Distal Convoluted Tubule

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[@BorisThePA]

You got me through undergrad and now I'm watching this for my PA school A&P class. Your lectures are the best, thank you for making them and being so thorough!

[@AKLECTURES]

Glad you to hear it Boris! Good luck with PA school!

[@BorisThePA]

@@AKLECTURES thanks!

[@TheSaintlySinful]

Finally...I have a clear understanding of the DCT reasbsorption mechanism...thank you very much, indeed!

[@nati19811981]

Great lectures.. one note - a verbal mistake at 5.30 min (proximal instead of distal)

[@kylewalter6714]

@ 5:26 you said "most of the absorption takes place in our nephron within the distal convoluted tubule" I believe you meant "proximal"?

[@brian.angels]

+The World of Science That's right. I noticed that, too.

[@mozasalim7069]

AK lectures are very good

[@mikekleanthous7023]

Great lecture, I wouldn’t pull it off without you, two things to note though. 1. You write on the board and refer to the transporter at the basolateral side of the cell, which moves Calcium outside the cell and Sodium in the cell, as Cotransporter. It should have been referred to as ANTIporter because it moves the Anions in opposite directions. A Cotransporter for example is the one found on the apical side of the cell, which transports both Chloride and Sodium in the cell. 2. You should refer to the H+ as Proton and not Hydrogen because it really has a huge difference in the following reactions.

[@ouzocombat8113]

5:32 within the proximal convoluted tubule ? Apart from that, thank you for your greate vids !! Undiscribable help with my exams !

[@jasonborn6043]

Presentation of distal tubule tomorrow, you honestly saved my life sir

[@AKLECTURES]

Jason Born thats awesome! best of luck on your presentation, let me know how it goes :)

[@YourDad-bs4hv]

How did it go?

[@Reetiika]

I LOVE YOU! The only reason I got a 4.0 in Animal Physiology is because of you

[@santhosh30899]

great video!!!You made me to understand a difficult coneot to look easy.Thank you so much Sir.really appreciate it!!!

[@chizzyokere6320]

Great lectures as always!

[@googleone9209]

Excellent, thorough as always! :-)

[@AKLECTURES]

+Anastasia Chouryguin Thanks Nastya.

[@googleone9209]

+AK LECTURES (Andrey K) Haha! Ya tak i dumala! Net, spasibo vam.

[@AKLECTURES]

Ya rad eto slishat' :-)

[@marlonfortes4921]

I am not sure if the effect of low Na+ concentration would lead to dilation of afferent arteriole. I would say that the angiotensin II, a vasoconstrictor factor, causes contraction of both afferent and efferent arterioles. However, it will affect more intensely the efferent arteriole. Thus, even though the flow decreases due to the afferent arteriole constriction, we'll see an increased hydrostatic glomerular pressure since the efferent arteriole is highly constricted ("it will be more difficult to leave the glomerulus").

[@7777blu]

Could you please post snapshots of the whiteboard drawings/descriptions as pdf files?

[@rakesh4787]

You made an error at 5:34 when you said most of absorption takes place at distal convoluted tubule. You pointed to proximal convoluted tubule which is right but said the wrong thing. Anyways, you are AWESOME. Thanks for the videos!

[@dante8605]

sir!....you are the best!

[@shuibabdullah4932]

thank you so much, it really helped me

[@AKLECTURES]

Shuib abdullah You're welcome! :)

[@navitameena6832]

Sir ji namaste sir ji aap kya dono subject padhte ho kya physiology or biochemistry

[@piussebald1927]

Hi, One thing i don´t understand is: Why is there a higher water content and lower NaCl concentration in the filtrate of the DCT when the BP in the body is low? Thanks in advance!

[@GoodbyeRubyTu3sday]

I'm wondering too

[@kaushalt563]

because DCT is impermeable to water. About 5-10% of Na+ is reabsorbed by the DCT When the blood pressure is low, aldosterone stimulates the principal cells (in the collecting tubules) and leads to increased sodium channel activity, leading to increased sodium reabsorption and along with it water (isoosmotically). ADH also acts on the V2 receptor and leads to insertion of aquaporin water channels on luminal side (leading to increased water reabsorption) Also, The macula densa cells sense the low NaCl to the DCT and this leads to increased renin release, and efferent arteriole vasoconstriction and increased GFR.

[@cattymed4419]

Thank ayou....so DCT is an Acidifier

[@kainatbatoor2339]

thankzzz a lot

[@nobrainer4771]

Why filtrate leaves loop of henle at 100mosm , which is so dilute and has more water content and go to the dct?

[@medgroup18-36]

genius

[@nellyhoffman6194]

Ak did you Explain the Loop of henle ?

[@AB-kf3jr]

Take a shot every time he says "distal convoluted tubule" I guarantee you don't make it to the end of the video.

[@mozasalim7069]

No you provide some notes sir

[@tariqmiller-green8528]

you made a mistake when you said most of the ions are absorbed in the dital convoluted tubule but only 5 percent is absorbed in the distal convoluted tubule

[@first6digits]

So when you say "reabsorption" that means leaving the filtrate and going into the interstitial fluid right?

[@ofoghbehinaein7477]

Can someone please have a conversation with me about the following subjects? I need to be able to explain them for A&P2 class but I don't know where to begin with. please help me! 1. Aging is one of the biggest upsets to the body’s homeostatic balances. Discuss the SPECIFIC consequences for each body system. Be prepared to discuss the interrelationships among systems in your answer. 2. Stress is also a huge upset to the body’s homeostatic balances. Discuss the SPECIFIC consequences for each body system. Be prepared to discuss the interrelationships among systems in your answer. 3. DNA is often called the “stuff of life”. Please be prepared to relate the specific relationship of one’s own DNA to the functioning of your body systems. 4. Cellular transport is a basic function of your body. Be prepared to relate any and all forms of cellular transport and the mechanisms which drive this process to all body systems. 5. Water is one of the fundamental components of your body. Please be prepared to discuss the specific interactions of water in all body systems. 6. Minerals are central to maintenance of appropriate body function. These minerals are stored for use and then can be used as needed. Please be prepared to discuss the sources of these minerals, the storage of these minerals and the uses of these minerals (primarily in electrolytic form) throughout body systems. (Ca2+, Na+, K+, H+,HCO3-, PO43-, Cl-)

[@nobrainer4771]

Why filtrate leaves loop of henle at 100mosm , which is so dilute and has more water content and go to the dct?

[@nobrainer4771]

Why filtrate leaves loop of henle at 100mosm , which is so dilute and has more water content and go to the dct?