

Thanks for watching Jennifer!

[@ms_bliss444]

Four years ago I had blood work done for MTHFR because my Mom said she had it. I’m a 31 year old female and want to have kids soon, so I’m taking this seriously. I have suffered from migraines (magnesium helped cure those), anxiety, depression, and low energy on and off for years. Now I know I am MTHFR C677T heterozygous and currently take the Methylfolate, however my doctor wants me to go to a Vascular Specialist to make sure the supplements I’m taking work in conjunction with my hormonal BC before I stop taking BC and start trying for children. Do you know if a Vascular Specialist is the right person to help with MTHFR? Seems like most doctors I mention this to are unaware.

[@drrajsree]

Functional medicine or Integrative Medicine specialists are more familiar with MTHFR. You can search for a provider on IFM.org Best wishes, RN

[@ClapSniping]

The birth control probably contributed to your depression, anxiety and energy levels. It’s literally poison and I hope you’re off of it now.

[@NikaBanana]

Actually leafy greens do not help those with MTHFR mutation as it’s not methyl folic acid

[@drrajsree]

Leafy greens do help as they have abundant folate, which promotes methylation pathways.

[@rangerdoc1029]

@@drrajsree They also have overabundant oxalates, which MTHFR patients are more likely to have a problem accumulating.

[@KishBish]

@@rangerdoc1029 correct.. I must avoid them or I'll be doubled over in severe pain for days..

[@joevans5713]

If you wilt the greens by light steaming or boiling, it reduces the oxalates significantly 😊

[@andyneale6533]

Thank you for the breakdown and a simple to follow explanation! Very helpful!

[@drrajsree]

Thanks so much for watching! 😊

[@kelleym3844]

Great video. Thank you for sharing 🙏

[@drrajsree]

Thanks for watching!

[@24carrotgold8]

My sister had the #1 symptom of MTHFR. She conceived a child without a skull. He delivered at 7 months and died 5 minutes later because his brain was crushed during delivery. My niece (different sister) had the defect identified prior to conception. She took the folate and B12 supplements recommended by her doctor and conceived twins. Penny was 2.9 lbs and Mark was 5 lbs. Autopsy on Penny's umbilical card show 1 missing artery. It was the supplements that enabled their birth. 👶👶🥰

[@drrajsree]

Thanks for watching. Very sorry to hear this.

[@Kuato]

Will humans please stop reproducing already. The collective human gene pool and corresponding microbiome have been systematically massacred to the point where the offspring coming out are literally piles of goo. JFC enough is enough. What on earth is the matter with you people.

[@jessbobess2530]

Thank you for this info. These supplements are so expensive. I’m looking at life extension brand. It’s only $10 and has great reviews. Wondering if this is ok. I see the difference is calcium and d I think. Thanks again,

[@drrajsree]

Thanks for watching. The best way to know if a supplement is working is to have a doctor check your labs to see if the numbers are improving.

[@jessbobess2530]

Rajsree Nambudripad, MD thank you!

[@heatherferguson3104]

Amazing!!!! Ive been sick for 6 years with chronic nausea and after so many tests and imaging..still no answer. But I have signs that point to MTHFR issues and after watching your video I will try to get my doctor to run labs looking for this. Wish I could see you for help! Blessings!!!

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes in your health, RN

[@marcierenee15]

What a fabulous video- thanks so much!

[@drrajsree]

Thanks so much for watching!

[@SanFranMission415]

Hi, I recently completed a Genomind Pharmacogentic Report (24 Gene) and one of the many defect genes I have was the C677T: C/T. My doctor recommended taking L-Methlyfolic and and exercising since antidepressants don’t work for me. The L-Metyfolic worked right away (next day) but only worked great for about a week. I don’t feel my doctor knows anything about the mthfr, so it leaves me doing my own research. Do you feel having my homocysteine levels checked it will give me an idea on why the folic stopped working? And if my homocysteine is very high, will the Methyl CPG, be a good option? When the Methlyfolic worked for me, I felt so normal for the first time I can remember. I really want that feeling back. I felt happy and very sharp for the first time ever. Thanks you.

[@drrajsree]

Hi , yes it's good to get your homocysteine checked. If you're in the US, we carry Methyl B complex and Methylation Support -- both are great for MTHFR. dr-rajsrees-public-supplement-store.myshopify.com/collections/essential-vitamins/products/methyl-b-complex dr-rajsrees-public-supplement-store.myshopify.com/products/methylation-support?_pos=1&_sid=58ca8f9cd&_ss=r

[@michaelpond813]

Take co q 10. D 3. And carnitine for depression. It really works great and energy is increased greatly. Also a veggie diet with exercise.

[@GodsChildrenOnEarth]

This was a the best video explaining MTHFR!

[@warriorjesusking9825]

My family found out we had this and I have not been the same since I was 16 year old and I'm 23 now and it has eaten me alive I am glad you made this video and help people understand what is happening to our generation and the one before Deuteronomy 28 I am a 70% and it made all my anxiety depression health issues and everything go away once I found this out and got the right stuff for it

[@drrajsree]

Thanks for watching.

[@mamabear6169]

How much did you take and how long did it take to feel better? My doc has me on 15mg of L-Methlyfolate

[@warriorjesusking9825]

@@mamabear6169 I take these vitamins called smarty pants with an owl on them magnesium potassium pills sundown plant matter not chemical made and I eat lots of greens like broccoli garlic you know farm organic food do not eat any clover valley and great value food it makes it worse especially the milk found hiland non GMO gluten free milk is okay

[@drrajsree]

@@mamabear6169 Thanks for watching

[@mariomello3495]

@@mamabear6169 did you take 15 mg? My doctor wants me in that too, for anxiety and social foby..

[@glenpetroski5865]

AMAZING info! Thank You Doc Rajsree; passing on your You Tubes onto many to be Blessed. glen

[@drrajsree]

Thanks for watching!

[@Danelle475]

This is amazing! I am learning so much from your educational videos. I need to move back to the OC so you can be my doctor too ❤

[@drrajsree]

Thank you so much!

[@chadsimmons8134]

I suffer from these very problems. I just had a genetics test done and this is something that came back. I have no understanding of this but your video has given hope that I could possibly see better results moving forward. I’ve never ate veggies like I should have and I’m definitely paying for it now. Ty

[@drrajsree]

Thanks so much for watching! 😊 Best wishes in your health!

[@joezagame5598]

Excellent overview. Thank you.

[@drrajsree]

Thanks for watching!

[@melodymulligan1067]

Wow!!! Best explanation ever! Thank you

[@drrajsree]

Thanks so much for watching! 😊

[@thibaud_92]

Again another great video! I have high homocysteine (27), I ordered right now a test for MTHFR mutation. Thank you Rajsree 🤩👍

[@drrajsree]

Thanks for watching! I'm sure you can get the homocysteine down in no time with Methyl B Complex!

[@King311___]

So bro what did u find? Where did you get it tested from? I have the same homocysteine level.

[@thibaud_92]

@@King311___ Hi bro I tested it in a private lab in belgium. I am in france. I have no mutation of this gene. I reduced already my homocysteine with b complex vitamines (high dosage). Check for a lab near your place that test it and take a good vit b complex.

[@King311___]

@@thibaud_92 ya man need to get my mthfr checked. However the walsh institute claims that mthfr testing is useless. Btw I started taking Life extension b complex a few days ago and feel great. I switched over from a lower strength brand. I also take 100mg benfotiamine as recommended by EOnutrition.

[@marzenarongione4968]

Excellent easy to understand and follow video. Thank you

[@drrajsree]

Thanks so much for watching! 😊

[@aaziz41]

Great presentation and knowledge

[@drrajsree]

Thank you for watching! Appreciate your feedback!

[@aymara1]

EXCELLENT video! Thank you!!!

[@drrajsree]

Thanks for watching!

[@aymara1]

@@drrajsree Dear Doctor, just called your office to make an appointment for my disabled son with MTHFR issues but you are not accepting new patients :( Is there a way you can make an exception? He really needs help! Thank you Dr ! Blessings

[@drrajsree]

@@aymara1 I can recommend a great integrative pediatrician -- Dr. Dane Fleidner in Mission Viejo, CA. Hopefully you can get an appointment with him for your son. Best wishes, RN

[@soheilarouhani2114]

Wow great information thanks so much DR 🙏🙏🙏❤❤❤

[@drrajsree]

Thanks for watching and commenting! Appreciate your kind feedback! Best wishes, RN

[@poncho1710]

Thank you for the easy explanation. Some videos make it so complicated and overwhelming .

[@drrajsree]

thanks for watching!

[@helenaprinsloo8336]

Thank you so much. 😂

[@jbchick17]

This was so helpful!!!

[@drrajsree]

Thanks for watching!

[@jleemassage]

Thank you so much !! I have been struggling with many issues only to be my own advocate and mentioned this to my primary care doctor, who then checked my homocystine levels which were through the roof at 49 !!!! I do have one copy see if I get the correct vitamin B supplements if this will turn it around with a healthier lifestyle and exercise. Thank you so much for this information. It is invaluable. I appreciate it so much thank you again.

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes in your health, RN

[@pradiptamishra5061]

Amezing abilities to impart knowledge with great presentation skill is praiseworthy. May GOD bless you. Thanks.

[@drrajsree]

Thank you so much for your support and blessings! It's great to hear from you.

[@miss_martyna]

Thank you so much for this!!!

[@drrajsree]

Thanks for watching

[@fjsn1]

Please make a video about MAO-A and Slow COMT ! Your helping so much with these videos!

[@drrajsree]

I cover slow COMT in my video on Estrogen Dominance. Thanks so much for watching! 😊

[@yavuzerol2567]

Thank you. Very good explanation

[@drrajsree]

Thank you so much

[@AliaKGupta]

Love your videos and thank you so much for sharing such important facts. This is the first time I’ve heard of MTHFR. I was wondering if you’ve been able to reverse RA with any of your patients with the supplements and food you mentioned or what was suggested for them that reversed RA. Thank you so much again for such an easy to comprehend detailed video.

[@drrajsree]

You would like my video on Autoimmune Disease which applies to RA and at the end I present a patient with RA who went into remission with my protocol: kzbin.info/www/bejne/oqCsk6unorOCrcU

[@elizabethmoses1186]

Thank for this wonderful information, it was very well presented but it was very challenging to watch this with the music, for me it detracted from being able to hear the great information you shared. I’m sorry to say anything negative bc this video really seems on point. I’m homozygous 677 with so many health challenges, I’m grateful I’ve had a wonderful integrative health team but I am currently at the point where I really need someone to connect some dots. I’ve learned it’s going to have to be “me” who does that, we have to be our own advocates and take better care of ourselves in every way🌻🌷

[@drrajsree]

thanks for watching

[@christopherwg4236]

Clear and concise 👍

[@drrajsree]

Thanks so much for watching!

[@timskolnik3819]

Phenomenal explanation. Thanks!!!

[@drrajsree]

Thanks so much for watching and for your kind feedback! 😊

[@miamullins673]

Love your videos. Very well explained. Very calming. Wish I were back in the states. Can't even get my kids bloods done here. Doctor said there's no reason. Despite the diagnosis of heds/pots, methane sibo and now having histamine intolerances /mcas. Mood changes, extreme fatigue

[@drrajsree]

Very sorry to hear this. Thanks so much for watching.

[@madelinemelocriollo1092]

Thank you for such a wonderful video. It explains everything so well. I've been looking for a video exactly like this, organized and it helped me understand this gene mutation so much better. I'm looking for a doctor in my area that understands the importance of this and my only question is how do we find professionals around the state who can help with this?

[@drrajsree]

Thanks for watching!

[@joeking2471]

Amazing explanation Dr thank you so much. ❤❤❤

[@drrajsree]

Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN

[@kellyneumann8234]

Great video, dear Dr. Rajsree! Would you kindly consider doing a video on the COMT gene specifically the slow one. Thanks so much!

[@drrajsree]

Thanks so much for watching. I cover COMT in my video on Estrogen Dominance you might like: kzbin.info/www/bejne/nqLQq2OroZV4nrs

[@enotuto8881]

Merci pour ces détails précis..

[@drrajsree]

Thank you for watching!

[@maliabella]

Super valuable. Thank you so much.

[@drrajsree]

Glad it was helpful!

[@RavensFoodPorn]

I just came across your video. Thank you so much for sharing this information!

[@drrajsree]

Thanks so much for watching! 😊

[@lyessamsung7431]

Very wonderful explanation, thank you, doctor

[@drrajsree]

Thanks so much for watching! 😊

[@PennyLane2024]

Wow! Subscribed! Thank you!!

[@drrajsree]

Thanks so much for your support!

[@rajashekargowdamp1915]

Excellent docter'thank you for your knowledgeble information

[@drrajsree]

Thanks so much for watching! 😊

[@PIPESANDSTRINGS]

Well presented Dr thanks for your efforts 😀. Good stuff

[@drrajsree]

Thanks so much for watching!

[@PIPESANDSTRINGS]

@@drrajsree my wife just got diagnosed B12 deficiency so I'm trying to learn and grow and help her 😀.

[@drrajsree]

@@PIPESANDSTRINGS Thanks for watching and best wishes on her health, RN

[@marioncinnirella4029]

Thank you you are very clear!!

[@drrajsree]

Thanks for watching!

[@khalidaliyasir4516]

Thank you for this wonderful health information

[@drrajsree]

Thanks so much for watching! 😊

[@yady170]

I am so excited because only with this knowledge one can have a totally different outcome in their health journey. Soooo thank ful for this video. Is this by any chance related to colitis? And can it be reversed like the examples you gave in the video?

[@drrajsree]

Thanks so much for watching. Are you talking about ulcerative colitis? If so, please check out my latest video on Autoimmune Disease.