A Pilot Study Investigates the Effects of Psilocybin for Migraine

In this episode, Dr. Emmanuelle Schindler presents data from a pilot study that investigated the effects of the psychedelic drug psilocybin in 10 people with migraine. She discusses the results of a single micro-dose of the drug, side effects, safety information and more.
*The contents of this podcast are intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. AMD and the speaker do not recommend or endorse any specific course of treatment, products, procedures, opinions, or other information that may be mentioned. Reliance on any information provided by this content is solely at your own risk.

[@BeThySelf]

Thank you for doing this work!

[@Gram1278]

dopepeddlers1, he got the best tips and helps. I’ve microdosed shrooms for about 6 months now and it has really helped my anxiety and depression and I’ll recommend it for anyone .,

[@clep398]

Thank you-- this is very helpful.

[@willbuck8552]

Have there been studies on the effects of Phenethylamines on migraines?

[@mccallbecca]

Is there a danger in dosing with psilocybin and taking rizatriptan simultaneously? Thank you for this great presentation! ❤ (Edit: coincidentally, 4 hours before this video posted, I experimentally microdosed psilocybin and took maxalt. I’m a chronic migraineur of 40 years ongoing.)

[@313gypsy]

How did it go for you

[@Gram1278]

dopepeddlers1, he got the best tips and helps. I’ve microdosed shrooms for about 6 months now and it has really helped my anxiety and depression and I’ll recommend it for anyone .,

[@Lemonz1989]

According to the website Clusterbusters, taking tryptamine based medications like rizatriptan, sumatriptan, zolmatriptan and so on, will block or interfer with the effects of psilocybin because they work on similar receptors in the brain. But there seemingly isn't any danger associated with it in normal therapeutic doses. I've had chronic migraines for 20 years or so, with 16 to 20 episodes a month, and I started microdosing between 0.2 to 0.3 grams of mushroom powder in gelatine capsules every 3 days last week, and haven't had one single migraine since. Normally I would have had at least 2 episodes by now. I've only had a normal tension headache twice in this period of time, where one aspirin was enough to treat it.

[@Dopebenedict]

@@Gram1278 i wouldnt recommend for everyone that is wildy unsafe. If you meet the requirements to undergo psychoactive therapy then yes i would reccomen but some people with signifigant mental issues or a family history should be very careful.

[@pauldudzinski1588]

How did it go?

[@Jedward108]

Is the dosing info correct (.143 mg/kg)? For a 158 pound person, that would be about 10 mg of psilocybin -- a tiny amount. Did the study use whole mushroom or some type of concentrated extract? It seems like typical microdoses are around 500mg. Thanks for this worthy information.

[@mv2woods]

Yeah this is the amount of pure psilocybin. Mushrooms are about 0.2% psilocybin when dry.

[@lullbluetooth]

SUMMARY: 🧠 What are psychedelics? Serotonin 2A receptor agonists like psilocybin, LSD, DMT Similar chemically to some migraine medications 📈 The study 10 patients took 0.143 mg/kg psilocybin (≈10 mg) Compared to placebo, psilocybin reduced: Migraine days/week by 50% Pain intensity Functional impairment by 50% Abortive meds used by 50% 😊 Results More migraine-free time after psilocybin No correlation between psychedelic effects and migraine improvement 😵 Side effects Short-lived lightheadedness, nausea, anxiety Some headaches the next day 🔬 Conclusions Single psilocybin dose reduced migraine burden Delayed next migraine Effects independent of psychedelic experience Demonstrated safety 📝 Future studies needed Larger samples, different doses, longer follow-up Repeat dosing schedule Test in more diverse populations