MTHFR and Mental Health

[@Lukas-ye4wz]

🎯 Key Takeaways for quick navigation: 00:00 *🧬 Knowing you have MTHFR raises awareness for better body care, especially regarding methylated B vitamins.* 00:14 *🧠 MTHFR deficiency can affect mental health, as seen with low B vitamin levels leading to severe depression.* 02:59 *⚙️ Methylation system regulates gene activity, crucial for neurotransmitter production and balance.* 04:20 *🔺 High homocysteine levels impair neurotransmitter synthesis, impacting mood, motivation, and cognition.* 06:28 *🔄 Oxidative stress can inhibit enzymes crucial for homocysteine metabolism, exacerbating mental health issues.* 08:55 *💡 Environmental factors and lifestyle choices can exacerbate MTHFR-related symptoms, even without genetic variants.* Made with HARPA AI

[@angelacarrillo4727]

Now how dose this affect someone who is also on 2 BP meds with uncontrolled hypertension, T2D and on Mounjaro which causes a slow emptying of the stomach which can affect absorption?

[@N17sd]

Thank you Dr. Ben lunch for being the best humane, kind , caring and conscientious doctor and person..God bless you and bless your family 🤗❤️

[@AmberPhlameDeB]

One of the most informative 10mn videos I've watched, thank you for being so clear and concise.

[@denisemoye495]

What also bugs me is that doctors will do a blood test and say you’re fine. Serum B12/Folate levels are pretty much worthless, it says what’s available but not what you’re able to absorb.

[@tinad6812]

Thank you. I can listen to you all day. 😊

[@nanasloves]

Hey Ben, please do a drill down on how to know when to use and not use a supplement. For instance, do you daily take a methylated B-complex daily?

[@jedipdx]

Dr. Ben is a genius.

[@JoeBanjo88]

You just answered MANY questions Ive had for years! Just tested...Homocysteine 18...low libido, low energy, moody. Going to hit the methyl donors hard and get checked for the genetic snp...THANK YOU SO MUCH

[@ssg9ssg989]

Glad to have found this channel. Great stuff. I started a methylated B complex today after finding out I had the MTHFR rs1801133 "AA" genotype associated with up to 70% reduced enzyme activity. Also found out I have a poor AGT genotype of GG. This has to do with angiotensinogen, which can influence aldosterone from the adrenals to regulate how kidneys absorb water/salt or not, thus regulating blood pressure. My pressure has been OK, but I do urinate quite often, and after being "asleep for 5 hours my chances of waking up are very high and I will have a full bladder to release if I don't try to drowsily ignore waking up to roll over and try to sleep more. This is true even if I don't rink much in the evening. Plus I notices that I do have some of he symptoms of high potassium and low sodium like heart palpitations, shortness o breath, confusion, restlessness, muscle weakness, spasms(as i fall asleep). Unsure where to look next to try to get to the bottom of this.

[@JoeBanjo88]

Thank you for the post...where did you get tested for the SNP?

[@ssg9ssg989]

@JoeBanjo88 a company in Canada in the province of BC called DNApower.

[@krystalship6245]

How can we regulate the Homocysteine

[@theshawnhunter]

Very informative video! Thank you, Dr. Ben Lynch!

[@janmartell9792]

I have all these, MTHFR, the low levels of B's and folate, but my homocysteine is not high. I worked with a functional medicine Dr for three yrs with no relief. I also have Hashimotos. Recently my depression is bad again ,so I just started taking antidepressants again.

[@angelacarrillo4727]

I am so sorry to hear this. Question. Did you Functional Med Dr help you balance your gut flora??

[@Fenixwillrise2025]

Gluten has to go with Hashimotos and depending on your age I would look at hormones. Estrogen and progesteron specially. HRT saved my life

[@Foxbearcubs]

Im a mother of four, one with none verbal autism. I have MTHFR . Im in Flordia for one year , prior was New York.. nobody listens to me here.. Im just trying to find help for my kiddos. They wont test them.. they dont recognize this as a mutation. Just was to help my kids. So glad i came across you Doc. They are now trying to push folic acid for my kids.but never tested. Finally they will test but for only mma and homocysteine. I dont fully agree with all this crap they speak.. and one of my sons has kidney and high bllod pressure... Iv cried so much. Everything is always medications. I dont like synthetic and dyes or fillers ect. Nothing like being told Im delusional or a crazy person. Its hard..just wish someone would hear me.

[@tammywilcoxon6664]

The homocysteine nutrients are so awesome! My son has had bad OCD issues, eyes that roll, brain fog, ADHD etc…. His folate is low on his blood test but every time we tried folate by itself it made him aggressive and he would hit himself. I just bought the homocysteine nutrients and the very first day of taking it his OCD and brain fog improved. Thank you So much Dr. Lynch! The doctor he was seeing said no folate because he is an undermethalater and it would make him worse so my son has struggled for 5 years with things getting worse. I’m just curious if you feel the TMG is what is helping or the riboflavin? Should he stay on this the rest of his life or once he gets better just take methl b12/folate?

[@SarahTree]

Thank you! I just found you a few weeks ago. You have helped me confirm a lot of my suspicions and turned me on to things I didn't even know. I just subscribed to your channel and will be ordering some of your products ( they are the only ones that look like they would work for me). Thanks again! I'll be watching some more of your older videos too. They look very helpful. 😊

[@mairenegarcia3156]

I have a question for you Dr. Lynch. My daughter has a severe MTHFR gene mutation. She also has a mental illness for which she has to take medications. Her treatment really improved after adding methylfolate. However, recently she became intolerant to high doses of methylfolate and it was reduced significantly causing her treatment to not work as well and some of the doses of medication had to go up. Do you advise using Folinic Acid instead or along with methylfolate to improve the efficancy of her meds. Is folinic acid easier to tolerate than methylfolate?

[@user-xv5gq7ne3e]

Is she taking a high dose methylated b12 too? Important to take both together

[@dinomiles7999]

B9 Methelfolate ! I agree So,so,so important for optimal health and life ❤. He's a WIZARD messenger ❤. Eyes mind heart and soul wide open. NO FEAR!

[@veronical3135]

Dr. Ben, you're a God sent. Thank you for sharing your knowledge. I'm interested in healing the gut. Do you have any info on that?

[@angelahalpin5042]

My daughter suffers with Major Depression Dr. Lynch do u take new patients where r u located I know she need to b tested to start with MTHFR vitamin. D3 etc need help ❤️

[@lisalamberton6486]

What if you have high folate and high-normal b12 levels without any supplements or much protein/veggies? Does it need to be cleared out?

[@g.s.5868]

you might have bad gut bugs that make b12

[@anatino]

@@g.s.5868how domne get rid of the bugs

[@BlackMarilynMonroe33]

You’re probably an undermethylator. You need to do things to improve your methylation.

[@DrNancyLivingCoCreatively]

Some of my glutathione is oxided. (ROS?) . You said in a SHEI point to use vitamin C. I love C. I take a NAC/GLUTATHIONE supplement I like

[@lauranilsen8988]

Does anyone know what he says between 5:30 and 5:40 about being a vegetarian? I listened 5 times and can’t figure it out cause he says it so fast. 😆

[@excalibur-w9c]

You can change the speed of the video in the settings

[@claum9993]

Can you put which of your supplements recommended if we have MTHFR ? To normalise it , thanks the protocol

[@markm4380]

Dr Lynch, Thansk for all the great videos and your passion for Genetics! Do you have any video's or info on how to manage a COMT GG (fast?) and MAOA TT (slow?) setup? 48 yrs old. My energy level is super low, some anxiety, taking an hour to go to bed, etc. Read your book and doing Strategene soon. Wondering what suppl to avoid and which to take if I have symptoms. Any guidence? Thanks !

[@laurenclapp1452]

Dr. Ben I’d give anything to have a consult with you. I have your stratogene download & also a nutrahacker. I’m so confused as to what I need to take. I’m afraid if I can’t figure this out I’m not going to make it. I feel that horrible. Please 🙏

[@jimmann4711]

hi dr ben any research on mthfr on who gets it more such as in certain race of people thanks

[@DrBenLynch]

yes lots- Hispanics, Italians, Chinese are the most likely to have MTHFR.

[@anaritap1]

Dr. Ben, is it safe for people with methylation problems, slow breakdown of catecholamines ( due to slow COMT and MAO) take liothyronine sodium for thyroid? I have severe hypothyroidism due to high reverse T3, but i am not sure if it will stress my body ...

[@rebeccagarner2576]

Morley Robbins book on copper/iron balance explains alot on how to lower that pesky oxidative stress..👀✨😉

[@ТимаТ-д2й]

doctor help, my homocesteine ​​is 70 µmol, I have mthfr tt and slc19a1 homozygote, I take methylfolate 400 µg and b12 1000 µg, homocesteine ​​decreases from 70 to 40 per month of taking supplements, what could be the problem? maybe in B12 transport? In Russia, doctors cannot help me; they prescribe folic acid and not methylfolate, what should I do? help please? I'm 31 years old, height 193, weight 83

[@terriem3922]

The state of Washington has just required tortillas to have folic acid added. It's already in many breads. Is there a way to add a form of folate that's friendlier? Not just the cheapest one that causes problems. I could refer your video to someone who could do something, but first have to get their attention.

[@lunchindinner]

Best glasses ever 👌

[@joanneurbanowicz4994]

Any suggestion for high levels of Aldosterone please high stress

[@h.1998]

Dr. Ben lynch, in your book You tell about the COMT gene. You can have both, slow and fast… can you explain how to deal with both of these mutations instead of them separately?

[@lenkavolnhals7197]

Thank you

[@brendasiron6350]

Dr. Lynch, I have the MTHR gene mutation and at age 16 they removed my thyroid gland because of a goiter. My T4 and T3 are reading normal in lab test. But my TSH is at 25.355. Normal they are saying is 0.550-4.780. What is wrong? I feel fine, a little stressed over the TSH. Please help me.

[@dfinite1111]

Just wishing the methylb’s didn’t make me so anxious and more nuts! I don’t think we all can take them, it’s too tricky and complicated. It’s not as simple as taking methyl bs, or adding tmg or choline or all the other little try-and-see remedies for those who maybe overmethylate etc. -If that even what it is.

[@christineconquest1817]

The Methylated Bs increase my anxiety 100% as does Glutamine. I wonder why?

[@N17sd]

A question; I tried glutathione and didn’t feel any difference like when I am on NAC , does that mean that always I have to use NAC only or I should mix? Thank you

[@g.s.5868]

your stomach breaks it down to the basic 3 elements... money in the toilet

[@aarontumbleton77]

What do you mean by money in the toilet? NAC and glutathione a waste of time and money to take?

[@dfinite1111]

Good question. I take both but is it okay to take both?

[@daughterofYahuah7]

What role does homocystine/MTHFR play in the release/production of oxytocin

[@JedaGolden]

Can it hurt to take Glutathione as a starting place? Thanks!

[@lenkavolnhals7197]

Please can you look at blood clot and trauma like all around trauma and bleeding

[@ScholasticusObscura]

Should I be taking a liposomal form of glutathione?

[@excalibur-w9c]

Always better imo

[@johnrdunbar]

Redox Signaling Molecules increase the production of glutathione

[@aarontumbleton77]

Hi Dr Ben, one of your very early videos from years ago mentioned briefly that C677T (C,C) is “good.” I’ve struggled to find any further information - can you please elaborate on having C677T (C,C)

[@aarontumbleton77]

I think it was your video from 8yrs ago that you did with High Intensity Health

[@DrBenLynch]

Hi there - I may have said that - but I now say that MTHFR C677 CC is typical and that MTHFR C677 CT or TT are the variants. One is not good and one is not bad. They are different. That's how I look at them now. To be clear for you, yes - the CC is 'good' but it's not actually 'good' - it's just what is typical - no variation and in genetic speak - it's wild type.

[@52msdiane]

Thank you Dr Ben! Is there any other way to determine if we have the MTHFR than testing through genetic testing (23 & me)? Would it be ok to give someone a methylcobalanine (seeking health that’s what I take I’m MTHFR) if they are not MTHFR? Basically I’m asking if anyone should be taking the dog crap cyano? Thx so much! 😊

[@DrBenLynch]

You can test through 23andme, Ancestry or SelfDecode. I like SelfDecode the most as it is privately held, I like the founder, Joe (great and smart guy) and they have a great privacy policy. selfdecode.com/?a_aid=seekinghealth and use code SDDRLYNCH to save 10% on your purchase. Then, you would get the raw data from their genetic test and run it through StrateGene which is the report I created. SelfDecode has reports too so if you're happy with what they offer, you would not need StrateGene. No one should use cyanocobalamin or folic acid. Both are trash. You would use either methylcobalamin, hydroxocobalamin, folinic acid or methylfolate. We have all these available at seekinghealth.com in lozenges, chewable multivitamins and capsules.

[@hearthomeacres3322]

Im still confused... im high histamine, skin rashes- mucous all of it, high estrogen, heterozygous MTHFR C677T, heterozygous mutation on COMT V158M, and mold toxicity for Ochratoxin A, mycophenolic acid, and Gliotoxins- all nearly off the chart (without exageration) what of your seeking health suppliments will help me? First to detox- then to get and stay well.

[@hearthomeacres3322]

Also, to clarify I had issues with NAC, and am no longer in the mold. My skin seems a bit worse with the NAC.

[@lenkavolnhals7197]

I watch many of you and sometimes I miss something out

[@dudoklasovity2093]

My doctor: You have MTHFR gene mutation. Me: What did you just call me? :-)

[@Xtreme090]

TL:DR Methylfolate supplements help me while plenty of choline with a sped up BHMT does not and it makes no sense to me. Does a high serum folate without taking in folic acid still mean that i need more methyl folate if supplementing helps? (In other words, does the Mfolate do anything else than create SAM with B12 and HC? because choline BHMT pathway should also take care of this as far as i know?) With my SNP's (comp het + MTHFD1's etc) i should create around 77% less methyl folate, I dont take folic acid at all and eat whole foods and my folate serum levels are high, yet when i stop taking methyl folate (only 120 mcg) i get a pale face and anxiety after a while, this does not make sense to me at all (B12 HoloTC was also fine). I do a lot of weight training and eat around 180g of protein, the methionine/choline alone from eggs and meat should give me enough SAM, yet the folate still helps me where the choline does not? i cant figure this out. No variations in MTR/MTRR, MAT, even have a sped up BHMT.

[@lenkavolnhals7197]

Melanin blue light also cortisol if us really much more to it

[@1aliveandwell]

So if lo methylation then what enzyme isnt made? and how increase it? if low methylation than maybe hi homocystein which reduces some neurotrans but raise glutamine(GABA makes me irritable)? Have found a tiny bit on occasion of extra vit C and vite E foods helping me. What form of choline?

[@ElizaFragmented]

Wowww you're a life saver

[@inittiela4934]

Guys i just wanna say that mthfr or mtrr doeasnt mean anything, if you have mthfr at least 50% reduction just take 3mg of suplemental ryboflavin because b2 highly speeds up mthfr, mtrr regenerates methylcobalamin but its only important if you are under huge stress in your live like injury or other problems, cbs enzyme is very important because of gluthatione so you want to suplement with nac(and maybe glycine), bhmt may lower your remathylation to methionine from homocysteine so its important to lower methylation demand by suplementing with creatine and if you have mutations in creatine synthesis or cbs it may lead generaly to overmethylation of system because your body compansate by methylating more so depending on mutation suplement with creatine or nac

[@TOPHER81SILVER]

I am interested in what you are saying here. Do you have any research you can point me to so I can share this with my doctor and add to my own protocol?

[@inittiela4934]

@@TOPHER81SILVER masterjohn chris have really good quality study based recommandations about methylation in general but in this case search for: Your “MTHFR” Is Just a Riboflavin Deficiency | Chris Masterjohn Lite

[@lenkavolnhals7197]

Seratonjn etc

[@Matlockization]

One day, I'm going to make sense of what this Doctor is talking about, as he is all over the place.

[@JoanneForget]

Refer to gary brecka explaining the mthfr gene.

[@angelacarrillo4727]

I understood but that may be because I've heard Gary Breka break it down. But the one thing I don't recall Gary Breka mentioning is to take MTG with Glutathione as Dr Lynch has explained.

[@denisemoye495]

Maybe he has adhd? It’s linked to mthfr and I have it…I jump all over the place too….😂

[@Matlockization]

@@denisemoye495 Two jumpers don't make a right !

[@terriem3922]

On of my favorite foods when I was 13 was chicken livers and onions. But now that I know how chickens are raised, I don't eat them anymore. I believe karma may have an effect on my body.

[@lenkavolnhals7197]

The thing is I am rught

[@Herbert_Knavs]

I highly doubt that Novak Djokovic is vegetarian. I believe that vegetarianism (speaking of Novak) is a smoke screen for competitors. 😉

[@lenkavolnhals7197]

Bilirubin

[@lenkavolnhals7197]

It all fits

[@lenkavolnhals7197]

Albumin

[@lenkavolnhals7197]

I write you some words but I am tired so only Single words

[@lenkavolnhals7197]

You all stick only to one topic

[@ryanlocati5695]

Hi Dr Ben, I have the mthfr and was born with transposition of the great arteries, my mom also has mthfr and was unfortunately taking folic acid when in was in utero. My mom also had multiple miscarriages before i was born. I am curious if there is a potential link between these factors? I have a sneaking suspicion there is a pattern here. Curious what your thoughts are. My mom gave me your book and we are working with Dr Dane buxbaum in arizona. Thanks have a good day

[@lenkavolnhals7197]

Caucasian people

[@lenkavolnhals7197]

Thank you