ANCA Vasculitis Pathophysiology

Grab your GOODIES here:
kristeenbarker...

[@debigdogk9563]

Always feels good to watch your teachings. Thank you 🙏🏾 for teaching and sharing ❤❤❤❤

[@kristeenbarker]

Yay! Thank you so much for tuning in! I've been working on some scripts for more immunology the war is over tutorials....hopefully this will be right up your street! Cannot wait to share :) And of course any content suggestions most welcome! Hope you have a great week

[@fendaadita3770]

Anca vasculitis made easy by kristeen 😍😍😍

[@kristeenbarker]

I'm so excited you found it helpful! :) Please let me know if there's anything else you'd like me to cover on here. Happy studies!

[@hanyelghazaly1506]

Thank you very much , however I have some questions if you please Why does ANCA associated vasculitis be restricted to small vessels ? Why there is a tendancy for granuloma formation in GPA while in MPA there is not ?

[@FoodieForce]

Great way to explain. What I am struggling to understand can you have a positive ANCA and weak positive MPO but when Elia is done the MPO is normal. Does this still mean MPA vasculitis is possible? 🤯

[@kristeenbarker]

This is a GREAT QUESTION. So like you say there are 2 tests for ANCA. There is an immunoflourescence test where they take healthy neutrophils and add the patient's serum and then the fluorescent marker to see if there is an anti-neutrophilic antibody present. So it's kind of like looking inside the cell at where the staining is cytoplasm/perinuclear for c-ANCA, p-ANCA. And it just means there is an antibody to some part of the neutrophil...but it's non specific. And this can happen in LOTS of autoimmune diseases and doesn't necessarily mean you have ANCA vasculitis. But the specific antibody testing for MPO and PR3 are much more helpful and will have an antibody titre value attached to them and generally point towards ANCA vasculitis. However in saying that 10% of patients with ANCA vasculitis do not have a detectable antibody at all! So in reply to your question i would say that when you have the positive ANCA but the negative MPO specific antibody that is very non specific and not diagnostic of ANCA vasculitis. Equally you can have ANCA with no detectable antibody...so it's always about taking the full picture into consideration and seeking a biopsy diagnosis where we can. I hope that answers your question.

[@ا.د.وفاءجابر]

You laugh too much ,,,