Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination.
This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals.
Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode: ai.hubermanlab.com/s/NOL4NN0X
Thank you to our sponsors
AG1: drinkag1.com/huberman
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Levels: levels.link/huberman
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Social & Website
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Journal Articles
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth: bit.ly/3TYHRoB
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing: bit.ly/3xcwRLc
Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway: go.nature.com/43DYYz2
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing: bit.ly/3J0sS77
Insulin-like growth factor 1 (IGF-1): a growth hormone: bit.ly/43WpDaN
MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism1: bit.ly/3PInRnA
Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure: bit.ly/3PJKrfB
Kisspeptin signalling and its roles in humans: bit.ly/4cBfMeh
Age-Related Changes of the Pineal Gland in Humans: A Digital Anatomo-Histological Morphometric Study on Autopsy Cases with Comparison to Predigital-Era Studies: bit.ly/3TGYzHv
Huberman Lab Episodes Mentioned
Dr. Natalie Crawford: Female Hormone Health, Fertility & Vitality: www.hubermanlab.com/episode/d...
Dr. Michael Eisenberg: Improving Male Sexual Health, Function & Fertility: www.hubermanlab.com/episode/d...
The Science of How to Optimize Testosterone & Estrogen: www.hubermanlab.com/episode/t...
Timestamps
00:00:00 Peptides
00:03:20 Sponsors: Mateína, Levels & Joovv
00:07:44 What is a Peptide?, Effects
00:12:06 Peptide Sourcing, Lipopolysaccharide (LPS)
00:14:48 Rejuvenation & Tissue Repair: BPC-157, Angiogenesis
00:21:50 BPC-157 & Tissue Injury; Mode of Delivery
00:27:53 BPC-157: Safety, Doses, Cycling, Tumor Risk
00:35:16 Sponsor: AG1
00:36:43 Tissue Repair: Thymosin Beta-4, TB-500
00:40:49 Growth & Metabolism: Growth Hormone, IGF-1, Risks
00:45:25 Secretagogues, Sermorelin, Tesamorelin, CJC-1295
00:52:21 Sponsor: LMNT
00:53:44 Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing
00:58:69 Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing
01:06:12 Longevity: Thymosin Beta-4, Epitalon (Epithalon)
01:12:09 Vitality: Melanotan, PT-141 (Vyleesi), Risks
01:17:21 Vitality: Kisspeptin
01:21:46 Peptides, Potential Benefits, Side-Effects & Risks
01:24:19 Zero-Cost Support, Spotify & Apple Reviews, Sponsors, KZbin Feedback, Momentous, Social Media, Neural Network Newsletter
#HubermanLab #Science #Health
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: www.hubermanlab.com/disclaimer

[@tapeshark]

I'm 42, have been prescribed benzos for insomnia since 14. my life was falling apart. Your first 3 episodes on sleep allowed me to fix a life long problem in days. No drugs, no benzos, its been 3 years. You saved me from the depths of insanity. I have recommended you to countless friends and will continue to do so. I owe you a debt of gratitude. Thank you.

[@monicasomesan2432]

I'm glad yo hear you had such a success story! I was wondering is there is something in particular that you feel was most helpful

[@tapeshark]

@@monicasomesan2432 Yes, it simply came down to getting sunlight in the morning before 8am and evening before sunset. This reset my circadian rhythm, my life hasn't been the same since, I have gone from dysfunctional to achieving so much in such a short time.

[@tapeshark]

@@monicasomesan2432 Absolutely! Getting sunlight before 8am and then getting light into my eyes during sunset. This was a game changer and effectively reset my circadian rhythm within days. I've always been on the computer until late at night / early morning. For the first week I didn't use my PC after 7pm and got to bed by 10pm. Since that first week I have never had an issue with sleep again. I can work until late at night / early morning on my PC and so long as get light in my eyes in the morning and evening on most days I never have sleep issues. Its sounds ridiculously simple and it was. The experience left me with complete disdain for the pharmaceutical industry, I can't count the number of drugs I have been prescribed for issues related to the problem both directly and peripherally. I take no need for any drugs anymore. I can see why they want to destroy this man and its disgraceful. He has lifted the vice like grip of big pharma on my life and countless others.

[@tapeshark]

@@monicasomesan2432 I've tried posting a response to this question 4 times. For some reason it keeps getting deleted after a few minutes. I apologise if you see multiple responses. To answer your question; get sunlight in your eyes first thing in the morning, preferably before 8am then do the same at sunset. It sounds so simple. It is. This practice reset my circadian rhythm. I have not had sleep issues since. Good luck.

[@wesley16057]

Same story for me minus the benzos

[@Sandy-of6gq]

Omg to see research on BPC-157 from my little ol med school from Croatia quoted on Huberman .... I'm having a moment lol

[@ivanzizic3209]

Os mi poslat link za tu studiju?

[@CopyVic]

🇭🇷

[@dameanvil]

00:14 🧬 Peptides are gaining attention for therapeutic use, beyond GLP1 analogues, focusing on tissue healing, longevity, and vitality. 02:32 💊 Peptides are categorized into prescription, gray market, and black market, with safety concerns increasing outside prescription use. 07:50 🧪 Peptides are small proteins made of amino acid chains, often exhibiting pleiotropic effects, influencing various cellular processes. 11:07 🧠 Therapeutic peptides rarely have single-target effects, commonly affecting multiple pathways and cell types. 14:34 🚑 It's crucial to obtain therapeutic peptides through a board-certified physician to ensure safety and efficacy, avoiding risks associated with gray and black market sources. 15:02 ⚕ Therapeutic peptides can be utilized for tissue rejuvenation and repair, impacting muscle, connective tissue, and gut health. 21:38 💪 BPC-157, a therapeutic peptide, promotes tissue repair through stimulating angiogenesis, encouraging fibroblast migration and growth, aiding in injury recovery. 22:20 🩺 Gastric juices historically used for tissue preservation and repair, even in gruesome scenarios like preserving severed fingers. 23:44 🧪 BPC-157, a peptide compound found in gastric juices, shows promise in tissue preservation and rejuvenation, but its mechanism of action outside the gut remains somewhat mysterious. 26:17 ⚠ Limited human clinical studies on BPC-157 make its effectiveness and optimal delivery method uncertain, despite anecdotal evidence and animal studies suggesting potential benefits for tissue repair. 28:48 💊 BPC-157 has a high safety profile, but caution is advised due to potential tumor growth risks associated with its mechanism of action involving upregulation of growth hormone receptors. 32:16 🚫 BPC-157 may pose risks for individuals with tumors due to its promotion of angiogenesis and vascular growth, potentially accelerating tumor growth. 36:53 💉 Thymosin beta-4 (TB-500) and thymosin beta-4 (Tβ4) are peptides gaining attention for tissue rejuvenation and repair, particularly in conjunction with BPC-157, but their efficacy in humans remains uncertain without clinical trials. 41:04 💪 Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) play crucial roles in metabolism, muscle growth, fat loss, and overall vitality, with GH secretion decreasing with age. 44:02 💉 Growth hormone and IGF-1 have various effects related to youthfulness, vitality, and energy, but indiscriminate growth may pose risks like tumor growth. 47:07 🏥 Category one peptides, such as CJC-1295, tesamorelin, and sermorelin, are FDA-approved and more thoroughly tested in humans for stimulating growth hormone release. 49:13 💤 Side effects of peptides like tesamorelin may include altering sleep patterns, potentially reducing REM sleep. 53:54 💊 Type two peptides, like ipamorelin and hexarelin, increase growth hormone release by mimicking or stimulating ghrelin, which can also increase hunger and anxiety. 56:41 ⚠ Hexarelin, while potent at increasing growthhormone, can lead to receptor desensitization and other adverse effects like increased prolactin levels. 01:00:38 🤝 Combining different peptides in cocktails may offer benefits but requires careful dosing and supervision by experienced healthcare providers. 01:03:52 ⚠ Augmenting the growth hormone pathway, whether by synthetic growth hormone or peptides, increases the risk of tumor growth and cancer due to the indiscriminate nature of growth hormone and IGF-1. 01:04:21 💊 Peptides like growth hormone secretagogues have potential benefits like faster injury recovery, but there's a trade-off between benefits and risks. 01:05:02 ⚠ Considerations for taking growth hormone secretagogues include age, potential tumor risks, using minimal effective dose, and assessing clinical need. 01:06:01 🧬 Peptides for longevity like Epitalon mimic naturally occurring peptides and show potential benefits in animal studies for suppressing tumor growth and adjusting circadian rhythm. 01:09:21 🌞 Peptides stimulating the melanocortin system, like Melanotan, can darken skin and potentially improve mood and libido, mimicking the effects of sunlight exposure. 01:20:55 💡 Kisspeptin peptides stimulate hormone pathways related to vitality and libido, potentially impacting mood, energy, and reproductive function, but their effects are still being researched.

[@stuartist]

What AI tool do you use to make summaries like this?

[@Max-db6hq]

Well done 👌

[@nicholaschia2304]

legend

[@seanriley5370]

❤ appreciate you

[@clasicthealchemist8076]

🐐

[@user-zj5hy5kv4w]

Dear Dr. Andrew I don't think you will read this comment, but I wanted to tell you that thanks to your videos, here in the Ukraine I am learning English and new interesting information. Thank you very much.

[@toutounr8120]

💛💙

[@exginto8053]

Putin khuilo

[@ElHolyBoy]

Slava Ukrania.

[@user-zj5hy5kv4w]

@@exginto8053 Of course)

[@user-zj5hy5kv4w]

@@ElHolyBoy Geroiam Slava!)

[@thecartoonclub7176]

Posting through like nothing happened… nothing can stop this man

[@pooroldnostradamus]

Stoic through and through

[@liviuKZ]

what happened

[@mahdman3]

🤣🤣😭💀

[@ponternal]

“If she catch me cheating I will never tell her sorry”

[@mahdman3]

​@@liviuKZ some disgruntled women online trying to shame and destroy this man. They're upset that he's not in a committed relationship with them.

[@daedra40]

This man is giving us all a World Class education right over here!

[@lenakunzx]

and can't even be honest about how he treats woman. Disgusting

[@DigiMyst]

@@lenakunzx What part of his love life do we need to learn to improve our health?

[@tired_of_everything0]

​@@lenakunzx cry about it

[@callesiren]

@@lenakunzxAnd HOW is his personal life even remotely relevant to science and his educational material?

[@rodolfoserrano3676]

​@@lenakunzx how is that???

[@seanaugust8081]

I’ve been giving my dog bpc-157 and it’s helped her tremendously. She developed digestive issues in her old age making her nauseous, stomach bloated, sometimes throwing up after eating. Since giving her bcc-157, her condition has improved dramatically. Her stomach is no longer bloated, she’s not nauseous, and hasn’t thrown up. She also doesn’t moan anymore if I pick her up.

[@dilettanter]

So cool! Glad it helped

[@joefortune]

Where and how did you get it??!!

[@seanaugust8081]

@@joefortune there are lots of sources online. I’ve used Nuscience and also Amino USA.

[@heatherhunter2223]

Thank you for this video and all of your videos. There is a reason why you created this platform… It’s needed. KEEP GOING ❤

[@shalekodemono]

Dr Huberman, thank you so much for the contributions you have made to informing and educating the public. I am a full-time student suffering from ADHD and many of your episodes have helped me manage my condition: focusing my eye sight without blinking helps me immediately regain focus, taking phosphotidyl serine has helped me with working memory, hyperactivity and executive dysfunction. I have cut down my alcohol intake, I have read the book and followed the advice of Anna Lembke, I can handle anxiety better with your breathing protocol, and I could give so many more examples of how your podcast has helped me. So thank you so much for that and THANK YOU for your interest in science 😊😊

[@a_tad_rad]

The real peptides were the friends we made along the way.

[@egibson2266]

Get out

[@Endur3..]

Real @a_tad_rad

[@namejantechao3207]

I fixed my insomnia because of your sleep protocol. Understanding why we need sunlight helped me go outside during different daytime and it definitely helped. I am not going to be budged by these so-called accusations targeting you. I understand so much about myself, my struggles, and my behaviors because of you, and can confidently say that you have changed my life in a significant way. I'm very interested in neuroscience now and if I decide to pursue my Ph.D. in NS, it will be because of you. Thank you, Mr. Huberman. I'm grateful to you.

[@missmattox5636]

I am a life-long night owl who has struggled with sleep my entire life. I have finally been able to get control of my sleep, schedule and life by following his protocols.

[@primaprimavera357]

You helped me to overcome my bad habits and I learned how to focus gratefully to your videos. Thank you for your work! Keep going. Your loyal follower, Julia.

[@jessicaballantyne7826]

Can you do an episode on the healing power of LAUGHTER? I know laughter yoga is something that improves sleep, pain and even speeds up healing. Would be great to understand what is going on in the body when we laugh :) 🙏🏼

[@pambain9415]

What a great idea!

[@theliberationstation8457]

im dealing with arthritis and chronic pain, and recently a best friend spent a few days with me and we laughed so much, my pain levels were wayyyy lower

[@Tash303]

Dr. Andrew Huberman, thank you for another info-packed episode. You are one of the greats of our time...way out in front as a scientist and teacher. Your contribution is felt around the world and it’s enormous! My health has improved so much thanks to what I have learned here. ❤️

[@olgazavilohhina6854]

¡Hola Profe! Just wanted to express my deepest gratitude for educating us every single week.Thank You for Your hard work and care for all of us.

[@pinkbug8u]

I've never heard of him till the controversy. Now I'm subscribed. Anybody that the media tries to smear I find out what they have to say. It's usually the truth or something beneficial to you. It's a good barometer for figuring out who you should listen to.

[@luminousdark0]

💯💯💯

[@nimimerkillinen]

seems very simple minded

[@KeithFlint350]

I've never heard of controversy about AH. What sort of media are you guys connected to?

[@SL-vv3xy]

Have you been living under a rock?

[@pinkbug8u]

@@nimimerkillinen looks like his fans like to insult people. lol. "Simple minded" "living under a rock". Okay cool guys. Master of intelligence. I didn't say I automatically believed them. I just said find out what they have to say. Geez Calm down. Yes you guys are superior. Feel better?

[@jackm.1628]

Dr. Huberman, could you do an episode on the most efficient learning techniques, like mind maps, interleaving, spaced repetition, etc.

[@YogaBlissDance]

He has some already on learning and mind...did you check his home page?

[@natashacro8148]

He did but not about actual method of learning

[@AndyKelch]

There’s a great book on the subject, called “Make it Stick: the Science of Successful Learning”

[@samjackson1619]

Thank you for what you do to improve people's lives! You've changed my life and countless others.

[@jonasgehrs530]

Huberman pretty much saved my live as in giving me selfguidance and effectivness after bad injury. Pretty exicited for this one. Was planning to try Oxytocin with my wife, so as always perfect timing. Thanks my man

[@loriej2687]

As usual, thanks for spreading SCIENCE for free! You’re a GOAT!

[@LNPS2]

Dr. Huberman, My kids (6 and 8 year old) and I listen to you most mornings on the way to school and work! It’s incredible how you can dissect complex topics in a way that anyone can understand. My 8 year old often repeats concepts you explain and asks me for clarification, thank you for all you do!

[@sirspongadoodle]

@@dustyoldhatthis influences his helpful information how?? The answer is it doesnt, you can get all crybaby about a character assassination or you can listen to the advice and do something genuinely useful…

[@sirspongadoodle]

@@dustyoldhatthis influences his helpful information how?? The answer is it doesnt, you can get all crybaby about a character assassination or you can listen to the advice and do something genuinely useful…

[@artix86]

You are a great parent, well done.

[@dustyoldhat]

@@sirspongadoodle see the problem is people like you who blindly trust someone you decide is infallible. It’s cult like mental behavior. Once you refuse to accept that someone has flaws that could affect their judgment, you’ll fall for anything from that person. Good luck

[@sirspongadoodle]

@@dustyoldhatin what way does my comment “blindly trust” andrew hubermen??? In truth it doesnt, however even if he were a rapist serial killer, it wouldnt mean what he is saying is any more or less true… in honesty i could care (less) what he does in his own life as if he is giving valuable information then… well, he is still giving valuable information… (Edit was the less part for some reason i forgot to add that in…)

[@awe124]

Dr. Huberman I have been taking peptides and read a book by William Seeds, MD. Your information was more granular and detailed as I’ve been taking peptides for over 1 year. I am learning something new daily especially about Sermorelin. I learned to wear my Fitbit to explore that REM decrease. I can’t thank you enough. Heck, wish I had friends like you, ha-ha. Have a good rest of your evening sir.

[@aminadepp]

Just wanted to show my support. Thanks for everything dr. Huberman! Your work is priceless!

[@user-ic1lo9wh5f]

Thank you for the work you put in to these podcasts

[@sammacnicoll4943]

You can tell when you are "bigtime" when parasites try to attach themselves to you and benefit from your achievements. I read the comments on "Rising The Hill" and EVERYONE supports you and acknowledges your great contributions to education and science. You are a powerful MAN and force for the best we can be....Respect to you Dr. Huberman, Sir.

[@Faye-el1bz]

He didn't do the research on peptides He does bring the science to our lives . He's very good at that .

[@williamtaittinger4529]

I still want the HAREM PROTOCOL

[@NotaNazgul]

@@williamtaittinger4529Give us the harem protocol! He must share it!

[@prayaanshmehta3200]

tissue repair: 21:50 BPC-157 36:43 TB-500 40:49 IGF-1 type 1 GH secreting peptides: -GHRH peptides 45:25 (“category 1”) sermorelin 47:25 tesamorelin 49:50 CJC-1295 50:39 -GHR peptides (“category 2”) 54:00 ipamorelin 54:46 hexarelin 55:40 GHRP’s 57:00 1:06:12 longevity: TB-500 epitalon 1:07:00 vitality: PT-141 1:16:15 kisspeptin 1:17:21 1:21:46 summary

[@user-ic1lo9wh5f]

When I used both bpc and tb after reconstructive shoulder surgery both my surgeon and physiotherapist had never seen such fast healing after this orthopedic procedure. I used sc injection not near the place of injury because I couldn't reach to my shoulder.

[@IanFergusonRealtor]

@@user-ic1lo9wh5f Yea, that seems to be the best duo

[@tarmon768]

Thank you

[@ruready4ou2rock]

This is so helpful

[@carljohnson850]

@@user-ic1lo9wh5f where did you buy it? i have torn my achilles tendon 4 weeks ago and i'm trying to get it right

[@brianp5555]

Just discovered this podcast. Wow what a wealth of information I feel blessed to be alive at a time when such high-quality information is so readily available. ❤

[@sorsha_sky]

Dr. Huberman, the information that you have shared over the last few years has improved my life in countless ways. What you do in your personal life doesn’t change that.

[@dustyoldhat]

It’s just about his “personal life” it’s also the fact he has stretched the truth about his lab. Read the article.

[@ghostrecon3834]

@@dustyoldhatzero credibility, i’ll pass.

[@tapeshark]

@@dustyoldhat zero credibility

[@dustyoldhat]

@@BrettM-lw2zt define “hit piece”

[@liw_lostinwonderland]

@@dustyoldhat zero credibility

[@JenniferMyers]

I wasn’t familiar with how peptides work. As usual I learned a ton which is why I return to this channel again and again. Thanks so much, Andrew and your team (I am assuming you have a team). Your dedication & commitment to bringing easy-to-comprehend science education to the masses does not go unnoticed! 🙏

[@Hazzard0]

Your awesome contribution to science and self development makes you bulletproof. Your message stands for itself and cant be hurt by mean people writing articles about your personal life.

[@amaydejaamar]

Here to say how life-changing your podcasts have been to me. I hope you continue to share your knowledge with us. Thank you

[@LinaKhull]

I'm a aesthetician. Before I only knew that Acetyl Hexapeptide-8 (Botox in a bottle) which is used widely in cosmetics and skincare products for its anti-aging properties. Now I learned more about peptides! Thank you for your insight. 🙏

[@miromulus]

Great new episode. Can't wait for the other 5

[@user-xt7pp5yy9w]

Keep going Andrew ❤

[@jonyklein12]

Very well done!You have cemented yourself as a real role model for everyone who is watching.

[@brightflower144]

Never explain, never complain

[@LoNoOr37]

I heard that before🤔😉👑

[@AM2K2]

👑

[@Eggcellent-lm5sv]

Pick up artist mantra. I mean Andrew is sort of a pick up artist but more so a psychopath/sociopath

[@YogaBlissDance]

This was likely filmed before the ARTICLE. Messy personal life...his content is still amazing.

[@stable-shadow]

Ha, exactly! I mean he can really skate board, and great at mooing to square his jaw....just let him and Lex jujitsu each other to completion and everything will be fine.....He's not a Doctor Doctor either obviously, he's a phD....you throw a rock you will hit hundreds of thousands......the color black has even said they are bailing on Huberman.....he's a douche but he has some great info...even if it's made up in his skull... 🕊️​@@Eggcellent-lm5sv

[@dm_podcast_takeways]

Many people were waiting for this one. Thanks :)

[@davidsaak2705]

True

[@user-mw4kg8cx8t]

which of the 6 peptides is your favorite?

[@dustyoldhat]

😂❤

[@adamkenny28]

Lamest joke known to man

[@KB-ur4nk]

They all are his long-term favs

[@SavoyPrimeable]

@@adamkenny28naw this was good

[@Lucas_Jeffrey]

he obviously likes sermorelin more than anything as he still takes it sometimes

[@sniperking6321]

You are an amazing teacher, do what you want in your personal life and enjoy it to the fullest!!

[@dre2407]

I'm here to support this man and to say I really really don't care about his personal life. I'm here for good and medically proven advice. The fact that people who never ever watch any of his podcasts are trying to deter his audience for issues that are unrelated and not their or our business is infuriating.

[@IXC.18]

You are trying you're hardest to discredit him but no one cares ​@@dustyoldhat

[@Beryl996]

​@@dustyoldhatspot on, Stanford will have none of those shenanigans soon enough

[@cherryl225]

i agree. its funny how many times have "women come forward" when someone, usually with integrity, rises to success via empowering people. it happens every single time, and many of those the smears are made up! i wish those followers could recognize patterns and smear campaigns.

[@puynavarro4912]

Gracias Andrew!!! In order to get collagen, what are best foods, or best brand to ingest. Is insufficiency of collagen, cause of pain or sensation, inside the bones, specially when ovulating?

[@soyonarafatjah9662]

Great summary for the layman… you mentioned CJC-1295 in that study with the 1 death. It’s because they used CJC-1295 with DAC to make it longer acting. Regular CJC without DAC does not have that effect. That difference should have been mentioned because many board certified physicians like myself use CJC-ipemorelin for patients with great success.

[@bodybeyondfit]

Thanks for clearing that up.

[@28copland]

I'm glad your still here Andrew, all you've done is try to help people and for people to try and cancel you says more about them then it ever will of you, keep going brother ❤

[@micheletx17]

Great podcast. Thank you for the information

[@hibabelimi5328]

Thank you so much. Very interesting topic!😊

[@Vincent-fv1ch]

Couldn't come at a better time, just ordered some of these a few days ago!

[@DMS1244]

Where did you buy? Peptide Sciences?

[@AnnaSorokina-yp2lj]

thank you for continuing to be the best resource for health and science!

[@ethimself5064]

In the past I damaged my lower spine permanently and a few years later my right knee permanently giving grief to my hips. All in all mostly ligaments and tendons/some cartilage. I decided to take Organic Collagen Hydrolyzed(peptides) classifies as Type 1, 2 and 3. After taking it(powdered) the first time I was near amazed that I had noticeable relief from pain and mobility. Yep, still using it. Not exactly what you are talking about, but noteworthy enough to mention

[@lorihilliard9956]

Would love to know where to purchase this! I have several spinal issues.

[@ethimself5064]

@@lorihilliard9956 A quality health food store

[@ethimself5064]

@@lorihilliard9956 Depends on what is wrong - typically works on ligaments and tendons

[@littlelowy7]

Don't say permanently and.then you make it so. There's peptides. Stem cells. Hard work. Miracles. You never know. Nothing is permanent. Keep going.

[@ethimself5064]

@@lorihilliard9956 Any quality health food store

[@Lucien451]

Thank you for the information. I have a knee injury and reconstruction, this is very helpful.

[@ebl7252]

Thank you for all you do to bring this information to us!

[@skyfly4696]

I love you doc, you changed my and many millions of other people's life. Keep your head up against those scammers 👊💯

[@Scott-SUP]

Andrew, your breakdown of peptides is enlightening. Understanding both benefits and risks empowers us. Thanks for the clarity!

[@chewbrocka6833]

Does a peptide have 6 chains

[@harariprof8230]

Peptides differ from the kind of protein. There are 4 types depending on their structures. Peptide is another word for protein, actually they're the bonds between amino acids. Chains of amino acids are called peptides.

[@dustyoldhat]

@@harariprof8230But do the six peptides have a group chat?

[@dustyoldhat]

They have a group chat

[@MrSagarcool14]

@@harariprof8230you didn’t get the joke

[@harariprof8230]

@@MrSagarcool14 I'm not interested in gossiping.

[@Cal693r]

Been waiting for a peptide deep dive! 😊

[@ndndndnnduwjqams]

Thanks for adding so much value Andrew!

[@docherb7]

Thank you for your commitment to education through science 🎉you’re a treasure

[@atlskyline1]

Where does one find these peptides that have been banned recently like Bpc 157? A clean source without LPS. Third-party tested. There has to be a source from other countries where it’s still legal

[@imjustlikebud]

From my doctor in Florida.

[@atlskyline1]

@@imjustlikebud He can get you the banned ones too like TB500?

[@imjustlikebud]

@atlskyline1 not sure tbh, what I know is legal here and I can get is bpc 157 and sermorelin

[@lizcox7286]

Just subscribed bc ive listened to a few and find the information extremely beneficial but also want the hit-piece on Huberman to backfire! Congrats on all that you do and more power to you!

[@jmomlopez]

I am currently on week 5 of taking cjc-1295 + ipamorelin 5 days per week, and I absolutely love it. I did speak with my doctor about the concern with the FDA and I feel safe to continue using these peptides.

[@HareKrishnaPerth]

Ive never heard of peptides. Lets get into this!

[@user-ij5ky4lr3x]

Keep that head down and keep working hard. The haters will be gone as soon as they find their next target to brigade and moral grand stand. Much appreciated content.

[@Kube_Dog]

"Keep that head down." I see what you did there! :)

[@chuckleezodiac24]

it's better to keep your head up!

[@Kube_Dog]

@@chuckleezodiac24 That's what got him into trouble, though.

[@user-ed4zl9pq7r]

Fantastic, I have a 130 mile drive to work and back. I appreciate the content and length of the podcasts, it makes my drive easier and my brain swell with information. Thank you, for the variety of engaging guests.

[@dustyoldhat]

you should move

[@isaacmartinez8226]

Andrew I want to show my gratitude towards your information you provide , I’m 25 years old and you help me understand things I would need to go to school for here on KZbin and it’s awesome thank you SIR!

[@Nedovolnite]

The turning point, which made the industry fight back at Huberman, was the episode with dr Robert Lusting, where Andrew said that he is thinking to act in a political way to fight the big food and pharma industries, like pressuring the officials or the legal authorities. This is a worldwide hundreds of billion business and they will never surrender without a fight! So Andrew have just one option to clear those BS, and win the hearts of the World - just go and do it! People will support you! Power to the people!!!

[@kamarieshines]

Good point! Don't mess with big pharma or these companies mass producing processed poison and calling it food..

[@cantbendknee]

Dude is sponsored by commercial enterprises like AG1 and multiple others. He is in no way fighting big pharma.

[@ZDatAlkiB]

Big pharma behind it all

[@charlsalash]

You can think whatever you want about the article on Huberman, but this has nothing to do with the big food and pharma industries. From what I gather, he enjoys steak (big food) and doesn't appear to be against drugs. It's just tiresome to see conspiracies as soon as an outcome differs from one's expectations. There are KZbinrs who pose a far greater threat to these industries, yet they haven't faced similar damaging articles.

[@HappyJiyoung]

Many people who can read beyond the main stream media propaganda sees it as big pharma hit piece. I think that too. Russell Brand Andrew Tate Donald Trump Andrew Huberman Main stream media wants to influence public wirh emotion provoking tactics. Sheeple will think “conspiracy theorist” who see deeper layers.

[@michaelkartsonis6332]

Post after post of people saying you save their lives

[@No-Gumph]

Thank you for taking the time to talk so informatively about this array of peptides. Sharing what their positive and negative impacts, along with doses and timeframes for taking them has been incredibly helpful. Thank you.

[@MultiThunder54]

Hey Dr. Huberman, Thanks for consistent and high quality content. I am a soon to be father and fitness enthusiast. I think it would be pretty useful if you had an episode about optimizing health and fitness during the first year of parenthood given the erratic sleep schedules and stress associated with early parenthood. It would be great to have strategies/protocols to optimize things like sleep, workouts, cognitive function, and general health. This isn't a topic I've seen explored by anyone in the fitness space or adjacent, and it would be very valuable to many in my age group who are becoming parents and want to avoid the "dad bod", and maintain high quality health and fitness. Thanks!

[@_JustClipped]

Screw the media for trying to discredit such an incredible and phenomenal scientist! This man is amazing! Screw the media

[@dustyoldhat]

I always find it funny when people refer to anything they don’t like as “the media” It’s not like CNN, Fox News, the BBC etc are all going after him. It was one expose in a not very widely read magazine based on first person sources. It’s not exactly “the media” it’s “a magazine” Sorry they exposed your hero. That’s why it’s dangerous to idol worship. But attacking the ones who exposed him doesn’t make him shiny and new.

[@Donkle365]

which media is doing that?

[@DigiMyst]

@@Donkle365 New York Mag and Twitter drones

[@dustyoldhat]

@@Donkle365 “the media” isn’t doing anything. A lot of people are triggered because their science daddy got called out for being a serial cheater by his ex girlfriends. “The media” is one magazine wrote an article about it. His super fans are triggered that’s all

[@cantbendknee]

What are your scientific credentials?

[@helenramos2370]

Thank you for sharing Dr Huberman ❤

[@aleeen1397]

What with cancer risk with hgh peptides when you have deficit of growth hormone? Is it the same or its not occuring when you want to balance your levels to optimal?

[@TracyRupp]

Ta 1 has been a miracle in my life! I was hoping to hear you talk on this!

[@CedricPoniewas]

How does it helped you ?

[@TracyRupp]

Cpk went to normal. Muscle weakness went away! Basically healed my overlapping autoimmune disease. However, I changed my diet and lifestyle as well!

[@patriciab111]

Would you consider doing an episode on personality disorders such as histrionic, paranoid, etc., and how to create and maintain boundaries? Thank you 🙏

[@MrGlopez6]

Thank you Andrew!

[@hasmukhkanabar2931]

I have been following your lectures for a long time dr Huberman and thank you so much for all that you do to enlighten others on healthy living I have very frequently referred your lectures to my patients for their well being as well

[@onebluestone]

Thank you so much for the amazing work you. I've benefited much from your offerings.

[@sophiajmc]

Its incredible how you can go in-depth in a topic that would seem complex to me, and make it perfectly understandable. 😁Thank you so much!

[@nickm8605]

Dr Huberman - thank you for more excellent content!

[@girlyslut]

hey andrew: i love watching you! i support you. keep up the excellent health videos. stay 🔥!

[@clesheanj]

Great video. I learned a lot.

[@tammyb8742]

God bless you and your work 🙏

[@rajibdeka2207]

Andrew Huberman - the Stoic Scientist. Salute sir.🙏🙏🙏

[@marshad.9149]

I’m so glad you addressed this subject. Almost every collagen supplement I buy has peptides on the label.

[@fdsa1981]

Thanks for the hard work!

[@fitnesssoup7553]

I've used BP-157 in the past for helping with tissue repair with very good results. It's quite helpful in combination with other treatments.

[@michellelauer4212]

Can you say where you got it?

[@rg33672ha]

Dear dr. Huberman I was diagnosed with acute anxiety 6 months ago to the extent that I had a constant tension type headache for 2 years. I took cbt and followed your protocols of health, mind, dopamine, exercise etc… Now I am in a generative drive I have never experienced before, I lost weight, put on muscle and have built an insane routine geared towards growth. It literally feels like I have control over my life now. It extremely saddens me to see the lengths the shit media would go to bring you down by attacking personally. Please note even Gandhi had personal flaws and we only look towards what he gave to people. You sir are a gem, a 1 in a million person! I feel extremely grateful for your contributions. Keep shining!

[@baeX900]

Phenomenal video. Thanks!

[@nickcorona-roman8948]

Dr Huberman, thank you for all you do. I have battled back pain due to musculoskeletal injuries from an accident. I have tried any and all remedies with nothing working but watching this episodes helps me stay motivated that there could be an option for me to heal. I’ve tried yoga, meditation, vitamins and mineral supplements, out patient physical therapy, etc. speaking with physicians is underwhelming as they don’t believe a 30yr male that is otherwise healthy is suffering from this pain but dismiss it as self inflicted anxieties and depressions. Don’t believe you’ll read this but thank you. I’d love to learn more how I can get my hands on this BPC 157.

[@thomasokeeffe4719]

Reverse hyper

[@mrt445]

Dr "Rizzerman" Huberman needs to teach us his pimping skills.

[@youtubemom497]

Be extremely sexy and fit, be a super smart scientist, be rich and/or famous and good at communicating. Or just maybe like one or 2 of those things and you will be good 😊

[@OksanaRutko]

Here to learn and show my support. Your content quite possibly saved my life, made me a better person, and last but not least helped me to be a better caregiver for those who are very dependent on me at the moment. Life is still harsh but I KNOW I am able to weather everything infinitely better because I stumbled across your content sometime ago. Nothing can change that, and I am eternally grateful. Looking forward to more science and learning 😊

[@tsubaka18]

Thank you dr andrew ,you have changed my life

[@ryanriley2145]

Is there any evidence or information regrading BPC 157 having an impact on dopamine receptors / sensitivity (?) and would there be any contraindications with medications that influence dopamine?

[@ScandinavianBob]

Thank you for another great video, Andrew. A suggestion for an upcoming topic: There are so many guys around the world suffering from p**n addiction, so it would be great if you could make a full episode on that. Millions of men around the world would be forever grateful. Guests could be, for example, MD Donald Hilton or perhaps Anna Lembke....

[@Dark_Angel555]

didnt' you saw all the news about huberman Bob ? he is also a "love addict" as he said it - it goes hand in hand with a porn addiction in my opinion - no sane person has to lie to all women and manipulate them just to keep them around for sex - clearly he is not the right person to make an episode on porn addiction

[@ScandinavianBob]

@@Dark_Angel555 Dude, don't believe everything you read out there. When a person gain fame / millions of followers, there will ALWAYS be haters trying to take them down. Even if it were true, that would not mean it takes anything away from the informative videos Huberman is creating. People are quick to judge and late to use logical thinking. Sad!

[@Dark_Angel555]

@@ScandinavianBob I used logical thinking and yes he still puts out informative videos but it depends on the subject - you cant be an expert on everythying - you also have your expertize on no PMO lifestyle ... doesnt mean you also know everything about cars or boats for example ... nobody is an expert on every subject on earth .

[@ScandinavianBob]

@Dark_Angel555 I and many others would be interested in an episode on porn addiction, coming from Andrew, someone who certainly knows a lot about the brain, regardless of what articles say about his private life. That's my point.

[@lilshack3458]

I have so much respect for you, Doctor 😎💪🇺🇲 hope you had a blessed easter

[@BrillGirl82]

😂

[@HolidayHouzCollective]

Thank you so much for this podcast!

[@jjuniper274]

Thank you Dr. Huberman!

[@patriciab111]

I really admire your ability to remain resilient and professional despite recent events. I would love to hear which mechanisms you find most helpful during challenging situations (broadly).

[@user-hu9zy9tb4u]

Great podcast as always. Thank you Dr Huberman, please keep doing what you do, your work is so important.

[@vegeta420z6]

Cool stuff. Devin Lerrot is using the heck out of peptides right now, have also heard MMA fighters talking about using peptides so its cool to have a better understanding.

[@smmhcm4938]

Does anyone know if BPC-157 would work on chronic Achilles tendonitis? I partially tore my Achilles 15 yrs ago and nothing has worked (PT, NSAIDs, PRP injections) and surgical debridement has been suggested but it may not be successful. I don't want to do surgery if it is not guaranteed to improve my current situation. I'm pretty limited in my activity level and used to jog, play tennis, etc... and now cannot. If it would help, where do you find a physician to do it?

[@Mike-dt1yg]

Look into the "Heavy Slow Resistance" PT protocol. For PRP, look into having it done with Regenexx. All the other PRP is likely not done correctly at the right concentrations and doesn't even qualify as PRP, and therefore won't work. FWIW I've tried BPC for about 2 months straight from a pharmacy and didn't see much success with my insertional Achilles tendonitis.

[@bentopp]

Congratulations on your honour from the matrix, for having the best content on the planet!

[@cantbendknee]

It's funny how you tate people use the word the 'matrix' when the two people who wrote that film were Trans and wrote it as an allegory for their transness.

[@JJ_Adventures]

@@cantbendknee no one gives af

[@Mili-bedili]

​@@cantbendknee Hey now, don't credit Tate for that term. He stole it and grifted off of it. Most people here know that guy's a joke.

[@snarlynx1]

@@cantbendkneeand that’s the thing none of y’all get. An analogy can work independently of the creators intent. How art works. Same thing with Fight Club bucko

[@cantbendknee]

@@JJ_Adventures They do and that's why you guys are pissing yourselves.