An Amino Acid Extends Lifespan By 25%

In this video we review a recent paper looking at taurine supplementation and its beneficial effects on healthspan and lifespan.
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🌐Links in this video
Taurine deficiency as a driver of aging
www.science.org/doi/10.1126/s...
Taurine linked with healthy aging
www.science.org/doi/10.1126/s...
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#taurine #lifespan #healthspan

[@ModernHealthspan]

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[@VenturiLife]

I've been supplementing with Taurine (1000mg/day) and something interesting happened, I started dreaming again, or remembering my dreams somewhat, which may indicate I'm getting better/deeper sleep.

[@loneranger7573]

I have been taking Taurine for more than 10 years! it has helped me with galbladder "sludge". no more pains after eating fats (I am keto) it helps thin your bile and cleans your liver as well. and helps energy. I use powder and the scoop in the jar is a 3 gram dose. take it every day, either in water but usually in my protein shake with berries.

[@user-co2lp3ob5g]

Thank you once again Dr Omole on KZbin for this information. Since following you (for some years now), my kidney stage results has decrease from stage 3 to stage 1. You saved me from dialysis. Thank you and please keep the videos coming!! God Bless

[@zoopi451]

I think writing tuarine in either the thumbnail or the title of the video is better because some ppl won't watch the video but will read the title and if they see it in the future they will think it is more legitimate and that extending lifespan is actually realistic.

[@ModernHealthspan]

Hi thanks for your comment and suggestion. We were debating whether to use taurine in the title or not. I may change it to include taurine in a while.

[@tobik2627]

It’s called clickbait and the only reason for a title like that

@@tobik2627ope, the video is about what the title says. The definition of clickbait is that the content is not in line with the title. What you mean is phrasing a title to generate curiosity and thus make people to click. That's a big difference. The OP also inadvertently justified the use of this technique. If the viewer prospect knows immediately what the video is about, will go on and will click on another video which used the aforementioned technique. Therefore the "honest" creator will lose in the competition. The reason is the manipulated minds of viewers plus human nature. It's a good title. It made me click even though I am into this medical stuff plus actively use the technique so I recognized immediately but I don't mind at all. One may demand obvious titles from creators but in youtube it means the money from views will go elsewhere and the creator has put all the efforts for no return. Not fair.

[@scottmiller2591]

Great reporting - really pulled the useful information together accurately.

[@ModernHealthspan]

Hi Scott, thanks!

[@jontpt]

Very nice video, and not a product plug in sight! Thanks for getting back to the type of reporting you do best.

[@ModernHealthspan]

Hi Jon thanks for your kind comments

[@rayyu8538]

Excellent report, Thank you Richard! Taurine seems promising and it's not expensive, great to know about this.

[@ModernHealthspan]

Hi Ray, thanks for sharing!

[@JonnyLWarren1]

@@matwolk7968why would it be more expensive later

[@lureup9973]

If research were ever to prove an affordable substance increases lifespan of humans by 25 % Some company will no doubt figure out how to corner the market on it

[@larryc1616]

​@lureup9973 vitamins, minerals, plant/fruit/vegetable supplements cannot be patented and monopolized only synthetic chemicals can.

[@lureup9973]

@@larryc1616 I never mentioned patents, only cornering the market.

[@seffard]

I appreciate you dont waste time going straight to the point.

[@thecheapdvdstore]

seaweed has up to 1,300 milligrams of taurine per 100 grams

[@andrewnorris5415]

:O

[@ModernHealthspan]

Hi thanks for sharing. I should have included that in the natural sources section.

[@SilverFan21k]

I’m glad you are having good KZbin success, and I see you having even more in the future.

[@ModernHealthspan]

Hi thanks for your kind comment!

[@shirleyharold3887]

Richard, thank you for this clear and concise review👍👍

[@ModernHealthspan]

Hi Shirley thanks for your kind comments!

[@LifeDIY]

Richard, thank you for sharing this! So interesting.

[@ModernHealthspan]

Hi Holly, thank you!

[@SilverFan21k]

Thanks for keeping us up to date about Taurine! 🎉💪

[@ModernHealthspan]

Hi Thanks for your comment!

[@TNT-km2eg]

Bend over and receive

[@askingwhy123]

There seems to be some confusion about the implied human dose. It's discussed at 8:08, but I also come to a similar conclusion using numbers from the Science paper: 10 g for an 80 kg person. In Fig. 4. "Taurine pathway affects health span in primates," monkeys were fed taurine [250 mg per kg body weight (T250), equivalent to T1000 in mice]. That gives us a 4:1 effect between mice and monkeys. In the graphy, T500 mice did much better than placebo mice, and often almost as well as T1000. Assuming that a human is more like a monkey, the T500 mouse dosage would roughly equate to 125 mg per kg. This works out to a dose of 10 g for an 80 kg human. Richard does then misspeak at 8:52, directly contradicting his own allosteric numbers.

[@charlessavoie2367]

20 of 500 mg capsules/day seems excessive but definitely should be taken with food, and carnosine should be taken away from taurine.

[@iewauhedoc9970]

@@charlessavoie2367 why should carnosine be taken away from taurine?

[@rene-rv6pp]

Beware with your liver. All this stuff goes there. You cant live without a liver

[@antonystringfellow5152]

Supplementing with NMN increases taurine, glutathione, collagen, etc. and reduces cellular senescence, activates stem cells and reduces protein misfolding, etc. If you're taking NMN, you probably don't need to supplement with any of these, nor with TMG, NAC, etc. DYOR - supplement companies will try to persuade you to spend all you have on their products. It's a huge and growing industry.

[@citizendc9]

@@charlessavoie2367 Powder form is much simpler to take. Two teaspoons.

[@peibol77spa]

Unless I'm missing something, 1000 mg/kg for a 75kg person is 75g, not 7.5g 🧐 Which btw seems to be quite a big dose per day...

[@markfitzy.86]

Sure dose 😮

[@davidsy0utube]

You are correct. And mice in the study were getting this huge dose.

[@ArtoPeltomaa]

It's possible to miss something.

[@lolawants2008]

8:46 Yes you are missing something. That wasn’t a recommended dose. It was citing a food safety authority which said they. Found it was *safe* up to 1000mg/kg. They were evaluating amounts in energy drinks & how much is safe.

[@ISpiritualAwakening]

There was a conversion factor (Allosteric) used to convert from the mice study to human. 8:06

[@juliefall2892]

I am a chronic migraine sufferers, Ive tried taurine and the magnesium supplement I take has a huge dose of taurine 3g . It works , I tried magnesium on its own it doesn't help. I spoke to a lady I met from South America she said try taurine that's what we use for migraine in my country. I can't remember which country but was in South America . Taurine was also prescribed for my hyperactive daughter who had yellow palms the naturopath said her liver was having a hard time dealing with chemicals I think he said the taurine helped her. Also celery juice seemed helpful too. Thank you for your excellent presentation.

[@RAY-bg2po]

Migraine get worsen by uric acid food and drinks, uric acid intervene nitric oxide production (here act as vessel dilator) . Celery clear uric acid.

[@ModernHealthspan]

Hi Julie, thanks for sharing your experience. It is great to hear that the combination of magnesium and taurine is working for you!

[@loneranger7573]

3 grams is average or regular dose. I have taken it daily as per my doctor's advice since 2011.

[@summerforever6736]

Stop eating sugar see what happens

[@daviddestrebecq9806]

Cysteine can produce taurine as well Perhaps one of the possible reasons why cysteine is so powerful. Taurine as well gives the power to our body to assimilate and retain better magnesium. So many pathways are concerned. Thanks for sharing

[@juliefall2892]

Yes I take a magnesium supplement which has 3 g of taurine in it per dose and it's brilliant for migraine. Magnesium on its own doesn't help , I'm a chronic migraine sufferer taurine works wonders.

[@juliefall2892]

Would tinned tuna have a good taurine amount or would it be destroyed in the cooking process?

[@daviddestrebecq9806]

@@juliefall2892 tuna has à lot of heavy métals in it .Lille fishes are better

[@ModernHealthspan]

Hi David thanks for sharing.

[@SpinStar1956]

Great presentation. Thanks! 😊

[@ModernHealthspan]

Hi thanks for your kind comment

[@SilverFan21k]

You make great content.

[@ModernHealthspan]

Hey thanks!

[@breannestahlman5953]

Impressive, Thank You ! ! !

[@lsd22252]

Brilliant thx Richard. I have quite a long history of taking at least a gram of taurine for the last five plus years. I'm just speculating but at least one definite benefit for me related to skin breakdown. In particular cracked lips. Remembering that our intestines are like skin turned inside out, my suspicion is that taurine could help maintain the intestinal tract. By going off taurine for a few months my cracked lips returned then went away again after I went back on daily taurine tablets. Based on the numbers from you & elsewhere I'm going to double my intake of taurine from my current ~1.5gms per day up to ~3gms per day which may optimise a range of benefits.

[@ModernHealthspan]

Hi thanks for sharing. It is always great to hear from people who are having positive effects in the real world.

[@richardcardinale7152]

Carnivore for life , best taurine source there.

[@TNT-km2eg]

Fried pig carcass asses . Lots of gravy . Ad some eggs with bacon . The more you eat , the more I'm happy . I love that odour coming from you

[@fredsmalley7004]

Due to many emergencies taking care of my mother, my fight or flight threshold is now very low. A gram of Taurine powder every day has been very helpful I go without it one day per week so that my body does not become insensitive to the supplementation.

[@breakinfree]

Are you implying that taurine is good for nervous system?

[@fredsmalley7004]

@@breakinfree HI. Please excuse my tardy reply. I'm saying that Taurine is good for MY sympathetic nervous system. When I told a naturopathic doctor that my fight or flight mechanism was easily triggered, he suggested the Taurine. So apparently it has worked for others..

[@Leoninmiami]

Very helpful!

[@lmwlmw4468]

Great video.

[@rc24888]

Richard - thanks so much for your vigilance! Can you comment on taurine, as it might reflect itself with Osteoporosis ? Thanks, another Richard~

[@ModernHealthspan]

Hi Richard, thanks for your question. Just looking at the paper, the tests were in female mice and showed improved bone mineral density in femur and spine. And the maximal load and stiffness of the femur improved. There are numbers for the BMD in fig 2 that the improvement was similar in both doses, though slightly higher in T1000 group. Finally they say that it "cured osteoporosis" in a model of menopause.

[@emergentform1188]

Wow, love it!

[@ddutton4716]

At 8:32, he discussed the safety of taurine. The news release mentioned was based on a 2009 neurotoxicity study. An earlier 1999 toxicological study did not reveal any indication of a genotoxic, teratogenic, or carcinogenic potential of taurine. They did not look into other toxic pathways.

[@ModernHealthspan]

Hi thanks for sharing the extra information!

[@ddutton4716]

@@ModernHealthspan The open paper is: The use of taurine and D-glucurono-γ-lactone as constituents of the so-called “energy” drinks

[@bruceolga3644]

@@ddutton4716 taurine isn't the issue 👁️

[@garyssimo]

most energy drinks hve 33 grams sugar in 8 ounces. Imagine gulping 66 grams in a 16 oz one? That will kill anyone! synthetic sweetners can be worse.

[@garyssimo]

66 grams sugar is about 16 teaspoons. Pour that into a pile and imagine ingesting it in liquid form which is the worst form.

[@thomasrebotier1741]

at 8:48 : 1,000 mg per kilogram of body weight makes 75 grams (not 7.5)

[@barrymantei7795]

Anyone who would take this high a dose of any supplement is insane

[@thomasrebotier1741]

@@barrymantei7795 my tought exactly. I think later in the video or is it in another, Richard mentions that there is a standard /12th factor when interpreting a mouse model into human terms. That would make the range 6.25g Still a lot.

[@davin8r]

​@@thomasrebotier1741not really. It comes in 1g capsules, so that's 2 caps with each meal

[@ModernHealthspan]

Hi Thomas, thanks for mentioning this. You are correct, it was my mistake.

[@user-yq8ck8yf3u]

The trouble is that Taurine is just one of many things that reduce with age.

[@ModernHealthspan]

Hi Thanks for your comment, though that sounds like a good thing.

[@johnthefisherman2445]

Hopefully we can find the root cause of all this decline.

[@charlessavoie2367]

@@johnthefisherman2445 You didn't know there is a curse operating in this world, that eventually kills everything. The Grand Canyon is an icon alluding to the early earth in which a vapor canopy existed in the atmosphere, filtering out harmful cosmic/solar radiation, enabling people to live past 900 years. If you accept evolution this will be meaningless.

[@rene-rv6pp]

It woul be interesting so make the complete list

[@ronm6585]

Thanks Richard.

[@chrismahfouz7709]

Thank you!

[@ddutton4716]

Thanks so much for digesting this for us. I hope the Interventions Testing Program can reproduce the encouraging mouse results. When taurine is made in the liver it consumes some methionine. If supplemented with quantities of taurine far in excess of what one makes naturally, it may reduce the amount of taurine made and thus raise methionine and therefore homocysteine.

[@zestopesto]

Thanks for sharing this information ddutton 📖

[@ModernHealthspan]

Hi thanks for your comment and sharing the info on methionine! It would be good to see this tried in the ITP. Or perhaps Aubrey could add it into his Robust Mouse Rejuvenation program

[@Vincent_Beers]

That might explain why energy drink abuse is leading to early heart disease, many of them are high in taurine. Seems like we need to find a safe dosage and not just take tons of it.

[@rene-rv6pp]

I didn't understand. Did this improved lifespan in healthy or unhealty mouse? Because if you give any missing nutrient to un unhealthy it will markedly improve

[@ddutton4716]

@@rene-rv6pp I read through the supplementary material for you. There was no indication that the yeast, worms, fish, mice, or monkeys were anything but healthy and standard.

[@wmp3346]

Will pick some up

[@jefflittle8913]

Ok, so both glycine and Taurine help (and didn't someone also say serine?), but overall high protein hurts. I can't help but think from your cysteine comments than there could be a gly-NAC connection, but I am wondering if the real mechanism is BCAA restriction (or improving the simple/branched chain amino acid ratio).

[@ModernHealthspan]

Hi Jeff, thanks for your comment. I think the evidence can be contradictory so it is difficult parse. Dr Lamming found that protein restriction extended lifespan especially the BCAAs. But we also see individual amino acids seem to help. At the moment, I personally am more in the Dr Peter Attia camp, which I understand as, in the real world, lean mass is more important, which requires higher protein intake.

[@tonyprice2256]

I prefer to get it along with all the other essential amino acids naturally from high quality free range animal products in the diet.

[@ModernHealthspan]

Hi Tony, thanks for sharing. That is a great way to get it.

[@msplateaugal]

Hi Richard, I see your list of daily supplements and it is very close to what I am taking. (I do not see BioGia anymore. I thought that helped with your bone health.) However, for convenience, I take everything after breakfast without an issue. Why do you spread them out during the day? I can see some might help with sleep. Is there anything else we should know about? Thanks for sharing, by the way. Your progress back in time has been very impressive and you spend so much time keeping up with what is going on, your stack is of considerable interest.

[@CyrilAndPriscilla]

BioGaia is still listed there, under his "midday" supplements.

[@msplateaugal]

@ModernHealthspan Hi Richard, I am thinking that many of your followers would like a lesson on when to take supplements. Perhaps you know an expert who could weigh in. Huberman would have a lot to say, and may already have a podcast on this. (I now see you still take BioGaia thanks to @CyrilAndPriscilla.) -Jenny

[@carolmaplesden916]

I just now stumbled on this channel not familiar with him but that is one of my issues is when to take some of my supplements and apparently some of them I'm taking too low of dose always searching and learning

[@ModernHealthspan]

Hi Thanks for you comment. It is time for me to re-do my supplements and review them all again. I will make a video when I have done this. I do take most in the morning but also take some later, a couple of reasons for this. One is two spread out the work the liver has to do (I don't know how much this matters). Another is to take the ones appropriate for sleep later in the day, such as apigenin, spermidine, HLA, Mg. I now take my NMN in the middle of the day, when I take whey protein. This is based on our conversation with Dr Zemel where increased leucine improved the effectiveness of NMN. (though I should note that he also said that when leucine is with the other amino acids the effect is a lot less, but it might help!). Some are also better with meals, for example omega-3 (based on conversation with Dr Bill Harris) so I take that after dinner.

[@carolmaplesden916]

@@ModernHealthspan yes thank you... I've been concerned that some of the supplements might not work well with each other I know you are correct about not over taxing the liver

[@yageroi]

Thanks!

[@__-tz6xx]

The thumbnail for this video reminded me of a video titled 'Cream by David Firth'

[@lovelyman6210]

Hi Dr.Richard. My question is Does Milk and/or Cheese contain Taurine? Thank you.

[@AL-rf2fr]

Nothing beats a good diet, exercise, plenty of sleep and no processed foods to extend lifespan .

[@paulawagstaff686]

That's a very good 'foundation' to start with. yes

[@Rittlesleo]

Don’t forget plenty of sunshine☀️

[@voxfan7403]

Can you please post a link to the research supporting your claim?

[@rhollyday]

Obviously, you're not old yet... LOL ❤️

[@Rittlesleo]

@@rhollyday I’m 67, but I don’t consider that to be old.

[@aluyiibizugbe7067]

That is why i use the Nutrlite all plants protein which contains the nine essential amino acid

[@thaidomain]

I would recommend Mr. Richard to take this supplement. It will maybe make him look younger.

[@robertgreenecpa7930]

I use taurine powder. It's inexpensive and tasteless. 1 5cc scoop = 1 teaspoon = 4.33 grams in a quart or liter of water and drink all day. It's easy to add some other powders like glutamine, creatine, glycine, TMG, etc.

[@ModernHealthspan]

Hi Robert, thanks for sharing, that sounds like a great plan.

[@japanstation1]

Taurine deficiency associated with: high glucose, hypertension, inflammation, Diabetes, Obesity, Abdominal obesity ... fascinating that every single one of those is also associated with high sugar intake. Since we know that low calorie high fat diets reduce inflammation, reduce the risk of obesity and hypertension, it makes me wonder if there is a causal link with taurine deficiency and low fat diets (and not just ageing in general).

[@MarmaladeINFP]

High-carb diet is often associated also with low intake of animal foods and animal fats. Most junk food, for example, contains little taurine-rich meat. And besides, meat is higher in taurine when fresh because it's concentrated in the liquid that can drip away.

[@Battery-kf4vu]

What I find a bit bizarre is that mice are not evolutionnary adapted to eat meat, and yet they live longer when eating something that is contained almost only in meat.

[@fryertuck6496]

What makes you think that? Mice will eat meat if it is available.

[@billpetersen298]

They probably do eat insects. My gerbils, would go nuts over a bug or spider.

[@RJ-is9ko]

They don't have the same dna as humans

[@i-primeproductions1517]

I guess they just didn’t get the “magical quote virus that carries 60,000,000 miles of programmed DNA information to turn them into meat eaters…. Or … they never involved at all 🤷‍♂️😂

[@danielh3719]

@@RJ-is9kono other animal does.

[@rhollyday]

Thanks for good video. But there is a small mistake. The study gave 1000mg/kg and you said that is equivalent 7.5g for 75kg person when actually it is 75g dose for 75kg person. This correction emphasizes your point about safety by factor of 10 :)

[@christianguthrie6614]

What is a minimum therapeutic dose? 1000mg twice daily? What about glycine and NAC. Can these be used when fasting?

[@user-pf5xq3lq8i]

What's the absorption rate? Is it worth taking as liposomal?

[@privateerburrows]

At 8:52 _"1000mg/kg ... which for a 75kg human means 7.5g"_ paraphrasing ... But 1000mg = 1g. 1g/kg x 75 kg = *75.0 grams* ... (NOT 7.5g). Great channel, in spite of this; my first time here, and I already subscribed. But now I really want to know where the above mistake comes from, and whether I can take 7.5 grams of taurine and live longer, or if I really need to consume 75 grams a day... 😲

[@francevenezia]

EVERYTHING goes down with age!

[@texastexas4541]

At 8:45 1000 mg/Kg equals 7.5 gm/75 Kg. Something is wrong here. 1000 mg is 1 gm and so it should be 75 gm/75 Kg. That is too much.

[@jackbuaer3828]

One author on the Paper suggested a human dose of 3- 6 grams based on the mice dosage.

[@mrjgilbert]

He divided it by 12.3 “allosteric conversion factor” to get to the recommended 6g. Idk anything about that conversion but that’s what was going on on that slide.

[@texastexas4541]

@@mrjgilbert NO, he clearly says the following.....1000 mg/Kg equals 7.5 gm/75 Kg. Watch it again.

[@larryc1616]

Just divide by 12 to convert mice dosage to human dosage so it's up to 6g/day

[@stevewolfbrandt4932]

Im taking Taurine with MNM and glycine with NAC. I expect to live to 150 years old.

[@healthdoc]

I think you mean allometric conversion of the dosage. Still a huge dose.

[@Rick_Sanchez_Jr.]

Taurine is child's play in terms of ORAC score. Dragon's blood sap has the highest known ORAC value of 2,897,110 giving it 6,000 times the antioxidant power of vitamin C, 800 times that of CoQ10, and 550 times that of vitamin E. Just as a comparison, Blueberries have an ORAC of 4,669 and turmeric 127,068. The second highest is Astaxanthin with an ORAC value of 2,822,200.

[@larryc1616]

Yeah but dragon's blood is not available in this dimension. Astaxanthin is good enough

[@izzzzzz6]

Taurine is in Red Bull. NFW! But pretty ironic how extreme sports people tend to die young!

[@sooooooooDark]

8:55 it would be 75g for a 75kg human, not 7.5 grams

[@jackbuaer3828]

I recall a author on the paper (A Columbia Researcher) suggested that the human equivalent dose would be 3 - 6 grams

[@sooooooooDark]

@@jackbuaer3828 i was refering to the safe upper limit he mentioned yes 3-6g is the effective dose for the positive effects talked about in the video

[@jimdandy8996]

Wow!

[@nootri]

No. He is correct. The european equivalent will recommend 8.58gs for that same 75kg person, that is 10% more. Good look getting 75 grams of taurine into you, you will NOT be constipated, that's for sure.

[@sooooooooDark]

@@nootri the article he showed on screen said 1000mg per kg of bodyweight 1000mg = 1g 1g * 75 = 75g no?

[@csx9000]

Correct me if I'm wrong, but 1mg = 0.001g, and hence 1000mg = 1g. Therefore 1000mg per kg of bodyweight for a 75kg person is 1 x 75 = 75g no?

[@gilbertgrejp]

1000mg=1g. 1g per kg body weight gives 75g for a 75 kg person.

[@jimdandy8996]

Thats a huge amount to choke down every day.

[@gilbertgrejp]

@@jimdandy8996 =likely safe to eat at normal doses

[@jimdandy8996]

@@gilbertgrejp Yeah, at "normal doses," which won't provide efficacy.

[@siddiqui49]

Interesting. However I remember Prof. Huberman mentions that exogenous taurine can damage eyes.

[@dennykeaton9701]

Ouch

[@VagoniusThicket]

So you will be blind but live10 years longer ! 😵

[@ModernHealthspan]

Hi Siddiqui, thanks for sharing. I had a quick look, I found one paper "Taurine and oxidative stress in retinal health and disease" that says it helps with retinal health. The other results I see are also positive (taurine helps eye health). Would be great to have a reference for negative impact of taurine on eyes.

[@siddiqui49]

@@ModernHealthspan thank you for informing me that the academic literature does not mention any such side-effects. However, Prof. Huberman had a bad experience. kzbin.infoUgkx8mjmJbMx9cS6U0VUoO59fBg9jsKC5pIm

[@Fohntuuli]

You remember, but can you go back and find the episode and reference to study where that result was?

[@kathyliin8438]

One doctor here on the internet claims Amino Acid will help get rid of Tinnitus. I am anxious to give this a try, and see if I can get rid of this dam buzzing in my ear. Its been going on for a good 5 years, every minute of the day, and its driving me crazy.

[@sondrejacobsen]

Very interesting. It seems that hard training increases the levels, so it is not so beneficial for athletic people. Will wait for randomized trial before I consider taking it

[@KenOtwell]

Training still doesn't increase it nearly as much as the amount used in these tests. Plus, all training can do is to help you retain it - not create it. You get most of it from foods regardless.

[@andrewnorris5415]

Could be b/c fit need MORE of it. Maybe they would get even more benefit from supplements. Best to wait until studies target them.

[@KenOtwell]

@@andrewnorris5415 Taurine is known to be safe, so there's no risk to jumping the gun. ;)

[@hoon_sol]

@@KenOtwell: The body makes taurine, so the idea that you're just retaining it is completely false. Exercising will increase taurine biosynthesis rates.

[@KenOtwell]

@@hoon_sol Google it. The body does not make enough taurine for it's needs - you need intake as well.

[@thomascenteni4884]

is it possible to get enough of it from diet (chicken, fish, beef)?

[@pat4005]

Thanks for the additional info. The only thing I would not trust anymore, is the NEJM.

[@bennytleilax]

I think it is interesting that, in the table of amounts of taurine in different meats and seafoods, the highest amount was in octopus, but that was the only mollusc in the list. I would like to know how much is in other molluscs.

[@hoon_sol]

Nori contains far more than octopus, though.

[@bennytleilax]

@@hoon_sol That is interesting. I eat some nori every day for iodine.

[@hoon_sol]

@@bennytleilax: Oh yeah, great source of a lot of nutrients for sure; even B12, as perhaps the only conclusively established plant source of it.

[@VagoniusThicket]

Took large doses of Taurine for 2 months and my zinger grew 4” longer ,,,then I woke up 😂🤏🏻🤭

[@roxyiconoclast]

Chicken had the second highest taurine content. Chicken also is a popular food in Japan, as I learned while living there for a couple of years. I always feel much better within hours after eating chicken. I’m not a fan of seafood, as I feel unwell after eating multiple servings, probably because I’m sensitive to iodine.

[@garyssimo]

I give my 18 yr old cat a pinch in his food. Hes in almost perfect health.Cats are very much in need of this. Also put the powder in my coffee as its tasteless.

[@MetalMakeover]

It said the body can get it from cysteine, so of you take NAC, N-acetyl-L-cysteine you probably wouldn't need to also take taurine separately.

[@carolmaplesden916]

thanks i needed to know that!!

[@ModernHealthspan]

Hi Luke, thanks for your comment. The body can indeed make taurine from cysteine. I am not sure that it would reach the same concentrations as if you take taurine itself. Having said that, NAC has its own benefits as well

[@MetalMakeover]

@@ModernHealthspan Maybe if you take taurine separately then the cysteine wouldn't need to be converted to it and would be available for other things, so I guess it might be better to take both.

[@peterz53]

Thanks. Been taking (500 mg/d) for 10+ years in order to help with vascular system and because I don't eat animal products and because of age. My dose is trivial compared to mouse study though. Will have to see about getting a blood test for taurine and whether there is a way to improve endogenous production. I already exercise.

[@ModernHealthspan]

Hi Peter, thanks for sharing. Please let us know if you decide to increase the dose.

[@peterz53]

@@ModernHealthspan I will be testing for plasma taurine levels as part of an amino acid profile, then adjusting according to raise to youthful (20 to 30 yo) levels over time. Arbitrarily jumping to 6 gms/d makes no sense if testing can help dial in dose.

[@2007vwbeetle]

@@peterz53 Can you take 1000 mg Taurine, 1000 mg Glycine and 600 mg NAC together?

[@2007vwbeetle]

@@ModernHealthspan Can you take 1000 mg Taurine, 1000 mg Glycine and 600 mg NAC together?

[@summerforever6736]

What is wrong with animal products??

[@marcc.e.wagner8789]

That is an awful lot of Taurine to take each day. Why exactly does it decrease with age? What happens metabolically to cause the blood levels to drop that much over time? Those are important questions that must be addressed.

[@loneranger7573]

Dude, everything drops as we age, especially hormones. our bodies become less efficient, and need more nutrients to repair. all diseases of aging are a consequence of low hormones. very few doctors have been trained in HRT for women or men. Remember, as we age, we dont function as well as we did when we were younger. everything slows and body must repair itself. energy wanes, keeping fit is harder, we have to eat a lot less calories as metabolism slows, if you dont eat a good amount of fresh meat, you arent getting much taurine and our bodies dont make it as well when we are over 40. therefore we must supplement nutrients and minerals for optimal quality of live. trust me, I've been on HRT and supplements since 2011 at age 51. I am now 63. my friends are falling apart, crunchy, sore joints, weight gain, saggy skin, exhaustion, miserable lives. Me, I'm aging backwards, thanks to supplementing many hormones that are prescribed to me by a hormone specialist, including thyroid, estrogen, progesterone, dhea (and testosterone as well for a short time, but I make enough now.) I'm at the gym 5x a week, thats where I met my new husband, who is 23 years YOUNGER than me. that's what hormone replacement and supplements like Taurine does for me.

[@Seeker_of_sense]

Not 7.5 grams for a 75 kg person, but rather 75 grams (1000 mg/kg BW).

[@jontpt]

You have to use the mouse to human conversion factor.

[@user-lu6ce4yc9g]

glutamine does the same for 30% increase in mouse lifespan and its the precursor for akg.

[@kennethlarsen2960]

Two grams glutamine 45 mins after breakfast boosts human growth hormone 440% 90 mins later. LA St Medical College.

[@rene-rv6pp]

Given that the maximun human lifespan is 120 years. A 25% improvement would put that to 150. I havent known ever from someone reached that

[@advertiserfriendlyusername5362]

I was already taking 6 grams/day (2 g, three times a day).

[@ModernHealthspan]

Hi thanks for sharing. Great to hear from people who are already taking that kind of dose.

[@joanstone6740]

So Red Bull must be great for you

[@littlevoice_11]

Is there taurine in chlorella? I notice it in seaweed which causes the bioaccumilation in fish. But are there other plants beyond seaweed? E.g. chlorella? Any herbs? Vegetables? Wheatgrass?

[@ModernHealthspan]

Hi thanks for your question. Yes, nori, the Japanese style seaweed has up to 1,300 mg per 100 grams. I am not sure of other plant sources.

[@littlevoice_11]

@@ModernHealthspan thank you

[@rene-rv6pp]

What i get to understand is that this studies are based in undernourished or sick animals. So they will improve for sure.

[@matthiasmaiwald8236]

8:49 - If I am not wrong, 1000 mg/kg for a 75 kg human would be 75 g, not 7.5 g. Or have I overlooked something?

[@ModernHealthspan]

Hi Matthias, thanks for commenting and no you have not missed anything, that was my mistake! Sorry.

[@christopherb6656]

70g of taurine is safe, so my just a few mg in drinks, hard to understand, seems the mice eat more

[@kulturfreund6631]

8:47 - 1000 mg (1g) per Kilogramm amounts to 75 g with a person of 75 Kg, not 7.5 g.

[@ModernHealthspan]

Hi Thanks for pointing this out! You are correct.

[@kulturfreund6631]

Thanks for taking note and thanks for your enriching work. Cheers from Berlin

[@bulkypug3811]

I drove a Ford Taurine but definitely didn't extend my life..

[@stevenr.2534]

It extended your life compared to driving a Ford Pinto😊

[@ikvangalen6101]

Is this hidden advertising for Red Bull????

[@richardprice9730]

All these researcges must cost millions ,intuitively makes sense the sulphur molecule veey imp for regen and development so yes we no liittle about this sort of info fascinating .

[@clemensrandow1628]

save dose of 1000 mg/kg, wich for a 75 kg person would be 75 g

[@littlevoice_11]

Is it taurine or is it the ratio of taurine to other amino acids? I think some amino acids increase aging

[@jefflittle8913]

My comments exactly. Although I also mentioned glyNAC as well.

[@Vincent_Beers]

Ratio matters, and cycling on/off so your body doesn't stop making its own. Homocysteine from taurine abuse can lead to heart disease and other side effects.

[@Vincent_Beers]

Ratio matters, and cycling on/off so your body doesn't stop making its own. Homocysteine from taurine abuse can lead to heart disease and other side effects.

[@ModernHealthspan]

Hi thanks for the question. They don't reference other amino acids in the paper and only the levels of taurine.

[@nickdipietro7797]

What about glycine ?

[@deanmindock3680]

We take glycine, about 3 tsp a day. Glycine helps detox or mitigate the effects of glyphosate plus has a relaxing effect.

[@giladkingsley]

1000 mg/kg is a ton!

[@iancormie9916]

Dosage 1 gram per kg. How much of this would a person really need to consume?

[@ModernHealthspan]

Thanks for the question. The 1g/kg was a mouse dose. The conversion normally uses a factor of 12.3 : 1 for humans which comes out at 6g for a 75kg person. 3 - 6 was also the amount that Dr Vijay Yadav mentioned.

[@j7ndominica051]

It's a component of protein. Why can't we eat more meat naturally like cats do? Is it not possible to eat the required amount? Buying these isolated supplements is unsustainable. There is also Creatine and Collagen marketed by big pharma. What was the reasoning behind putting it in energy drinks before this study came out? Poor mice in labs.

[@MarmaladeINFP]

Taurine is concentrated in fluids. So, meat that is hung, ground, or sitting on a meat rack will lose taurine content. Few modern people eat fresh meat, which might mean taurine intake would be lower. That is why taurine supplementation could potentially benefit even those on a meat-heavy diet. But it's definitely beneficial for anyone restricting meat intake, though it demonstrates why meat restriction is a bad idea for health.

[@j7ndominica051]

Thank you.

[@tim57243]

There has to be a tradeoff here. Taurine is a simple chemical that we already make endogenously. If more taurine made things unambiguously better then we would have already evolved greater endogenous taurine production than we already have.

[@jarrylwirth672]

Evolution doesn’t select for longevity. Successful adaptations are those that help us live long enough to successfully reproduce, and thus pass on our genes. Once we’ve finished reproduction, evolution couldn’t care less how long we live.

[@ModernHealthspan]

Hi Tim, thanks for sharing. Here are my thoughts, in biology, there is always a trade-off. Humans need taurine in the diet when very young but later can make taurine from cysteine so it is not essential for us. Cats require it through life. Maybe because they eat nothing but meat it was never worth developing the ability. However I think the main thing is that taurine is beneficial in later adulthood. This is not something that evolution cares about very much, so even if the ability to make more taurine when you are over 50 is unambiguously good, there would be no selective pressure to develop it.

[@Fohntuuli]

Well, we need vitamin C but we don't make it as tropical animals we would get it from fruits daily. We would get enough taurine from fish and seafood but how many of us eat those daily? So suplementing is sensible as we eat carbs etc these days that are not rich in taurine.

[@billpetersen298]

Eggs?

[@abhishektiwari1777]

Is there any interaction b/w taking taurine and glycine together?

[@PollyAmorous]

No they are both amino acids. Glycine is better at bedtime with NAC. Taurine is better in the morning for energy. Both should be taken on empty stomach.

[@shus5787]

Big pharma will say its a drug lol

[@rc24888]

If it can't be monetized, it doesn't exist!@

[@dr.davidgerstenaminoacidth2421]

Taurine is used in energy drinks, but I’ve never seen research that shows that taurine boosts energy. Perhaps it is just marketing.

[@wetguavass]

Tacos extends lifespan by 30%

[@fryertuck6496]

That would be 10g per day, basically x10 times the bottle dose of 1g.

[@ModernHealthspan]

Hi thanks for sharing

[@dgpreston5593]

Please recheck your statement re: the NOAEL. 1000mg per Kg for a 75 Kg person is 75x1000 or 75,000mg or 75grams.that is 10x (1000%) off from your spoken statement of 7.5grams.

[@AUniqueHandleName444]

How does a 1g dose in a mouse translate to a human dose? It seems huge.

[@danieltaylor9376]

How does cooking affect taurine? Are their any studies?

[@ModernHealthspan]

Hi Daniel, thanks for the question. I had a look and can find an old study looking at taurine in milk and yes, it decreases with heat. This may of course be because of other chemicals in milk reacting with it.

[@danieltaylor9376]

@@ModernHealthspan How does the heat affect it and by how much? Any indications? Do you have a link to the study?

[@ttfan3257]

Taurine

[@smartobserver3644]

I think I had a feeling of overdose event with taurine. I think it was because I have taken the more dryer Now supplement and without food Vs the fluffier one from Solgar. I'm not sure I think I had effect of like lowering of sensetivity to little dopamine. Like receptors maladapted and became less sensitive. So i stopped using it. Since i was getting similar effect from nmn. I think the useful effect is glucose related. The mental affect of overdose stayed for like 2 years. Just now i am recovering from it. I am not sure about it. It was a feeling.

[@ModernHealthspan]

Hi thanks for sharing, that is interesting. How much were you taking at the time?