APOE TREM and Microglia in the Pathogenesis of Tau-mediated Neurodegeneration with David Holtzman MD

David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of A and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Recorded on 09/16/2019. [Show ID: 35262]
More from: Brain Channel
(www.uctv.tv/brain)
UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service - by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(www.uctv.tv)

[@zionayokunnu1086]

If TREME2 limits Abeta seeding, why is PLX before Abeta deposition decreasing it?

[@mistahtom]

So in the E4 phenotypes, there’s upregulation of pro-inflammatory genes and downregulation of protective housekeeping genes in microglia 39:28

[@jyotii1188]

Can u please mention the paper. It will be helpful ...pleaseeeeeee

[@SparksandBubbles]

Please look at work of Dr. Nemechek..... Right this alley