Rheumatoid Arthritis Pathophysiology (signs and symptoms)

[@LWalks64]

Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.

[@ushasehgal2816]

Very nice video but what is the treatment of this Arthritus

[@ENFPerspectives]

People can see how it moves the bones, criples amd deteriorates them. How could they not think its anything but extremely painful?

[@praveenarao2582]

Thank you 👍

[@dropdeaddown69]

How are you at present? How you managed your RA? What kind of treatment you went through? Can you plz lemme know I would be grateful for that .

[@MadradiRudy]

Cupping therapy in your hand can help

[@CheriCheriLady95]

You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!!

[@MrZalada]

AHAHAHAH Pethana!!

[@CheriCheriLady95]

***** με ποιο πραγμα ακριβως?

[@CheriCheriLady95]

***** ποια συνωνυμια? :P

[@MrZalada]

Εχω μια συμφοιτητρια Elena KK κι ημουν σιγουρος οτι ηταν αυτη.

[@CheriCheriLady95]

***** ααα οκ

[@ammerrstf838]

I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview

[@Jonases_20]

Can u be my bf

[@lengde16]

You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :) And just as always, awesome work!

[@rittenbrake1613]

😂😂😂😂😂” please take care of yourself “

[@savankate7239]

Do anyone still doubt natural herbs? I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on surgery, injections and drugs each time they are sick. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, Cancer, hepatitis, etc. I've seen it with my own eyes. I was cured of Arthritis and my Sister and her Husband were cured of herpes by dr Osemuahu who uses natural herbs to cure different kind of illness. Even Dr. Osemuahu proved to the whole world that natural herbs can cure all diseases and he cured countless of people using natural herbs. I know is hard to believe but am a living testimony. There is no harm in trying herbs. Contact Dr Osemuahu(whatsap no): [phone] or email: [e-mail] Come and thank me later ✌️✌️

[@Melike-hi7qt]

how u doing now mate

[@majaber1]

" You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.

[@halimcremer]

thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.

[@aripnvm]

Same here l was searching about the pathogenesis in different books and in internet but yes i finally understand it after watching this video. Sry for my bad english

[@tastedpurple1492]

same! I dont have a biology background until undergraduate but this video is soooo well made and easy to understand

[@randayousif8887]

OMG 😮 I have an exam about RA tomorrow and your explanation helps me alot thank very much sir!

[@RenegadeRanga]

Awesome video which I will have to re watch numerous times.

[@tataxyz123]

From a patient stand point doctors should listen to their patients have compassion and BELIEVE them.

[@rickfearn3663]

Exceptional clarity. Images and words provide a clarity not possible with other pedagogies.

[@nadimsheikh]

I have never come across a better teacher all my life

[@saraturner1208]

Thanks for the information. I was diagnosed with RA 6 months ago and I have been trying to learn as much as I can. Unfortunately I’m not very educated so a lot of this went over my head, however, the diagrams did help!

[@_ahab2012]

-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation. - cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation. - Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion . - Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases. - When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands). - T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc. - They also help in expression of RankL that .....etc. - Plasma cells are responsible for inflammation too. Through cytokines and antibodies. - Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion. - Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation - Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint. - Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction. - Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..

[@growingsoul3028]

Highly appreciable 👍

[@royscott9370]

​@@growingsoul3028lie not true

[@BunnyNevermore]

u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!

[@Happy-healthy-holistic]

Allopathy can’t cure you. And overtime you will be made to depend on immune suppressants, then comes the complications of the medicine, then surgery and you will be ultimately exhausted of hospital visits! Start on traditional or alternative medicine, follow a healthy food and lifestyle. I was earlier diagnosed as having rheumatoid arthritis, SLE. Now, I got my RA test become negative with homoeopathy. Rheumatologist and an Orthopedician were completely surprised as according to allopathy, once RA factor becomes positive, it will remain so forever. I too was surprised and enquired the lab to recheck if there was some mistake, they gave the sample to another lab and I got the same negative result. I have been on homoeopathy for many years. Take care. I’m still on crutches but improving over time. Much better than 5 years back. And that pain which was there every second even at rest has turned out to be almost nil at rest... but still have it while moving and is tolerable. My movements were greatly restricted to the extent that someone should help to even turn around in bed but now I can do it myself and from past 1 month, though a little difficult I am able to get up myself and go to toilet with the crutches. I had severe digestion problems too that I always vomited some of what I ate every time but now... there is almost no vomiting but still have belches. Hoping to return to complete normalcy soon. I am not on any other medication. Wish you get well soon.

[@mrsamandabernier]

I think this might be my favourite video on KZbin, wow. Thanks.

[@belovedchaos1]

This makes a lot of sense... both from testing and symptoms to reasons for swelling. Much appreciated!

[@franciscacuffy7136]

You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always

[@lEmiliee]

First year medical school here ; You just saved my life. A M A Z I N G video and thank you soooo much :)

[@umaanand4864]

Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.

[@naziahaidar762]

How is life with RA?? How do you perform ur daily activities??

[@asmaagoda3925]

Excellent,simple illustration . Thank you

[@lvdigitalart883]

You have no idea how much this just helped me!! Thank you for this absolutely beautiful presentation.

[@shannonhendrix9520]

This disease is so hard to understand and explain. Thank you for the very detailed breakdown!

[@doctorkartk]

I missed ur lectures in 2006 ..that's when i joined med school..

[@enikofulop794]

I saw this video so many times. No it's much more clear.. Thank you. ❤🎉😊

[@MasinaTai86]

Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).

[@hianahs]

your lectures are life saving. thank you for your time!!

[@aayatprasad8111]

Be blessed sir!! We medicos owe you for providing such beautiful explanation n pics to memorize!! 😇

[@SaiwanMaerufSaiwanbio]

Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .

[@LatFlare]

Well-explained with beautiful, easy-to-understand illustrations. Thank you!

[@ViolinMD]

Great video Armando!!

[@hapilee5844]

I have RD and I thank you for a concise video that helped me understand my dis~ease😢

[@sarahrtseidel]

Amazing video and linking of the markers -> tissue -> symptoms!

[@1015SaturdayNight]

I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!

[@abdullahalimaykac4098]

You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video

[@basshardabboussi3496]

Awesome! He should put a picture of the final drawing to print :)

[@saramhussain]

Basshar Dabboussi he does for 15 dollars lol check his site

[@jerson4384]

Basshar Dabboussi amazing teaching skills!

[@DWNelson90]

For the record as a sufferer of RA, your joints will be in pain regardless of inflammation. My doctor seems to think there is no pain without inflammation.

[@nikolateslaize]

Exactly! And it is so hard to convince them. -But all your blood test seems normal arghhh :)

[@curious.soul.]

Living in the hell of pain and yet to be diagnosed but your comment scared this chicken even more. Thanks for the video.

[@DWNelson90]

@@curious.soul. my experience had doctors scratching their head for a year before they diagnosed me as sero-negative RA. They havent given me time to explain, they just run tests and have me leave with 4 prescriptions to medications that dont seem to work for me. Eventually I stopped seeing doctors lol.

[@DWNelson90]

@@curious.soul. best thing to do is keep moving. Move those joints because they're suppose to move. If its suppose to move and doesnt WD40 if it moves and its not suppose to Duct tape.

[@curious.soul.]

@@DWNelson90 As of now I'd be happy if I can make through the day independently. But point taken about the moving part once it gets a bit better. Thank you for your words. Hope you feel better soon.

[@promybari-hassan2982]

This video was seriously the best!! Everything was explained simply!

[@jakedejesa2173]

I was tasked to discuss the pathophysiology of RA and I couldn't understand a thing. This helped me to thoroughly understand it. Thanks, mate!

[@jingshen2165]

Very impressive and easy to understand the whole picture of Rheumatoid arthritis. Thanks!

[@saidgd8744]

Wow, just wow, thanks dude, you're awesome, you helped me so much for my med school work, greetings from Mexico

[@MrPrincebass99]

Clear and simple explanation of a complex disease. Well done!

[@lisahowland144]

wow what a superb vid! Easy to understand with great drawings. Much appreciated

[@IHaveMagicPowers]

This made so much more sense to me in the context of bringing together immune and inflammatory responses. Thank you!!

[@nowsheramedicalcollege9277]

Brilliant teacher wish you best of luck sir

[@stickom]

Spot on!!! Immunology simple, nice! (I would omit 5:46 fibroblast migration and extraarticular involvement basically everything pass 13:30)

[@pix_7l]

. . ഹൃദയത്തിൽ സ്പർശിക്കുന്ന ഈ ഇടയിൽ ഇറങ്ങിയ ചുരുക്കം ചില ഗാനങ്ങളിൽ ഒന്ന്, എന്തായാലും ഒരുപാടിഷ്ട്ടമായി.

[@احمدعبدالله-و7ح9ص]

what a wonderful explanation. thanks again from Yemen Aden.

[@ArthritisLife]

So so helpful, thank you for this detailed and visually appealing explanation!

[@hamzamuhammadgm4749]

Great sir .. I really like your explanation and way of teaching

[@armughanaymen3916]

you should scan your notes and upload them so that we can print them that would be so helpful

[@vinaypharmacist5838]

i don`t have any word to say about your way of delivery, content ,,,,,, but i would like to say awesome.... thanks a lot........ plz update more videos for helping us

[@muhaimenulislam389]

Please make a video on Juvenile Idiopathic Arthritis. It will be very helpful.

[@bditnfi9506]

you are the best (from Alegria)

[@vidyabijo6925]

best video!!!!!! concise precise, covering everything except treatment and lab inv... pls make a second video to cover those parts tooo

[@Abreutie]

Thank you very much ! I'm listening to you from France, I have understood all of the video, it was really clear thanks !

[@proffezur]

excellent, as usual

[@ChewdaGum21]

Zu Nobi

[@TransformChantel]

This is beautiful! I understand RA so much more better now. Thank you soooooooooo much!

[@donkeybenjamin]

Excellent!!! It is really a very clear presentation. THANKS VERY MUCH.

[@monakhalid6120]

Ur explaination is best est of all. After a lot of struggle I found it. 😍

[@marwamokhtar8469]

Thanks alot for this brilliant and concise presentation , It takes much effort and time .

[@7D7N7A7]

Thanks for making use of all of these great abilities in order to help people I think about the great efforts make to accomplish this organized smart work Please continue this great work

[@7D7N7A7]

Made*

[@desertfox8583]

Great video. Really helps me with my studies.

[@jujulepew]

wow thanks so much for this brilliant explanation of how RA is triggered and develops.

[@Azufer13792]

Thanks, the video is awesome (and even clearer than many medical textbooks)!

[@shkokurda2098]

dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.

[@sofianetamine3060]

fabulous explanation

[@miteshkapadiya8511]

Thanks a lot!

[@jordanbdailey]

your drawing skills are so good!

[@fei_studio_]

What a great informative video, thanks for sharing!

[@hanchybananchy]

Really great explanation and summary! Thanks :)

[@pastor.petertnagarajurehob700]

Exelant explanation very Good information for RA patients

[@divyaduggal5950]

Beautifully explained!!!

[@xxamulyaxx]

awesome..... it really helps me a lot... but please don't use yellow marker / pen in your videos ... thanks

[@nisuda]

you have made an extraordinary job describing RA. Now, what hope is there for those who suffer with this terrible disea?

[@yashvyas9979]

what a video... awesome sir great explanation..!!!! thank you..!!!!👌👌

[@KristopherWilliams_tahmson]

Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys May I ask what textbook you’re using for this information?

[@linkeongkimfunctionalfoodn2576]

Fantastic work and easily understood! Thanks a lot.

[@aathmikagovindh733]

Thanks a lot this will help me in my upcoming individual presentation

[@arfafiroz5332]

Superbbbbbbb...Thankssssss.. I have been avoiding its pathophysio. Since long...but uade this a cup of coffee fo mee.... Thnaks

[@sergiopina3485]

This is the best video ever! I love u

[@jessmfox]

Your videos are incredibly useful. Thank you so much :)

[@nigelutton3178]

absolutely wonderful as always - nice preparation for my exam this afternoon. Always a joy to watch these videos. So clear and informative.

[@soniaosei-anim9597]

The yellow marker is hard to read. Can you kindly use a more visible marker? You’re doing a great job though. Thank you

[@radhikasingh8535]

Simple and goodexplanation. What about the treatment? Pls help as I have started suffering from it.

[@gohiljayrajsinh-ju6pk]

Thanks for this video will helping to study . Thankyou so much

[@judithjara7584]

Excellent explanation as always!

[@peacedawn5719]

Thank you very much. From 🇩🇿

[@olivergood1999]

great video, thanks for the help!

[@Kim-ix6yv]

Excellent video, thank you so much

[@wonderjodocus]

This video has helped me a lot. Thanks

[@vibhamallikarjun]

You are just amazing!! Thank you so much for making it so easy!😊

[@ahasidic7172]

its been about a year almost since i first noticed a red little bump on my right hand... it rapidly got worse, finger to finger to finger, next hand finger to finger, leg to leg foot to foot wrist to wrist... im 20 and it sure does suck. big time, and i stupidly waited a decent amount of time before going to a rhumatologist. if thus methatrexate dont work i am toast. Never thought id be jelous of people being able to eat whatever they want and drink and smoke as much weed as they want. life changed let me tell you.

[@ishikawshalyab.a.d2768]

Thank you so much it is really helpful. I got lot of ideas from that video, for my review article.❤️❤️

[@ahmetcadrc5480]

Thanks for the work put in

[@kasunekneligoda2354]

This was just awesome! Great clip :)

[@dougdrago5401]

Way to go....! Super duper...now tell me about ankylosing spondylitis please!!

[@christianemelki9413]

what a champion!!! great video

[@songokutan]

Great video, your explanations are pretty nice!

[@pamparompa630]

thanks for all of the information. love your videos please make more

[@AhmadSmairat]

you are doing a great job. as usual, Thx a lot