Anti Neutrophilic Cytoplasmic Antibodies (ANCA)

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This is different from antinuclear antibodies (ANA) which are antibodies against the nucleus.
Anti-neutrophilic cytoplasmic antibodies (ANCA) have several patterns; the most important two being the cytoplasmic ANCA (c-ANCA) and the perinuclear ANCA (p-ANCA).
Anti-neutrophilic cytoplasmic antibodies (ANCA) are associated with vasculitis, such as granulomatosis with polyangiitis (Wegener granulomatosis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), rapidly-progressive glomerulonephritis (RPGN), anti-glomerular basement membrane antibodies (ant-GBM or Goodpasture's syndrome), as well as inflammatory bowel disease-associated. vasculitis.
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In brief, Anti-neutrophilic cytoplasmic antibodies (ANCA) are IgG autoantibodies against the cytoplasm of the neutrophils and monocytes​ and are associated with vasculitis, but they don't correlate with disease activity or symptoms. If you like my videos, please consider leaving a tip at www.paypal.me/...
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[@MedicosisPerfectionalis]

My dad is.

[@catherinerivera6646]

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[@susmitabasu8751]

There are very few videos which ends and i am like,"What? Already?" Thank you for such great teaching.😍

[@hamiswael2993]

I’m a lab tech and still needed this though, as I hate doing anything without a proper background 🥲. Thank you, your explanation is great ✨

[@MedicosisPerfectionalis]

I appreciate you!

[@aravindsondur2379]

Your sense of humor is awesome!!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@tamilspeaker2507]

Man your roast at 12:03 is phenomenal . You are really know how to make learning fun

[@MedicosisPerfectionalis]

I appreciate you!

[@SpiralDesignWorks]

A family member was diagnosed with ANCA today. I really appreciate the explanation.

[@MedicosisPerfectionalis]

Thanks 🙏 How is he/she doing?

[@exatiqurrahman3116]

My Dad's diagnosed with this. How did it go for your family member?

[@turtguyakadanz]

Your lectures are always hilarious but also informative haha, love them. The shade at those watching TV LOL, golden.

[@MedicosisPerfectionalis]

Thank you!

[@DrAzadSingh]

U r just too good man. A fan of ur style of explaining things with ease. 👍👍👍👍

[@Simp_medicine]

Feels like a friend teaching me!!

[@MedicosisPerfectionalis]

Haha 😂 Thank you ☺️

[@TarsalMule]

Its really interesting to learn about the process behind my disease. I have Granulomatosis with polyangiitis (Wegeners disease). I only wish they knew the real cause of it cause that really interests me most. Whether I was always a ticking timebomb ready to blow or some infection just caused my body to mess up so badly. Appreciate the video though I learned quite a bit

[@MedicosisPerfectionalis]

Thank you! Best of luck to you!

[@meskes4059]

That, my friend, is indeed the million dollar question

[@ScottieBibble]

I’m only here to find out what p-ANCA and MPO meant - I now know it’s the same thing and it showed up on my vasculitis (UV or HUV - not sure which one yet) testing! You are hilarious and even though I have NO medical background, I get it (kinda but that’s only because there are other things I’d need to research to see the whole picture)

[@MedicosisPerfectionalis]

Awesome 👏 Thank you so much for your encouragement. I wish you the best of luck!

[@ScottieBibble]

Medicosis Perfectionalis thank you! I am going to binge watch all your relevant videos in the morning lol

[@faizankhan-jp2my]

How does antibodies going inside a well maintained cell wall of neutrophils??

[@VeLaBella28]

you crack me up! love these videos so helpful!

[@MedicosisPerfectionalis]

Thank you so much!

[@jerrymj]

Excellent way of making things clear

[@MedicosisPerfectionalis]

Thanks 🙏

[@poscardo]

Hahaha plural of pancreas , you are so funny AND smart !Love your videos

[@MedicosisPerfectionalis]

Thank you so much 😊 Can you please help me by sharing?

[@anomalyp8584]

I truly don't get this...HOW is a medical professor not able to explain this stuff in 1+ hour, while you do the job in 13 minutes.

[@MedicosisPerfectionalis]

Thank you so much 😊 Would you please help me by sharing?

[@anomalyp8584]

@@MedicosisPerfectionalis will do

[@shosho-349]

Lab technician is also a doctor and without him u r nothing All my respect

[@hello-jc2eq]

Sir, love your teaching... You are fabulous 🤩🤩🤩 especially, your taunts of "you idiot!!" feels like we are attending live class

[@milaersoz3250]

Sarcastic narrative style...!!!😈😈😈 Love it .....!!! 🤟🤙🤟

[@MedicosisPerfectionalis]

Thank you 🙏

[@kadiryazc7451]

Your explanation is awesome ! Im really enjoyed. Thanks!

[@MedicosisPerfectionalis]

My pleasure 😇

[@shuvoislam8104]

Unbelievably brilliant bro

[@MedicosisPerfectionalis]

Thank you so much 😊

[@moonyeenjanncasera-balic4498]

Thank you so much, learning a lot and fast!:)

[@MedicosisPerfectionalis]

My pleasure 😇

[@juansgb99]

thank you is very clear!!

[@MedicosisPerfectionalis]

My pleasure!

[@davidmbeckmann]

Very good and nicely done!

[@rm5127]

Nurses do too like you..I know because I'm a nurse and I like you.

[@MedicosisPerfectionalis]

I appreciate you so much!

[@pratibha6693]

After seeing your video I feel both smart and "idiot" haha

[@MedicosisPerfectionalis]

I was joking 🙃

[@4489005]

Hahaha not to be confused with Inca. Amazing stuff and the diss against lab technicians and pharmacists.

[@MedicosisPerfectionalis]

Thank you 😊

[@emanuele2398]

Thank you very much

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@nabilakhan5771]

Awesome lecturer 😁

[@MedicosisPerfectionalis]

Thank you 😊

[@sarahyousef9204]

amazing thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@batoolqassim9715]

Thanks!! 🙊

[@MedicosisPerfectionalis]

My pleasure 😇

[@TheUlumpa]

Lifesaver as always ❤

[@MedicosisPerfectionalis]

Thank you!

[@ladyhawk464]

Lol... I was watching 📺 😂😂😂😂 and the video at the same time

[@MedicosisPerfectionalis]

:)

[@fakhriakakar1867]

Don’t say rubbish about lab scientist, without them the clinicians are blind!

[@MedicosisPerfectionalis]

I agree..I was simply joking :)

[@fakhriakakar1867]

@@MedicosisPerfectionalis I know you were joking :) but I couldn't help myself!

[@TheAyyoub93]

Does having p-anca and c-anca in the blood(low titer) mean you have vasculitis or they need to be higher then 1:80(positive) to be consider positive thank you .

[@MedicosisPerfectionalis]

They need to be positive. BTW, There is no lab test with 100% accuracy. Talk to your doctor, please!

[@ItsMe-jr6kd]

thanks a ton the egyptian doctor 💪🎩😍

[@MedicosisPerfectionalis]

My pleasure!

[@xyuilo]

Hi, i have ASCA IgA, IgG positive , said also slightly positive. Do i have a crohn? I had deep veins thrombosis after covid vacc. And once lupus positive of two taken - second neg. I have problems in abdominal zone😢

[@noorahmed6811]

Thank you great teacherrr🌻

[@MedicosisPerfectionalis]

Thank you 🙏

[@andrewfletcher2213]

“The letter “C” is the third letter in the alphabet. “3” is the third number in, I dunno, the numerobit? “ Laughed pretty hard at that one while learning about tests I’m getting done.

[@jeanetteraichel8299]

I tested positive in July for cANCA, PR3 negative and now test negative. The ELISA test isn't listed as being done, only immunouorescence....I'm confused is there a high false positive/negative?

[@bluesquirrel2472]

Thank you

[@MedicosisPerfectionalis]

Thank you so much for your comment 🙏

[@touseefbeig915]

Nice

[@MedicosisPerfectionalis]

Thank you!

[@finalfuk779]

Please make video about ASCA

[@MedicosisPerfectionalis]

In GIT

[@islamfazle_rabbi3193]

give me the full serial of rheumatogy lecture

[@yourwellbeing95]

Excellent

[@MedicosisPerfectionalis]

Thank you!

[@alfiosampieri3140]

Great ! Tnks 🙌

[@meenakshithind2656]

Can anyone tell me in which book i can get this aal

[@MedicosisPerfectionalis]

I am sorry I didn’t understand your question!

[@akshaybn97]

Bravo

[@MedicosisPerfectionalis]

👏

[@arwasaleh9745]

My was positive and 180 is that bad my doctor won’t get back too am panicking please let me know Thankyou

[@MedicosisPerfectionalis]

What was the reference range in your lab?

[@arwasaleh9745]

140

[@arwasaleh9745]

And Thankyou for replyin

[@MedicosisPerfectionalis]

I don’t know 🤷‍♂️ A single lab test doesn’t mean anything in its own. It has to be taken into consideration while analyzing the results of the history, physical exam, and other labs.

[@shaneandoy5087]

How about having 80% of eosinophils?

[@laanaalove]

Parasites

[@pixeluser175]

Can it be a fully healthy person is ANCA positive?

[@MedicosisPerfectionalis]

It’s possible.

[@pixeluser175]

@@MedicosisPerfectionalis Thank you. I am tested positive. But ANA negative, no further action.

[@MedicosisPerfectionalis]

That’s for your physician and you to determine based on your symptoms, physical exam, and other diagnostic investigation modalities. Good luck!

[@castrodagoat5842]

what medical specialty does medicosis do?

[@MedicosisPerfectionalis]

Medicosis doesn’t :)

[@laanaalove]

​what????????? Are you just a professor then?

[@fighterforever1897]

Great......

[@MedicosisPerfectionalis]

Thank you 🙏

[@user-ps3sj4zt2i]

Missing your insults ❤

[@fraserbetley9633]

Great!

[@MedicosisPerfectionalis]

Thanks 😊

[@alanwaterman1328]

So CRP is a crap diagnostic test.

[@rebel0086]

wow

[@MedicosisPerfectionalis]

Thanks 🙏

[@user-yy6er4ok8b]

Under estimation of lab technician is not cool tho . They are a scientist also they have their role .

[@ChiefsBulls587]

Don't take shots at our pharmacists! They'll save your ass.

[@MedicosisPerfectionalis]

😁😁😂

[@miguelmaturana8757]

Your lectures are great but you should stop using unnecessary words such as “idiot”, “stupid”, “freaking”, etc

[@MedicosisPerfectionalis]

Thanks for your honest feedback!

[@bughesamiombu2909]

It makes his lectures unique . If you don't like it don't watch but you are entitled to your opinion

[@meskes4059]

Sounds like he got your attention on that particular bit by using those words, which means his tactic worked. I say he keep on keeping on.

[@codrut913]

[@MedicosisPerfectionalis]

:)

[@omrherdan1643]

Nice

[@MedicosisPerfectionalis]

Thank you 🙏