Acute Radiation Syndromes (CNS vs GI vs Hemopoietic)

[@Thugbert0]

I am a FM physician. Currently stationed in Japan. Thank you for this video, it covered more here than in medical school. Great content!

[@HowRadiologyWorks]

You’re welcome ☺️

[@HowRadiologyWorks]

Thanks for letting me know where you are

[@sarahkay5624]

Love your videos! Just came across when preparing for my PhD defense in radiation biology! Greeting from Germany!

[@HowRadiologyWorks]

Guten tag Sarah. Thanks for dropping me the note here. Good luck on your defense. Hopefully the outcome is deterministic.

[@dr.lazarus7497]

@@HowRadiologyWorks and Me prepping for my Public Health and Preventive Medicine boards!! :D MDMPH!

[@farahsikder5319]

This was very useful. Watching all the videos. Love the animations you put. Thank you very much.

[@HowRadiologyWorks]

Thanks Farah, appreciate your support. Make sure to share them with your friends too.

[@brfisher1123]

The fact that bone marrow syndrome occurs at the lowest doses among the three seems to be tied to leukemia being the most common form of cancer that whole body exposure to high doses of amounts of ionizing radiation can cause.

[@eilishcj9663]

Thank you.Very good information.

[@HowRadiologyWorks]

You’re welcome, thanks for taking the time to drop the comment.

[@alexandrosgkloumpos6779]

beautifully explained and totally helped for my presentation thank you! :)

[@HowRadiologyWorks]

You’re welcome. Thanks for the comments

[@Mr-sd7ez]

Hello I'm a student(biology) and after watching Chernobyl TV show I got really interested in the effects of ionizing radiation on the human body.Unfortunately,I can't understand every single aspect.Why is there a phase when people seem almost healthy and they are asymptomatic.Is it due to the fact that the cells are still doing fine but the moment they die the new won't replace them and THAT is when the syndrome hits hard?I've read about free radicals,DNA damage,and "burns" are understandable but why don't victims progressively get worse?

[@HowRadiologyWorks]

Hi Vorbild, The CDC has a nice table describing the difference phases: www.cdc.gov/nceh/radiation/emergencies/arsphysicianfactsheet.htm#table1 . The description in the video is mostly on the manifest illness stage but these symptoms take some time to occur depending on how frequently the cells normally reproduce in the body. So after the immediate effects (i.e. Prodromal stage (N-V-D stage)) there is some time before the final or manifest symptoms arise. I think this is basically what you said as well. These acute effects are caused by cell death.

[@lukebuke34]

thats because your own autoimmune system is shutting down so there arent symptoms for a while. The damage starts to manifest after the latency period.

[@taraswertelecki3786]

Anyone who absorbs five Grays or more is doomed to die one way or another. For example, one of the fatalities at Chernobyl was a security guard, who was not in the building during and after the explosions. She was however on the property, and absorbed six Gray of radiation, which resulted in death by ARS. Most who died there absorbed far more than that, some victims absorbed 25 gray or more because of exposure to the lethally radioactive graphite and fuel fragments scattered by the explosions. Several where in the the reactor hall or on the roof where radiation levels were up to 30,000 Rads and hour, or more trying to lower control rods manually or fighting fires in a burning, fissioning reactor core.

[@TheNettforce]

Taras-this is consistent with the video. Chernobyl was a very unfortunate accident. Luckily these type of incidents are rare historically. On this channel we focus on diagnostic radiology and this is for context of very high dose scenarios

[@elric5371]

Um 5 Gray is certainly survivable, Klavida Luzganova the security guard your talking about got a dose estimated at 5.5Gy. She received little radiation burns and began recovering until she was given s bone marrow transplant which resulted in infection causing renal hepatic failure which led to a massive haemorrhage in her brain causing death, it was an unfortunate death. Anatoly Tormazin, at Chernobyl received a dose of 8.7Gy as well as radiation burns to 40% of his body, he rejected s bone marrow transplant and developed pneumonia and septicaemia yet miraculously managed to survive and is still alive and well right now as we speak. And only 1 person received 25Gy, Lelechenko and that was it the next highest dose was Pravik at 16Gy.

[@taraswertelecki3786]

@@elric5371 Did you see "one way or another?" Dying by acute radiation syndrome or later of cancer, leukemia or organ failure due to radiation poisoning is still death by radiation poisoning.

[@elric5371]

@@taraswertelecki3786 not by acute radiation poisoning, as I stated after 5Gy chances of survival immediately drop, survival later in life is also reduced but they aren’t doomed to die, as Tormazin shows, he is alive today without cancer, Luzganova would of likely survived if she wasn’t administered a bone marrow transplant, similarly Degtryarenko who got 5Gy would of survived if he hadn’t had such massive thermal burns or an internal dose.

[@elric5371]

@@taraswertelecki3786 so your not doomed to die one way or another.

[@tamarag4986]

How common is that? Is that something we need to consider before going to radiology school?

[@HowRadiologyWorks]

Tamara- these are at extreme radiation doses and were mainly observed following the atomic bombing of Hiroshima and Nagasaki and the Chernobyl nuclear power plant disaster. As a Radiologic Technologist properly using the equipment you will not encounter radiation doses anywhere near these levels (i.e. orders of magnitude lower doses). We cover them so that you know the extreme cases and the importance of safety procedures but this should not influence your decision to go to radiology school.

[@sniffmypeepee9169]

actully the ld-50 is 4gy about 400 rads 500gy+ is 100% lethal

[@HowRadiologyWorks]

Thanks sniff, yeah I said around 5gy for ld50 and that is at the higher end of estimates I have seen and ld100 is around 10gy. www.cdc.gov/nceh/radiation/emergencies/arsphysicianfactsheet.htm

[@drrrajkumar262]

Nice explained

[@HowRadiologyWorks]

Thanks for liking and dropping the comment

[@bulgingbattery2050]

3.6 Roentgen

[@HowRadiologyWorks]

Bulging could you provide some more context?

[@bulgingbattery2050]

@@HowRadiologyWorks kzbin.info/www/bejne/g5iYeYKkppytepI

[@elric5371]

@@HowRadiologyWorks hbo show on Chernobyl is what he is referencing. Also Anatoly Tormazin got a full body irradiation of 8.7Gy and beta burns to over 40% of his body, he rejected s bone marrow transplant and developed pneumonia and sepsis, yet he survived and is alive today.