Apoptosis (2006) by Drew Berry wehi.tv, sound design Franc Tétaz

Animation exploring a signal transduction pathway that induces Apoptosis.
Published "Molecular Animation of Cell Death Mediated by the Fas Pathway", Sci. STKE 2007 (380)
Sound design is intentionally horror, as you witness a diseased cell self-distruct.
Inspired by "Alien" and "The Shining"

[@masonat76]

Why aren't educational animated movies to this quality more common? I love these videos, it's nice to visualize the knowledge we have but can't observe with our eyes.

[@crystalyzzed]

Because people will start questioning a random based origin of life

[@GNParty]

Probably because of the existential dread that comes with knowing that all life will die within 0.00000000001% of the entire time the universe exists before time becomes meaningless thanks to Black Holes and possibly Proton Decay.

[@skibidibopmmdada78]

@@GNParty r/iamverysmart

[@GNParty]

@@skibidibopmmdada78 Thanks for the compliment. 😁

[@skibidibopmmdada78]

@@GNParty it was an insult

[@Lior621]

I am dumbfounded by the complexity of this thing

[@King-Salem]

I am awfully dumbfounded by The greatest GOD who created the complexity of this thing.

[@muffinandcake5247]

@@King-Salem you really shouldn't mention god in a scientific video

[@muffinandcake5247]

@@faiqaalmutairi2105 shut the fuck up herpes dipshit

[@King-Salem]

@@muffinandcake5247 I said the truth only. Do you still believe such complexity was made by itself? If yes, I would agree if windows 10 was made by itself. As a programmer, it is IMPOSSIBLE for me to believe that this complexity was made by itself.

[@muffinandcake5247]

@@King-Salem if a complex being requires the existence of God as an answer. Then what is the explation to the existence of God. Did god created itself? If so then where is the consistency? It seems like your logic is flawed

[@GCAT01Living]

The sound design on this is other worldly.

[@Chaos------]

People are impressed by the structures themselves, but what always impressed me the most was how these pieces fly around throughout the vast space of the cell and zero in on the correct areas with extreme precision, and with no visible mechanism to bring them together. What makes it even more impressive is that 85% of the contents are edited out in these videos. So what looks clear and open is really quite densely packed and extremely active.

[@Vnifit]

I mean it's that crazy, you could imagine them like magnetic puzzle pieces, where they go around attaching to whatever is near them, but only if they fit. Each protein and enzyme is made to fit with another to do some specific job. Although you are correct about the contents, it would be completely filled with other molecules not shown for clarity sake.

[@gelatinocyte6270]

*Edit: never mind.* The interior of a cell is not exactly a "vast (empty) space" - unless, of course, if we only care about the nuclei and electrons; in which case, everything, even solid objects, are "vast empty spaces" - but, like the first replier said, it is filled with other molecules that are not shown _for clarity's sake._

[@agata_cz]

Well everything is orchestrated by gene expression and then of course organelles allow compartmentalisation of biochemical processes and molecules, so it’s pretty organised and quite crowded living space. Cells are quite compact rather than vast.

[@quark31]

It's also the chemical encironment such as the pH, chemical gradients that also plays a role. It is not in.vacuum.

[@donaldviszneki8251]

>no visible mechanism :3

[@Unkempt_Whizard]

This is covered on the last exam in cell biology. Kind of sad to see the thing you have become so attached to throughout the semester kill itself, lol.

[@sarcomak982]

Rest assured it does so for a very good reason. The main reason is an error while replicating. Apoptosis is a safety measure by the cell to ensure neighboring cells or new cells produced by it are not harmed

[@beliebingINtwilight]

+Unkempt Whizard look I'm doing a cell biology module now, exam is in 2 weeks

[@Unkempt_Whizard]

***** good luck!

[@beliebingINtwilight]

Unkempt Whizard lol thanks I'm going to need it

[@GNParty]

​@@sarcomak982 Would an "error in replicating" potentially caused cancer cells? Or is this for any sort of virus/infection?

[@jasamcarcina]

It's two dofferent signal pathways described here. The one started with the T-cell is the extrinsic pathway, the one induced by cytochrome-c released is the intrinsic pathway. They both result in caspase-3 activation and protein and cytoskeleton cleavage.

[@veganbackpacking-8559]

I too missed a clear distinction between the two because now it seems like it's all one process. But then they also could include the Bax-part which triggers the release of cytochrome C :)

[@irina-mariapalaghia8506]

and what happens w the bubbles? they travel freely in the interstitial space??

[@jasamcarcina]

@@irina-mariapalaghia8506 If remembered anything on the subject I'd give you a meaningful response. 9 years ago was a different life :D

[@evergreen1326]

@@jasamcarcina 🤣🤣🤣 I understand you

[@lorenzveggetti2210]

@@irina-mariapalaghia8506 and become a snack for macrophages

[@keaganhesse8005]

The poor cell was bullied into suicide by the T cell smh, we live in a terrible world

[@keaganhesse8005]

I️ want that cell to know that it was a beautiful cell and nobody can tell it otherwise

[@dilukhin]

T-killer is a kinda policeman or soldier, there was no bulling by other "regular" cells. But yes, apoptosis can be initiated by other reasons, when the cell somehow causes damage to the organism. For example, neuron can kill itself when it translate too much signals.

[@sobanudlz]

@@keaganhesse8005 Imagine having cancer cells lol

[@RONALDB62]

Think God is aware ?

[@naturewatcher7596]

It just disassembled itself. Wandering what happened to those bubbles left of it? Absorbed by other cells? Or removed from the body?

[@johnmacward]

Simply mind blowing what the body does.

[@ImKingLouie]

It seems so apocalyptic.

[@yummypiano]

apoptocalyptic!

[@gelatinocyte6270]

Apopcalyptic

[@Uthael_Kileanea]

It is.

[@ThePhantomSafetyPin]

For that cell, it is the apocalypse. Also "Apoptosis" is a good band name.

[@MCGeorgeMallory]

Cells are so awesome! "Attention: You have been discovered to be diseased, and are scheduled for deletion. Please attempt to do as complete a job as possible." "Command has been received and verified. Thank you for the notification. Now proceeding to self-destruct..."

[@wolfgangmoz]

Mission: Apoptozsis!!!

[@ninjasiren]

Cancer cells: No, I won't apoptosis

[@ThePhantomSafetyPin]

Really kind of sad to watch, but very impressive. How amazing our bodies are... Also is it just me or would "Death Ligand" be a great name for a band?

[@XFz2nLDWo73x95]

It's also mind-blowing that we personify the "life" of the cell as ending but really it's just atoms and molecules reacting to one another. How "life" figured this out is deeply perplexing.

[@davidolufemipopoola2182]

@@XFz2nLDWo73x95 Yep! I see everything as interactions between atoms, but it's at a higher level..

[@chiefwakanda2889]

Dibs!!

[@chiefwakanda2889]

@@XFz2nLDWo73x95 can the same be said at the macro level with humans in general?

[@gbrown6594]

Hmmmm.

[@zainranjha2788]

Exceptional work! Hats off to the entire team, particularly the animator.

[@LCARS43278]

I had apoptosis once but I cured it and now I'm immortal.

[@suckerpunch2007]

You sound suspiciously like a malignant cell... :D

[@superdog797]

nerds

[@stavshmueli6932]

@@superdog797 Nerds are the reason why you can even use your smartphone, let alone pretty much everything that surrounds you.

[@jensen333]

This comment thread is gold!

[@GNParty]

@@jensen333 Go back to Reddit.

[@ErinChristeyICT]

We love this animation of the apoptotic cascade! It is a very helpful training tool for our company, which specializes in apoptosis and caspase assays. Thanks!

[@janellevanhofwegen5605]

My first time watching a cell die.

[@raahul1303]

Be strong

[@baboongotmyspoon9973]

Was this directed by David Lynch?

[@308KingsRoad]

All this work being done Unbeknownst to us Is simply amazing.

[@lanecomartin3644]

4 minutes of flying dip n dots

[@samlau96]

i cried watching this T.T

[@williamwixon]

So mind-boggling. Again, thank you all so much for bringing this to us. It really is amazing to see a “death ligand”. ❤️ all the videos, it is so fantastically complex!

[@paxguerilla]

I LOVE the sound effects! My cells sound just like that, too.

[@ThrivewithSierra]

This almost felt like I was watching a horror film - creepy!! But excellent animation and really helps bring the story to life.

[@wudgee]

I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

[@Jeleky]

So there are two pathway shown here. The first one was the extrinsic pathway activated by Killer T cells and the second was the intrinsic pathway which is activated by p53 activating the production of BH3 proteins which form a channel on the outer membrane of the mitochondria which allows for release of cytochrome c. Apoptosis ends with phagocytes eating the bleb or little vesicles at the end. The phagocyte should have been included because apoptosis leaves no trace of the cell behind after it is destroyed. This is a big difference between apoptosis and necrosis.

[@kerchowthedrummer]

This is literally one of the coolest videos, ever

[@Luunnariiss]

This is so freaking amazing, the best way to learn it visually!

[@kotsaris87]

2:27 amazing sound choice

[@probability_density]

I can't explain it, but there's something that feels almost sacred about programmed cell death

[@maxnullifidian]

This seems a lot like a very complex 3-dimensional cellular automaton!

[@andreagradidge3752]

Fantastic! I've been learning about Apoptosis on Coursera and this video really helps me to understand the process.

[@FutureAIDev2015]

It's amazing how tightly controlled this process is

[@LivvieLynn]

Love these videos. Yet, I can see how it can be difficult to follow if you're not familiar with the process already.

[@devendrakhandelwal5468]

Thank you so much 🙏🙏 amazing representation 👍👍👍

[@drss5063]

What an amazing video! Thank you for sharing!

[@sangeetaamarkarmath9714]

This youtube channel is still the same😊😊thanks for being consistent in all these 12 years.

[@WEHImovies]

Since 1998... kzbin.info/www/bejne/fYPbdqKLp8mIerM

[@philsmith7398]

Brilliantly done! Many thanks

[@uswaamjad2486]

Your video is just amazing. I cannot even explain your perfection in words. Thanks alot for sharing such a nice video 👍👍👍

[@devendrakhandelwal5468]

Excellent presentation beyond the limitation

[@rachelspixiedust]

an absolutely awesome video - thank you!

[@ayushmandwal7939]

Love it how it shows the complexity of cell death beautifully...

[@Tv_bro127]

It’s so satisfying how they just cling to that cell

[@philisacoolguy1]

why is the music so ominous

[@RustyNova]

I like how the mitochondria is just... "We're dying? Alright, I'll make it faster"

[@regulate.artificer_g23.mdctlsk]

*Mitochondrion. Mitochondria is plural.

[@luftwaffle3766]

@reg gen ...there’s multiple mitochondria doing that so it’s plural

[@demetronix]

thanks the video was very informative :) but is it just me or was this really scary ?? :D

[@akasbaakop3md502]

it was a bit. lol

[@Akos843]

Its scary, because its supereffective and merciless...like a machine.

[@wishmaster6]

Because sound effects are really cripyy

[@Er404ChannelNotFound]

Amazing simulation

[@Zeeonamission]

Why it feels like I'm watching a horror movie and there is an intense death scene and the back sounds are effecting in its way.

[@bendandsnatch2683]

God, this is like the cellular 10 plagues. Perfect sound design

[@GalbertReloaded]

Amazing video, my best compliments to the authors. I highly recommend to watch it while playing the video "Craig Armstrong - Escape (Full Version)" instead of the original audio, it becomes much more emotioning! =]

Wondeful Biochemistry with many details!

[@nvmisnvm]

These animations are SO GOOD!!

[@outsiderperro]

awesome!!! great job guys, thank you so much

[@soco2020]

Coolest video I've seen this year! I love Biomedical Science, thank you!

[@WEHImovies]

Many more of our animations in the wehi.tv KZbin playlist kzbin.info/aero/PLD0444BD542B4D7D9

[@FEURVERM]

@@WEHImovies oh they came back 10 years ago

[@giuliomirosalico5311]

Beautiful, thanks

[@Captain.Mystic]

One thing i guess i never considered is that the cell membrane is still hydrophobic, which is probably how a lot of viruses can end up having their own shield of protein or other means of reproduction even after the cell has been destroyed. But thats very clearly shown here with how the cell still tries to keep its form even after its "popped"

[@timeryly4468]

Im studying this and wow the simulation really makes it feel more real if that makes sense Anyway great video 👍

[@zeyads.el-gendy4227]

U guys are brilliant

[@Quran.And.Science]

Good work!!

[@user-cm8xv8wf5b]

fantastic video

[@christ_ie3714]

Oh my goodness. I've just found the best channel on KZbin 😍😍😍

[@Rivendicato]

Very informative. Thank you.

[@Elusefelier]

What an amazing video!! Great job.

[@LayZeeBro]

This is the best and most accurate simulation of apoptosis I have seen and I'm a medical student.

[@JAKLABELREC]

Wow! That was incredible

[@b14blah]

Great! Thanks for making.

[@MillenniumHealth]

I am writing a book TBI - A clinical Approach to Diagnosis and Treatment. Find me at tbimedlegal and have spent the past 6 weeks reading articles on Apoptosis, Necrosis and Authphagy. Your film is excellent and makes sense. When I return to Melbourne with Pathlabs, I owe you a tall one for the efforts and accomplishment... Excellent work..

[@danielaaseff9120]

Great video!!!

[@dookiecheez]

Gave me a major horror film vibe. Awesome stuff.

[@Lolwutdesu9000]

Anyone else get shivers from watching this? My face felt tingly...

[@yasmmincortes]

Very good illustration about how a bad cell dies by associated proteins and substrates activation for initiate apoptosis.

[@splagyetsi3287]

I'm a software engineer and found this animation fantastic. Nice to learn new things.

[@LuizaPlatilha]

Incredible 👏👏

[@StevenMP1993]

Amazing!

[@alexandrudanielmartinas3615]

Thank you,good video

[@Samantha-sg7lp]

AMAAAZING. Makes me want to take a college course on micro biology

[@user-ce3rl4vk3l]

Amazing video, liked so much. Also the comments section feels like home

[@israelcolchadorojas1830]

Beautiful

[@LE0NSKA]

this straight up gives me anxiety but I can't look away

[@annagalligos9134]

stunning

[@numericalcode]

This is amazing!

[@nicks9359]

Mind boggling!

[@kabirusahabi5629]

Many thanks to you guys. Its all clearer now.......much more clearer.

[@o_sch]

What always is hard for me to get is how there are so many of any particular protein saturated in an area so that these things can happen. Like how are there enough of those proteins that destroy others just floating around for them to activate? Or the ones that initially bond to the death protein from the T-cell. Even in things like RNA transcription, how is there enough tRNA in the area for every amino acid. How is there enough ATP everywhere? How are there enough DNA bases floating around in the nucleus. Where do those DNA bases even come from, afaik they arent made by RNA and ribosomes?

[@lkyle5256]

This video is amazing!!!! very very beautifu

[@Cafecortao]

the best audio

[@stefanomarano5310]

congratulation for the clip

[@jamesbaldington1150]

Great animation folks! I'm using all these animations to study for the USMLE, haha! :)

[@pavloskazakopoulos7280]

What a masterpiece!!!

[@Greyhunter123]

For some reason this is really, really scary. Great vid though, really eye opening!

[@richardcabeza2087]

Amazing....

[@YoshiRider9000]

2:54 >I'm putting together a team, for one last job.

[@willy4129]

Terrifying yet fascinating...

[@howardjames9543]

I have subscribed just after watching your cell videos they are awesome

[@WEHImovies]

Our wehi.tv biomedical animation KZbin playlist kzbin.info/aero/PLD0444BD542B4D7D9

[@andrewflowers1755]

FASCINATING !!! 💥💯💢💫💫⚡

[@luckssj]

Very good, I am glad that I know how to get rid of all of the trash 🗑

[@ashwinnarayanVlog]

This video needs more views.

[@abdullahmagdy19]

سبحان الله العظيم ﴿ أَمْ خلقوا مِن غير شئٍ أمْ هُمُ الخالقون﴾

[@FutureAIDev2015]

"Death Ligand" would be a cool name for a metal band

[@mrniceguy4277]

What about the caspase-recruitment domain (CARD, subunit on caspase 9)?

[@scottmale69]

Amazing

[@Japonicmen]

Excellent