Ageing, Cellular Senescence and Senolytics: The Path to Translation | Prof James Kirkland

In this #webinar, Prof James Kirkland, Director of the Robert and Arlene Kogod Centre on Ageing at Mayo Clinic, talked about about cellular senescence in ageing, therapeutic potential of senolytics, current clinical trials and the path to translation.
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References:
- Closing video source: • Meet the 77-Year-Old B...
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Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.
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All of the proceedings of this webinar, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved to the speaker or NUS. No statement or presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript or other use of the material presented at this course without the permission of the speaker or NUS is prohibited to the full extent of common-law copyright in such material.

[@brianfjlynch]

Prof Kirkland's clarity of purpose and personal humility is inspirational. Hard to underestimate the importance of taking this early science into general clinical application. Touch wood.

[@somadas2792]

Such important work. I truly hope that his vision of having international support & funding comes together so that we can see all the benefits to be had with senolytics & other age-related disease interventions.

[@eugeniebreida1583]

Huge thanks to Dr. Jim Kirkland !

[@SirTenenbaum]

Amazing Q&A session and amazing presentation!

[@-Kerstin]

Great information in this presentation. Seems to really get you up to speed on the work on cellular senescence

[@SejalPatelDrSej]

Great presentation. Please remove the into ad in the beginning it’s not good for viewership.

[@lavoter]

When will the human trials on fisetin & quercetin be published?

[@Pakistan-Icecream]

Good video.

[@goraneriksen9461]

So taking Metformin and taking Fisefin together daily is not useful? Do I understand this correct?

[@abritrn]

That is what I understood. Dr. Kirkland’s research has always used senolytics in a “hit and run” fashion- meaning intermittently. Usually the studies use the senolytic for two days once a month or something similar. He states it takes at least a week to six weeks for senescent cells to be produced.

[@csemrau78]

Looks like I'm going to do a washout of Metformin before my next round of Fisetin.

[@peterhatch206]

I find the source Singapore accent very hard to understand . Sub titles would be useful ..

[@davidg.johnson7574]

Sad that clinical trials on senolytics are for drugs that will only be avaiable to a chosen few that have a specific disease. Unfortunately aging is not yet classified as a disease so these new drugs won't be prescribed to everyone.

[@justinp2149]

quick tip - lose the intro! EVERYBODY despises intros longer than about 3 secs.

[@deniseprimavera9903]

Completely agree! One viewing was enough. Don’t need to watch this before every video! On the positive side, these videos are great. Please keep them coming!

[@deansusec8745]

I dont even know why alternative news media even needs an intro!

[@TheSport78]

Was any reasoning given as to why you shouldn't give a SASP suppressor with a senolytic? Kirkman mentioned how very little senolytic activity happens when you combine the two.

[@dapawap]

Too difficult to listen to?

[@immortalityIMT]

In reference to 55:20 Immortality IMT is a cryptocurrency trying to solve the funding problem in longevity medicine. Probably worth supporting.

[@gen0megen0me93]

1)49min if personal immune system does overtake small number of senescent cells, than wouldnt fixing late 20s decline of immune system solve all the senescent cells problems? Btw if macrophages clear those senescent cells why thymus at that age declines? Is there some connection? Sorry for such an unrelated question from evolutionary biology: Is senescence cells amount a subject to evolution? Does demethylation of gametogenesis act against evolutionary filter againtst senescence? That obviously on the top of the faster reproducing - faster evolving contradiction to only reason why fit aging and old age reproducing would be the main evolutionary pro helthspan extending factor.

[@KJ-um1gq]

Great question regarding preserving the late 20’s immunity

[@michaelsigismonde7958]

Let's hope this is more than just philosophy. Philosophy won't make anyone younger. The only thing that will work is hard, scientific research by people like professor David Sinclair of Harvard University.

[@stephenrose6641]

Please ditch the opening song

[@christopherellis2663]

Who had a transplant(ation)... 😮 a what? That's the process not the act.

[@eugeniebreida1583]

Sadly the non-native-to-English speaker needs further practice, prior to further presenting to the English speaking public.

[@keithhaken172]

Lose the accent.

[@phaedruswlf]

Come on man get rid of that music