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The Cardinals stunningly defeated the #11 Tigers, 33-21. It is Louisville's first-ever win over Clemson. The Tigers had a chance to tie the game at 10 before halftime, but the kick was blocked. From there Louisville went on a 23-7 run to get the road upset in Death Valley. Louisville running back Isaac Brown ran for a career-high 151 yards and a touchdown on 20 carries. Quarterback Tyler Shough went 17-32 for 156 with a rushing touchdown. For Clemson, running back Phil Mafah ran the ball 30 times for 171 yards and two touchdowns. Quarterback Cade Klubnik finished the game 33-56 for 228 yards and a touchdown, with 43 rushing yards.