ADRENOCORTICOTROPIN (ACTH) & THE REGULATION OF CORTISOL by Professor Fink

In this video lecture, Professor Fink describes the Regulation of Cortisol (Glucocorticoids) via CRH and Adrenocorticotropin (ACTH). Included in the detailed discussion is the Negative Feedback Loop involved in homeostatically maintaining circulating plasma Cortisol levels. Reference is made to the actions of Cortisol and the clinical uses of synthetic glucocorticosteroids like prednisone, Addison's Disease (Hypoglucocorticoidism), Cushing's Disease & Cushing's Syndrome (Hyperglucocorticoidism) and its clinical presentation, Anti-inflammatory action, Immunosuppression (lymphocytopenia), and the role of Stress in affecting the secretion of Cortisol & its link to "belly fat" & immune suppression.
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/
“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp

[@Hurteem]

EVERY classroom needs a Professor Fink. Thank you for helping me get through A&P. My professors pretty much pass out outdated handouts & read them back verbatim. You on the other hand, clearly explain it all. I'm soooooo grateful for you.

[@cintyadealmeida5699]

What a blessing it is to listen to your lectures! Thank you Professor Fink!

[@GutPlate367]

As a nurse and writing an essay on this topic I find this very helpful as it reinforces the books I have been reading and Professor Fink has made it easier to understand

[@ninetyandthree]

I'd also like to express my sincere gratitude to professor Fink. I absolutely love your lectures. They've been a tremendous help to me. Thank you very much.

[@MwinyiMumbo]

With your lectures I find anatomy and physiology easy.thank you professor.

[@juanrossi3]

This lecture was incredible, Professor Fink! It explained so many things! Thank you so much!

[@WijiWijicreepcreep]

you are my hero! Ive never retained so much info like i just did from your lecture. You are the BEST professor, your students are very lucky. Thank you for posting these lectures.

[@igorilyasov2057]

You, Prof. Fink, are an amazing professor! Your detailed information is explained with something we relate to makes information not just stick but changes the way i perceive things. Thank you!

[@professorfink]

thank you for your kind words

[@sundassyeda1821]

Dear Prof. Fink, you are the finest professor I have come across. You teach with such clarity and enthusiasm that make us students want to learn. I wish I had the opportunity to seat in your class but being hundreds of miles away, I still greatly benefit from your online lectures. Thank you so much for your videos, you have helped so many of us confused and struggling A&P students. I think other A&P professors should def. learn from you on how to teach. Thank you sir, may God bless you :)

[@shannie602]

Professor fink has saved my life many many times

[@mg4le]

Clear, informative and concise style of teaching - excellent lecture. Thank you.

[@IsThereAPubeOnMyHead]

this man is nothing short of a hero

[@ajarangel1115]

Thanks for all your great videos Prof. Fink! Your explanations and your able to tie A&P to pathophysiology and pharmacology may get me through RN school. Thanks again and please keep them coming!!

[@NicoleBrass]

Simply amazing! Thank you so much for sharing your knowledge with everyone who’s checked out your channel. You make my journey into the medical field so much more enjoyable.

[@JasonTsimplis]

That was just amazing !! The way you explain things is brilliant, i really wish i had a professor like you. Thank you for the valuable information !!

[@shahadatlouba9312]

finally! now I understand. thank for sharing your classes.

[@appybee]

Thanks, Professor! :) Really helpful summarization.

[@arshadmahmood5486]

Rich of knowledge sir

[@sam352]

Professorfink Thank you. You are amazing!

[@jennifermuller9714]

Thank you for the lecture. I am always looking for good lectures about my subjects Glad I found this one very detailed and helps me to better understand things now

[@thithinwehtun]

You are wonderful, professor.

[@lezajohnsonlittle8884]

Amazing. you have helped me understand what I thought was a very complex mechanism, thank you.

[@jaigarner5466]

Thank You! I love you!

[@dreamier85]

Really it is a very good explanation that I have never seen like this about glucocorticoid hormones. your method of using figures is amazing .

[@anassalaas5860]

More than amazing Really Thank You

[@loveXcake]

Thank you!

[@johntindell9591]

Thx a lot

[@25sweetspicy]

love your videos!

[@marianac.echenique1446]

wow THANK U

[@koooooliooooo6399]

The volume was on max when he yelled STRESS. All mine, my mothers, my fathers, my sisters, my dogs, my cats, my neighbours pituitariIs released glucocorticoids

[@morningchaos]

you are awesome! At one point when you said STRESS! it scared me lolx, but totally going to remember that STRESS! will cause the trigger of CRH > ACTH > Cortisol

[@suadkacar357]

the best

[@chenlynn951]

Thank you very much! Amazing lecture!!!

[@agronberisha2727]

than how to stop this cortisol flow how to escape this issue??

[@aishakendrick4044]

Thank you so much! Your lectures have helped to support my basic understanding of physiology. This has allowed me better synthesize the information in my graduate lectures. Which by the way, not as interesting as your lectures.

[@MsTommyknocker]

Will you do a lecture on the opioids??

[@ashnaali4029]

Primary, secondary and tertiary abnormalities occurs in this case too like thyroid gland??

[@professorfink]

Correct.

[@thatssomedical1935]

thanks! from where cab we get the sheets ?

[@nimopari6600]

Is the lecture complete? Addison disease isn't describe enough. ..!

[@positivevibes7425]

Does taking prednisone or any other corticosteroid drug has an effect on secretions of aldostetone thus retaining Na and increasing BP?

[@professorfink]

Prednisone (& most other commonly prescribed anti-inflammatory corticosteroids) have relatively minimal direct mineralocorticoid [Aldosterone-like] action. [Prednisone has a 4:1 anti-inflammatory to salt-retaining action.]

[@positivevibes7425]

professorfink Thank you so much sir. You are the best! :)

[@wassimabdou7649]

Hello Profesor, you mentioned in your video that patients ''who take glucocorticosteroid everyday may cause cushing syndrome. If it is because of the renal gland it is called cushing disease''. Is in it suppose to be the opposite? I mean the disease is due to glucocorticosteroid intake ? Thank you for your videos :)

[@professorfink]

Cushing's Disease is due to disease/disorder in the body (such as a tumor in of the Adrenal gland; or "Secondary" Cushing's Disease caused by a tumor in Pituitary). Cushing's "Syndrome" presents the same symptoms, but it is coincident with the use of glucocorticosteroids like prednisone.

[@NguyenNguyen-cy7hp]

Your lectures are always wonderful. I just want to make an adjustment: Cushing's syndrom is when there's too much amount of cortisol in the body regardless of the cause (pathologic or iatrogenic). Cushing's disease on the other hand is when there's a tumor on the adeno-hypophysis causing excess level of ACTH.

[@MrZimmaframe]

how can i reduce anxiety and insomnia? and would taking testosterone help relieve the high levels of cortisol?

[@bswgd8]

Relax. Most anxiety/insomnia is caused by stress and lifestyle and not by a pathologic mechanism or primary hormonal imbalance. Exogenous testosterone messes up the feedback mechanism in the hypothalamus-pituitary axis and you stop producing your sex hormones.Unless you are deficient in a hormone you want to let your body control the show or it throws everything else out of whack. If you have the option try activities that relax you or something along that line to reduce stress.

[@jkidd3383]

what happens if I drink Benadryl? one tab every night? would it hurt my liver ?I drink a lot of water though.. thanks sir..

[@simuna5708]

I really really want to learn u.

[@immaculateskills]

Amazing Lecture definitely an AH HAH moment : - )

[@TKOOKC]

Thanks Good Job entertaining.. "Stress" LOL keep those students awake.

[@mataeleseete5271]

STRESSSS!!!! 😳