Alport syndrome - causes, symptoms, diagnosis, treatment & pathology

Рет қаралды 50,313

Күн бұрын

Пікірлер: 32

@jessli369 Жыл бұрын

My doctor told me I was just a carrier, except I have all the symptoms and I'm actually a patient! Most doctors dont understand this disease well. Great video for a patient too! Thank you💕

@osmosis Жыл бұрын

Glad to help, Jess! ❤️

@lov.2.g 2 ай бұрын

What are you symptoms which you told your doctor btw

@vincentmette3427 2 жыл бұрын

These videos are so helpful, thank you!

@osmosis 2 жыл бұрын

You're welcome, Vincent! 🙏🏼

@vincentmette3427 2 жыл бұрын

@@osmosis Plus you read the comments, which is another point for you guys!

@Rene-uz3eb 11 ай бұрын

Extra iron is bad for collagen, and the a1a1a2 is weaker collagen and more easily damaged. I assume that's the reason for symptoms in alport carriers, since carriers should be asymptomatic. Vitamin C specifically (dramatically) increases gene expression for production of the Alport impacted collagen 4 subtypes, that should probably help a lot (I take 1 g sodium ascorbate powder daily. I used to take much more, had great skin benefit but dropped it because of fear it caused cramps. I know better now, that was lack of calcium intake, so I'll ramp up the C) Some general comments: Magnesium deficiency leads to net collagen deposition in the heart. That sounds awfully similar to thickening of basement membrane in advanced Alport. And the reason could be thiamine supplementation, since I believe it is recommended for kidney disease since ckd tends to result in thiamine deficiency. There is high suspicion that extravagant thiamine doses (which are the only doses you can buy, 100x rda requirement) depletes magnesium rapidly. Why are there more women being treated for alports than men? If most of the cases are X linked (as claimed and only logical), then it should dominate in men, not women... no fda approved treatments for alport exist Reading the 2012 study that is used everywhere to 'show' that ace inhibitors prolong life in alport: "Abnormal composition of the glomerular basement membrane due to AS leads to extensive matrix deposition, inflammation, and fibrosis.5,6 These are major components of progressive renal failure in literally all CKDs" so are they saying alport is indistinguishable from CKD other than some genetic markers? Sure enough, vision impairment is also common in CKD. As is hearing loss.. Regarding the ace inhibitor graph in the study: so the untreated relatives just woke up one day on dialysis, or how does that work? Ok this is what the graph means: they basically grabbed relatives of their patients who went on dialysis but were not in their treatment group. They are much older than group 2 and 1, and we have no idea how they got to being really sick, or how they were treated elsewhere. Whereas we know the children selected in group T1, were totally fine, and still are, other than alport genetic diagnosis. I rest my case.

@abuzzybee2342 Жыл бұрын

Thank you now I'll get more points in Quizbowl

@ahsanullah8689 Жыл бұрын

Excellent presentation.thanks

@osmosis Жыл бұрын

You are welcome! 🙏🏼

@stephaniewhite6322 Жыл бұрын

My husband has alport syndrome and had holes in his macula and had to have surgery on both.

@ruben_9868 2 жыл бұрын

Do you know of the channel Cognito? These two channels share many similarities, even the intro sound. Do you own both?

@meerf 2 жыл бұрын

Thankyou so much osmosis , You are doing a great job...

@osmosis 2 жыл бұрын

It's always our pleasure to help, Yasmeen! 🙏🏼 ❤️ 😊

@waelfadlallah8939 2 жыл бұрын

Clever presentation

@osmosis 2 жыл бұрын

Thanks, Wael! ❤️

@egzonmemedi6518 2 жыл бұрын

Hands down you guys have the best medical videos on KZbin.

@osmosis 2 жыл бұрын

Thanks for the nice feedback, Egzon! 💕

@estherasiedu5857 Жыл бұрын

Thank you for this video. Please can you make a video for primary hyperoxaluria

@osmosis Жыл бұрын

Thanks for your recommendation, Esther! Our team will be taking this into consideration. Have a nice week! 💖

@ParticularCoconut 2 ай бұрын

Here after a phone call from my nephrologist after a genetic test.

@doctorjunaid3924 Жыл бұрын

Hey osmosis ,great fan ,i am consuming vedios from ur app for atleast 1 year.CAN YOU PLEASE MAKE THE VEDIOS ON CANCER BEC ONLY 1 VEDIO IS PRESNT THERE. AND LIKE web version y can’t we read transcript on app

@osmosis Жыл бұрын

Thanks for your recommendation! Our team will be taking this into consideration. Have a wonderful week! 💖