A Dummies Guide to Pink Cell (Oncocytic) Renal Tumors

Renal tumors exhibiting "pink" or "eosinophilic" cytoplasm is a diagnostic challenging, diverse, and rapidly evolving spectrum of renal carcinomas with varying clinical significance. In this group of tumors, distinction from a biologically benign Oncocytoma is critically important. Learn in this video, how you can use a simple yet effective diagnostic approach to make an accurate diagnosis.

[@pnaratasoy1724]

Thank you very much

[@amassry2276]

Thank you very much for this fantastic and illustrative lecture ❤

[@Dee-bomb]

Thank you for great lecture! Unfortunately cannot see the complete tables bc of your lecture box in the lower right corner😭

[@rajalbshahExperturologicpath]

Sorry about that

[@mathieugallo9561]

Thanks a LOT (Low grade Oncocytic Tumor) ;) !

[@zainabazis1360]

Thanks sir . This lecturer helpfully for residents

[@xipetotecxe9191]

Thanks it was clear (even if it was pink) as usual! Thanks for your pedagogy on this HOT (high grade oncocytic tumor) subject 😁

[@omerali2690]

Thanks a lot sir. Your channels is of great help for residents and pathologists alike. You are an awsome teacher. Love and respect!

[@rajalbshahExperturologicpath]

Thank you Omer for kind comment and appreciation! I am glad that hard work I am putting is being useful 🙏

[@amerakmal7281]

Excellent presentation. Truly appreciate your concise and precise practical approach. Many thanks.

[@SandhyaRamachandran]

Thank you ! What would the IHC be in a Hybrid Oncocytic Tumour please..?

[@redaelhawary8815]

Thanks

[@renuthomas7726]

Excellent talk highlighting a very practical approach to the expanding spectrum of Rccs

[@rajalbshahExperturologicpath]

Thank you, Renu for the feedback! I appreciate it

[@bitannaik3192]

Nice morphological information

[@chandramouleeswarik9215]

Wonderful lecture

[@mohitrajpal266]

Sir i am extremely grateful to you Your Videos are very helpful I will definitely recommend this channel to all me colleagues

[@rajalbshahExperturologicpath]

Thank you very much, Mohit! I appreciate your kind words!

[@mohitrajpal266]

Sir i have a question What is the diagnostic criteria for pure small cell carcinoma of the prostate? And should Gleason grading be done for it

[@mohitrajpal266]

Although unrelated to this lecture want to know

[@rajalbshahExperturologicpath]

@@mohitrajpal266 Same that you would apply at other site. Highly proliferative tumor, high N:C ratio, salt and pepper type chromatin pattern, nuclear molding and numerous mitosis. PSA is typically undetectable or reduced and Ki67 is greater than 80 to 90%. One of the neuroendocrine markers are typically positive. TTF1 positive in half of cases. You typically elicit history of previous prostate adenocarcinoma treated with androgen deprivation therapy. Pure de novo small cell carcinoma is rare. You do not grade small cell carcinoma

[@mohitrajpal266]

Thank You Sir

[@maramjassem8781]

Very nice lecture 🌸

[@eduardosanojacastellano9402]

gracias por sus videos, siempre son de ayuda

[@mineshgandhi9578]

Really good ...very informative talk..rajalbhai

[@rajalbshahExperturologicpath]

Thank you very much, Minesh!

[@priyankamaheshwari5033]

Thank u sir for this new world of RCC s!! May i ask how does the gross features differ in these variants? Do these molecularly different ones have variegated appearance too? And how about the tan brown cut surface of oncocytomas and chr RCC, is it seen in these other oncocytic variants??

[@aniqahshamimi8300]

Tq❤

[@priyankamaheshwari5033]

Thank i sir for this new world of RCC How does the gross features differ??

[@rajalbshahExperturologicpath]

Hi Priyanka! Thank you for the question. Gross features can be helpful but only to a certain extent. When you see yellow tumor, you think about clear-cell RCC and when you see mahogany brown, you think about oncocytoma. New varieties of tumors, in my opinion does not have any distinctive characteristics which may range from gray white/tan cut surfaces.

[@priyankamaheshwari5033]

@@rajalbshahExperturologicpath thank u Sir

[@priyankamaheshwari5033]

Thank u soo much

[@priyankamaheshwari5033]

Do they have mahogany brown cut surface too or variegated appearance?

[@renuthomas7726]

Will the eosinophilic variant of chromophobe RCC show the same immunoprofile as conventional chromophobe? Especially regarding CK7?

[@rajalbshahExperturologicpath]

Good question, Renu! Cd117 expression would be strong but CK7 expression is often not diffuse like classic chromophobe. For a eosinophilia tumor that is CD117 positive, careful morphological evaluation is still critical