Aphthous Ulcers / Canker Sores - Pathophysiology, Triggers, Types & Treatment

Aphthous ulcers also called recurrent aphthous stomatitis (RAS) or simply known as canker sore is a common ulcerative inflammatory condition of the oral cavity. The reported prevalence in the general population varies between 5% to 66%. It typically starts in childhood or adolescence as small recurrent, painful, round, or ovoid ulcers with well-defined erythematous margins, and a central yellow or gray floor.
The lesions have a recurrent nature meaning that they are episodic once they appear for the first time in an individual’s mouth.
The exact cause or etiopathogenesis for aphthous ulcers (canker sores) is unknown, however, it’s thought that ulceration might result from a sudden activation of the cell-mediated immune system at the site of ulceration leading to the liberation of cell signaling molecules or cytokines like TNF-alpha and some other interleukins. These cytokines cause antigen expression on oral epithelial cells. The oral epithelial cells are then recognized by T lymphocytes which then trigger a cytotoxic response and the epithelial cells are phagocytized by immune cells resulting in ulceration.
Some known triggers can cause the stimulation of such an immune response
Video (diagrams+editing) & Voiceover:
Dr.Maryam Kazman
Become a Patreon and Get Exclusive Rewards:
/ dentalmaniak
Join me on facebook:
/ dentalmaniak. .
instagram: / dentalmaniak

Best video about the canker sore! The only channel I saw that covered what happen in the celular scale.

[@DentalManiaK]

Thanks for the feedback :)

[@twinklesingh97]

Ma'am, Thank you for uploading this video. This was really so helpful. Very clear and concise. It helps us to study and revise quickly most of the topics. Earlier, I used to think there are many KZbin channels to help out students studying medicine, but finding a good channel on KZbin that helps out the students studying Dentistry, is a rare thing. I'm lucky to have found this channel. Thanks for putting in so much of efforts for helping the students. I really can't thank you enough for this. 🙏 Heartfelt Appreciation for your hardwork and dedication. 🌟 Warm Regards 💐 Stay Blessed 😊 Stay Safe 👍 Now and always 🌸

[@DentalManiaK]

Thank you so much Twinkle for your never ending loving comments ❤️

[@twinklesingh97]

@@DentalManiaK Most Welcome Ma'am. 😊 You deserve all appreciation for creating this amazing channel. 🌟 May the Almighty bless you infinitely with more of happiness, good health and prosperity. 🌟 Stay Blessed 😊 Stay Safe 👍 Now and always 🌸

[@AmitisL]

Very helpful, thank you

[@afeezjimoh8263]

This is really helpful. Thanks a lot

[@oishuu6542]

My exam period is running and I'm also suffering from Apthous Ulcer 😫😫

[@naturehealus9074]

The only Herbal doctor on KZbin who could actually cure HSV with herpes is #Drokooboh so many people also testify to me but didn't contacted anyway Cause 99% out of 100 people in US have herpes....

[@dr.muhammadbarzakh]

Amazing,

[@janewangare4703]

Thank you

[@hsajjad421]

Nice

[@robjudy1926]

You are so cool and cheerful I’m hsv 2 free all thanks to Dr Oseghale Sunday Herbal Home you can be free too😊

[@misheckkaluba2613]

What's the causative agent for Aphthous stomatitis?

[@jamiluyakubu2813]

Really appreciate you Dr Igho Channel on KZbin for bringing back happiness, for giving me a permanent cure to my HSV 2, Thank you so much, friends join me to Thank him for what he has actually done for me and I Pray to you all for a good life and good health, & most especially to you Dr Igho

[@martindoyle766]

Vitamin b12 b9 b2 b3 will help zinc folate dental hygienist care and a good probiotic and prebiotic good mouth wash might help you as you must strengthen your immune system 😢

[@rishabhSingh-ww1py]

Mam can it occur at same place again and again

[@marieholmes7765]

#driyaremoses herbal remedies.