Amyloid Beta Processing

In this video, we review amyloid beta (Aβ) generation from amyloid precursor protein (APP), Aβ endocytosis and intracellular trafficking, and mechanisms of Aβ-induced cell death and neuroinflammation.

[@AmyFerguson]

This music makes me feel happy about the process :)

[@KrisAmos]

What mechanism mediates the beta/gamma secretase cleavage? At least in this video, it seems to initiate the entire cascade, or at least is a culprit in the main machinery that's responsible.

[@tatianahawaii13]

Good question

[@ashsmart6895]

presilin is responsible for the secretase production.

[@rambles2727]

I been wondering the same thing myself

[@ashsmart6895]

PS-1 (chromosome 15) and PS-2 (chromosome 1)