An interview with Dr. Pimentel - How to recover from SIBO and what do we really know?

In this episode I talk with Dr. Mark Pimentel, a leader in the small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS) world.
We talk about what his team is doing to push research forward for SIBO and IBS, new developments in SIBO, breath testing and gasses produced, as well as things that will be coming out soon for treatment.
In this episode, we cover:
What is SIBO [4:29]
What the team is working on [5:46]
Keeping an open mind as a scientist [9:02]
The controversy of breath testing [10:01]
Hydrogen sulfide [13:24]
This episode is sponsored by FODZYME, the world's first enzyme blend that targets FODMAPs, gas-causing carbohydrates and common gut triggers.
Mixing FODZYME with your food allows the enzymes to integrate and break down the FODMAPs lactose, GOS, and fructan, before they can affect your gut. Through a unique formula and powder form for maximum efficacy, FODZYME can help you reduce overall FODMAP load, support better digestion and enable nutritional diversity for optimal health.
Say goodbye to digestion drama with the help of FODZYME. Learn more at fodzyme.com and use code GUTSHOW at checkout to save 20% off any single order
Mentioned in this episode:
REIMAGINE Study: csmast.com/current-research/
Breath testing for SIBO and IMO: www.ncbi.nlm.nih.gov/pmc/arti...
Research articles from the MAST team: csmast.com/scientific-articles/
Indian consensus statements on IBS: pubmed.ncbi.nlm.nih.gov/36961...
Join the MASTER Method Membership: www.ibsmastermethod.com/maste...
About our guest:
Mark Pimentel, MD, is a Professor of Medicine at Cedars-Sinai. Dr. Pimentel is also the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai, an enterprise of physicians and researchers dedicated to the study of the gut microbiome in order to develop effective diagnostic tools and therapies to improve patient care. Dr. Pimentel is also a Professor of Medicine at the Geffen School of Medicine, University of California, Los Angeles (UCLA.)
As a physician and researcher, Dr. Pimentel has served as a principal investigator or co-investigator for numerous basic science, translational and clinical investigations of irritable bowel syndrome (IBS) and the relationship between gut flora composition and human disease. This research led to the first ever blood tests for IBS, ibs-smartTM, the only licensed and patented serologic diagnostic for irritable bowel syndrome. The test measures the levels of two validated IBS biomarkers, anti-CdtB and anti-vinculin.
A pioneering expert in IBS, Dr. Pimentel’s work has been published in the New England Journal of Medicine, Annals of Internal Medicine, American Journal of Physiology, American Journal of Medicine, American Journal of Gastroenterology and Digestive Diseases and Sciences, among others. Dr. Pimentel has presented at national and international medical conferences and advisory boards. He is a diplomate of the American Board of Internal Medicine (Gastroenterology,) a fellow of the Royal College of Physicians and Surgeons of Canada and a member of the American Gastroenterological Association, the American College of
Gastroenterology, and the American Neurogastroenterology and Motility Society.
Learn more about Dr. Pimentel’s work:
www.cedars-sinai.org/research...
Twitter: / mastprogram
Instagram: @mastprogram
Connect with Erin & the Gutivate team:
IG: @erinjudge.rd or @gutivate
Website: www.gutivate.com
Schedule a consult: bit.ly/gutivateconsult
FREE: IBS Fundamentals Mini Course:
www.ibsmastermethod.com/ibs-f...
Join The GUT Community:
The Facebook group for those with IBS and digestive health conditions to connect, encourage one another, and dive deeper into the topics we cover on The Gut Show. Join here: / thegutcommunity
Track your symptoms & understand your body better
My Gut Journal is a 90 day gut tracker to build awareness in your mind & body. Get yours at gutivate.com/store/mygutjournal

[@Pdk764]

So glad a Dr. is looking outside of the box!! I have pcos,estrogen dominance and methane sibo. They wanted to do a complete hysterectomy but I followed Chris Wark and cut out sugar and processed foods. 1 year later all pre cancer is gone. Sibo etc etc has to have something to do with excess sugar consumption because as a child and still till this day I CRAVE sugar on an unbelievable scale. Maybe no everyone does Idk but processed sugar must play some role.

[@rosmarycaraballo4785]

Thank you so much for all you do. This is beyond helpful. Thanks for sharing the references

[@gutivate]

You’re welcome!

[@isaaclavoie]

Thanks for having Dr Pimentel on! We are blessed to have a scientist who is willing and able to explain whats really happening in IBS. I've been watching this space closely as I'm 1 year into my IMO journey. Its pretty amazing how much has changed since I first understood my issues stemmed from SIBO.

[@Pdk764]

What have you learned? Please share with us who are also suffering with IMO?

[@funghouls5498]

Good interview. Thank you for sharing

[@FighterFred]

This material has been known for many years. It's the same info in all videos. What's lacking is treatment.

[@Ruktiet]

Treatment lacking? Wth are you talking about? We’ve got rifaximin, neomycin, metronidazole, bismuth, mucolytics, prokinetics such as prucalopride, domperidon, low-dose erythromycin, herbal antibiotics like oregano oil, berberine, allicin, or herbal prokinetics like ginger/artichoke extract, and much more.

[@gutivate]

Yea we covered why treatment is still lagging. I want more data on that right now too but as covered, it’s not available quite yet. If I knew, I’d tell you

[@bertwoodshack6617]

Thank you for an excellent interview ❤

[@raewise6345]

If you watch Microbiome Labs (Kiran) videos and presentations on KZbin, there really are treatments laid out. I take notes and then start researching products.

[@user-sr3jc1ih4z]

Appreciate hearing Dr. Pimentel, but where are the answers on how to truly treat it?

[@raewise6345]

My microbiome dysfunction started with a c-diff infection 15 months ago. These podcasts are helping me as well. Thank you ⚡❤️

[@gutivate]

That’s a story I see way too often! It’s a rough recovery but keep at it and it’ll pay off!

[@HugoFTW]

How are you treating this, I"m in the same boat as you.

[@raewise6345]

@@HugoFTW after watching dozens of functional Drs/GI's/ researchers and others who have healed, I decided to follow Dr Rajsree SIBO protocol. She has multiple KZbin videos. I also researched all the supplements suggested throughout all these videos/articles etc., trying to find quality ingredients (without some that we DON'T need) ..I decided to use her products as well. I bought 7 of her SIBO supplements. I am about 1 month into the treatment. It's gradual, 4 phases. I am feeling about 80% better, and that's HUGE.

[@Carol-vx8ru]

Would a elementral diet help thanks

[@GrampalettasCamp]

If I haven’t taken the Trio test but have high methane 41-79 and low H2

[@candacekerr4139]

I have SIBO and LPR. If you fix SIBO, can that help with LPR?

[@Pdk764]

I had both. LPR is terrible. I went on an omad diet (one meal a day) I cut out all processed sugar,white bread,cakes etc etc. I ate a whole good diet. Doing this allowed my body time to rest and digest. I have slow motility so my body needed this time so that the mmc was able to “clean” its self each time. Omad NOT Obad (one buffet a day) Do this for life but it will start to work in 3 weeks or less if you truly follow it. I ate organic fruit, maple syrup and honey on this diet and had no problems. My cavity also healed.

[@moondrop3013]

@@Pdk764Did eating OMAD heal the LPR?

[@prashant8264]

Neomycin is not available in my country 😟 Any alternative to neomycin in case of methane dominant SIBO

[@nonenone6357]

Allicin from allimax

[@ReallifeRyn]

Neomycin, in canada is not available either but METRONIDAZOLE (Flagyl) is!! Its the same. Ask for Metronidazole 500mg 3Xday for 14 days

[@lisacoleman4226]

Does he study gastritis?

[@nutrihealthaura]

I have that. And in my case, it's caused by bile reflux. It's a nightmare.