An Outlook on Biotechnology with Sam Kulkarni, CEO CRISPR Therapeutics

Today, 20 years after we sequenced the first human genome, we’re starting to see the fruits of genomics. Instead of treating symptoms, researchers are focused on finding cures for once chronic and fatal diseases. We’re starting to reimagine medicine in ways previously thought impossible. This week on the For Your Innovation Podcast, we’re joined by Dr. Samarth Kulkarni, Chief Executive Officer of CRISPR Therapeutics. Sam joined CRISPR in early 2015 as Chief Business Officer. Two years later, in 2017, he was appointed to CEO. In addition to his expertise in biotech strategy and operations, Sam has spearheaded initiatives in personalized medicine, immunotherapy, and other therapeutic technologies. In today’s episode, we’re also joined by ARK’s CEO/ CIO, Cathie Wood, who helps provides her insights on macrotrends currently affecting the biotech industry as we come out of last week’s J.P. Morgan Health Care conference. Tune in to hear more on costs of genomic therapies, AI integration, and why Sam believes the “roaring twenties” of biotech may be on the horizon.
Key Points From This Episode:
• Why today is an exciting time for biotech
• Why Cathie believes macro factors, such as fears of inflation and valuations, are determining the present course of genomics companies
• Innovations and Improvements emerging in the biomedical innovation space
• The importance of former iterations of patented CRISPR-Cas9 for future treatments
• Will the timeline for advancing drugs to market shrink with time?
• Potential gene-editing developments in the near future - including the balance of ex vivo and in vivo
• The possibilities of what it will take to expand human life, while also treating rare diseases
• Sam on why having a capital base for sustainable funding could lead to better long term effects
• Moonshot Ideas and the next 10 years
Tweetables:
“Every pharma company will have to have a cell gene therapy unit otherwise you risk being left behind” - @CrisprSam
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[@s.s.4916]

He is an wonderful CEO, he explains things very clearly and avoids unnecessary jargon so that ordinary viewers can understand what these companies are doing. This proves his credibility unlike many other professionals who just talk around questions and never really give clear answer. I am gonna collect some CRSP during this dip.

[@HassanWorld]

He is amazing.💫

[@RJZII]

THIS WAS A SUPERB INTERVIEW WITH SAMARTH KULKARNI. I HAVE WATCHED IT 2X NOW. BEST INTERVIEW HE HAS GIVEN (ALL HIS PRESENTATIONS HAVE BEEN GREAT). THANK YOU

[@mushroomthump]

Perspective on point. Very inspiring, I could listen them talk all day. Cathy is amazing, first time hearing Sam, also very impressive.

[@jeetjoshi1543]

This discussion has taught me so much about bio-tech investing. Great questions from the host, Ali.

[@libertysprings2244]

Finally a good time to buy arkk. I also bought some Roku and Zm individually since it seems like the bubblish phase is past.

[@mattyfatstaxs]

Every interview I watch of Samarth, I leave impressed. He’s very understated in how good he is at being a biotech Ceo.

[@sergiiloskutov]

Thank you Ali, Sam & Cathie for an amazing interview! Very informative.

[@davidanalyst671]

no, its not informative. Sam was daydreaming through the entire interview. Go watch an interview of an actual drug company. Moderna is knocking it out of the park. When you ask him what his drug pipeline is, he gives you a straightforward answer instead of changing the subject 3 times

[@HassanWorld]

Great interview it was!!! ❣

[@robertfrank6058]

Ali you did a great job! Keep up the good work! You are awesome!

[@RJZII]

I would love to see an interview with Dr Emmanuelle Charpentier. We never see enough of her

[@santomenon3689]

Fabulous . Disruptive and thanking you for thinking out loud for humanity's sake.

[@MADMAX7330]

This is gold!

[@dannie6958]

This interview was absolutely brilliant

[@Adam-uz3hj]

Great interview

[@Nuninecko]

There should be software to level the voice of every speaker to the same level, to avoid the listener being so dynamic with the volume buttons all the time :)

[@jameserickson1330]

It’s called a compressor. The uploader would have to apply it to the audio though and tweak it to taste.

[@peteemond7611]

Nice overview of how CRISPR could disrupt the pharma sector. The IP and Regulatory process components of the puzzle could possibly outweigh target identification/therapy development as time to market and valuation drivers. Although they have their own issues,AgTech and VetTech might be worth considering as side plays with lower regulatory hurdles.

[@RJZII]

SAMARTH KULKARNI IS AN OUTSTANDING CEO.

[@andy-for-real]

Very smooth interview flow with lots of good questions from Ali. I can see the preparation and passion she has, which helped to induce such a good interview with Sam. I saw this multiple times, lots of gold esp things that Sam didn't talk about during other interviews or conferences. Again, really good preparation from Ali, thank ARK for such a great interview.

[@andy-for-real]

I found gold in areas such as: 1) the use of AI and op tactics which lead to ROIC in manufacture and screening efficiency. 2) future landscape (in- vs ex- vivo; proportion of gene; role of small molecules, regen med etc) 3) framework used ie. evolving tech through learning and iterations --- next gen Areas I would love Ali to help investors to dig deeper esp potential risks: 1) reason of Tony's rather sudden departure, and any impact to timelines 2) competitiveness eg. any base editor, new cas, tapping AI via partnership eg. Insitro, Exscientia, Schrodinger etc 3) patent battle risk eg. impact of losing fundamental patents; what if losing all outstanding patent cases

[@sepehrjelveh414]

Great Interview 💯 ThankYou 🙏🏼

[@joeyherman3841]

Thank you

[@aliciabutler9049]

Thanks so much for this wealth of information on Crispr..

[@HassanWorld]

If you want more information on CRISPR, just check our channel Alicia. 🦍

[@diegooriani]

Fascinating.

[@florenciovela7570]

love spacex. We traveled to Boca Chica to the the starshing get built. & we got the S dual motor fsd last Christmas 🎄 😎 still have the cybertruck tri motor or 4 motor fsd on order, i got lots of solar & backup battery system to charge them both. love tsla stock

[@Juliapak]

very cool cathie!! I work as an engineer making platform gig apps like uber, lyft etc.

[@dalongzhu4723]

smart guy indeed , good info here , ill buy some for long term

[@syrupgoblin4920]

Brilliant

[@curioussand1339]

Hopefully people are aware than only Type 1 diabetes needs treatment. Type 2 can pretty much be reversed in 14 days on diet alone. Main principle is to stay clear of sugar. This includes various kinds of natural fruit-juices.

[@96manuel96ify]

sounds hard. Better to cure it.

[@charlesrotramel4033]

Wow!

[@cameronvincent]

Watching this at midnight my time have to get up tomorrow at 5 Worth watching even if I get up late

[@901cali]

Yes. Me too

[@treyod4158]

Why? It's not time sensitive. It'll be here after work tomorrow 😂😂

[@thenewmayorofcrazytown7392]

I think Ark need to invest in something disruptive for Sam's audio.

[@glitchlife4639]

I second this

[@USGrant21st]

Cathie is a gift that keeps giving, SARK is doing great.

[@luckieoleary6459]

I like the new intro

[@Dan-is2cy]

Love Ark but fot God's sake, could you please do something about the audio? This issue has been dragged behind for so long, so hard to hear even at highest volume.

[@Artem-qx4qb]

They have invested in audio disruption technology

[@mariobnyctube]

Grab a good mike and tell us about revenue for the love of god.

[@Micro2Macr0]

Don't care what the idiots say, you're still brilliant and time will prove that.

[@jimmyitzeloconnor5238]

Getting ready for prime time. Does any one know what Halppens to a spring when it is compressed and then released?

[@tafadzwachikuvanyanga8046]

It either breaks or mooons hard

[@quantaca5773]

It makes that cartoony "boing" noise?

[@Artem-qx4qb]

it flies uncontrollably and hits you in the face

[@frankymacf]

I’d like to see another Ark discussion on genomics following the USPTO decision at the end of February

[@dannyk7733]

Hello, when can i buy the ARK ETF in Europe (Germany)? it is currently not possible 😞

[@andersstengaardjensen2208]

Hi - do you know anything about NF1? Can Crispr help reverse that condition soon? (NF: Neurofibromatosis)

[@FitWithPete]

Is there anything in the future that may be a problem for crispr tech? Things like that it wont be allowed etc?

[@tradingwithtornada123]

Love Cathy! If I may, Crsp has been taking a beating because of its lacking in obtaining consistent revenue streams. Besides, it's a method that many companies will use, so it is the ability to generate sales would dictate its future and attraction to shares holding.

[@FeroxX_Gosu]

Time to load up on the DIP!

[@glennd62]

Holding ARKK, but starting to think about does Cathy Wood compare to Gregor MacGregor? Only time will tell.

[@iamawebgeek]

This guy is so true about people seeing value in mostly bullshit nowadays

[@mushroomthump]

💯

[@somethingginterestingg4275]

Why does no one ask one of the important q? How does crispr make money

[@Rant47]

they don't know that word. investors pay for their experience and disruptions. it is not about money, it is about science. sorry bro

[@HoangAnhNguyen-sg9iv]

Thank you for your discussion. Personally I expect the growth stocks, especially biotech will hit their bottoms very soon, and after that we’ll skyrocket to the top until the end of this market cycle. Hope Ark Invest will stay strong and reassure investors to hold tight until that happens. Wish Ms. Cathie good health and many luck in the future.

[@thereisnospoon9590]

Not just "hold tight", but also buy more. It is a great opportunity. That's what I'm doing.

[@BTFD0618]

was his thoughts on Natural Drugs

[@claudiutoader9762]

I am wondering if they are using ZOOM or TEAMS :))

[@MJB0328]

She is too easily impressed and gets tilted to go all in. Concerning for her ETF investors. I believe market is teaching Cathie to do better to protect her investors. They aren’t staying after 60% haircut. It’s unheard of ETF. I say at this point you are better off investing yourself than have someone who is losing money day after day for over a year now. For example her average in TDOC is 170. Go buy it now for 75-6. And hold.

[@seek3n]

Didn't ark got out of crisper? Or was it ilmn

[@marktaylor3921]

I can hear Cathie but i cannot hear him, turn up the volume!

[@andrebudiman4506]

Down down down down down

[@sloshy13]

Can anyone see which books are behind Ali? Ali, if you see this, I’d love to ask if you could recommend books to better understand genomics

[@vancouverlife1]

Maybe take a screen grab and zoom the image?

[@HassanWorld]

Ask her on Twitter haha, or I will for you.

[@george6977]

👍

[@advocationx9663]

Amazing strategist Cathy Woods is. I would marry Intellect and intelligence. Not to mention the remainder for obvious reasoning

[@advocationx9663]

Looks like a bot has infiltrated with WApp invitations

[@faxian12]

Volume Up please :)

[@kalidasa_in]

The low audio volume is off-putting.

[@juneribaldi7093]

Yes Thank you all Great interview on Biotech There's a private company. Out of Maryland called American Gene Technologies Making Big Progress on there HIV cure program. GENE THERAPY There just about to wrap up Phase 1 clinical. Trail Data looking very impressive . I'd love to see if anyone here is invested with them?. Or plan to ? There CEO name is Jeff Calvin. He's VERY dedicated My question to. Sam how much longer once you take a dive into there company would you estimate before they go to market . . Sam &Cathy. Do you believe there company evulation is correct? Appreciate. A response @your convenience this year Stay Blessed 1 and All.

[@XtechnoPOLAKX]

No audio. Works great

[@MADMAX7330]

I had to restart KZbin to get audio

[@BTFD0618]

Pumping ur bags again

[@djbowler3333]

Okay. Robotics. Energy storage. AI. Block chain. Fine. But MRNA and Crisper and Drug development take SOOOOO long. And my son has Cystic Fibrosis. So, I know the value of Vertex Pharmaceuticals. Trikafta is a miracle. But it took FOREVER. And the average retail investor doesn't have a 20 year time line

[@Kenny-tl7ir]

How about Ark Invest in Sam’s microphone

[@goldnutter412]

OK;LG :)

[@hectormercado2206]

No Stream.

[@DeezNuts-zy5ci]

I’m really puzzled why Cathie says their stock must rally just because they are having breakthroughs in their technology and that it was at the same levels in 2018. Have you ever thought that it was massively overpriced back in 2018?? The stock is not even profitable and has no clear path to profitability , why should it be higher than where it is priced now, just because it was at this level 3 years ago??

[@twong6531]

The share price is down 70% down CRISPR! from January 2021...holy me

[@somethingginterestingg4275]

People forget that if you're down 80%, you need a 400% rally just to break even

[@switzerland]

@@somethingginterestingg4275 oops

[@sanslash18121992]

Take action immediately by giving out a clarification post or people will lose their money , there are dozens channels naming themselves ark invest..

[@todsharigian9877]

Ok

[@cb4354]

I'll be shorting ARKK

[@98riviera]

He skipped over pricing...

[@williamdiggs7881]

Oh my miss Ali. I'm getting a macro trend right now.

[@dennisp7689]

When are you all allowed to go short?

[@ethair8975]

that sam guy is legit

[@afonsomanu]

Unlike regular tech, bio-tech innovation will not be able to generate revenues on an ongoing basis as the technology continues to evolve. Apple for example was able to release the first iPhone, sell it, work in the background on the second and so forth, knowing most of those initial customers would be back for more next year and then some. This is fantastic business. We see first gen, second gen, crispr but at the end of the day we will need to wait for the ‘iPhone 10’ equivalent before crispr becomes a commercial product. This is beautiful, I’m invested, but let’s stop using tech as a catch all Goldilocks term. Everything in our world was tech at one stage. Not everything is a great iterative business model.

[@vbzstealth8667]

Wen Moon??

[@FeroxX_Gosu]

When Lambo?

[@Agent77X]

No curses to boost any ArkG shares! Cruspr share which I purchase in high $190s is around $65! I do not anymore $ to average down anymore! 😫

[@somethingginterestingg4275]

You only need a 300% rally to break-even don't sweat it 😅 pretty much the same with her whole fund. Im here with you though. Down 40% on her arkg fund. Will need practically a 100% rally to break even. I love her perspective and thesis but Christ has her timing and buy-prices been awful.

[@normalizedaudio2481]

Look how nice the office is. They spend a lot on their own comfort.

[@treyod4158]

Wow. So your whole takeaway from this informative interview is that they have nice offices😂😂Please don't waste your money in investing, you have no idea

[@Jigsawmaster1]

@@treyod4158 lmao 🤣

[@TheKanjina.MooreFamily]

@@treyod4158 I know right. When people think small, they will stay small.

[@MrSensis]

What pharma needs, is a boosterdose of responsibility.

[@linusleblanc6348]

Hopefully the ARK funds will rebound after being obliterated lately.

[@hanssocaciu2837]

Great stuff. Sam would make a great college professor, but not a good businessman. There is no fire in his belly for the future prospects of the company. Would have liked to see some excitement (!)

[@96manuel96ify]

did u even watch the podcast?

[@o.m.kaya-ozturk1091]

I understand what you mean. Sam should be more bold in his statements.

[@96manuel96ify]

@@o.m.kaya-ozturk1091 He said that "our goal is to become a multi hundred if not a trillion dollar company" If that isn't bold i dont know what is

[@Thebt7]

Think people are so use to the over hyped CEOs of this world. Bear in mind that we are still recovering from the Theranos saga, so not having a CEO over hype is actually the best sign as an investor. The fact that he is willingly to build the company systematically without the hype is the best buy signal for the long term.

[@XtechnoPOLAKX]

Good thing I can read lips

[@ryangosha644]

volume low from the other guy

[@johnd01]

Is there a chance that this technology could be effective for diabetics? Millions of dollars could be saved if there was a fix for diabetics.

[@tabottietjen3186]

Yes, please cure type 1. It would be a game changer for millions o fpeople!

[@96manuel96ify]

Crispr Therapeutics are working on curing diabetes. Type 1 as a starter

[@johnd01]

@@tabottietjen3186 Even if they only cured type 2 the medical costs nationwide would be greatly reduced.

[@gaseousclay6126]

Pipe dreams. Not proven. Error rate is high. Unstable base pairs.

[@HassanWorld]

My two questions: how did we get to 120 patients dosed (which program has how many, etc.), and can we expand on the heart disease portion? This is the first time I believe $CRSP is mentioning the two.

[@benharris8335]

CTX001 has had 40 patients dosed ( data provided on 22 ) - CTX110 had 26 and I assume that will be a similar number for 120 & 130 which gets you to circa 120.

[@HassanWorld]

@@benharris8335 Wait each Car-T program has over 25 patients? Can you confirm this?

[@cmhwilder]

still crashing and burning in the premarket....just fyi

[@reggie888s]

sort your sound levels out ffs

[@petergunn9603]

Could CRISPR be used to scramble not repairing the mitochondrial DNA of cancer cells to cure cancer? Essentially starving the cancer cell.

[@rreagan007]

I'm invested in ARK funds, but there is no easy way to say this. All of the ARK funds have crashed catastrophically. When your funds are all down 50%, 60%, or 70% from their highs less than a year ago, it's really, really bad, especially when the S&P 500 is only down 4.5% from its all-time high. The goal of any good asset manager isn't just to make the highest return possible, it's to make good returns in a consistent way and to avoid catastrophic collapses in value like we have seen in ARK funds.

[@JR-wm5ny]

buy some index fund, ARK is not for you, sell all your shares to us

[@somethingginterestingg4275]

@@NomzWithDarren volatile barely explains this though. She' getting closer to losing all the gains since covid started. I love her perspective. But her timing on buying stocks has been horrific. A good portion of her stocks are down 50-80% from highs. Idt people realise that if you have a stock down 80%, you need a 400% rally just to break even. And I don't see any slowing down of her fund decreasing in value. Maybe her timing is just off. But without tesla, her whole funds would be destroyed rn.

[@somethingginterestingg4275]

@@NomzWithDarren it hasn't outperformed the sp500 over the past 5 years by a lot

[@Michellelevy18]

It is discouraging to be so down. I have lost a lot in ark funds on paper. Hopefully she will be right and in five years we will have earned a lot. I would have liked to avoid catastrophic losses too, I think that is a reasonable ask.

[@DeezNuts-zy5ci]

@@NomzWithDarren by a lot? Sorry to burst your bubble. Did you know, since the covid crash, ark and snp are at exactly the same returns?

[@olyguy2000]

Crisper has a great mission, but it lost more than half its value in 2021. A looooooong term hold.

[@USGrant21st]

That's how a short term speculation turns into a long-term investment. 😂

[@Agent77X]

I cannot wait to breakeven and cash out!😀

[@spootnik00]

$SARK! haha

[@paulgurnett7605]

LOL everyone getting Annoyed with Cathy wood. All growth is down …wait …wish I bought lower though tbf. DCA

[@ChristianHedman]

Can barely hear that guy unfortunately

[@wallstreetmikey]

Bionano genomics!!!

[@lapju7538]

🙌🙌🙌 diamond hand bngo

[@sembiotic3468]

Lmao rekt

[@P__114]

Lol ARK. Used to be credible and then bought $HOOD. Anyone trusting the ARO team after that is foolish.

[@user-tx9zg5mz5p]

There's no money in cures...

[@work41]

buy $SABS instead = = in Operation Warp Speed

[@Zk8et]

Grandma cathie PLEASE stop buying $HOOD vlad is making you look bad. 😂😂😂

[@sumitagg1]

Sam has no idea about how companies are valued and should keep his mouth shut. Valuation is company agnostic. It is simply the present value of all future cash flows. Apple has generated more cash over the past 10 years and is going to grow even more in the next 10 years than crispr or any pharma company. Cathy, you should know better. This is such a bad interview and i wonder if it truly represents how Cathy really thinks.

[@olegprytula2881]

Farma is corrupt

[@seltenfotog3115]

Watched this and saw what a silly investment this is. What I see is man trying to control God's invention and investment (he gave his only son). Crsp is an impossible rabbit hole investment and this salesman knows it. Waste your money on the "hope" that man will figure out their impossible mission if you want to, but for this reasom (hope rabbit hole).....I'm out.

[@Thebt7]

Think you need to find a specific fund for your beliefs. The entire industry is not only Sam btw.